Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Pearson MS, Tedla BA, Mekonnen GG, et al. Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study. Lancet Microbe 2021; published online August 31. https://doi.org/10.1016/S2666-5247(21)00150-6. Appendix and supplementary materials table of contents Table 1. Serum and urine sample cohorts used in this study. 3 Table 2. Top 20 antigens with significantly higher IgG responses in the serum and urine of infected versus non-infected individuals. 4 Table 3. Subset of arrayed antigens inducing an antibody signature able to most effectively discriminate between infected and non-infected populations using sera or urine. 6 Table 4: Diagnostic accuracy of antigens using serum of individuals from Schistosoma haematobium endemic populations determined by ELISA. 7 Table 5: Diagnostic accuracy of antigens using urine of individuals from Schistosoma haematobium endemic populations determined by ELISA. 7 Materials and methods 8 References 14 Table S1. Antigens used in construction of the S. haematobium protein microarray 15 Table S2. Fold change of IgG responses between infected and non-infected (S. haematobium- endemic) populations resulting from serum sample probing of S. haematobium protein microarrays. 40 Table S3. Fold change of IgG responses between infected and non-infected (S. haematobium- endemic) populations resulting from urine sample probing of S. haematobium protein microarrays. 67 Figure S1. Schematic of PoC-ICT design. 94 Figure S2. Scatterplot showing correlation of S. haematobium infection intensity (urine egg burden) with individual mean SI of all spots resulting from probing of S. haematobium protein arrays with different diagnostic fluids. 95 Figure S3. Receiver operating characteristic curve showing diagnostic performance (area under the curve - AUC) of the minimal antibody signature in each diagnostic fluid. 96 Figure S4. Amino acid alignment and percent identity matrix of S. haematobium TSPs. 97 Figure S5. Antibody responses to combinations of cell-based recombinant versions of top-ranked proteins generated by ELISA with human urine from S. haematobium-endemic populations. 98 Table S4. Diagnostic accuracy of antigen combinations using urine of individuals from Schistosoma haematobium-endemic populations determined by ELISA. 99 1 Figure S6. Frequency of recognition (FoR) patterns based on IgG ELISA responses to combinations of cell-based recombinant versions of top-ranked proteins and Sh-SEA using urine from infected individuals in S. haematobium-endemic populations. 100 Figure S7. Serum IgG ELISAs showing recognition of S. haematobium diagnostic antigens by other schistosome species. 101 Figure S8. Amino acid alignment of S. haematobium diagnostic antigens and homologs from S. mansoni, S. japonicum and H. sapiens. 102 2 Table 1. Serum and urine sample cohorts used in this study. Country Sample Cohort size (n) Egg burden Study component* Range Heavy & (n [%]) Moderate# (n [%]) Light^ (n [%]) Egg negative/ CAA positive (n [%]) Egg negative/ CAA negative (n [%]) A E ICT SS Mashonaland East province, Zimbabwe serum 201 0·3-743 64 [31·8] N/A 137 [68·2] 0 [0·0] 0 [0·0] ü ü Lambarene, Gabon serum 56 0-1265 13 [23·2] N/A 25 [44·6] 4 [7·1] 14 [25·0] ü ü ü ü Mashonaland East province, Zimbabwe urine 97 0-1008 31 [32·0] N/A 59 [60·8] 6 [6·2] 1 [1·0] ü ü Lambarene, Gabon urine 27 0-1265 5 [18·5] N/A 12 [44·4] 0 [0·0] 10 [37·0] ü Pemba/Unjuga islands, Zanzibar urine 152 0-540 7 [4·6] N/A 60 [39·5] 4 [2·6] 81 [53·3] ü Northern Samar, The Philippines serum 21 24-5616 134 [58·3] 54 [23·5] 42 [18·3] 0 [0·0] 0 [0·0] ü Gondar, Ethiopia serum 230 10-650 3 [14·3] 8 [38·1] 10 [43·5] 0 [0·0] 0 [0·0] ü Cairns, Australia urine 15 - - - - - - ü ü Leiden, The Netherlands serum 10 - - - - - - ü ü ü ü *A = array, E = ELISA, ICT = immunochromatographic test, SS = species specificity. &For S. haematobium infection, heavy egg burden ³50 eggs/10 ml urine; for S. mansoni and S. japonicum infection, heavy egg burden >400 eggs per gram faeces. #As per WHO guidelines, S. haematobium infection is grouped into only heavy or light egg burden; for S. mansoni and S. japonicum infection, moderate egg burden = 101-400 eggs per gram faeces. ^For S. haematobium infection, light egg burden = 1-49 eggs/10 ml urine; for S. mansoni and S. japonicum infection, light egg burden = 1-100 eggs per gram faeces. 3 Table 2. Top 20 antigens with significantly higher IgG responses in the serum and urine of infected versus non-infected individuals. Antigen (WBPS14$ Accession) Description # P value fdr* Selection method for array inclusion^ Serum MS3_10186 IPSE# 3×2 x 10-22 2×5 x 10-20 bioinformatic MS3_10385 neuroserpin# 3×2 x 10-20 1×6 x 10-17 proteomic (T, AES, EV) MS3_02553 saposin containing protein# 1×1 x 10-17 3×8 x 10-15 proteomic (T, EV) MS3_09207 hemoglobinase (C13 family) # 4×2 x 10-17 1×0 x 10-14 proteomic (EV) MS3_09198 CD63 antigen# 2×9 x 10-16 5×8 x 10-14 proteomic (T, EV) MS3_07972 ferritin, heavy polypeptide 1 7×1 x 10-16 1×2 x 10-13 proteomic (AES, EV) MS3_01370 CD63 antigen 3×1 x 10-15 3×8 x 10-13 proteomic (T, EV) MS3_05950 16 kDa calcium-binding protein# 1×0 x 10-13 1×0 x 10-11 proteomic (T, AES, EES) MS3_06828 calcium-binding mitochondrial carrier protein SCaMC-1 1×3 x 10-12 1×0 x 10-10 proteomic (T) MS3_01658 phospholipase D3 5×5 x 10-11 4×2 x 10-9 proteomic (AES, EV) MS3_06368 5'-AMP-activated protein kinase subunit beta-1 6×9 x 10-11 4×7 x 10-9 bioinformatic MS3_07892 guanine nucleotide-binding protein subunit beta 1×5 x 10-10 9×5 x 10-9 proteomic (T) MS3_01466 band 7 protein 6×4 x 10-10 3×5 x 10-8 bioinformatic MS3_00180 putative programmed cell death protein 8×4 x 10-10 4×4 x 10-8 proteomic (T, EV) MS3_08105 peptidyl-prolyl cis-trans isomerase B 1×1 x 10-9 5×7 x 10-8 bioinformatic MS3_06193 PUR-alpha-like protein# 1×8 x 10-9 8×5 x 10-8 proteomic (AES) MS3_09175 aquaporin-3 (AQP-3) 3×4 x 10-9 1×5 x 10-7 proteomic (T, EV) MS3_09779 cathepsin B-like peptidase (C01 family) 7×6 x 10-9 3×0 x 10-7 proteomic (EV) MS3_09828 Rho GDP-dissociation inhibitor 2 9×3 x 10-9 3×3 x 10-7 bioinformatic MS3_10252 steroid dehydrogenase, putative 1×2 x 10-8 4×3 x 10-7 bioinformatic Urine MS3_10385 neuroserpin# 4×2 x 10-11 4×2 x 10-11 proteomic (T,A ES, EV) 4 MS3_06193 PUR-alpha-like protein# 1×8 x 10-7 1×8 x 10-7 proteomic (AES) MS3_10186 IPSE/alpha# 1×8 x 10-7 1×8 x 10-7 bioinformatic MS3_02553 saposin containing protein# 4×3 x 10-6 4×3 x 10-6 proteomic (T, EV) MS3_01466 band 7 protein 3×5 x 10-8 3×5 x 10-8 bioinformatic MS3_07702 troponin T 2×0 x 10-5 2×0 x 10-5 proteomic (T, AES, EV) MS3_04688 zinc finger CDGSH domain-containing protein 1 7×7 x 10-5 7×7 x 10-5 proteomic (T) MS3_00996 sh3 domain grb2-like protein B1 (endophilin B1) 8×6 x 10-5 8×6 x 10-5 proteomic (T, AES, EV) MS3_09198 CD63 antigen# 8×6 x 10-5 8×6 x 10-5 proteomic (T, EV) MS3_07481 fimbrin, putative 1×2 x 10-3 1×2 x 10-3 proteomic (T, AES, EV) MS3_09207 hemoglobinase (C13 family) # 1×3 x 10-3 1×3 x 10-3 proteomic (EV) MS3_07178 putative ferritin 2×3 x 10-3 2×3 x 10-3 proteomic (T, AES, EES, EV) MS3_05950 16 kDa calcium-binding protein# 3×6 x 10-3 3×6 x 10-3 proteomic (T, AES, EES) MS3_02428 cytochrome b-c1 complex subunit 7 3×6 x 10-3 3×6 x 10-3 proteomic (T) MS3_00180 putative programmed cell death protein 3×7 x 10-3 3×7 x 10-3 proteomic (T, EV) MS3_01257 BC026374 protein (S09 family) 4×1 x 10-3 4×1 x 10-3 bioinformatic MS3_01857 paramyosin isoform 1 4×5 x 10-3 4×5 x 10-3 Proteomic (EES) MS3_04820 putative zinc transporter 4×5 x 10-3 4×5 x 10-3 bioinformatic MS3_03509 protein jagged-1b 4×9 x 10-3 4×9 x 10-3 bioinformatic MS3_09779 cathepsin B-like peptidase (C01 family) # 5×1 x 10-3 5×1 x 10-3 proteomic (EV) $WormBase ParaSite online database, version 14 https://parasite.wormbase.org/Schistosoma_haematobium_prjna78265/Info/Index/ #hits common to serum and urine. *false discovery rate. ^proteins for array inclusion selected from bioinformatic analysis of second-generation S. mansoni array12 or proteomic analysis of S. haematobium T,17 ES,17 EES,17 SEA17 or EV.16 T = adult tegument, AES = adult excretory/secretory products, EES = egg excretory/secretory products, SEA = soluble egg antigen, EV = adult extracellular vesicles. 5 Table 3. Subset of arrayed antigens inducing an antibody signature# able to most effectively discriminate between infected and non-infected populations using sera or urine. Antigen (WBPS14$ accession) Description Serum IgG response Urine IgG response Fold change^ Infected (%)* AUC& (95% CI) Fold change^ Infected (%)* AUC& (95% CI) MS3_10385 neuroserpin+ 47×47 81×07 0×88 (0×83-0×92) 90×02 91×15 0×93 (0×85-1×00) MS3_10186 IPSE 14×59 95×47 0×88 (0×83-0×92) 50×96 87×61 0×88 (0×80-0×97) MS3_06193 PUR-alpha-like protein 8×58 53×09 0×71 (0×64-0×79) 29×67 79×65 0×83 (0×75-0×91) MS3_01466 band 7 protein 3×71 66×26 0×69 (0×62-0×75) 12×18 52×21 0×75 (0×66-0×84) MS3_05950 16 kDa calcium-binding protein 4×18 69×55 0×76 (0×70-0×82) 5×64 56×64 0×72 (0×62-0×82) MS3_09198 CD63 antigen+ 4×81 95×88 0×79 (0×73-0×85) 7×39 91×15 0×83 (0×73-0×92) MS3_09779 cathepsin B-like peptidase (C01 family) + 8×85 32×92 0×84 (0×76-0×93) 2×56 26×55 0×66 (0×55-0×76) MS3_07972 ferritin, heavy polypeptide 1+ 13×33 55×97 0×86 (0×80-0×92) 2×36 45×13 0×65 (0×54-0×76) MS3_09207 hemoglobinase (C13 family) + 5×31 30×45 0×78 (0×71-0×84) 2×97 34×51 0×68 (0×57-0×78) MS3_01370 CD63 antigen+ 4×53 32×51 0×78 (0×71-0×84) 2×23 38×05 0×66 (0×56-0×77) # A minimum of four antigens is predicted to achieve the most effective discrimination between infected and non-infected populations using sera or urine. $ WormBase ParaSite online database, version 14 https://parasite.wormbase.org/Schistosoma_haematobium_prjna78265/Info/Index/ + Antigens were identified from proteomic analysis of S. haematobium EVs.16 ^ mean of the log2-transformed fold change of the signal intensity between the infected and non-infected population * Percentage of infected population samples (positive by egg microscopy or CAA) that are positive by array probing. & Area under the curve (AUC) value determined from receiver-operator characteristic (ROC) curve analysis of the IgG response to each antigen. 