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dc.contributor.authorIbarra-Meneses, Ana Victoria 
dc.contributor.authorCarrillo, Eugenia 
dc.contributor.authorSánchez, C
dc.contributor.authorGarcía-Martínez, J
dc.contributor.authorLópez Lacomba, D
dc.contributor.authorSan Martín, Juan Víctor
dc.contributor.authorAlves, F
dc.contributor.authorAlvar, Jorge 
dc.contributor.authorMoreno, Javier 
dc.date.accessioned2020-06-08T07:39:07Z
dc.date.available2020-06-08T07:39:07Z
dc.date.issued2016-08
dc.identifier.citationClin Microbiol Infect . 2016 Aug;22(8):739.e1-4es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10287
dc.description.abstractNo field method exists for identifying asymptomatic individuals in areas where Leishmania infantum is endemic. This work reports that, 24 h after stimulating whole blood with soluble Leishmania antigen (SLA), plasma interferon-γ (IFN-γ) and interleukin-2 (IL-2) become significantly elevated in samples from asymptomatic individuals (n=47) compared with those from negative controls (n=50), all of them recruited from a blood bank. When compared with the reference test SLA-lymphoproliferative assay, IL-2 appears as a new, 100% sensitive and specific marker for asymptomatic individuals with a positive cellular response (compared with 100% and 84.78%, respectively, for IFN-γ). Further studies in other transmission areas and in other cohorts of exposed people need to be performed to confirm these results. Once validated, IFN-γ and IL-2 levels in SLA-stimulated whole blood could be reliably used in the field to estimate the prevalence of those asymptomatic individuals with Leishmania-specific cellular immune responses.es_ES
dc.description.sponsorshipWe gratefully acknowledge the financial support of the Drugs for Neglected Diseases Initiative (DNDi) by the Department for International Development (DFID) , UK and the Swiss Agency for Development and Cooperation (SDC) , Swizerland; and of the Instituto de Salud Carlos III via the Tropical Diseases Research Network ( RICET RD12/0018/ 0003 and RD12/0018/0008 ) (www.ricet.es) and via the ISCIII-AES project ‘ Impact of a leishmaniasis outbreak in the southwest of Madrid in the immunosuppressed population ’ ( PI13/00440 ). EC was supported by a research contract funded via VII PN I+D+I 2013-2016 and FEDER Funds ( RICET RD12/ 0018/0003 ).es_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionAMes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAsymptomatic Diseases es_ES
dc.subject.meshLeishmania infantum es_ES
dc.subject.meshAdult es_ES
dc.subject.meshBiomarkers es_ES
dc.subject.meshCytokines es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInterleukin-2 es_ES
dc.subject.meshLeishmaniasis, Visceral es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshYoung Adult es_ES
dc.titleInterleukin-2 as a marker for detecting asymptomatic individuals in areas where Leishmania infantum is endemic.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID27265372es_ES
dc.format.volume22es_ES
dc.format.number8es_ES
dc.format.page739.e1-4es_ES
dc.identifier.doi10.1016/j.cmi.2016.05.021es_ES
dc.contributor.funderDepartment for International Development (Reino Unido) 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderRETICS-Investigación colaborativa en Enfermedades Tropicales (RICET-ISCIII) (España) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1469-0691es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.cmi.2016.05.021es_ES
dc.identifier.journalClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseaseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RICET RD12/0018/ 0003es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD12/0018/0008es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI13/00440es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RICET RD12/ 0018/0003es_ES
dc.rights.accessRightsopen accesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional