Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/10151
Vaccine effectiveness in preventing laboratory-confirmed influenza in primary care patients in a season of co-circulation of influenza A(H1N1)pdm09, B and drifted A(H3N2), I-MOVE Multicentre Case-Control Study, Europe 2014/15
Valenciano, Marta | Kissling, Esther | Reuss, Annicka | Rizzo, Caterina | Gherasim, Alin ISCIII | Horváth, Judit Krisztina | Domegan, Lisa | Pitigoi, Daniela | Machado, Ausenda | Paradowska-Stankiewicz, Iwona Anna | Bella, Antonino | Larrauri, Amparo ISCIII | Ferenczi, Annamária | Lazar, Mihaela | Pechirra, Pedro | Korczyńska, Monika Roberta | Pozo, Francisco ISCIII | Moren, Alain
Euro Surveill. 2016;21(7):pii=30139.
Influenza A(H3N2), A(H1N1)pdm09 and B viruses co-circulated in Europe in 2014/15. We undertook a multicentre case-control study in eight European countries to measure 2014/15 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed all or a systematic sample of ILI patients. We compared the odds of vaccination of ILI influenza positive patients to negative patients. We calculated adjusted VE by influenza type/subtype, and age group. Among 6,579 ILI patients included, 1,828 were A(H3N2), 539 A(H1N1)pdm09 and 1,038 B. VE against A(H3N2) was 14.4% (95% confidence interval (CI): -6.3 to 31.0) overall, 20.7% (95%CI: -22.3 to 48.5), 10.9% (95%CI -30.8 to 39.3) and 15.8% (95% CI: -20.2 to 41.0) among those aged 0-14, 15-59 and ≥60 years, respectively. VE against A(H1N1)pdm09 was 54.2% (95%CI: 31.2 to 69.6) overall, 73.1% (95%CI: 39.6 to 88.1), 59.7% (95%CI: 10.9 to 81.8), and 22.4% (95%CI: -44.4 to 58.4) among those aged 0-14, 15-59 and ≥60 years respectively. VE against B was 48.0% (95%CI: 28.9 to 61.9) overall, 62.1% (95%CI: 14.9 to 83.1), 41.4% (95%CI: 6.2 to 63.4) and 50.4% (95%CI: 14.6 to 71.2) among those aged 0-14, 15-59 and ≥60 years respectively. VE against A(H1N1)pdm09 and B was moderate. The low VE against A(H3N2) is consistent with the reported mismatch between circulating and vaccine strains.
influenza | influenza vaccine effectiveness | multicentre case-control study | vaccines and immunisation
Adolescent | Adult | Aged | Case-Control Studies | Child | Child, Preschool | Europe | European Union | Female | Humans | Infant | Infant, Newborn | Influenza A Virus, H1N1 Subtype | Influenza A Virus, H3N2 Subtype | Influenza B virus | Influenza Vaccines | Influenza, Human | Laboratories | Male | Middle Aged | Population Surveillance | Primary Health Care | Seasons | Sensitivity and Specificity | Vaccination | Young Adult | Outcome Assessment, Health Care | Vaccine Potency
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