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dc.contributor.author | Moreno, Santiago | |
dc.contributor.author | Rubio, Rafael | |
dc.contributor.author | Viciana, Pompeyo | |
dc.contributor.author | Bernardino, Jose Ignacio | |
dc.contributor.author | Blanco, José Ramón | |
dc.contributor.author | Bernal, Enrique | |
dc.contributor.author | Asensi, Víctor | |
dc.contributor.author | Pulido, Federico | |
dc.contributor.author | Amo, Julia del | |
dc.contributor.author | Hernando Sebastian, Victoria | |
dc.contributor.author | Sobrino-Vegas, Paz | |
dc.date.accessioned | 2020-06-05T07:15:15Z | |
dc.date.available | 2020-06-05T07:15:15Z | |
dc.date.issued | 2016-05 | |
dc.identifier.citation | J Infect . 2016 May;72(5):587-96. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/10280 | |
dc.description.abstract | To analyze the impact of late presentation (LP) on overall mortality and causes of death and describe LP trends and risk factors (2004-2013). Cox models and logistic regression were used to analyze data from a nation-wide cohort in Spain. LP is defined as being diagnosed when CD4 < 350 cells/ml or AIDS. Of 7165 new HIV diagnoses, 46.9% (CI95%:45.7-48.0) were LP, 240 patients died. First-year mortality was the highest (aHRLP.vs.nLP = 10.3[CI95%:5.5-19.3]); between 1 and 4 years post-diagnosis, aHRLP.vs.nLP = 1.9(1.2-3.0); and >4 years, aHRLP.vs.nLP = 1.5(0.7-3.1). First-year's main cause of death was HIV/AIDS (73%); and malignancies among those surviving >4 years (32%). HIV/AIDS-related deaths were more likely in LP (59.2% vs. 25.0%; p < 0.001). LP declined from 55.9% (2004-05) to 39.4% (2012-13), and reduced in 46.1% in men who have sex with men (MSM) and 37.6% in heterosexual men, but increased in 22.6% in heterosexual women. Factors associated with LP: sex (ORMEN.vs.WOMEN = 1.4[1.2-1.7]); age (OR31-40.vs.<30 = 1.6[1.4-1.8], OR41-50.vs.<30 = 2.2[1.8-2.6], OR>50.vs.<30 = 3.6[2.9-4.4]); behavior (ORInjectedDrugUse.vs.MSM = 2.8[2.0-3.8]; ORHeterosexual.vs.MSM = 2.2[1.7-3.0]); education (ORPrimaryEducation.vs.University = 1.5[1.1-2.0], ORLowerSecondary.vs.University = 1.3[1.1-1.5]); and geographical origin (ORSub-Saharan.vs.Spain = 1.6[1.3-2.0], ORLatin-American.vs.Spain = 1.4[1.2-1.8]). LP is associated with higher mortality, especially short-term- and HIV/AIDS-related mortality. Mid-term-, but not long-term mortality, remained also higher in LP than nLP. LP decreased in MSM and heterosexual men, not in heterosexual women. The groups most affected by LP are low educated, non-Spanish and heterosexual women. | es_ES |
dc.description.sponsorship | This work has been partially funded by the RD12/0017/0018 project as part of the Plan Nacional R + D + I and co-financed by ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER) . | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Cause of Death | es_ES |
dc.subject.mesh | Delayed Diagnosis | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Aged | es_ES |
dc.subject.mesh | Cohort Studies | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | HIV Infections | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.subject.mesh | Survival Analysis | es_ES |
dc.title | Impact of late presentation of HIV infection on short-, mid- and long-term mortality and causes of death in a multicenter national cohort: 2004-2013. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 26920789 | es_ES |
dc.format.volume | 72 | es_ES |
dc.format.number | 5 | es_ES |
dc.format.page | 587-96 | es_ES |
dc.identifier.doi | 10.1016/j.jinf.2016.01.017 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1532-2742 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.jinf.2016.01.017 | es_ES |
dc.identifier.journal | The Journal of infection | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/RD12/0017/0018 | es_ES |
dc.rights.accessRights | open access | es_ES |