Browsing by Keyword "HIV-1 genetic diversity"
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Publication Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain.(Multidisciplinary Digital Publishing Institute (MDPI), 2021-01-12) Cañada-Garcia, Javier Enrique; Delgado, Elena; Gil, Horacio; Sanchez-Martinez, Monica; Benito, Sonia; Garcia-Bodas, Elena; Gómez-González, Carmen; Canut-Blasco, Andrés; Portu-Zapirain, Joseba; Sáez de Adana, Ester; De la Peña, Mireia; Ibarra, Sofía; Cilla, Gustavo; Iribarren, José Antonio; Martínez-Sapiña, Ana; Thomson, Michael M; Instituto de Salud Carlos III; Red de Investigación Cooperativa en Investigación en Sida (España); Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF); Basque Government (España); Comunidad de Madrid (España)The extraordinary genetic variability of human immunodeficiency virus type 1 (HIV-1) group M has led to the identification of 10 subtypes, 102 circulating recombinant forms (CRFs) and numerous unique recombinant forms. Among CRFs, 11 derived from subtypes B and C have been identified in China, Brazil, and Italy. Here we identify a new HIV-1 CRF_BC in Northern Spain. Originally, a phylogenetic cluster of 15 viruses of subtype C in protease-reverse transcriptase was identified in an HIV-1 molecular surveillance study in Spain, most of them from individuals from the Basque Country and heterosexually transmitted. Analyses of near full-length genome sequences from six viruses from three cities revealed that they were BC recombinant with coincident mosaic structures different from known CRFs. This allowed the definition of a new HIV-1 CRF designated CRF108_BC, whose genome is predominantly of subtype C, with four short subtype B fragments. Phylogenetic analyses with database sequences supported a Brazilian ancestry of the parental subtype C strain. Coalescent Bayesian analyses estimated the most recent common ancestor of CRF108_BC in the city of Vitoria, Basque Country, around 2000. CRF108_BC is the first CRF_BC identified in Spain and the second in Europe, after CRF60_BC, both phylogenetically related to Brazilian subtype C strains.