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dc.contributor.authorMartínez-Martín, Pablo 
dc.contributor.authorMacaulay, Dendy
dc.contributor.authorJalundhwala, Yash J
dc.contributor.authorMu, Fan
dc.contributor.authorOhashi, Erika
dc.contributor.authorMarshall, Thomas
dc.contributor.authorSail, Kavita
dc.date.accessioned2020-06-02T07:57:28Z
dc.date.available2020-06-02T07:57:28Z
dc.date.issued2019
dc.identifier.citationMov Disord . 2019 Feb;34(2):236-245es_ES
dc.identifier.issn0885-3185es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10248
dc.description.abstractParkinson's disease is a progressive, disabling neurodegenerative disorder associated with significant economic burden for patients and caregivers. The objective of this study was to compare the direct and indirect economic burden of Parkinson's patients' caregivers with demographically matched controls in the United States, in the 5 years after first diagnosis of Parkinson's disease. Policyholders (18-64 years old) linked to a Parkinson's disease patient (≥2 diagnoses of Parkinson's disease; first diagnosis is the index date) from January 1, 1998 to March 31, 2014, were selected from a private-insurer claims database and categorized as Parkinson's caregivers. Eligible Parkinson's caregivers were matched 1:5 to policyholders with a non-Parkinson's dependent (controls). Multivariable regression adjusted for baseline characteristics estimated direct costs (all-cause insurer cost [medical and prescription] and comorbidity-related medical costs; patient out-of-pocket costs) and indirect costs (disability and medically related absenteeism costs). Income progression was also compared between cohorts. A total of 1211 eligible Parkinson's caregivers (mean age, 56 years; 54% female) were matched to 6055 controls. In adjusted analyses, Parkinson's caregivers incurred significantly higher year 1 total all-cause insurer costs ($8999 vs $7117) and medical costs ($7081 vs $5568) (both P < 0.01) and higher prescription costs (range for years 1-5, $2506-2573 vs $1405-$1687) and total out-of-pocket costs ($1259-1585 vs $902-$1192) in years 1-5 (all P < 0.01). Parkinson's caregivers had significantly higher adjusted indirect costs in years 1-3 (range for years 1-3, $2054-$2464 vs $1681-$1857; all P < 0.05) and higher cumulative income loss over 5 years ($5967 vs $2634 by year 5; P for interaction = 0.03). Parkinson's caregivers exhibited higher direct and indirect costs and greater income loss compared with matched controls. © 2018 International Parkinson and Movement Disorder Society © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.es_ES
dc.description.sponsorshipThis study and manuscript were funded by AbbVie. The design, study conduct, and financial support for the study were provided by AbbVie. AbbVie participated in the study design, research, interpretation of data, writ- ing, reviewing, and approving the manuscript.es_ES
dc.language.isoenges_ES
dc.publisherWiley es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshCost of Illness es_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshAdult es_ES
dc.subject.meshCaregivers es_ES
dc.subject.meshComorbidity es_ES
dc.subject.meshDisabled Persons es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshParkinson Disease es_ES
dc.subject.meshTime Factors es_ES
dc.subject.meshUnited States es_ES
dc.subject.meshYoung Adult es_ES
dc.titleThe long-term direct and indirect economic burden among Parkinson's disease caregivers in the United States.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID30589953es_ES
dc.format.volume34es_ES
dc.format.number2es_ES
dc.format.page236-245es_ES
dc.identifier.doi10.1002/mds.27579es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1531-8257es_ES
dc.relation.publisherversionhttps://doi.org/10.1002/mds.27579es_ES
dc.identifier.journalMovement disorders : official journal of the Movement Disorder Societyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional