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dc.contributor.authorPorcuna, Jesús 
dc.contributor.authorMenéndez-Gutiérrez, María Piedad 
dc.contributor.authorRicote, Mercedes 
dc.date.accessioned2020-06-09T14:26:56Z
dc.date.available2020-06-09T14:26:56Z
dc.date.issued2020-05-08
dc.identifier.citationCurr Opin Pharmacol. 2020; 53:27-34es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10308
dc.description.abstractMacrophages are key immune cells that reside in almost all tissues of the body, where they exert pleiotropic functions in homeostasis and disease. Development and identity of macrophages in each organ are governed by tissue-dependent signaling pathways and transcription factors that ultimately define specific tissue-resident macrophage phenotypes and functions. In recent years, nuclear receptors, a class of ligand-activated transcription factors, have been found to play important roles in macrophage specification in several tissues. Nuclear receptors are thus important targets for therapies aimed at controlling the numbers and functions of tissue-resident macrophages. This review outlines current knowledge about the critical roles of nuclear receptors in tissue-resident macrophage development, specification, and maintenance.es_ES
dc.description.sponsorshipThis work was supported by grants from the Spanish Ministerio de Ciencia e Innovacion (MCI) (SAF2017-90604-REDT-NurCaMein, RTI2018-095928-BI00), La Marato de TV3 Foundation (201605-32), and the Comunidad de Madrid (MOIRB2017/BMD-3684) to M.R, and the Formacion de Profesorado Universitario (FPU17/01731) program (MCI) to J.P. The CNIC is supported by the MCI and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleMolecular control of tissue-resident macrophage identity by nuclear receptors.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID32403022es_ES
dc.format.volume53es_ES
dc.format.page27-34es_ES
dc.identifier.doi10.1016/j.coph.2020.04.001es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderFundació La Maratóes_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1471-4973es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.coph.2020.04.001es_ES
dc.identifier.journalCurrent opinion in pharmacologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Señalización de los Receptores Nucleareses_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2017-90604-REDT-NurCaMeines_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RTI2018-095928-BI00es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional