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A cancer-associated point mutation disables the steric gate of human PrimPol
A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells
A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers
A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate.
A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants.
A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance
A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors
A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways.
A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancer
A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions
A mutation in the POT1 gene is responsible for cardiac angiosarcoma in
TP53-negative Li-Fraumeni-like families
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer
A Novel Approach for the Identification of Pharmacogenetic Variants in MT-RNR1 through Next-Generation Sequencing Off-Target Data.
A novel community driven software for functional enrichment analysis of extracellular vesicles data
A novel deep targeted sequencing method for minimal residual disease monitoring in acute myeloid leukemia
A novel nano-immunoassay method for quantification of proteins from CD138-purified myeloma cells: biological and clinical utility
A novel targeted RNA-Seq panel identifies a subset of adult patients with acute lymphoblastic leukemia with BCR-ABL1-like characteristics.
A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma