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Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice.
Functional reprogramming of polyploidization in megakaryocytes.
Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma.
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.
Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth
Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis
The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras
Uncoupling fork speed and origin activity to identify the primary cause of replicative stress phenotypes