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dc.contributor.authorCastaño, Argelia 
dc.contributor.authorCutanda, Francisco
dc.contributor.authorEsteban-Lopez, Marta 
dc.contributor.authorPärt, Peter
dc.contributor.authorNavarro Rivas, Carmen 
dc.contributor.authorGomez Perez, Silvia 
dc.contributor.authorRosado, Montserrat
dc.contributor.authorLopez-Herranz, Ana 
dc.contributor.authorLopez-Martin, Estrella 
dc.contributor.authorExley, Karen
dc.contributor.authorSchindler, Birgit K
dc.contributor.authorGovarts, Eva
dc.contributor.authorCasteleyn, Ludwine
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorFiddicke, Ulrike
dc.contributor.authorKoch, Holger M
dc.contributor.authorAngerer, Jürgen
dc.contributor.authorDen Hond, Elly
dc.contributor.authorSchoeters, Greet
dc.contributor.authorSepai, Ovnair
dc.contributor.authorHorvat, Milena
dc.contributor.authorKnudsen, Lisbeth E
dc.contributor.authorAerts, Dominique
dc.contributor.authorJoas, Anke
dc.contributor.authorBiot, Pierre
dc.contributor.authorJoas, Reinhard
dc.contributor.authorJiménez-Guerrero, José A
dc.contributor.authorDiaz-Lopez, Gema 
dc.contributor.authorPirard, Catherine
dc.contributor.authorKatsonouri, Andromachi
dc.contributor.authorCerna, Milena
dc.contributor.authorGutleb, Arno C
dc.contributor.authorLigocka, Danuta
dc.contributor.authorReis, Fátima M
dc.contributor.authorBerglund, Marika
dc.contributor.authorLupsa, Ioana-Rodica
dc.contributor.authorHalzlová, Katarína
dc.contributor.authorCharlier, Corinne
dc.contributor.authorCullen, Elizabeth
dc.contributor.authorHadjipanayis, Adamos
dc.contributor.authorKrskova, Andrea
dc.contributor.authorJensen, Janne F
dc.contributor.authorNielsen, Jeanette K
dc.contributor.authorSchwedler, Gerda
dc.contributor.authorWilhelm, Michael
dc.contributor.authorRudnai, Peter
dc.contributor.authorKözépesy, Szilvia
dc.contributor.authorDavidson, Fred
dc.contributor.authorFischer, Mark E
dc.contributor.authorJanasik, Beata
dc.contributor.authorNamorado, Sónia
dc.contributor.authorGurzau, Anca E
dc.contributor.authorJajcaj, Michal
dc.contributor.authorMazej, Darja
dc.contributor.authorTratnik, Janja Snoj
dc.contributor.authorLarsson, Kristin
dc.contributor.authorLehmann, Andrea
dc.contributor.authorCrettaz, Pierre
dc.contributor.authorLavranos, Giagkos
dc.contributor.authorPosada De la Paz, Manuel
dc.identifier.citationEnviron Res. 2015 Aug;141:58-68.es_ES
dc.description.abstractThe toxicity of methylmercury (MeHg) in humans is well established and the main source of exposure is via the consumption of large marine fish and mammals. Of particular concern are the potential neurodevelopmental effects of early life exposure to low-levels of MeHg. Therefore, it is important that pregnant women, children and women of childbearing age are, as far as possible, protected from MeHg exposure. Within the European project DEMOCOPHES, we have analyzed mercury (Hg) in hair in 1799 mother-child pairs from 17 European countries using a strictly harmonized protocol for mercury analysis. Parallel, harmonized questionnaires on dietary habits provided information on consumption patterns of fish and marine products. After hierarchical cluster analysis of consumption habits of the mother-child pairs, the DEMOCOPHES cohort can be classified into two branches of approximately similar size: one with high fish consumption (H) and another with low consumption (L). All countries have representatives in both branches, but Belgium, Denmark, Spain, Portugal and Sweden have twice as many or more mother-child pairs in H than in L. For Switzerland, Czech Republic, Hungary, Poland, Romania, Slovenia and Slovakia the situation is the opposite, with more representatives in L than H. There is a strong correlation (r=0.72) in hair mercury concentration between the mother and child in the same family, which indicates that they have a similar exposure situation. The clustering of mother-child pairs on