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dc.contributor.authorGarcia-Alvarez, Monica 
dc.contributor.authorPineda-Tenor, Daniel 
dc.contributor.authorJimenez-Sousa, Maria Angeles 
dc.contributor.authorFernandez-Rodriguez, Amanda 
dc.contributor.authorGuzmán-Fulgencio, María 
dc.contributor.authorResino, Salvador 
dc.date.accessioned2020-05-12T08:49:14Z
dc.date.available2020-05-12T08:49:14Z
dc.date.issued2014-11
dc.identifier.citationHepatology. 2014 Nov;60(5):1541-50.es_ES
dc.identifier.issn0270-9139es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10052
dc.description.abstractUNLABELLED: There is growing evidence that vitamin D is related to chronic hepatitis C (CHC) pathogenicity. We analyzed the relationship of vitamin D status with advanced liver fibrosis (ALF) in CHC treatment-naïve patients and sustained virologic response (SVR) in CHC patients on pegylated interferon alpha plus ribavirin (pegIFNα/ribavirin) therapy. We performed a meta-analysis of all eligible studies published to date (April, 2014) in PubMed, SCOPUS, LILACS, and the Cochrane Library, assessing plasma/serum vitamin D levels related to ALF and/or SVR. Pooled odds ratios (ORs) were estimated by either fixed or random effects models. Fourteen studies were selected from the literature search, seven for ALF (1,083 patients) and 11 for SVR (2,672 patients). For liver fibrosis, low vitamin D status was related to a diagnosis of ALF, with the cutoffs of 10 ng/mL (OR=2.37, 95% confidence interval [CI]=1.20, 4.72) and 30 ng/mL (OR=2.22, 95% CI=1.24, 3.97) being significant, and a near-significance for 20 ng/mL (OR=1.44, 95% CI=0.99, 2.12). Regarding SVR, a significant heterogeneity among studies was found (P<0.001), and we only found a significant association with SVR for a vitamin D cutoff of 20 ng/mL (OR=0.53, 95% CI=0.31, 0.91). When meta-analysis was performed excluding the outliers, significant pooled ORs were found for all patients (10 ng/mL [OR=0.48, 95% CI=0.34, 0.67] and 20 ng/mL [OR=0.58, 95% CI=0.45, 0.76]) and GT1/4 patients (10 ng/mL [OR=0.53, 95% CI=0.34, 0.81] and 20 ng/mL [OR=0.54, 95% CI=0.39, 0.74]). CONCLUSION: Low vitamin D status in CHC patients is associated with a higher likelihood of having ALF and lower odds of achieving SVR following pegIFNα/ribavirin therapy.es_ES
dc.description.sponsorshipSupported by grants from Fondo de Investigación de Sanidad en España (FIS) [Spanish Health Founds for Research], grant number PI11/00245 ; and Red Espaola de Investigación en SIDA (RIS) [AIDS Research Network] grant number RD12/0017/0024; D.P.T., M.G.F., M.A.J.S., and M.G.A. are supported by “ Instituto de Salud Carlos III,” grant numbers CM12/00043, RD12/0017/0024, CD13/0001 and CD12/00442, respectively.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAntiviral Agents es_ES
dc.subject.meshHepatitis C, Chronic es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLiver Cirrhosis es_ES
dc.subject.meshVitamin D es_ES
dc.titleRelationship of vitamin D status with advanced liver fibrosis and response to hepatitis C virus therapy: a meta-analysises_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID24975775es_ES
dc.format.volume60es_ES
dc.format.number5es_ES
dc.format.page1541-50es_ES
dc.identifier.doi10.1002/hep.27281es_ES
dc.contributor.funderFondo de Investigaciones Sanitariases_ES
dc.contributor.funderRed Temática Cooperativa de Investigación en Sida (España)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.identifier.e-issn1527-3350es_ES
dc.relation.publisherversionhttps://doi.org/10.1002/hep.27281es_ES
dc.identifier.journalHepatology (Baltimore, Md.)es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI11/00245es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CM12/00043,es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD12/0017/0024es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CD13/0001es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CD12/00442es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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