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dc.contributor.authorGinhoux, Florent
dc.contributor.authorSchultze, Joachim L
dc.contributor.authorMurray, Peter J
dc.contributor.authorCano-Ochando, Jordi 
dc.contributor.authorBiswas, Subhra K
dc.date.accessioned2020-06-16T08:45:09Z
dc.date.available2020-06-16T08:45:09Z
dc.date.issued2016-01
dc.identifier.citationNat Immunol . 2016 Jan;17(1):34-40.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10454
dc.description.abstractMacrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed unknown aspects of their development and function. Following development, macrophages are activated by diverse signals. Such tissue microenvironmental signals together with epigenetic changes influence macrophage development, activation and functional diversity, with consequences in disease and homeostasis. We discuss here how recent discoveries in these areas have led to a multidimensional concept of macrophage ontogeny, activation and function. In connection with this, we also discuss how technical advances facilitate a new roadmap for the isolation and analysis of macrophages at high resolution.es_ES
dc.description.sponsorshipF.G. and S.K.B. are supported by core funding from the Singapore Immunology Network (A*STAR).es_ES
dc.language.isoenges_ES
dc.publisherNature Researches_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshMacrophages es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMacrophage Activation es_ES
dc.titleOCHANDO, JORDI New insights into the multidimensional concept of macrophage ontogeny, activation and function. POSTPRINTes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID26681460es_ES
dc.format.volume17es_ES
dc.format.number1es_ES
dc.format.page34-40es_ES
dc.identifier.doi10.1038/ni.3324es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1529-2916es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/ni.3324es_ES
dc.identifier.journalNature immunologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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