6 Table 4: Diagnostic accuracy of antigens using serum of individuals from Schistosoma haematobium- endemic populations determined by ELISA. Antigen AUC in cohort (95% CI) Zimbabwe Gabon All MS3_10385 0×79 (0×68-0×91) 0×83 (0×71-0×95) 0×80 (0×70-0×91) MS3_10186 0×85 (0×78-0×92) 0×98 (0×94-1×00) 0×88 (0×82-0×94) MS3_09198 0×82 (0×73-0×91) 0×86 (0×75-0×96) 0×82 (0×74-0×91) MS3_01370 0×93 (0×88-0×98) 0×95 (0×88-1×00) 0×93 (0×89-0×97) Sh-TSP2 0×97 (0×94-1×00) 1×00 (1×00-1×00) 0×98 (0×95-1×00) Sh-SEA 0×97 (0×94-0×99) 1×00 (1×00-1×00) 0×97 (0×95-1×00) Table 5: Diagnostic accuracy of antigens using urine of individuals from Schistosoma haematobium- endemic populations determined by ELISA. Antigen AUC in cohort (95% CI) Zimbabwe Zanzibar All MS3_10385 0×95 (0×90-0×99) 0×57 (0×46-0×69) 0×78 (0×71-0×86) MS3_10186 0×96 (0×92-1×00) 0×66 (0×55-0×77) 0×69 (0×62-0×77) MS3_09198 0×94 (0×90-0×98) 0×66 (0×51-0×81) 0×78 (0×67-0×88) MS3_01370 0×89 (0×82-0×96) 0×69 (0×56-0×82) 0×81 (0×72-0×89) Sh-TSP2 0×98 (0×96-1×00) 0×93 (0×87-0×99) 0×96 (0×93-0×99) Sh-SEA 0×77 (0×68-0×87) 0×82 (0×68-0×95) 0×79 (0×69-0×90) 7 Materials and Methods Ethical Statement Ethical approval for collection of samples from individuals from Zimbabwe was obtained by the Medical Research Council of Zimbabwe. Urine samples from this country were collected as part of a previous study investigating the diagnostic potential of host-exposed S. haematobium proteomes1 (approval MRCZ/A/1710). Sample collection from individuals from Gabon was approved by the Comite de Ethique Regional Independent de Lambarene (protocol no. 06/08). The Zanzibar Medical Research Ethics Committee in Stonetown, Zanzibar (ZAMREC; reference no. ZAMREC 0003/Sept/011), the Ethikkommission beider Basel (EKBB) in Basel, Switzerland (reference no. 236/11) and the Institutional Review Board of the University of Georgia in Athens, GA, USA (project no. 2012-10138-0) approved the collection of samples from Zanzibar as part of a recently concluded five-year study on urogenital schistosomiasis elimination2. Collection of Schistosoma japonicum- infected samples was approved by the Institutional Review Board of the Research Institute for Tropical Medicine, Department of Health Manila, the Philippines (Institutional Review Board Numbers 2012-13-0 and 2015-12) and the Human Research Ethics Committee, QIMR Berghofer Medical Research Institute, Brisbane, Australia (Ethics Approval: Project P524). Collection of Schistosoma mansoni-infected samples was approved by the Institutional Review Board of the University of Gondar, Ethiopia. Study design and cohorts On collection, all serum and urine samples were stratified based on egg burden as determined by microscopy analysis of urine samples (high, ≥50 eggs per 10 ml urine; or light, 1-49 eggs per 10 ml urine). Egg-negative samples were further tested for the presence of CAA using the up-converting phosphor lateral flow CAA assay3 and were classified as being egg negative/CAA positive or egg negative/CAA negative. Serum and urine samples from individuals from non-endemic areas were used as non-endemic negative controls. Protein arrays were probed with serum and urine samples from individuals from the S. haematobium-endemic regions of Mashonaland East province, Zimbabwe and Lambarene, Gabon. Validation of array results was conducted by ELISA using the same cohorts of serum samples from Zimbabwe and Gabon and the same cohort of urine samples from Zimbabwe only (the Gabon urine cohort had been exhausted from array probing). Additional ELISA validation was performed using urine samples from individuals from Pemba and Unjuga islands, Zanzibar, sites of a recent five-year study into S. haematobium elimination. Immunochromatographic test evaluation was performed with serum samples from the Gabon cohort (the Zimbabwe cohort had been exhausted from ELISA validation) (table 1). 8 S. haematobium protein array feature selection and construction The primary criterion for the selection of proteins to be included on the S. haematobium protein array was the presence of the protein in surface and secreted proteomes of the parasite as these molecules are likely to be exposed to the host upon infection, and their cognate antibodies contained within the immune repertoire of infected individuals. Accordingly, proteins present in the adult S. haematobium tegument, soluble excretory/secretory products (ES) and EVs, ES from the egg stage,1,4 and S. haematobium orthologues of proteins present in the S. mansoni schistosomula tegument proteome5 (650 proteins in total) were selected for the array. The remaining ~350 proteins (for a ~1,000 feature array) consisted of S. haematobium orthologues of select proteins featured on the next generation S. mansoni proteome array6. Open reading frames (minus predicted signal peptides and flanked by 20 bp sequences corresponding to the recombination sites of the pXI array expression vector7 to facilitate cloning by homologous recombination) for all selected proteins (table s1) were codon optimised for expression in E. coli and commercially synthesised and cloned in pUC57 by either Twist Bioscience (sequences < 1.8 kb) or ProteinCT (sequences > 1.8 kb). Synthesised genes were PCR amplified by primers corresponding to the pXI recombination sites and cloned into pXI, in-frame with the vector’s 5’ HA and 3’ HIS tag-encoding sequences, using in vivo recombination8. Proteins encoded by each purified plasmid were expressed in vitro (RTS 100 E. coli HY kit – 5 Prime, MD, USA) according to the manufacturer’s instructions and printed onto eight-pad nitrocellulose-coated AVID glass slides (Grace Biolabs, OR, USA) with an Omnigrid 100 microarray printer (Genomic Solutions, Ann Arbor, MI, USA). Vector containing no insert was similarly “expressed” and printed (in multiple locations) to act as a negative control and multiple empty spots were left on each pad to serve as background controls. Purified human IgG, anti-human IgG and parasite extracts (S. haematobium adult- and egg- stage ES products, soluble egg antigen and adult-stage tritonX-100-soluble extract) were also printed as positive controls. Expression quality control was assessed by detection of N-terminal HA and C-terminal HIS tags as previously described7. Probing of S. haematobium protein arrays with human sera and urine Serum IgG responses to arrayed antigens were determined by probing with human serum (1:50 in array blocking buffer/10% E. coli lysate) as previously described7 with the exception that an anti-human IgG-Qdot conjugate (1:100 in array blocking buffer) was used as the secondary/detection antibody and so tertiary incubation with a separate detection reagent was not needed. Urine IgG responses were determined by probing arrays in the same 9 way except that human urine samples were first concentrated 15-fold and buffer-exchanged into PBS before being diluted 1:5 in array blocking buffer/10% E. coli lysate and applied to the arrays. S. haematobium protein array data analysis and bioinformatics Datasets generated from probing arrays with serum and urine were analysed separately. After substracting slide backgrounds, the signal intensity (SI) of each spot was background corrected using the “group average” method, where the mean SI of the negative control (empty vector) spots were subtracted from the SI of each protein spot. Corrected SIs were then transformed using the variance stabilizing normalization (vsn) method7 in GMine (http://cgenome.net/gmine) using the VSN Bioconductor package.9 Proteins were defined as IgG reactive if the mean of the transformed SI for all infected individuals was greater than the mean plus 1.5 standard deviations (SD) of the transformed SI of all non-endemic negative individuals. Significance differences between mean antibody responses in the infected versus non-infected groups were determined by Student’s t-test and p values adjusted for multiple statistical comparisons. Receiver-operating characteristic (ROC) curves and area under curve (AUC) values were generated for each significantly reactive antibody response using the ROCR R package and the proteins inducing those responses were ranked in order of significance. Antibody signature identification A set of antigens capable of producing an antibody signature which could most effectively discriminate between infected and non-infected individuals, using either serum or urine as the diagnostic fluid, was identified. Firstly, for each dataset, all antigens inducing an antibody response that was significantly upregulated (after correction for multiple testing) between the infected and non-infected populations were selected (serum, n = 208; urine, n = 45). From these, antigens inducing antibody responses with a frequency of positivity (reactivity) in less than 30% of the infected population (serum, n = 178; urine, n = 7) and more than 30% of the non-infected population (serum, n = 9; urine, n = 13) were also excluded. Antigens in these trimmed datasets (serum, n = 21; urine, n = 25) were sorted by greatest to least fold change in mean SI between the infected and non-infected populations and frequency of reactivity in the infected population. The top antigens in each dataset were used to build a support vector machine classifier, the performance of which was evaluated by Monte Carlo cross-validation. Iteratively, 15 samples were randomly selected as the training set and the remaining samples were used as the test set. The model was then fit to the training data, and the predictive accuracy of the model in classifying samples as infected or 10 non-infected was assessed using the testing set. This process was repeated 4 times. The predictive performance of the model was then evaluated by averaging the ROC curves across all 4 Monte Carlo cross-validation runs. Selection of EV-derived TSPs TSPs present in the S. haematobium EV proteome were sorted by abundance (peptide spectrum counting), and the most abundant TSPs with homologues of diagnostic efficacy reported in the literature (n=3) were selected for further assessment. Recombinant protein production in E. coli Eight antigens, selected from the immune signature and EV proteomic set (MS3_10385, MS3_10186, MS3_06193, MS3_01466, MS3_05950, MS3_09198, MS3_01370 and Sh-TSP-2), were cloned into the NdeI and XhoI sites of the pET41a E. coli expression vector, such that the N-terminal GST tag was removed, to prevent the detection of non-specific immune responses upon ELISA validation of recombinant proteins. Pilot expression experiments showed Sh-TSP-2 to be expressed in soluble form and all other antigens to be expressed in insoluble form. Expression of MS3_06193, MS3_01466 and MS3_05950 were at levels too low to warrant further development. Large-scale protein expression was induced for 24 h in E. coli BL21(DE3) by addition of 1 mM Isopropyl beta-D-1-thiogalactopyranoside (IPTG) using standard methods. Cultures were harvested by centrifugation (8,000 g for 20 min at 4°C), re-suspended in 50 ml lysis buffer (50 mM sodium phosphate, pH 8.0, 300 mM NaCl, 40 mM imidazole) and stored at -80°C. Cell pellets were lysed by three freeze-thaw cycles at - 80°C and 42°C followed by sonication on ice (10 ´ 5 s pulses [70% amplitude] with 30 s rest periods between each pulse) with a Qsonica Sonicator. Insoluble material was pelleted by centrifugation at 20,000 g for 20 min at 4°C. The supernatant was discarded (except for the Sh-TSP-2 lysate, where the supernatant was kept and the insoluble material discarded) and inclusion bodies (IBs) were washed twice by resuspension in 30 ml of lysis buffer followed by centrifugation at 20,000 g for 20 min at 4°C. IBs were then solubilized sequentially by resuspension in 25 ml lysis buffers containing either 2 M, 4 M or 8 M urea, end-over-end mixing overnight at 4°C and centrifugation at 20,000 g for 20 min at 4°C. Finally, supernatants containing solubilized IBs were diluted 1:4 in lysis buffer containing 8M urea and filtered through a 0.22 μm membrane (Millipore). Solubilized IBs were purified by immobilized metal affinity chromatography (IMAC) by loading onto a prepacked 1 ml His-Trap HP column (GE Healthcare) equilibrated with lysis buffer containing 8M urea at a flow rate of 1 ml/min using an AKTA-pure-25 FPLC (GE Healthcare). After washing with 20 ml lysis buffer containing 8M urea, bound His- 11 tagged proteins were eluted using the same buffer with a stepwise gradient of 50-250 mM imidazole (50 mM steps). The supernatant containing Sh-TSP2 was similarly purified except that buffers did not contain urea. Fractions containing recombinant proteins (as determined by SDS-PAGE) were pooled and concentrated using Amicon Ultra-15 centrifugal devices with a 3 kDa MWCO and quantified using the Pierce BCA Protein Assay kit. The final concentration of each protein was adjusted to 1 mg/ml and proteins were aliquoted and stored at - 80°C. ELISA validation of serum and urine IgG responses The same serum samples used to probe the protein microarrays (Zimbabwe and Gabon cohorts) were used to measure IgG responses against each antigen by indirect ELISA. Microlon high-binding 96-well microtiter ELISA plates (Greiner) were incubated overnight at 4°C with protein (either MS3_10385, MS3_10186, MS3_09198, MS3_01370 or Sh-TSP-2 - 2 μg/ml in 0.1 M Na2CO3/NaHCO3, pH 9.6) and, after washing with PBST, the plates were blocked for 2 hours at RT with 100 μl of PBST/5% BSA. Fifty microliters of sera (1:50 in PBST/1% BSA) were added to the wells and incubated overnight at 4°C, then the plates were washed with PBST and 100 μl of goat anti-human IgG-HRP (Sigma, 1:5000 in PBST) was added to the plates. Plates were incubated for 1 hour at RT, washed with PBST and developed with 3,3’,5,5’-tetramethylbenzidine. Plates were read at a wavelength of 405 nm on a POLARstar Omega (BMG Labtech) microplate reader. Urine IgG responses to each antigen were measured in the same way (using the Zimbabwe cohort of samples used to probe the arrays as well as the Zanzibar cohort of samples) except that plates were blocked in PBST/5% skimmed milk powder and urine samples were diluted 1:10 in PBST. Urine IgG responses to multiple antigens were performed in the same way and plates were coated with 2 μg/ml of each antigen mixture. Assays were performed in triplicate and blank-corrected values were plotted using Graphpad Prism 7. Reactivity cutoffs were determined as the average plus 3SD of the values of the non-endemic negative group. ROC curves were also generated using Graphpad Prism 7 and significant differences between mean antibody responses of each infected group and the non-infected group was determined by Student’s t-test, *p≤0.05, **p≤0.01, ***p≤0.001, ****p≤0.0001. Analysis of species specificity Sera from Kato-Katz- and SEA-positive cohorts of individuals from areas endemic for S. japonicum (Northern Samar, The Philippines; n=21)10 or S. mansoni (Gondar, Ethiopia; n=230)11 only were tested by ELISA (as described previously in this study) to determine their reactivity with MS3_01370 or Sh-TSP-2, the two top- 12 performing antigens by ELISA. For each antigen tested, the Gabon cohort of serum samples from S. haematobium infected individuals were used as positive controls. Pilot development of PoC-ICTs For PoC test development, a lateral flow ICT was commercially designed (Serve Science, Bangkok, Thailand) (figure s1). The conjugate pad was coated with 10 OD of gold-conjugated mouse anti-human IgG (to capture any human IgG present in the applied serum). Either recombinant (1.0 mg/ml) MS3_01370.1 or Sh-TSP2 (the two antigens with greatest diagnostic capacity as determined by ELISA) were sprayed at the test line (to capture any antigen-specific human IgG/anti-human IgG gold-conjugate complex) and 1.0 mg/ml anti-mouse IgG was sprayed at the control line (to capture anti-human IgG gold-conjugate and serve as an internal validation). To test samples with the ICT, 5 μl of serum (diluted 1:10 in buffer BS-007) was applied to the sample reservoir, 3 drops (approximately 100 μl) of buffer BS-007 was applied to the sample reservoir and the test was read after 15 mins. For each strip, a band at the test and control lines was considered a positive result, a band at the control line only was considered a negative result and a test was considered invalid if there was no band at the control line. Band intensity on positive tests were scored on a four-point scale from most (+4) to least (+1) intense. A score of 0 was given for a negative result. 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Nutr J 2012; 11: 108. 14 Table S1: antigens used in construction of the S. haematobium protein microarray Antigen (WBPS14* Accession) Description Predicted SP?# Selection method for array inclusion^ 2008-Sh-TSP2 Tetraspanin 2 Yes proteomic (T, EV) MS3_00004 Lysosomal alpha-glucosidase Yes proteomic (AES, SEA, EV) MS3_00006 Pre-mRNA-splicing factor 38B No bioinformatic MS3_00047 14-3-3 epsilon No proteomic (T, AES, EES, SEA, EV) MS3_00048 putative reticulon/nogo No proteomic (T, EV) MS3_00054 TWiK family of potassium channels protein 18 Yes bioinformatic MS3_00066 putative sperm nuclear basic protein PL-I isoform PLIb No bioinformatic MS3_00076 Deoxyhypusine hydroxylase No bioinformatic MS3_00143 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial No proteomic (T) MS3_00147 eukaryotic translation initiation factor 5A No proteomic (T, AES, EV) MS3_00148 Peptidase S1 S6 chymotrypsin Hap active site Yes bioinformatic MS3_00151 Prenylcysteine oxidase 1 No proteomic (T) MS3_00178 Small nuclear ribonucleoprotein-associated protein B No bioinformatic MS3_00180 putative programmed cell death protein No proteomic (T, EV) MS3_00183 Calcium-binding EF-hand,domain-containing protein No proteomic (EES, SEA) MS3_00187 Guanine nucleotide-binding protein G(o) subunit alpha No proteomic (T, EV) MS3_00196 Protein NDRG3 No proteomic (T, EV) MS3_00203 Pro-neuregulin-2, membrane-bound isoform Yes bioinformatic MS3_00223 Oxalate:formate antiporter No proteomic (EV) MS3_00242 Signal recognition particle protein 19 No bioinformatic MS3_00257 Regulator of microtubule dynamics protein 1 No proteomic (T, AES) MS3_00277 cAMP-dependent protein kinase type II regulatory subunit No proteomic (T, AES, EES, SEA, EV) MS3_00286 aldo-keto reductase family 1, member B4 (aldose reductase) No proteomic (T, AES, EES, SEA) MS3_00287 40S ribosomal protein S6 Yes bioinformatic MS3_00294 cytochrome b5 reductase 1 No proteomic (T) MS3_00312 optic atrophy 1-like protein, opa1 No proteomic (T) MS3_00316 Ubiquitin-conjugating enzyme E2 G1 No bioinformatic MS3_00353 rab-related GTP-binding protein No bioinformatic MS3_00361 putative alpha-actinin No proteomic (T, AES, EV) MS3_00383 putative dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase No bioinformatic MS3_00403 tar DNA-binding protein, putative No bioinformatic MS3_00404 Density-regulated protein No proteomic (EV) MS3_00405 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial No bioinformatic MS3_00412 putative endophilin B1 No proteomic (T, EV) MS3_00413 60S ribosomal protein L8 No bioinformatic MS3_00440 pyruvate dehydrogenase (lipoamide) No bioinformatic MS3_00447 Homeobox protein abdominal-B No bioinformatic 15 MS3_00449 SJCHGC08006 protein No bioinformatic MS3_00450 Mxi neural development protein No bioinformatic MS3_00452 Lysosomal Pro-X carboxypeptidase No proteomic (AES, EV) MS3_00494 putative 40s ribosomal protein S18 No bioinformatic MS3_00498 hypotheticial protein No bioinformatic MS3_00499 Tissue alpha-L-fucosidase No proteomic (AES, SEA) MS3_00504 ER membrane protein complex subunit 7 Yes bioinformatic MS3_00508 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial No proteomic (T, SEA) MS3_00560 AChain A, Uridine phosphorylase No proteomic (SEA, EV) MS3_00569 G2/mitotic-specific cyclin-B2 No bioinformatic MS3_00604 Ribosomal Protein, Small subunit No bioinformatic MS3_00610 Ester hydrolase C11orf54-like protein No proteomic (AES, EES, SEA) MS3_00625 NADH dehydrogenase (ubiquinone) flavoprotein 1 No bioinformatic MS3_00663 Aspartate aminotransferase, cytoplasmic No proteomic (T, AES, SEA) MS3_00665 putative camp-regulated phosphoprotein No bioinformatic MS3_00668 Replication protein A 70 kDa DNA-binding subunit No bioinformatic MS3_00670 SJCHGC09518 protein No bioinformatic MS3_00676 Persulfide dioxygenase ETHE1, mitochondrial No proteomic (T, AES) MS3_00702 ribosomal protein S16 No bioinformatic MS3_00703 Tricarboxylate transport protein No bioinformatic MS3_00719 putative palmitoyltransferase ZDHHC12 No bioinformatic MS3_00756 Sodium/potassium-transporting ATPase subunit alpha No proteomic (T, EV) MS3_00769 Transmembrane protein 50A No bioinformatic MS3_00779 cellular nucleic acid-binding protein No bioinformatic MS3_00785 T-complex protein 1 subunit gamma No proteomic (T, AES, EES, SEA, EV) MS3_00787 Ectonucleoside triphosphate diphosphohydrolase 1 No proteomic (T, AES, EV) MS3_00800 Serine/threonine-protein kinase haspin No bioinformatic MS3_00805 Alanine aminotransferase 2 No proteomic (AES) MS3_00808 Polyadenylate-binding protein 2 No bioinformatic MS3_00812 Splicing factor U2AF 35 kDa subunit No bioinformatic MS3_00844 putative cystinosin Yes bioinformatic MS3_00850 protein kinase No bioinformatic MS3_00859 Fibrillin 2 No bioinformatic MS3_00862 thioredoxin peroxidase No proteomic (AES, EES, SEA, EV) MS3_00876 Neuronal calcium sensor 2 No bioinformatic MS3_00880 Glioma pathogenesis-related protein 1 precursor No proteomic (T, AES) MS3_00881 Yes proteomic (EES) MS3_00886 putative syntenin No proteomic (T, EV) MS3_00891 GLIPR1-like protein 1 No proteomic (T) MS3_00900 Guanylate kinase No proteomic (EES) 16 MS3_00931 putative nascent polypeptide associated complex alpha subunit (nac alpha) No proteomic (EV) MS3_00934 F-box only protein isoform 1 No bioinformatic MS3_00939 PI-PLC X domain-containing protein 1 No bioinformatic MS3_00996 sh3 domain grb2-like protein B1 (endophilin B1) No proteomic (T, AES, EV) MS3_01001 vesicle-associated membrane protein 2 No bioinformatic MS3_01004 COX assembly mitochondrial protein 1 No bioinformatic MS3_01014 intraflagellar transport protein 20 No bioinformatic MS3_01016 Alpha-tocopherol transfer protein-like No proteomic (EV) MS3_01030 Activin receptor type-2A No bioinformatic MS3_01049 Alpha-tocopherol transfer protein-like No proteomic (EV) MS3_01051 Synaptophysin (Major synaptic vesicle protein p38) No bioinformatic MS3_01053 tropomyosin, putative No bioinformatic MS3_01095 putative smirv1 protein Yes proteomic (T, EV) MS3_01096 Universal stress protein No proteomic (T, SEA, EV) MS3_01104 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog No proteomic (EES) MS3_01105 Universal stress protein No bioinformatic MS3_01114 hypothetical protein MS3_01114 No bioinformatic MS3_01124 small subunit ribosomal protein S2e No bioinformatic MS3_01141 tRNA-splicing endonuclease subunit Sen2 No proteomic (EV) MS3_01153 putative tetraspanin-CD63 receptor No proteomic (EV) MS3_01160 Stomatin-like protein 2, mitochondrial No proteomic (T) MS3_01193 putative pre-mRNA-processing ATP-dependent RNA helicase prp5 No bioinformatic MS3_01218 putative RNA-binding protein 18 No bioinformatic MS3_01240 syntaxin, putative No proteomic (EV) MS3_01245 activator protein 4 (ap4), putative No bioinformatic MS3_01257 BC026374 protein (S09 family) Yes bioinformatic MS3_01261 Phosphoenolpyruvate carboxykinase [GTP] No proteomic (T, AES, EES, SEA, EV) MS3_01262 SJCHGC09353 protein No bioinformatic MS3_01274 ribosomal protein L7a No bioinformatic MS3_01276 putative phosphatidylcholine transfer protein No bioinformatic MS3_01286 putative copii-coated vesicle membrane protein P24 Yes bioinformatic MS3_01289 1-pyrroline-5-carboxylate dehydrogenase No proteomic (T, EES) MS3_01302 Deoxyhypusine synthase No proteomic (AES) MS3_01313 SJCHGC04069 protein No bioinformatic MS3_01318 putative merlin/moesin/ezrin/radixin No proteomic (AES, EV) MS3_01328 DnaJ subfamily C member 28 No bioinformatic MS3_01333 RutC family protein No bioinformatic MS3_01337 Universal stress protein No proteomic (T) MS3_01339 putative ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c isoform 2a precursor No bioinformatic MS3_01348 High mobility group protein DSP1 No bioinformatic 17 MS3_01353 basigin related No bioinformatic MS3_01364 Tropomyosin isoform 2 No proteomic (AES, EES, SEA) MS3_01365 putative Bax inhibitor-1 No bioinformatic MS3_01370 CD63 antigen No proteomic (T, EV) MS3_01386 Protein diaphanous 2 No proteomic (T) MS3_01406 putative mitochondrial import receptor subunit tom22 No proteomic (T) MS3_01422 rna-binding ras-gap sh3 binding protein related No bioinformatic MS3_01425 PC3-like endoprotease variant A No proteomic (T, AES) MS3_01435 Ribosomal protein L11 No bioinformatic MS3_01445 putative transformer-2 protein No bioinformatic MS3_01466 Band 7 protein No bioinformatic MS3_01478 polymorphic mucin variant No proteomic (EES) MS3_01483 proteasome (prosome macropain) subunit alpha type 4 No proteomic (SEA, EV) MS3_01504 SJCHGC00710 protein No proteomic (T, EV) MS3_01516 gynecophoral canal protein No proteomic (AES) MS3_01527 High mobility group protein DSP1 No proteomic (EES) MS3_01542 acetyl-CoA C-acetyltransferase No proteomic (AES) MS3_01558 Protein YIPF6 No bioinformatic MS3_01585 PDZ and LIM domain protein Zasp No bioinformatic MS3_01597 Deoxyribodipyrimidine photo-lyase No bioinformatic MS3_01600 Histone H2A No bioinformatic MS3_01611 putative malate dehydrogenase No bioinformatic MS3_01627 T-complex protein 1 subunit eta No proteomic (EES, EV) MS3_01636 putative lysosome-associated membrane glycoprotein No proteomic (EV) MS3_01643 putative lysosome-associated membrane glycoprotein No bioinformatic MS3_01650 Adenylate kinase No proteomic (T, AES, EES, EV) MS3_01653 Ras-related protein Rap-1b No proteomic (T, EV) MS3_01658 Phospholipase D3 No proteomic (ES, EV) MS3_01664 Glycosyltransferase 1 domain-containing protein isoform 4 No bioinformatic MS3_01668 putative zinc finger protein No bioinformatic MS3_01686 Minor histocompatibility antigen H13 No bioinformatic MS3_01693 Proteinase inhibitor I25, cystatin,domain-containing protein Yes bioinformatic MS3_01705 cathepsin F (C01 family) No bioinformatic MS3_01710 Small nuclear ribonucleoprotein Sm D3 No bioinformatic MS3_01749 Putative aminopeptidase W07G4.4 No proteomic (T, SEA, EV) MS3_01761 putative histone H2A.1 No bioinformatic MS3_01764 putative tropomyosin No proteomic (AES, EES, SEA) MS3_01771 signalase (S26 family) No bioinformatic MS3_01775 putative DNA-binding protein No bioinformatic MS3_01777 putative elongation factor 1-gamma No proteomic (SEA) 18 MS3_01780 Eukaryotic initiation factor 4A No bioinformatic MS3_01833 putative cystoskeletal protein tektin No proteomic (EES) MS3_01840 Hypothetical Schistosoma spp. protein UPF0506 No proteomic (T, EV) MS3_01852 Zinc finger protein ZPR1 Yes proteomic (T) MS3_01857 Paramyosin isoform 1 No proteomic (EES) MS3_01870 CCR4-NOT transcription complex subunit 7 No bioinformatic MS3_01871 14-3-3 epsilon 2 No proteomic (T, EV) MS3_01898 CD36-like class B scavenger receptor No proteomic (EV) MS3_01899 Prolyl endopeptidase No proteomic (AES) MS3_01902 putative 40s ribosomal protein S4 No bioinformatic MS3_01905 putative tetraspanin No proteomic (EV) MS3_01922 putative actin No proteomic (T, AES, EES, SEA, EV) MS3_01934 putative carbonic anhydrase No proteomic (T, EV) MS3_01937 Hypothetical Schistosoma spp. protein UPF0506 No bioinformatic MS3_01938 Proliferating cell nuclear antigen No bioinformatic MS3_01952 Annexin A13 (Annexin XIII) No proteomic (T, AES, EV) MS3_01964 putative annexin No proteomic (T, AES, EV) MS3_01972 Leptin receptor overlapping transcript-like 1 No bioinformatic MS3_01983 putative ATPase inhibitor isoform 2 No proteomic (T) MS3_01988 Voltage-dependent anion-selective channel protein 2 No proteomic (T) MS3_02001 putative tumor protein d52 No proteomic (EES) MS3_02027 20S proteasome subunit alpha 7 No proteomic (AES, EES) MS3_02041 Protein BUD31 homolog No bioinformatic MS3_02044 Casein kinase I isoform gamma-1 No proteomic (EV) MS3_02048 Receptor expression-enhancing protein 5 No proteomic (T) MS3_02050 Ras-related protein RABA2a No proteomic (EV) MS3_02085 Mitochondrial import receptor subunit TOM70 No proteomic (T) MS3_02086 Cytochrome c No proteomic (T, AES, EES, SEA) MS3_02087 Acidic leucine-rich nuclear phosphoprotein 32-related protein (ANP32/acidic nuclear phosphoprotein-like protein) No proteomic (EV) MS3_02088 Netrin receptor DCC No bioinformatic MS3_02136 malate dehydrogenase No proteomic (T) MS3_02141 putative 60s ribosomal protein L13a No bioinformatic MS3_02155 Proteasomal ubiquitin receptor ADRM1 No bioinformatic MS3_02157 Protein max No bioinformatic MS3_02160 Tubulin beta-2C chain No bioinformatic MS3_02162 putative placenta-specificprotein 8 protein (C15 protein) (Onzin) No proteomic (T, AES, EV) MS3_02172 Tumor suppressor candidate 3 (Protein N33) Yes bioinformatic MS3_02176 Microsomal glutathione S-transferase 3 No proteomic (T) MS3_02202 ribosomal protein S10 No bioinformatic MS3_02234 putative tfiid subunit No bioinformatic 19 MS3_02237 ring finger protein 168 No bioinformatic MS3_02256 SJCHGC08335 protein No proteomic (AES) MS3_02275 Putative BTB/POZ domain-containing protein No proteomic (EES) MS3_02289 Corepressor interacting with RBPJ 1 No bioinformatic MS3_02307 putative isocitric dehydrogenase subunit alpha No proteomic (T, EES) MS3_02314 tubulin alpha-1A chain No proteomic (T, AES, EES, SEA, EV) MS3_02318 gamma-glutamyltransferase-like protein 3 (T03 family) No proteomic (T, EV) MS3_02343 V-type proton ATPase subunit B No proteomic (EV) MS3_02346 Serine/threonine-protein phosphatase PP1-beta catalytic subunit No proteomic (AES, EV) MS3_02356 DM9 domain-containing protein No proteomic (EV) MS3_02359 DM9 domain-containing protein No proteomic (T, AES, EV) MS3_02368 SAR1 gene homolog B No proteomic (T) MS3_02375 Ras-related protein Rab-30 No proteomic (T, EV) MS3_02393 SUZ domain-containing protein 1 No bioinformatic MS3_02396 Pleckstrin homology domain-containing family B member 2 No bioinformatic MS3_02407 SJCHGC06436 protein No proteomic (EES) MS3_02425 Enolase No proteomic (T, AES, EES, SEA, EV) MS3_02428 Cytochrome b-c1 complex subunit 7 No proteomic (T) MS3_02442 putative polyadenylate binding protein No bioinformatic MS3_02453 Microtubule-associated protein RP/EB family member 1 No bioinformatic MS3_02460 Sorting nexin-3 No bioinformatic MS3_02465 actin beta/gamma 1 No proteomic (T, AES, EV) MS3_02474 hypothetical protein MS3_02474 No bioinformatic MS3_02476 SJCHGC00797 protein No proteomic (T, AES, EV) MS3_02486 SJCHGC02563 protein No proteomic (T, AES, EV) MS3_02489 SJCHGC06012 protein No bioinformatic MS3_02494 SJCHGC01166 protein No proteomic (T, AES, EV) MS3_02499 putative serpin No proteomic (AES) MS3_02504 ATPase, H+ transporting, lysosomal accessory protein 1 No proteomic (T, EV) MS3_02538 Alanine aminotransferase 2 No bioinformatic MS3_02539 prominin (prom) protein, putative No proteomic (T, EV) MS3_02545 putative glucose transport protein No proteomic (T, AES, EV) MS3_02553 saposin containing protein No proteomic (T, EV) MS3_02593 putative cytosolic purine 5-nucleotidase No proteomic (EV) MS3_02637 SJCHGC06845 protein Yes bioinformatic MS3_02641 ribosomal protein S8 No bioinformatic MS3_02653 60S ribosomal protein L26 No bioinformatic MS3_02674 SJCHGC09134 protein Yes proteomic (AES, EV) MS3_02681 Transmembrane protein 256-like protein No bioinformatic MS3_02685 putative prohibitin No proteomic (T, EES) 20 MS3_02688 97 kDa heat shock protein No proteomic (T, EES, SEA, EV) MS3_02690 synaptotagmin, putative No proteomic (T) MS3_02709 Tropinone reductase 2 No bioinformatic MS3_02734 O-acetyl-ADP-ribose deacetylase MACROD2 No proteomic (T, AES) MS3_02747 putative fatty acid binding protein No proteomic (EES) MS3_02752 dihydrolipoamide dehydrogenase No proteomic (AES, EES, SEA) MS3_02758 Solute carrier family 2, facilitated glucose transporter member 2 No bioinformatic MS3_02787 Mitochondrial import receptor subunit TOM34 No proteomic (EV) MS3_02802 ceramide kinase No bioinformatic MS3_02804 small subunit ribosomal protein S30e No bioinformatic MS3_02805 Saposin-like,IPR008139 Saposin B,domain-containing protein No proteomic (AES, EV) MS3_02807 proteasome subunit alpha 6 (T01 family) No proteomic (EES, SEA, EV) MS3_02838 AN1-type zinc finger protein 6 (Zinc finger A20 domain-containing protein 3) No proteomic (T, AES, EES, SEA, EV) MS3_02855 putative selenoprotein T No bioinformatic MS3_02856 Fructose-bisphosphate aldolase isoform 3 No proteomic (T, AES, EES, SEA, EV) MS3_02899 SLIT and NTRK-like protein 2 No proteomic (AES) MS3_02928 putative serine/threonine-protein phosphatase PP2A regulatory subunit No proteomic (T, AES) MS3_02944 Extracellular superoxide dismutase [Cu-Zn] precursor Yes bioinformatic MS3_02951 Putative adenosylhomocysteinase 3 No bioinformatic MS3_02952 DnaJ subfamily B member 9 isoform 2 Yes bioinformatic MS3_02954 putative dtdp-glucose 4-6-dehydratase No bioinformatic MS3_02991 V-type H+-transporting ATPase subunit E No proteomic (EV) MS3_02999 Galectin-3-binding protein A No proteomic (EES) MS3_03041 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 No bioinformatic MS3_03047 Tektin-4 No proteomic (EES) MS3_03054 chaperonin containing TCP1, subunit 5 (epsilon) No proteomic (SEA) MS3_03079 nalp (nacht, leucine rich repeat and pyrin domain containing)-related No proteomic (EV) MS3_03084 putative beta thymosin No proteomic (T, AES) MS3_03091 putative pdz and lim domain protein No bioinformatic MS3_03096 glucose-6-phosphate isomerase No proteomic (T, AES, EES, SEA, EV) MS3_03101 Peptidyl-glycine alpha-amidating monooxygenase No bioinformatic MS3_03119 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 No bioinformatic MS3_03127 Putative actin-interacting protein 1 No proteomic (AES, SEA, EV) MS3_03130 putative tRNA(His) guanylyltransferase Yes bioinformatic MS3_03140 40S ribosomal protein S3A, putative No bioinformatic MS3_03171 Ribosomal protein S15Aa No proteomic (EES, SEA) MS3_03192 25 kDa integral membrane protein No bioinformatic MS3_03193 tetraspanin TE736 No bioinformatic MS3_03206 ATP:ADP antiporter No proteomic (T, EES) MS3_03226 Leucine-rich repeat-containing protein 57 No proteomic (T) 21 MS3_03231 H/ACA ribonucleoprotein complex subunit 2 No bioinformatic MS3_03269 SJCHGC05509 protein No bioinformatic MS3_03270 putative phosphatidylinositol-4-phosphate 5-kinase, type I, alpha No bioinformatic MS3_03295 putative atp synthase beta subunit No proteomic (T, EES) MS3_03301 putative atp synthase beta subunit No proteomic (T, EES, SEA) MS3_03304 Translocon-associated protein subunit delta No proteomic (T, EV) MS3_03350 DEP domain-containing protein 5 No bioinformatic MS3_03372 syntaxin-binding protein 1 No proteomic (EV) MS3_03381 Tubulin beta chain No proteomic (T, AES) MS3_03385 putative rna binding motif protein 4,lark No proteomic (AES) MS3_03400 Stress protein DDR48 (DNA damage-responsive protein 48) Yes bioinformatic MS3_03405 eggshell precursor protein No bioinformatic MS3_03406 Pro-His-rich protein No bioinformatic MS3_03417 Major egg antigen No proteomic (T, EV) MS3_03419 integral membrane G protein-coupled receptor isoform 2 No bioinformatic MS3_03420 Major egg antigen No proteomic (AES) MS3_03424 putative elongation factor ts No bioinformatic MS3_03427 Major egg antigen No proteomic (AES) MS3_03429 putative protease Yes bioinformatic MS3_03443 ADP-ribosylation factor 4-like No proteomic (T) MS3_03453 Katanin p60 ATPase-containing subunit A-like 2 No proteomic (EV) MS3_03461 low-density lipoprotein receptor (ldl) Yes bioinformatic MS3_03509 Protein jagged-1b Yes bioinformatic MS3_03511 putative sj-Ts4 protein No bioinformatic MS3_03513 glutathione peroxidase, putative No proteomic (SEA) MS3_03534 UTP--glucose-1-phosphate uridylyltransferase No proteomic (SEA) MS3_03558 chloride intracellular channel 4 Yes proteomic (AES, EV) MS3_03569 Protein transport protein Sec61 subunit alpha-like 1 No bioinformatic MS3_03571 putative cationic amino acid transporter No bioinformatic MS3_03576 Y+L amino acid transporter 2 No bioinformatic MS3_03577 ribosomal protein S14 No bioinformatic MS3_03599 ribosomal protein L27 No bioinformatic MS3_03603 SJCHGC06759 protein Yes bioinformatic MS3_03615 putative elongation factor tu (ef-tu) No proteomic (T) MS3_03618 Mitochondrial inner membrane protein OXA1L No bioinformatic MS3_03625 Ubiquitin-conjugating enzyme E2 G2 No bioinformatic MS3_03641 ribosomal protein S8 No bioinformatic MS3_03655 nervana 2 No proteomic (T, EV) MS3_03662 sugar nucleotide epimerase related No bioinformatic MS3_03695 Rab effector MyRIP No proteomic (T) 22 MS3_03726 Stromal membrane-associated protein 1 No proteomic (EV) MS3_03768 putative tensin No proteomic (T) MS3_03775 Transketolase No proteomic (T, AES, EES, SEA, EV) MS3_03776 Mitochondrial deoxynucleotide carrier No