basis of their fish consumption revealed some interesting patterns. One is that for the same sea fish consumption, other food items of marine origin, like seafood products or shellfish, contribute significantly to the mercury levels in hair. We conclude that additional studies are needed to assess and quantify exposure to mercury from seafood products, in particular. The cluster analysis also showed that 95% of mothers who consume once per week fish only, and no other marine products, have mercury levels 0.55 μg/g. Thus, the 95th percentile of the distribution in this group is only around half the US-EPA recommended threshold of 1 μg/g mercury in hair. Consumption of freshwater fish played a minor role in contributing to mercury exposure in the studied cohort. The DEMOCOPHES data shows that there are significant differences in MeHg exposure across the EU and that exposure is highly correlated with consumption of fish and marine products. Fish and marine products are key components of a healthy human diet and are important both traditionally and culturally in many parts of Europe. Therefore, the communication of the potential risks of mercury exposure needs to be carefully balanced to take into account traditional and cultural values as well as the potential health benefits from fish consumption. European harmonized human biomonitoring programs provide an additional dimension to national HMB programs and can assist national authorities to tailor mitigation and adaptation strategies (dietary advice, risk communication, etc.) to their country's specific requirements.es_ES
dc.description.sponsorshipThe DEMOCOPHES Project (LIFE09 ENV/BE/000410) is jointlyfunded by the European Commission programme LIFEþ(50%),with the remaining 50% being provided by the participatingcountries (see the national implementation websites accessible via The CO-PHES Project that provided the operational and scientific frame-work was funded by the European Commission Seventh Frame-work Programme-DG Research (Grant agreement no. This work would not have been possiblewithout the additional funding from the Spanish Ministry ofAgriculture, Food and Environment (MAGRAMA) and The Instituteof Health Carlos III (ISCIII) Agreement, SEG 1112/10es_ES
dc.publisherElsevier es_ES
dc.subjectHuman Biomonitoringes_ES
dc.subjectMercury in haires_ES
dc.subjectSea fishes_ES
dc.subjectSeafood productses_ES
dc.subject.meshAdult es_ES
dc.subject.meshChild es_ES
dc.subject.meshData Interpretation, Statistical es_ES
dc.subject.meshEnvironmental Monitoring es_ES
dc.subject.meshEurope es_ES
dc.subject.meshFeasibility Studies es_ES
dc.subject.meshFemale es_ES
dc.subject.meshFood Contamination es_ES
dc.subject.meshHair es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMethylmercury Compounds es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshMothers es_ES
dc.subject.meshPilot Projects es_ES
dc.subject.meshRural Population es_ES
dc.subject.meshSurveys and Questionnaires es_ES
dc.subject.meshSuburban Population es_ES
dc.subject.meshWater Pollutants, Chemical es_ES
dc.subject.meshFood Preferences es_ES
dc.subject.meshSeafood es_ES
dc.titleFish consumption patterns and hair mercury levels in children and their mothers in 17 EU countrieses_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.contributor.funderUnión Europea. Comisión Europea es_ES
dc.contributor.funderUnión Europea. Comisión Europea. 7 Programa Marco es_ES
dc.contributor.funderMinisterio de Agricultura, Alimentación y Medio Ambiente (España) es_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.identifier.journalEnvironmental researches_ES
dc.repisalud.centroISCIII::Instituto de Investigación de Enfermedades Rarases_ES
dc.repisalud.centroISCIII::Centro Nacional de Sanidad Ambientales_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/SEG 1112/10es_ES
dc.rights.accessRightsopen accesses_ES

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional