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dc.contributor.authorAroca-Crevillen, Alejandra 
dc.contributor.authorAdrover, Jose M 
dc.contributor.authorHidalgo, Andrés 
dc.date.accessioned2020-06-12T10:10:44Z
dc.date.available2020-06-12T10:10:44Z
dc.date.issued2020-04
dc.identifier.citationFront Immunol. 2020; 11:576es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10379
dc.description.abstractRhythms in immunity manifest in multiple ways, but perhaps most prominently by the recurrent onset of inflammation at specific times of day. These patterns are of importance to understand human disease and are caused, in many instances, by the action of neutrophils, a myeloid leukocyte with striking circadian features. The neutrophil's short life, marked diurnal variations in number, and changes in phenotype while in the circulation, help explain the temporal features of inflammatory disease but also uncover core features of neutrophil physiology. Here, we summarize well-established concepts and introduce recent discoveries in the biology of these cells as they relate to circadian rhythms. We highlight that although the circadian features of neutrophils are better known and relevant to understand disease, they may also influence important aspects of organ function even in the steady-state. Finally, we discuss the possibility of targeting these temporal features of neutrophils for therapeutic benefit.es_ES
dc.description.sponsorshipThe project that gave rise to these results received the support of a fellowship from la Caixa Foundation (ID 100010434), fellowship code for AA-C was LCF/BQ/DR19/11740022. JA was supported by fellowship BES-2013-065550 from Ministerio de Ciencia, Innovacion y Universidades (MCIU). This work was supported in part by grant RTI2018-095497-B-I00 from MCIU, HR17_00527 from La Caixa Foundation, and TNE-18CVD04 from the Leducq Foundation to AH. The CNIC was supported by the MCIU and the Pro-CNIC Foundation, and was a Severo Ochoa Center of Excellence (MCIU award SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers in Biosciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleCircadian Features of Neutrophil Biology.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID32346378es_ES
dc.format.volume11es_ES
dc.format.page576es_ES
dc.identifier.doi10.3389/fimmu.2020.00576es_ES
dc.contributor.funderFundación La Caixaes_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderLeducq Foundationes_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1664-3224es_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2020.00576es_ES
dc.identifier.journalFrontiers in immunologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BES-2013-065550es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RTI2018-095497-B-I00es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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