bioinformatic MS3_03789 family T2 unassigned peptidase (T02 family) Yes bioinformatic MS3_03800 hypotheticial protein No proteomic (T) MS3_03802 Transitional endoplasmic reticulum ATPase No proteomic (T, AES, EES, SEA, EV) MS3_03814 EF-hand domain-containing protein 1 No proteomic (EES, SEA) MS3_03817 putative cationic amino acid transporter No bioinformatic MS3_03818 MIT domain-containing protein isoform 3 No proteomic (T) MS3_03824 ribosomal protein L10a No bioinformatic MS3_03853 osteopetrosis associated transmembrane No bioinformatic MS3_03856 SJCHGC05495 protein No bioinformatic MS3_03863 Golgi to ER traffic protein 4-like protein No bioinformatic MS3_03872 Putative complexin-1 No proteomic (EES) MS3_03918 Transmembrane 9 superfamily protein member 4 No bioinformatic MS3_03933 Severin No proteomic (T, AES, EV) MS3_03937 putative gelsolin No proteomic (T, AES, EES, SEA, EV) MS3_03938 ras-like protein 3 No proteomic (T, EV) MS3_03963 dynein light chain type 1 No bioinformatic MS3_03973 putative sm29 No proteomic (T, AES, EV) MS3_03976 14-3-3 protein, putative No proteomic (T, AES, EV) MS3_03977 14-3-3 protein, putative No proteomic (T, AES, EES, SEA, EV) MS3_03979 putative vesicle-associated membrane protein (vamp) No proteomic (AES) MS3_03988 receptor for activated PKC, putative No bioinformatic MS3_03992 putative growth hormone inducible transmembrane protein No bioinformatic MS3_04011 Co-chaperone protein isoform 1 No proteomic (EV) MS3_04025 Vacuolar H ATPase No bioinformatic MS3_04053 Neuronal acetylcholine receptor subunit alpha-2 Yes proteomic (EV) MS3_04063 adenylosuccinate lyase No proteomic (SEA) MS3_04083 putative glypican No bioinformatic MS3_04100 Palmitoyl-protein thioesterase 1 No proteomic (AES) MS3_04117 SJCHGC02809 protein No bioinformatic MS3_04147 hypothetical protein MS3_04147 Yes bioinformatic MS3_04157 hypothetical protein MS3_04157 Yes bioinformatic MS3_04158 Clumping factor A precursor (Fibrinogen-binding protein A) (Fibrinogen receptor A), putative No proteomic (T, AES) MS3_04178 ubiquinol-cytochrome c reductase cytochrome c1 subunit No proteomic (T) MS3_04179 THO complex subunit 4 No bioinformatic MS3_04193 Phosphopantetheine-binding,domain-containing protein No proteomic (T) MS3_04206 ATP synthase subunit O, mitochondrial No proteomic (T) 23 MS3_04221 26S proteasome non-ATPase regulatory subunit 10 No bioinformatic MS3_04225 Aspartate aminotransferase, mitochondrial No proteomic (T, EES, SEA) MS3_04227 Egg protein CP3842 Yes bioinformatic MS3_04261 Ribosomal Protein, Small subunit No bioinformatic MS3_04262 Histone H1B Yes bioinformatic MS3_04266 SJCHGC06358 protein No proteomic (EV) MS3_04267 Globin-3 No proteomic (EES, SEA) MS3_04268 hypothetical protein MS3_04268 No proteomic (EV) MS3_04269 Cercarial stage-specific protein isoform 2 No bioinformatic MS3_04275 putative tegumental protein No proteomic (T, EV) MS3_04276 SJCHGC06242 protein No proteomic (T, AES, EV) MS3_04279 Saposin B domain-containing protein No proteomic (AES) MS3_04285 Peptidyl-prolyl cis-trans isomerase No proteomic (T, AES, EES, SEA, EV) MS3_04286 Hematopoietic lineage cell-specific protein isoform 1 No bioinformatic MS3_04307 fatty acid binding protein No proteomic (T, AES, EES, SEA, EV) MS3_04311 putative annexin No proteomic (AES, SEA) MS3_04342 citrate synthase No proteomic (T, AES, EES, SEA) MS3_04347 ER degradation-enhancing alpha-mannosidase-like protein 2 No proteomic (EV) MS3_04355 Ras-related protein Ral-A No proteomic (T, EV) MS3_04364 putative small nuclear ribonucleoprotein Sm D2 No bioinformatic MS3_04375 Zinc finger, C2H2-type domain-containing protein No bioinformatic MS3_04386 Isochorismatase domain-containing protein 2, mitochondrial No proteomic (T) MS3_04437 putative DNA double-strand break repair rad50 ATPase Yes proteomic (AES) MS3_04449 Adenosylhomocysteinase A No proteomic (AES, EES, SEA, EV) MS3_04453 Basic-leucine zipper (BZIP) transcription factor, domain-containing protein isoform 1 No bioinformatic MS3_04474 hypothetical protein MS3_0018310 No proteomic (T, AES, EV) MS3_04493 putative mitochondrial import receptor subunit TOM40 homolog No proteomic (T) MS3_04499 NADH dehydrogenase (ubiquinone) Fe-S protein 8 No bioinformatic MS3_04526 subfamily T1A non-peptidase homologue (T01 family) No proteomic (AES, EES, SEA, EV) MS3_04540 RuvB-like protein 2 No bioinformatic MS3_04550 glyoxalase I No proteomic (T, AES, SEA) MS3_04559 Eukaryotic translation initiation factor 5 No bioinformatic MS3_04564 Growth hormone-regulated TBC protein 1-A No proteomic (EV) MS3_04582 6-phosphofructokinase No proteomic (T) MS3_04584 6-phosphofructokinase No proteomic (T, AES, EV) MS3_04595 Programmed cell death 6-interacting protein No proteomic (T, AES, SEA, EV) MS3_04598 putative annexin No proteomic (EV) MS3_04609 putative 26S proteasome non-ATPase regulatory subunit 11 No bioinformatic MS3_04617 Lysosomal protective protein Yes proteomic (AES, EV) MS3_04642 Glutathione S-transferase omega-1 isoform 1 No proteomic (EES) 24 MS3_04646 Omega-amidase NIT2 No proteomic (AES, SEA) MS3_04680 Ras-related protein Rab-14 No proteomic (T) MS3_04688 Zinc finger CDGSH domain-containing protein 1 No proteomic (T) MS3_04717 ribosomal protein related Yes proteomic (SEA) MS3_04767 putative vesicular amine transporter No bioinformatic MS3_04774 Cathepsin L-like proteinase precursor No proteomic (EV) MS3_04778 Phosphoglycerate kinase No proteomic (T, AES, EES, SEA, EV) MS3_04781 Ribosomal protein L9 No bioinformatic MS3_04799 Armadillo repeat-containing protein 1 No bioinformatic MS3_04800 hypothetical protein MS3_04800, partial Yes bioinformatic MS3_04817 SJCHGC02432 protein No bioinformatic MS3_04820 putative zinc transporter Yes bioinformatic MS3_04827 Ubiquinone biosynthesis protein COQ7-like protein No bioinformatic MS3_04873 putative prefoldin subunit 2 No bioinformatic MS3_04887 putative UDP-galactose-4-epimerase No proteomic (T, SEA, EV) MS3_04896 S-phase kinase-associated protein 1 No bioinformatic MS3_04920 Mastin precursor Yes proteomic (EV) MS3_04932 1,4-alpha-glucan-branching enzyme isoform 2 No proteomic (AES, EES, EV) MS3_04962 Interferon-related developmental regulator 1 No bioinformatic MS3_04981 hydroxymethylbilane synthase No proteomic (EV) MS3_05000 putative sodium/potassium-transporting ATPase subunit beta-3 No proteomic (T, EV) MS3_05002 Rabenosyn-5 No bioinformatic MS3_05011 Secreted Protein Acidic and Cysteine Rich Yes bioinformatic MS3_05016 Xaa-Pro dipeptidase No proteomic (AES) MS3_05024 Syntaxin-binding protein 1 No proteomic (T) MS3_05026 putative actin-depolymerizing factor No proteomic (AES, SEA) MS3_05034 Voltage-dependent anion-selective channel protein 2 No proteomic (T, EES) MS3_05038 Ubiquitin-fold modifier 1 No proteomic (AES, EES) MS3_05040 ADIPOR-like receptor No bioinformatic MS3_05047 Calmodulin No proteomic (AES, EES, SEA) MS3_05050 Innexin unc-7 No bioinformatic MS3_05077 Guanine nucleotide-binding protein subunit beta No proteomic (EV) MS3_05125 hypothetical protein MS3_05125 No proteomic (T, AES, EV) MS3_05126 Eukaryotic translation initiation factor 1A No bioinformatic MS3_05142 Ribosomal protein L24 No bioinformatic MS3_05150 putative sarcoplasmic calcium-binding protein (SCP) No proteomic (T, AES, SEA, EV) MS3_05157 tetraspanin, putative No proteomic (EV) MS3_05170 putative bcl-2 homologous antagonist/killer (bak) No proteomic (T) MS3_05192 programmed cell death, putative No bioinformatic MS3_05203 UPF0764 protein C16orf89 isoform 4 Yes bioinformatic 25 MS3_05213 RNA-binding protein 12 No proteomic (EES) MS3_05216 cysteine protease inhibitor No proteomic (T, EES) MS3_05219 putative tyrosine 3-monooxygenase No bioinformatic MS3_05222 asparaginyl-tRNA synthetase No proteomic (EV) MS3_05226 tetraspanin, putative No proteomic (AES, EV) MS3_05230 small subunit ribosomal protein S17 No bioinformatic MS3_05252 DM9 domain-containing protein No proteomic (T, AES) MS3_05280 Histone H3.3 No bioinformatic MS3_05283 Adenylosuccinate synthetase No proteomic (AES, SEA) MS3_05284 Ubiquitin-conjugating enzyme E2 R2 No bioinformatic MS3_05289 putative tetraspanin 18, isoform 1 No proteomic (EV) MS3_05322 family S9 non-peptidase homologue (S09 family) No proteomic (T) MS3_05326 Acetylcholinesterase No bioinformatic MS3_05332 putative beta-galactosidase Yes proteomic (AES) MS3_05337 Allatostatin-A receptor Yes bioinformatic MS3_05350 Formin-binding protein 1 No proteomic (EV) MS3_05351 Dynein light chain No proteomic (T, AES, EV) MS3_05352 putative dynein light chain No proteomic (EV) MS3_05360 Coiled-coil domain-containing protein 25 No bioinformatic MS3_05370 SJCHGC02540 protein Yes bioinformatic MS3_05387 putative arf gtpase-activating protein No bioinformatic MS3_05389 putative p30 dbc protein No bioinformatic MS3_05391 putative 40s ribosomal protein S9 No bioinformatic MS3_05425 14 kDa subunit splicing factor 3b No bioinformatic MS3_05427 Charged multivesicular body protein No bioinformatic MS3_05437 Serine/threonine-protein phosphatase No proteomic (T) MS3_05447 Synaptosomal-associated protein 25 No proteomic (EV) MS3_05465 Isocitrate dehydrogenase [NADP], mitochondrial No bioinformatic MS3_05484 fragile X related 1, frx1 No bioinformatic MS3_05495 Lysophospholipid acyltransferase 5 No proteomic (T) MS3_05496 Solute carrier family 43 member 3 No bioinformatic MS3_05516 AChain A, Purine-nucleoside Phosphorylase No proteomic (EES, SEA) MS3_05520 putative methylthioadenosine phosphorylase No proteomic (AES) MS3_05530 Rab GDP dissociation inhibitor alpha No proteomic (T, AES, EES, SEA, EV) MS3_05539 folylpolyglutamate synthase No bioinformatic MS3_05555 venom allergen-like (VAL) 7 protein No bioinformatic MS3_05586 plasma membrane calcium-transporting atpase,putative No proteomic (T) MS3_05587 Plasma membrane calcium-transporting ATPase 2 No bioinformatic MS3_05595 porphobilinogen synthase No proteomic (AES, SEA) MS3_05600 Four and a half LIM domains protein 2 No bioinformatic 26 MS3_05602 putative prothymosin alpha-B No bioinformatic MS3_05614 Neuronal calcium sensor 2 No bioinformatic MS3_05631 Taurocyamine kinase No proteomic (T, AES, EES, SEA, EV) MS3_05639 putative ribosomal protein L13 No bioinformatic MS3_05646 hypotheticial protein Yes bioinformatic MS3_05676 Cytosolic Fe-S cluster assembly factor NARFL Yes bioinformatic MS3_05677 Activator of 90 kDa heat shock protein ATPase homolog 1 No proteomic (T, EV) MS3_05686 Eukaryotic translation initiation factor 3 subunit J-B No proteomic (T) MS3_05715 hypothetical protein MS3_05715 No proteomic (T, EV) MS3_05718 Myosin-2 essential light chain No proteomic (SEA, EES) MS3_05730 putative endoplasmin No bioinformatic MS3_05734 Proteasome subunit alpha type-7-like No proteomic (SEA, EV) MS3_05735 16 kDa calcium-binding protein isoform 2 No proteomic (T, AES, EV) MS3_05739 hypothetical protein MS3_05739 No bioinformatic MS3_05748 zinc finger protein, putative No bioinformatic MS3_05754 Guanine nucleotide-binding protein G(q) subunit alpha No bioinformatic MS3_05761 protein FAM50 No bioinformatic MS3_05836 putative phospholipid-transporting ATPase IIB No proteomic (EV) MS3_05837 SJCHGC09124 protein No bioinformatic MS3_05896 putative 60s ribosomal protein L23a No bioinformatic MS3_05908 Ubiquitin-conjugating enzyme E2 L3 No proteomic (T, AES) MS3_05910 putative rab5 No proteomic (T, EV) MS3_05911 Dynein light chain 2, cytoplasmic No proteomic (EES, SEA, EV) MS3_05913 putative tensin No proteomic (T, AES) MS3_05939 putative Lysosomal Pro-X carboxypeptidase precursor Yes proteomic (AES, EV) MS3_05945 TATA box-binding protein-associated factor RNA polymerase I subunit A No bioinformatic MS3_05950 16 kDa calcium-binding protein No proteomic (T, AES, EES) MS3_05952 Tegument antigen No proteomic (AES, EV) MS3_05953 Rho-related GTP-binding protein isoform 1 No proteomic (T, EV) MS3_05958 Antigen Sm21.7 No proteomic (T, AES, EES, SEA, EV) MS3_05959 Tegument antigen No proteomic (T, AES, EV) MS3_05960 Tegument antigen No proteomic (AES, EES, SEA, EV) MS3_05976 putative rab No proteomic (T, EV) MS3_05999 phosphoglycerate kinase 1 No proteomic (T, AES, EES, SEA, EV) MS3_06009 Proteasome subunit alpha type-2 No proteomic (SEA, EV) MS3_06022 putative eukaryotic translation initiation factor 2 gamma subunit (eif-2-gamma) No bioinformatic MS3_06069 Store-operated calcium entry-associated regulatory factor No proteomic (T) MS3_06075 F-actin-capping protein subunit beta No proteomic (EV) MS3_06080 Alpha-soluble NSF attachment protein No proteomic (EV) MS3_06101 apoferritin-2 Yes proteomic (AES, EV) 27 MS3_06108 Fasciclin-1 isoform 2 No bioinformatic MS3_06112 SJCHGC07210 protein Yes bioinformatic MS3_06125 serpin, putative No proteomic (EV) MS3_06126 sulfide quinone reductase, putative No proteomic (T) MS3_06147 putative aldehyde dehydrogenase No proteomic (T) MS3_06149 DnaJ subfamily B member 4 No proteomic (AES, EES) MS3_06161 ATPase, H+ transporting, lysosomal, V0 subunit c No bioinformatic MS3_06167 Dynein assembly factor with WDR repeat domains 1 No bioinformatic MS3_06193 PUR-alpha-like protein No proteomic (AES) MS3_06211 SJCHGC04876 protein No bioinformatic MS3_06214 hypothetical protein MS3_06214 Yes bioinformatic MS3_06223 Acyl-coenzyme A thioesterase 8 No proteomic (AES, SEA) MS3_06243 Eukaryotic translation initiation factor 6 No bioinformatic MS3_06248 SJCHGC06557 protein No proteomic (AES, EV) MS3_06257 Exocyst complex component 5 No bioinformatic MS3_06258 Glutamine--tRNA ligase No bioinformatic MS3_06276 20S proteasome subunit beta 4 No proteomic (AES) MS3_06283 Dexamethasone-induced Ras-related protein 1 No bioinformatic MS3_06296 Splicing factor 3B subunit 2 No bioinformatic MS3_06299 Transmembrane protein isoform 3 No bioinformatic MS3_06327 transmembrane-lke protein isoform 1 Yes bioinformatic MS3_06347 putative gtp-binding protein rit No bioinformatic MS3_06348 Mitochondrial-processing peptidase subunit beta No proteomic (T, EES, SEA) MS3_06368 5'-AMP-activated protein kinase subunit beta-1 No bioinformatic MS3_06380 Adenylyl cyclase-associated protein 1 No proteomic (T, SEA, EV) MS3_06400 Epididymal secretory protein E1 precursor (Niemann Pick type C2 protein homolog) Yes bioinformatic MS3_06403 Golgi SNAP receptor complex member 1 No bioinformatic MS3_06424 Translocator protein No bioinformatic MS3_06430 putative mitochondrial ATP synthase B chain No proteomic (T) MS3_06431 putative tropomodulin No bioinformatic MS3_06449 putative mitochondrial 39S ribosomal protein L27 (L27mt) (MRP-L27) No bioinformatic MS3_06462 Universal stress protein No proteomic (T) MS3_06468 putative membrane protein isoform 1 No bioinformatic MS3_06471 Translationally-controlled tumor protein homolog No proteomic (AES, EV) MS3_06482 AChain A, Glutathione S-transferase 28 Kda No proteomic (T, AES, EES, SEA, EV) MS3_06488 RecQ-mediated genome instability protein 1 No bioinformatic MS3_06500 isocitrate dehydrogenase (NAD+) No bioinformatic MS3_06507 putative 6-phosphogluconate dehydrogenase No proteomic (AES, SEA, EV) MS3_06532 Hormone receptor 4 (dHR4), putative Yes bioinformatic MS3_06538 SJCHGC05602 protein Yes bioinformatic 28 MS3_06539 G1/S-specific cyclin-D2 No bioinformatic MS3_06551 EH domain-containing protein 1 No proteomic (EV) MS3_06559 Kynurenine--oxoglutarate transaminase 3 No proteomic (T, AES) MS3_06583 ng-dimethylarginine dimethylaminohydrolase No proteomic (T, AES, EES, EV) MS3_06592 hydroxyacylglutathione hydrolase No proteomic (T, AES, SEA) MS3_06608 nardilysin (M16 family) No proteomic (T) MS3_06649 putative dna repair protein xp-E No proteomic (AES) MS3_06668 ribosomal protein L35 No bioinformatic MS3_06669 T-complex protein 1 subunit zeta No proteomic (EV) MS3_06677 Dehydrogenase/reductase SDR family member 1 No bioinformatic MS3_06680 putative mannose-6-phosphate isomerase No proteomic (AES) MS3_06690 putative rassf No bioinformatic MS3_06704 Alpha-1, 3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform 2 No bioinformatic MS3_06707 lipase maturation factor No proteomic (T) MS3_06719 putative phosphoglucomutase No proteomic (SEA) MS3_06729 putative dual-specificity phosphatase No bioinformatic MS3_06732 Ubiquitin-60S ribosomal protein L40 No proteomic (EES) MS3_06736 family C2 unassigned peptidase (C02 family) No proteomic (AES) MS3_06740 Stromal cell-derived factor 2 Yes bioinformatic MS3_06745 eukaryotic translation elongation factor 1 beta 2 No proteomic (AES) MS3_06746 ADP-ribose pyrophosphatase, mitochondrial precursor No proteomic (AES, EES, SEA) MS3_06748 Tubulin beta-2C chain No proteomic (T, AES, EES, EV) MS3_06769 60S ribosome subunit biogenesis protein NIP7 No bioinformatic MS3_06789 ATP synthase, subunit d Yes bioinformatic MS3_06798 Retinol dehydrogenase 14 No proteomic (T, AES, EV) MS3_06807 SJCHGC01113 protein No bioinformatic MS3_06825 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial No proteomic (T) MS3_06828 Calcium-binding mitochondrial carrier protein SCaMC-1 No proteomic (T) MS3_06832 3'(2'), 5'-bisphosphate nucleotidase No proteomic (T, AES, SEA, EV) MS3_06834 putative succinate dehydrogenase No bioinformatic MS3_06868 La-related protein 6 No bioinformatic MS3_06877 Long-chain-fatty-acid--CoA ligase 5 No bioinformatic MS3_06889 NADH dehydrogenase (ubiquinone) Fe-S protein 7 No bioinformatic MS3_06898 Protein MEMO1 No proteomic (AES) MS3_06914 proteasome (prosome macropain) subunit beta type 4 No proteomic (AES, SEA) MS3_06918 Protein DJ-1 No proteomic (T, AES, EES, SEA, EV) MS3_06928 T-complex protein 1 subunit delta No proteomic (AES, SEA, EV) MS3_06944 putative profilin splice variant 4 No proteomic (T, EV) MS3_06947 X-box-binding protein No bioinformatic MS3_06950 Three prime repair exonuclease 1 No bioinformatic 29 MS3_06979 putative growth factor receptor-bound protein No bioinformatic MS3_06994 ribosomal protein L28 No bioinformatic MS3_07002 SJCHGC06187 protein No bioinformatic MS3_07010 1-acyl-sn-glycerol-3-phosphate o-acyltransferase No bioinformatic MS3_07037 Zinc finger with UFM1-specific peptidase domain protein No bioinformatic MS3_07045 Dehydrogenase/reductase SDR family member 1 No proteomic (T) MS3_07061 Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase No bioinformatic MS3_07096 SJCHGC06267 protein No bioinformatic MS3_07105 Mitogen-activated protein kinase 3 No proteomic (EV) MS3_07125 cytochrome c oxidase subunit IV No proteomic (T) MS3_07126 Exosome complex component RRP41 No bioinformatic MS3_07156 acyl-CoA:glycerol-3-phosphate acyltransferase No bioinformatic MS3_07158 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial No proteomic (SEA) MS3_07178 putative ferritin No proteomic (T, AES, EES, EV) MS3_07195 Ribosomal protein S11 No bioinformatic MS3_07213 SJCHGC01055 protein No bioinformatic MS3_07231 ornithine--oxo-acid transaminase No proteomic (EES, SEA) MS3_07273 Lamin-B receptor No bioinformatic MS3_07280 protein kiaa0174, putative No bioinformatic MS3_07294 venom allergen-like (VAL) 28 protein Yes proteomic (EES, SEA) MS3_07299 Protein canopy 4 Yes bioinformatic MS3_07304 Protein jagunal 1 No bioinformatic MS3_07337 putative dolichyl-diphosphooligosaccharide-protein glycosyltransferase Yes bioinformatic MS3_07345 Inorganic pyrophosphatase No proteomic (T, AES, EES, SEA, EV) MS3_07347 SJCHGC01026 protein No proteomic (EV) MS3_07363 Heterogeneous nuclear ribonucleoprotein K No proteomic (AES, EES) MS3_07370 actin beta/gamma 1 No proteomic (AES) MS3_07372 Phosphatase 2A inhibitor I2PP2A No proteomic (AES, EES, EV) MS3_07374 Actin alpha cardiac muscle 1 No proteomic (EV) MS3_07390 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial No bioinformatic MS3_07395 Vesicular integral-membrane protein isoform 3 No bioinformatic MS3_07403 Glutamine synthetase No proteomic (SEA) MS3_07405 putative immunoglobulin domain superfamily (sensory guidance protein) No proteomic (AES) MS3_07406 putative deferrochelatase/peroxidase YfeX No bioinformatic MS3_07411 putative deferrochelatase/peroxidase YfeX No proteomic (T) MS3_07419 putative spfh domain protein 1 precursor No bioinformatic MS3_07420 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 Yes bioinformatic MS3_07422 hypothetical protein MS3_07422 No proteomic (EV) MS3_07464 F-type H+-transporting ATPase subunit alpha No proteomic (T, EES, SEA) MS3_07465 Prostatic acid phosphatase No proteomic (AES, EV) 30 MS3_07467 putative atp synthase alpha subunit mitochondrial No proteomic (T, EES) MS3_07473 putative marvel-containing potential lipid raft-associated protein No proteomic (T, EV) MS3_07481 fimbrin, putative No proteomic (T, AES, EV) MS3_07487 putative succinate dehydrogenase No proteomic (T) MS3_07509 putative cop-coated vesicle membrane protein P24 (emp24/gp25l family) Yes bioinformatic MS3_07520 putative 26s proteasome non-ATPase regulatory subunit No bioinformatic MS3_07531 Peroxiredoxin, Prx3 No proteomic (T, AES, SEA) MS3_07565 SJCHGC01333 protein No bioinformatic MS3_07569 tetraspanin, putative No bioinformatic MS3_07587 programmed cell death protein, putative No bioinformatic MS3_07590 Reticulon-4-interacting protein 1-like protein, mitochondrial No bioinformatic MS3_07593 Sorcin No proteomic (EV) MS3_07594 Immunoglobulin-like domain-containing protein Yes proteomic (T, AES, EV) MS3_07600 rab11, putative No proteomic (EV) MS3_07606 phosphoglycerate mutase No proteomic (T, AES, EES, SEA, EV) MS3_07612 40S ribosomal protein No bioinformatic MS3_07617 putative map kinase phosphatase No proteomic (EV) MS3_07637 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10 No bioinformatic MS3_07650 hypothetical protein MS3_07650 No bioinformatic MS3_07651 Ubiquitin-conjugating enzyme E2-24 kDa No bioinformatic MS3_07685 FChain F, Histone H4 No proteomic (AES, EES, SEA, EV) MS3_07686 Histone H4 No proteomic (AES, EV) MS3_07693 putative titin No proteomic (T, AES) MS3_07702 Troponin T No proteomic (T, AES, EV) MS3_07716 phosphatidylinositol transfer protein No bioinformatic MS3_07729 putative hsp40, subfamily A, members 1,2,4 No proteomic (T, EV) MS3_07737 histone H2A No proteomic (EES) MS3_07738 MEG-8 family No bioinformatic MS3_07757 Casein kinase II subunit alpha No proteomic (EV) MS3_07763 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial No proteomic (T) MS3_07795 IQ domain-containing protein G No bioinformatic MS3_07799 Reticulon-4 (Neurite outgrowth inhibitor) No bioinformatic MS3_07816 E3 ubiquitin-protein ligase No bioinformatic MS3_07822 SJCHGC04172 protein Yes bioinformatic MS3_07823 egg protein CP391S-like protein Yes bioinformatic MS3_07824 putative centromere protein A (cenp-A) (centromere autoantigen A) No bioinformatic MS3_07831 putative shc transforming protein No proteomic (EV) MS3_07854 putative rab-2,4,14 No proteomic (T, EV) MS3_07874 26S proteasome non-ATPase regulatory subunit 12 No bioinformatic MS3_07885 rab-related GTP-binding protein No bioinformatic 31 MS3_07892 Guanine nucleotide-binding protein subunit beta No proteomic (T) MS3_07905 adenylate cyclase isoform 1 No proteomic (T) MS3_07918 hypothetical protein MS3_07918 No bioinformatic MS3_07944 Spliceosome RNA helicase DDX39B No bioinformatic MS3_07968 cell division control protein 45 No proteomic (EV) MS3_07972 ferritin, heavy polypeptide 1 No proteomic (AES, EV) MS3_07988 putative ef hand containing protein Yes proteomic (AES) MS3_07994 hypotherical protein No bioinformatic MS3_08000 glycerol-3-phosphate dehydrogenase 1 No proteomic (T, AES, SEA, EV) MS3_08004 Calcyphosin-like protein No bioinformatic MS3_08008 aminoacylase (M20 family) No proteomic (AES, EES, SEA) MS3_08019 putative immunophilin No proteomic (AES, EES, SEA) MS3_08024 