Browsing by Keyword "Coronavirus disease-2019"
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Publication Cardiometabolic Therapy and Mortality in Very Old Patients With Diabetes Hospitalized due to COVID-19(2021) Ramos Rincón, José Manuel; Pérez-Belmonte, Luis M.; Carrasco-Sánchez, Francisco Javier; Jansen-Chaparro, Sergio; De-Sousa-Baena, Mercedes; Bueno-Fonseca, José; Pérez-Aguilar, Maria; Arévalo-Cañas, Coral; Bacete Cebrian, Marta; Méndez Bailón, Manuel; Fiteni Mera, Isabel; González García, Andrés; Navarro Romero, Francisco; Tuñón de Almeida, Carlota; Muñiz Nicolás, Gemma; Gonzáez Noya, Amara; Hernández Milian, Almudena; García-García, Gema-María; Alcalá-Pedrajas, José-Nicolás; Herrero García, Virginia; Corral-Gudino, Luis; Comas Casanova, Pere; Meijide Mírguez, Héctor; Casas Rojo, José Manuel; Gómez Huelgas, Ricardo; SEMI-COVID-19 NetworkBackground: The effects of cardiometabolic drugs on the prognosis of diabetic patients with COVID-19, especially very old patients, are not well known. This work was aimed to analyze the association between preadmission cardiometabolic therapy (antidiabetic, antiaggregant, antihypertensive, and lipid-lowering drugs) and in-hospital mortality among patients ?80 years with type 2 diabetes mellitus (T2DM) hospitalized for COVID-19. Method: We conducted a nationwide, multicenter, observational study in patients ?80 years with T2DM hospitalized for COVID-19 between March 1 and May 29, 2020. The primary outcome measure was in-hospital mortality. A multivariate logistic regression analysis was performed to assess the association between preadmission cardiometabolic therapy and in-hospital mortality. Results: Of the 2 763 patients ?80 years old hospitalized due to COVID-19, 790 (28.6%) had T2DM. Of these patients, 385 (48.7%) died during admission. On the multivariate analysis, the use of dipeptidyl peptidase-4 inhibitors (adjusted odds ratio [AOR] 0.502, 95% confidence interval [CI]: 0.309-0.815, p = .005) and angiotensin receptor blockers (AOR 0.454, 95% CI: 0.274-0.759, p = .003) were independent protectors against in-hospital mortality, whereas the use of acetylsalicylic acid was associated with higher in-hospital mortality (AOR 1.761, 95% CI: 1.092-2.842, p = .020). Other antidiabetic drugs, angiotensin-converting enzyme inhibitors, and statins showed neutral association with in-hospital mortality. Conclusions: We found important differences between cardiometabolic drugs and in-hospital mortality in older patients with T2DM hospitalized for COVID-19. Preadmission treatment with dipeptidyl peptidase-4 inhibitors and angiotensin receptor blockers could reduce in-hospital mortality; other antidiabetic drugs, angiotensin-converting enzyme inhibitors, and statins seem to have a neutral effect; and acetylsalicylic acid could be associated with excess mortality.