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dc.contributor.author | Flores, Juana M | |
dc.contributor.author | Blasco, MA | |
dc.contributor.author | Mulero, Francisca | |
dc.contributor.author | Martinez Rodriguez, Paula | |
dc.date.accessioned | 2020-06-09T16:34:38Z | |
dc.date.available | 2020-06-09T16:34:38Z | |
dc.date.issued | 2015-07-14 | |
dc.identifier.citation | Cell Rep. 2015;12(2):286-99. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/10312 | |
dc.description.abstract | Idiopathic pulmonary fibrosis (IPF) is a degenerative disease of the lungs with an average survival post-diagnosis of 2-3 years. New therapeutic targets and treatments are necessary. Mutations in components of the telomere-maintenance enzyme telomerase or in proteins important for telomere protection are found in both familial and sporadic IPF cases. However, the lack of mouse models that faithfully recapitulate the human disease has hampered new advances. Here, we generate two independent mouse models that develop IPF owing to either critically short telomeres (telomerase-deficient mice) or severe telomere dysfunction in the absence of telomere shortening (mice with Trf1 deletion in type II alveolar cells). We show that both mouse models develop pulmonary fibrosis through induction of telomere damage, thus providing proof of principle of the causal role of DNA damage stemming from dysfunctional telomeres in IPF development and identifying telomeres as promising targets for new treatments. | es_ES |
dc.description.sponsorship | Research in the Blasco lab is funded by the Spanish Ministry of Economy and Competitiveness Projects SAF2008-05384 and CSD2007-00017, the European Union FP7 Projects 2007-A-201630 (GENICA) and 2007-A-200950 (TELOMARKER), the European Research Council (ERC) Project TEL STEM CELL (GA#232854), the Korber Foundation, the AXA Research Fund, Fundacion Botin, and Fundacion Lilly (Spain). F.B. is ICREA Academia, Generalitat de Catalunya, Spain. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Cyclin-Dependent Kinase Inhibitor p21 | es_ES |
dc.subject.mesh | DNA Damage | es_ES |
dc.subject.mesh | DNA Repair | es_ES |
dc.subject.mesh | Disease Models, Animal | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Idiopathic Pulmonary Fibrosis | es_ES |
dc.subject.mesh | Lung | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Mice, Inbred C57BL | es_ES |
dc.subject.mesh | Mice, Knockout | es_ES |
dc.subject.mesh | Radiography | es_ES |
dc.subject.mesh | Tamoxifen | es_ES |
dc.subject.mesh | Telomerase | es_ES |
dc.subject.mesh | Telomere | es_ES |
dc.subject.mesh | Telomere Shortening | es_ES |
dc.subject.mesh | Telomeric Repeat Binding Protein 1 | es_ES |
dc.subject.mesh | Failure | es_ES |
dc.title | Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 26146081 | es_ES |
dc.format.volume | 12 | es_ES |
dc.format.number | 2 | es_ES |
dc.format.page | 286-99 | es_ES |
dc.identifier.doi | 10.1016/j.celrep.2015.06.028 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Unión Europea | |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | |
dc.contributor.funder | Korber Foundation | |
dc.contributor.funder | Fundación AXA | |
dc.contributor.funder | Botín Foundation | |
dc.contributor.funder | Fundación Lilly | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2211-1247 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.celrep.2015.06.028 | es_ES |
dc.identifier.journal | Cell reports | es_ES |
dc.repisalud.institucion | CNIO | es_ES |
dc.repisalud.orgCNIO | CNIO::Grupos de investigación::Grupo de Telómeros y Telomerasa | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/EC/FP7/201630 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/SAF2008-0538 | es_ES |
dc.rights.accessRights | open access | es_ES |