cathepsin B No proteomic (T, AES) MS3_08037 putative ribonuclease z, chloroplast No proteomic (AES) MS3_08042 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase No bioinformatic MS3_08059 Ferritin-1 heavy chain No proteomic (AES, SEA, EV) MS3_08087 putative dead box ATP-dependent RNA helicase No bioinformatic MS3_08094 putative secretory carrier membrane protein No bioinformatic MS3_08105 Peptidyl-prolyl cis-trans isomerase B Yes bioinformatic MS3_08144 TM2 domain-containing protein 3 No bioinformatic MS3_08157 Trematode Eggshell Synthesis domain containing protein Yes bioinformatic MS3_08158 Trematode Eggshell Synthesis domain containing protein Yes bioinformatic MS3_08159 Trematode Eggshell Synthesis domain containing protein Yes bioinformatic MS3_08160 Proactivator polypeptide No proteomic (AES, EES, EV) MS3_08161 Female-specific protein 800 Yes bioinformatic MS3_08162 RNA-binding protein EWS No bioinformatic MS3_08169 Casein kinase II subunit beta No bioinformatic MS3_08176 Adenylate kinase isoenzyme 6 isoform 1 No bioinformatic MS3_08178 hypothetical protein MS3_08178 No proteomic (AES) MS3_08210 Survival of motor neuron-related-splicing factor 30 No bioinformatic MS3_08216 putative transaldolase isoform 1 No proteomic (T, AES, SEA) MS3_08220 eukaryotictranslation initiation factor,putative No proteomic (EV) MS3_08262 Cell division control protein 42-like protein No proteomic (T) MS3_08276 Basement membrane-specific heparan sulfate proteoglycan core protein No proteomic (AES) MS3_08283 putative glypican Yes bioinformatic MS3_08337 putative cation-transporting atpase worm No bioinformatic MS3_08361 Elongation factor 2 No proteomic (T, AES, EES, SEA, EV) MS3_08366 putative crp1/csrp1/crip1 No proteomic (T, AES) MS3_08391 putative talin No bioinformatic MS3_08398 NADH dehydrogenase ubiquinone 1 beta No bioinformatic 32 MS3_08399 T-complex protein 1 subunit theta No proteomic (EES, EV) MS3_08413 Zinc finger and BTB domain-containing protein No bioinformatic MS3_08415 Coatomer subunit epsilon No bioinformatic MS3_08432 phosphatase 2C No bioinformatic MS3_08440 Cathepsin K No proteomic (AES) MS3_08444 Tegument antigen No bioinformatic MS3_08446 Tegument antigen No proteomic (T, AES, EV) MS3_08450 Putative aminopeptidase W07G4.4 No proteomic (T, AES, EES, EV) MS3_08455 COP9 signalosome complex subunit 7b No bioinformatic MS3_08460 AChain A, Thioredoxin Peroxidase No proteomic (EES, SEA, EV) MS3_08472 Calreticulin Yes proteomic (T, EES, SEA) MS3_08479 eukaryotic translation elongation factor 1 alpha 2 No proteomic (T, AES, EES, SEA, EV) MS3_08480 High affinity cationic amino acid transporter 1 No proteomic (T) MS3_08498 Cathepsin C Yes proteomic (SEA, EV) MS3_08503 venom allergen-like (VAL) 6 protein No proteomic (T, AES, EV) MS3_08504 venom allergen-like (VAL) 6 protein No proteomic (T, AES) MS3_08509 ATP-dependent RNA helicase DED1 No bioinformatic MS3_08530 peptidylprolyl isomerase No proteomic (T, AES, EES, EV) MS3_08533 GTP-binding nuclear protein Ran No bioinformatic MS3_08539 H/ACA ribonucleoprotein complex subunit 1 No bioinformatic MS3_08593 putative guanine nucleotide-binding protein beta 5 (G protein beta5) No bioinformatic MS3_08607 putative zinc finger protein No proteomic (T, EV) MS3_08613 mitogen-activated protein kinase kinase 1 No proteomic (EV) MS3_08618 Ribosomal protein S5a No bioinformatic MS3_08625 putative annexin No bioinformatic MS3_08636 calcineurin B No bioinformatic MS3_08655 LIM domain-containing protein unc-97 No bioinformatic MS3_08663 Serine/threonine-protein kinase NIM1 No proteomic (EV) MS3_08689 Synaptic vesicle membrane protein VAT-1-like protein No proteomic (T, AES, EV) MS3_08692 Pre-mRNA-processing factor 19 No bioinformatic MS3_08717 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 No bioinformatic MS3_08723 Annexin A7 No proteomic (T, AES, EV) MS3_08725 putative annexin No proteomic (T, AES, EV) MS3_08726 putative ribosomal protein S2, eukaryotic and archaeal form No bioinformatic MS3_08727 SJCHGC09795 protein No bioinformatic MS3_08737 Kazal-type serine protease inhibitor domain-containing protein 1 Yes bioinformatic MS3_08776 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit No bioinformatic MS3_08805 Protein C20orf11 homolog No bioinformatic MS3_08808 proteasome (prosome, macropain) subunit, beta type 5 No proteomic (EES, EV) MS3_08811 putative ribosomal protein L4 No bioinformatic 33 MS3_08823 Transmembrane protein 85 No bioinformatic MS3_08826 Alcohol dehydrogenase class-3 No proteomic (AES) MS3_08839 putative 60s ribosomal protein L6 No proteomic (AES) MS3_08840 AP-2 complex subunit sigma No bioinformatic MS3_08871 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial No bioinformatic MS3_08891 Mitochondrial carnitine/acylcarnitine carrier protein No proteomic (T) MS3_08903 putative poly(p)/ATP NAD kinase No bioinformatic MS3_08907 alkaline phosphatase No proteomic (T) MS3_08925 Aldehyde dehydrogenase X, mitochondrial No proteomic (EES, SEA, EV) MS3_08926 60 kDa heat shock protein, mitochondrial No proteomic (T, EES, SEA, EV) MS3_08929 hypotherical protein No bioinformatic MS3_08937 Pyruvate kinase PKM No proteomic (T, AES, EES, SEA, EV) MS3_08943 hypothetical protein MS3_0013354 No bioinformatic MS3_08945 Dipeptidyl peptidase 3 No bioinformatic MS3_08953 Golgi phosphoprotein 3 No bioinformatic MS3_08954 dihydropyrimidinase (M38 family) No proteomic (EV) MS3_08975 DnaJ subfamily C member 5 No bioinformatic MS3_08996 Cytochrome C Oxidase No proteomic (EES) MS3_08999 Vesicle-associated membrane protein 8 No proteomic (EV) MS3_09000 chmp1 (chromatin modifying protein) (charged multivesicular body protein), putative No bioinformatic MS3_09070 alkaline phosphatase Yes proteomic (T, EV) MS3_09073 phosphatidylcholine-sterol acyltransferase (lecithin-cholesterol acyltransferase)/ Phospholipase A No bioinformatic MS3_09076 Ectonucleoside triphosphate diphosphohydrolase 4 No proteomic (T, EV) MS3_09086 Glycogenin-1 isoform 2 No proteomic (SEA, EV) MS3_09089 putative ATP-dependent RNA helicase ddx6 No bioinformatic MS3_09110 putative rac gtpase No proteomic (T) MS3_09119 eukaryotictranslation initiation factor,putative No bioinformatic MS3_09124 Nucleotide exchange factor SIL1 No bioinformatic MS3_09128 L-2-hydroxyglutarate dehydrogenase, mitochondrial No bioinformatic MS3_09160 putative arginine/serine-rich splicing factor No bioinformatic MS3_09161 Thymidylate kinase No proteomic (AES) MS3_09175 Aquaporin-3 (AQP-3) No proteomic (T, EV) MS3_09188 SJCHGC04269 protein No bioinformatic MS3_09190 Geranylgeranyl pyrophosphate synthase No proteomic (T, AES) MS3_09198 CD63 antigen No proteomic (T, EV) MS3_09207 hemoglobinase (C13 family) Yes proteomic (EV) MS3_09229 NudC domain-containing protein 2 No bioinformatic MS3_09231 Guanine nucleotide-binding protein subunit beta No proteomic (EV) MS3_09233 superoxide dismutase 1, soluble No proteomic (T, AES) MS3_09240 Protein l(2)37Cc No proteomic (T) 34 MS3_09253 hypotheticial protein Yes proteomic (AES, EV) MS3_09271 60S ribosomal protein L14, putative No bioinformatic MS3_09273 Regulator of nonsense transcripts 3A No bioinformatic MS3_09274 KH domain-containing, RNA-binding, signal transduction-associated protein 1 No proteomic (EES) MS3_09276 transcription elongation factor B, polypeptide 2 No proteomic (AES) MS3_09283 ribosomal protein L3 No bioinformatic MS3_09286 putative adenylate kinase 1 No proteomic (T, EES) MS3_09287 putative uv excision repair protein rad23 No bioinformatic MS3_09290 putative pyruvate dehydrogenase No proteomic (T, SEA) MS3_09296 Cysteine desulfurase No proteomic (T) MS3_09305 adenine phosphoribosyltransferase No proteomic (AES, EV) MS3_09333 Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) No bioinformatic MS3_09353 Histone H1-delta No proteomic (EES) MS3_09371 putative nebulin No proteomic (AES) MS3_09396 Complement C1q tumor necrosis factor-related protein 3 No bioinformatic MS3_09406 23 kDa integral membrane protein No bioinformatic MS3_09415 putative cop-coated vesicle membrane protein P24 (emp24/gp25l family) No bioinformatic MS3_09426 hypothetical protein MS3_09426 No bioinformatic MS3_09427 Receptor-type tyrosine-protein phosphatase gamma No bioinformatic MS3_09434 V-type proton ATPase subunit F No proteomic (EV) MS3_09443 Synaptosomal-associated protein 25 No bioinformatic MS3_09457 putative succinate dehydrogenase iron-sulfur protein Yes proteomic (T) MS3_09465 Methionine aminopeptidase 1D, chloroplastic/mitochondrial No bioinformatic MS3_09473 histidine triad nucleotide binding protein 1 No proteomic (AES, EES, SEA) MS3_09489 Stress-70 protein isoform 1 No proteomic (T, SEA) MS3_09510 Phosphate carrier protein, mitochondrial precursor No proteomic (T, EES) MS3_09521 putative clathrin coat adaptor ap3 medium chain No bioinformatic MS3_09536 putative flotillin-1 No bioinformatic MS3_09546 synaptic glycoprotein sc2 related No bioinformatic MS3_09569 subfamily C1A unassigned peptidase (C01 family) Yes bioinformatic MS3_09613 hypothetical protein MS3_09613 No proteomic (EV) MS3_09619 putative carbonyl reductase No proteomic (EES) MS3_09620 carbonyl reductase 1 No proteomic (T, AES) MS3_09626 serine/threonine-protein phosphatase 4 regulatory subunit 2 No bioinformatic MS3_09632 ATP synthase gamma subunit No bioinformatic MS3_09634 Ras-related protein Rab-3C No proteomic (T) MS3_09638 putative ATP-dependent RNA helicase DHX36 No bioinformatic MS3_09640 putative myosin-10 (Myosin heavy chain, nonmuscle IIb) No proteomic (EV) MS3_09644 long-chain-fatty-acid--CoA ligase No proteomic (T) MS3_09652 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase No proteomic (EV) 35 MS3_09662 Vacuolar-sorting protein isoform 2 No bioinformatic MS3_09682 thioredoxin 1 No proteomic (T, EES, SEA) MS3_09683 Zinc finger DBF type isoform 2 No bioinformatic MS3_09684 Bone marrow proteoglycan Yes bioinformatic MS3_09690 putative kunitz-type protease inhibitor Yes bioinformatic MS3_09691 putative small subunit ribosomal protein S27Ae No bioinformatic MS3_09692 Protein FAM98A No bioinformatic MS3_09698 CD9-like protein Sm-TSP-1 No bioinformatic MS3_09700 Iron/zinc purple acid phosphatase-like protein No proteomic (AES) MS3_09735 putative ribonuclease t2 No proteomic (EES, SEA) MS3_09739 High affinity copper uptake protein 1 No proteomic (EV) MS3_09744 Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp), putative No bioinformatic MS3_09778 cathepsin B-like peptidase (C01 family) No proteomic (AES) MS3_09779 cathepsin B-like peptidase (C01 family) Yes proteomic (EV) MS3_09780 10 kDa heat shock protein, mitochondrial No proteomic (T, AES, EES, SEA) MS3_09793 putative chromobox protein No bioinformatic MS3_09810 steroid dehydrogenase, putative No proteomic (T) MS3_09826 Protein FAM136A No bioinformatic MS3_09828 Rho GDP-dissociation inhibitor 2 No bioinformatic MS3_09829 THO complex subunit 3 No bioinformatic MS3_09846 20 kDa calcium-binding protein No proteomic (AES, EES, SEA, EV) MS3_09865 Coatomer subunit delta No bioinformatic MS3_09879 3-hydroxyacyl-CoA dehydrogenase type-2 No bioinformatic MS3_09903 Thimet oligopeptidase No proteomic (T, AES, EES) MS3_09942 putative rab-18 No bioinformatic MS3_09952 26S proteasome regulatory subunit T4 No bioinformatic MS3_09958 putative Stress-induced-phosphoprotein 1 No proteomic (T, EES, SEA, EV) MS3_09961 eupitrilysin (M16 family) No proteomic (SEA) MS3_09970 complement inhibitory receptor No bioinformatic MS3_09993 bestrophin-related protein No bioinformatic MS3_10002 putative alpha-galactosidase/alpha-n-acetylgalactosamini da se No proteomic (EES, SEA) MS3_10017 AChain A, Thioredoxin Glutathione Reductase No proteomic (AES, SEA) MS3_10022 Proteasome assembly chaperone 2 No bioinformatic MS3_10028 Cytochrome b561 No bioinformatic MS3_10036 Neutral