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dc.contributor.author | Medrano, Luz Maria | |
dc.contributor.author | Garcia-Broncano, Pilar | |
dc.contributor.author | Berenguer, Juan | |
dc.contributor.author | González-García, Juan | |
dc.contributor.author | Jimenez-Sousa, Maria Angeles | |
dc.contributor.author | Guardiola, Josep M | |
dc.contributor.author | Crespo, Manuel | |
dc.contributor.author | Quereda, Carmen | |
dc.contributor.author | Sanz, José | |
dc.contributor.author | Canorea, Isabel | |
dc.contributor.author | Carrero, Ana | |
dc.contributor.author | Hontañón, Victor | |
dc.contributor.author | Muñoz-Fernández, Ma Ángeles | |
dc.contributor.author | Resino, Salvador | |
dc.date.accessioned | 2020-05-12T08:46:28Z | |
dc.date.available | 2020-05-12T08:46:28Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | AIDS. 2018 Jun 1;32(9):1095-1105 | es_ES |
dc.identifier.issn | 0269-9370 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/10051 | |
dc.description.abstract | OBJECTIVES: Immune dysregulation is a hallmark of HIV and hepatitis C virus (HCV) infections. We aimed to evaluate the relationship between liver stiffness measurement (LSM) and biomarkers of T-cell activation, bacterial translocation, inflammation, endothelial dysfunction, and coagulopathy in HIV/HCV-coinfected patients. DESIGN: Cross-sectional study. METHODS: We studied 238 HIV/HCV-coinfected patients, 32 healthy controls, and 39 HIV-monoinfected patients. Patients were stratified according to LSM into four groups: less than 12.5, 12.5-25, 25-40, and more than 40 kPa. T-cell subsets were measured using flow cytometry and plasma biomarkers using immunoassays. RESULTS: HIV/HCV-coinfected patients had higher biomarker levels of immune activation in peripheral blood [T-cell activation (CD4CD38 and CD8CD38), bacterial translocation (soluble CD14), inflammation [IL-1b, IL-6, IL-8, IL-18, IFN-γ-inducible protein 10 (IP-10)] endothelial dysfunction [soluble vascular cell adhesion molecule 1 (sVCAM1), soluble intercellular cell adhesion molecule 1 (sICAM1), and soluble tumor necrosis factor receptor 1 (sTNFR1)], and coagulopathy (plasminogen activator inhibitor-1)] than healthy controls and HIV-monoinfected patients. Moreover, in HIV/HCV-coinfected patients, a direct relationship between LSM and immune activation [T-cell activation (CD8CD38 bacterial translocation (lipopolysaccharide), inflammation (IL-8, IP-10), endothelial dysfunction (sVCAM1, sICAM1, and sTNFR1), and coagulopathy (D-dimer)] was found. Subsequently, patients were stratified into different fibrosis stages, finding that patients with cirrhosis who had LSM at least 40 kPa showed higher biomarker values of immune activation [T-cell activation (CD4CD38 and CD8CD38), bacterial translocation (lipopolysaccharide), inflammation (IL-8, IL-6, IP-10), endothelial dysfunction (sVCAM1, sICAM1, and sTNFR1), and coagulopathy (D-dimer)] than patients from the other three groups (<12.5, 12.5-25, and 25-40 kPa). CONCLUSION: T-cell activation, bacterial translocation, inflammation, endothelial dysfunction, and coagulopathy increased with the severity of liver fibrosis in HIV/HCV-coinfected patients, particularly in patients who had LSM at least 40 kPa. | es_ES |
dc.description.sponsorship | We want to particularly acknowledge the patients in this study for their participation and to the Spanish HIV HGM BioBank integrated in the Spanish AIDS Research Network (RIS) and collaborating Centers for the generous gifts of clinical samples used in this work. The HIV BioBank, integrated in the Spanish AIDS Research Network, is supported by the Institute of Health Carlos III, ISCIII, Spanish Health Ministry (grant no. RD06/0006/0035 and RD12/0017/0037) as part of the State Plan for Scientific and Technical Research and Innovation and cofinanced by ISCIII-Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund (ERDF) and Foundation for Research and Prevention of AIDS in Spain (FIPSE). This study would not have been possible without the collaboration of all the patients, medical and nursing staff and data managers who have taken part in the project [The GESIDA 3603b Cohort Study Group (Supporting document), which show all collaborators]. The RIS Cohort (CoRIS) is funded by the ISCIII through the Spanish AIDS Research Network (RIS C03/173 and RD12/0017/0018) as part of the State Plan for Scientific and Technical Research and Innovation and cofinanced by ISCIII-Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund (ERDF). The current study was supported by grants from Instituto de Salud Carlos III (ISCII; grant numbers PI14/01094 and PI14CIII/00011) and Ministerio de Sanidad, Servicios Sociales. e Igualdad (grant number EC11–241). The study was also funded by the RD16CIII/0002/0002 and RD16/0025/0017 projects as part of the Plan Nacional R + D + I and cofunded by ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER). J.B. is an investigator from the Programa de Intensificación de la Actividad Investigadora en el Sistema Nacional de Salud (I3SNS), Refs INT15/00079 and INT16/00100. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott Williams & Wilkins (LWW) | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject.mesh | Bacterial Translocation | es_ES |
dc.subject.mesh | Biomarkers | es_ES |
dc.subject.mesh | Coinfection | es_ES |
dc.subject.mesh | Cross-Sectional Studies | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Flow Cytometry | es_ES |
dc.subject.mesh | HIV Infections | es_ES |
dc.subject.mesh | Hepatitis C, Chronic | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Inflammation | es_ES |
dc.subject.mesh | Liver | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Severity of Illness Index | es_ES |
dc.subject.mesh | Lymphocyte Activation | es_ES |
dc.title | Elevated liver stiffness is linked to increased biomarkers of inflammation and immune activation in HIV/hepatitis C virus-coinfected patients | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 29438197 | es_ES |
dc.format.volume | 32 | es_ES |
dc.format.number | 9 | es_ES |
dc.format.page | 1095-1105 | es_ES |
dc.identifier.doi | 10.1097/QAD.0000000000001787 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Fundación para la Investigación y la Prevención del Sida en España | |
dc.identifier.e-issn | 1473-5571 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1097/QAD.0000000000001787 | es_ES |
dc.identifier.journal | AIDS (London, England) | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/RD06/0006/0035 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/RD12/0017/0037 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/RIS C03/173 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/RD12/0017/0018 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PI14/01094 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PI14CIII/00011 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/RD16CIII/0002/0002 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/RD16/0025/0017 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/INT15/00079 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/INT16/00100 | es_ES |
dc.rights.accessRights | open access | es_ES |