ceramidase No proteomic (EV) MS3_10044 Eukaryotic translation initiation factor 3 subunit G No bioinformatic MS3_10083 SJCHGC02513 protein No bioinformatic MS3_10085 thioredoxin 1 No proteomic (T, AES, EES, SEA, EV) MS3_10116 60S ribosomal protein L23 No bioinformatic MS3_10138 Glycine receptor subunit alpha-3 Yes bioinformatic 36 MS3_10141 glyceraldehyde 3-phosphate dehydrogenase No proteomic (SEA, EV) MS3_10148 lipopolysaccharide-induced tumor necrosis factor-alpha factor No bioinformatic MS3_10161 GTP-binding protein ypt2 No proteomic (T) MS3_10177 Eukaryotic translation initiation factor 3 subunit F No bioinformatic MS3_10184 Gamma-crystallin related domain-containing protein Yes proteomic (T, AES, EES, SEA) MS3_10186 putative interleukin-4-inducing protein precursor Yes bioinformatic MS3_10187 disulfide-isomerase ER-60 precursor (ERP60) No proteomic (T, AES, EES, SEA) MS3_10188 protein kinase No bioinformatic MS3_10193 Ras-related protein Rab-2B No proteomic (T, EV) MS3_10194 Charged multivesicular body protein 5 No proteomic (EV) MS3_10209 Major egg antigen No proteomic (T, AES, EES, SEA, EV) MS3_10221 Transmembrane emp24 domain-containing protein 4 precursor Yes bioinformatic MS3_10225 transcript=A_05711 gene=A_05711 No bioinformatic MS3_10249 Proteasome subunit beta type-7 No proteomic (EV) MS3_10252 steroid dehydrogenase, putative Yes bioinformatic MS3_10288 putative tpa_exp: ORF3 No bioinformatic MS3_10292 Zinc finger CCCH domain-containing protein 3 No bioinformatic MS3_10297 ribosomal protein L30 No bioinformatic MS3_10305 DNA mismatch repair protein Msh2 No bioinformatic MS3_10345 putative alpha-galactosidase/alpha-n-acetylgalactosamini da se No proteomic (EES, SEA) MS3_10378 26S proteasome regulatory subunit S3, putative No bioinformatic MS3_10385 Estrogen-regulated protein EP45 precursor Yes proteomic (T, AES, EV) MS3_10397 60S acidic ribosomal protein P0 No bioinformatic MS3_10421 40S ribosomal protein S12 No bioinformatic MS3_10423 putative phospholipid-transporting ATPase IA No bioinformatic MS3_10440 Endonuclease/exonuclease/phosphatase family domain-containing protein 1 No bioinformatic MS3_10459 nucleoside diphosphate kinase homolog 5-like No bioinformatic MS3_10471 putative atp-dependent RNA helicase No bioinformatic MS3_10472 putative n-acetyltransferase No bioinformatic MS3_10475 seryl-tRNA synthetase No bioinformatic MS3_10485 GPI-anchored membrane protein 1 No bioinformatic MS3_10486 Ras-related protein RABH1b No proteomic (T) MS3_10489 Eukaryotic translation initiation factor 4H No bioinformatic MS3_10492 putative ribosomal protein L31 No bioinformatic MS3_10493 tyrosinase precursor No bioinformatic MS3_10499 hypothetical protein MS3_10499, partial No bioinformatic MS3_10510 putative l-lactate dehydrogenase No proteomic (T, AES, SEA, EV) MS3_10513 putative ribosomal protein L15 No bioinformatic MS3_10572 T-complex protein 1 subunit alpha No proteomic (T, EES, SEA, EV) MS3_10588 Alkaline phosphatase No proteomic (EES, EV) 37 MS3_10590 importin alpha 3,4, putative No proteomic (EV) MS3_10591 hypothetical protein MS3_10591, partial No proteomic (EV) MS3_10600 Ribosomal protein S19a No bioinformatic MS3_10607 hypothetical protein MS3_10607 No bioinformatic MS3_10619 AFG3-like protein 2 No bioinformatic MS3_10671 Gamma-soluble NSF attachment protein No proteomic (EV) MS3_10687 Cathepsin B-like cysteine proteinase No bioinformatic MS3_10713 putative heat shock protein 70 (hsp70) Yes proteomic (T, AES, EES, SEA, EV) MS3_10721 von Willebrand factor A domain-containing protein No proteomic (AES, EV) MS3_10729 cytochrome c oxidase subunit III No bioinformatic MS3_10736 calponin-related protein No proteomic (T, AES) MS3_10753 putative triosephosphate isomerase No proteomic (T, AES, EES, SEA, EV) MS3_10772 Glycoside hydrolase subgroup catalytic core No proteomic (EV) MS3_10785 4-hydroxybutyrate coenzyme A transferase No proteomic (T, SEA) MS3_10803 putative phospholipid-transporting ATPase IIB No proteomic (T) MS3_10811 Proteinase inhibitor I32, inhibitor of apoptosis,domain-containing protein No bioinformatic MS3_10816 glutamate dehydrogenase, putative No proteomic (T, EES, SEA) MS3_10820 cercarial elastase (S01 family) Yes bioinformatic MS3_10847 Histone H2B No proteomic (EES, EV) MS3_10898 putative ubx domain containing protein No proteomic (EES) MS3_10900 putative adenosine kinase No bioinformatic MS3_10931 serpin, putative No proteomic (T, AES, EV) MS3_10935 SJCHGC06112 protein No bioinformatic MS3_10943 ubiquitin-conjugating enzyme E2 F No bioinformatic MS3_10956 putative neuroendocrine protein 7b2 Yes bioinformatic MS3_10998 nucleoside-diphosphate kinase No proteomic (T, AES, SEA) MS3_11045 putative heterogeneous nuclear ribonucleoprotein k No bioinformatic MS3_11059 putative heat shock protein No proteomic (T, AES, EES, EV) MS3_11074 small subunit ribosomal protein S27 No bioinformatic MS3_11076 sugar nucleotide epimerase related No bioinformatic MS3_11077 SJCHGC02796 protein No bioinformatic MS3_11103 Four and a half LIM domains protein 2 No bioinformatic MS3_11139 Ras-related C3 botulinum toxin substrate 1 No proteomic (T, EV) MS3_11161 putative glutaredoxin, grx No bioinformatic MS3_11226 Major vault protein No proteomic (AES, SEA, EV) MS3_11239 putative plasminogen activator inhibitor 1 RNA-binding protein No bioinformatic MS3_11247 Lysine--tRNA ligase No bioinformatic MS3_11250 Heterogeneous nuclear ribonucleoproteins A2/B1 isoform 1 No proteomic (EES) MS3_11273 Aquaporin-9 (AQP-9) (Small solute channel 1) No proteomic (T) MS3_11280 putative alpha-galactosidase/alpha-n-acetylgalactosamini da se No proteomic (AES, EV) 38 MS3_11293 heat shock 70kDa protein 1/2/6/8 No proteomic (T, AES, EES, SEA, EV) MS3_11376 Clathrin heavy chain 1 isoform 3 No bioinformatic MS3_11411 putative heat shock protein 70 No proteomic (T, AES, EES, SEA, EV) MS3_11428 Major egg antigen No proteomic (T) MS3_11429 large subunit ribosomal protein L7e No bioinformatic MS3_11432 Actin alpha cardiac muscle 1 No proteomic (AES, EES) MS3_11484 neuroblast differentiation-associated AHNAK-like No proteomic (AES, EES, SEA) MS3_11509 putative 60s ribosomal protein L12 No bioinformatic MS3_11526 putative programmed cell death No proteomic (EES) MS3_11537 SJCHGC07871 protein No proteomic (T, AES) MS3_11544 glutathione S-transferase 26 kDa No proteomic (AES) No hits tetraspanin family isoform 2 No bioinformatic No hits NF-YA subunit No bioinformatic No hits pre-mRNA processing protein prp39-related protein No bioinformatic No hits Uncharacterised protein No bioinformatic No hits fascin, putative No proteomic (AES) No hits putative SAM pointed domain containing ets transcription factor No bioinformatic No hits ribosomal protein L18 No bioinformatic *WormBase ParaSite online database, version 14 https://parasite.wormbase.org/Schistosoma_haematobium_prjna78265/Info/Index/ # antigen sequences were interrogated for the predicted presence of a signal peptide (http://www.cbs.dtu.dk/services/SignalP-4.1/) and the SP (if any) was not included in gene synthesis ^proteins for array inclusion selected from bioinformatic analysis of second-generation S. mansoni array or proteomic analysis of S. haematobium T, ES, EES, SEA or EV. T = adult tegument, AES = adult excretory/secretory products, EES = egg excretory/secretory products, SEA = soluble egg antigen, EV = adult extracellular vesicles. 39 Table S2. Fold change of IgG responses between infected and non-infected (S. haematobium-endemic) populations resulting from serum sample probing of S. haematobium protein arrays. Antigen P value FDR AUC AUC AUC Mean Mean Fold Positive Positive Positive Positive (WBPS14* Lower Upper infected non Change infected non infected non accession) CI CI infected infected (%) infected (%) MS3_10186 3.20E-22 2.50E-20 0.88 0.83 0.92 12.79 10.11 14.58509332 232 14 95.47325103 48.27586207 MS3_10385 3.20E-20 1.60E-17 0.88 0.83 0.92 12.08 8.22 47.46535481 197 1 81.06995885 3.448275862 MS3_02553 1.10E-17 3.80E-15 0.88 0.82 0.94 12.01 9.16 17.28778203 187 3 76.95473251 10.34482759 MS3_09207 4.20E-17 1.00E-14 0.78 0.71 0.84 8.84 7.17 5.31217083 74 0 30.4526749 0 MS3_09198 2.90E-16 5.80E-14 0.79 0.73 0.85 11.95 10.38 4.806648198 233 24 95.88477366 82.75862069 MS3_07972 7.10E-16 1.20E-13 0.86 0.8 0.92 9.98 7.39 13.32977666 136 1 55.96707819 3.448275862 MS3_01370 3.10E-15 3.80E-13 0.78 0.71 0.84 9.06 7.55 4.526731986 79 0 32.51028807 0 MS3_07231 3.10E-15 3.80E-13 0.79 0.73 0.86 8.53 9.61 0.339595514 29 7 11.93415638 24.13793103 MS3_05530 8.10E-14 9.00E-12 0.81 0.75 0.88 8.74 9.64 0.406569651 20 8 8.230452675 27.5862069 MS3_05950 1.00E-13 1.00E-11 0.76 0.7 0.82 10.96 9.53 4.178699213 169 4 69.5473251 13.79310345 MS3_04157 2.60E-13 2.40E-11 0.8 0.73 0.87 8.01 9.25 0.289384189 10 3 4.115226337 10.34482759 MS3_06828 1.30E-12 1.00E-10 0.84 0.77 0.91 8.19 6.54 5.206990291 28 0 11.52263374 0 MS3_01658 5.50E-11 4.20E-09 0.83 0.76 0.9 7.72 6.46 3.525429425 10 0 4.115226337 0 MS3_06368 6.90E-11 4.70E-09 0.86 0.78 0.93 7.91 6.44 4.349245639 13 0 5.349794239 0 MS3_08399 7.10E-11 4.70E-09 0.76 0.69 0.83 8.7 9.64 0.390627826 37 9 15.22633745 31.03448276 MS3_07892 1.50E-10 9.50E-09 0.78 0.7 0.85 7.59 6.65 2.559985051 4 0 1.646090535 0 MS3_00779 4.40E-10 0.000000026 0.78 0.71 0.85 8.67 9.46 0.453844785 18 5 7.407407407 17.24137931 MS3_01466 6.40E-10 0.000000035 0.69 0.62 0.75 10.9 9.59 3.706173728 161 8 66.25514403 27.5862069 MS3_00180 8.40E-10 0.000000044 0.77 0.69 0.85 9.33 7.96 3.935351144 74 0 30.4526749 0 MS3_08105 1.10E-09 0.000000057 0.76 0.69 0.84 8.72 9.65 0.394553701 35 8 14.40329218 27.5862069 MS3_06193 1.80E-09 0.000000085 0.71 0.64 0.79 10.72 8.57 8.584858702 129 2 53.08641975 6.896551724 MS3_09175 3.40E-09 0.00000015 0.75 0.67 0.82 7.89 7.1 2.203397617 10 0 4.115226337 0 MS3_09286 5.70E-09 0.00000025 0.71 0.63 0.8 8.9 9.75 0.427414925 51 10 20.98765432 34.48275862 MS3_08937 0.000000006 0.00000025 0.68 0.61 0.76 9.08 9.71 0.532591796 54 8 22.22222222 27.5862069 MS3_09779 7.60E-09 0.0000003 0.84 0.76 0.93 9.05 6.87 8.846315677 80 2 32.9218107 6.896551724 MS3_09903 8.50E-09 0.00000033 0.72 0.64 0.8 8.54 9.33 0.453844782 12 3 4.938271605 10.34482759 MS3_09828 0.000000009 0.00000033 0.76 0.68 0.84 8.37 7.21 3.189934848 33 0 13.58024691 0 MS3_10252 0.000000012 0.00000043 0.77 0.69 0.85 9.03 7.92 3.034358752 51 0 20.98765432 0 MS3_04774 0.000000013 0.00000044 0.75 0.67 0.83 7.88 7.03 2.339648349 6 0 2.469135802 0 MS3_03127 0.000000022 0.00000072 0.84 0.75 0.93 8.24 6.99 3.490345675 15 0 6.172839506 0 MS3_09780 0.000000026 0.00000083 0.73 0.65 0.81 9 9.77 0.463013063 46 11 18.93004115 37.93103448 40 MS3_08826 0.000000033 0.000001 0.74 0.66 0.81 8.09 7.24 2.339647836 10 0 4.115226337 0 MS3_08087 0.000000039 0.0000012 0.81 0.72 0.89 8.7 7.43 3.560853717 29 0 11.93415638 0 MS3_06532 0.000000049 0.0000014 0.76 0.68 0.84 10.19 9.05 3.126768404 127 4 52.26337449 13.79310345 MS3_05600 0.000000086 0.0000024 0.81 0.72 0.9 7.46 6.55 2.484326791 4 0 1.646090535 0 MS3_01478 0.00000011 0.0000028 0.69 0.61 0.76 9.02 9.54 0.594520542 37 4 15.22633745 13.79310345 MS3_02001 0.00000011 0.0000028 0.7 0.62 0.77 9.22 9.94 0.486752252 77 12 31.6872428 41.37931034 MS3_08530 0.00000011 0.0000028 0.71 0.63 0.79 8.88 9.63 0.472366546 46 7 18.93004115 24.13793103 MS3_09632 0.00000012 0.000003 0.68 0.59 0.77 7.41 6.6 2.247911323 18 0 7.407407407 0 MS3_09638 0.00000012 0.000003 0.76 0.68 0.84 7.88 7.02 2.363162244 4 0 1.646090535 0 MS3_00886 0.00000016 0.0000038 0.77 0.69 0.84 9.29 8.17 3.064854423 71 1 29.218107 3.448275862 MS3_04920 0.00000019 0.0000044 0.76 0.68 0.84 8.4 7.27 3.095657844 27 1 11.11111111 3.448275862 MS3_08925 0.00000021 0.0000048 0.68 0.6 0.76 8.98 9.62 0.527292418 45 9 18.51851852 31.03448276 MS3_03662 0.00000022 0.0000049 0.77 0.69 0.86 8.23 7.37 2.363161463 13 0 5.349794239 0 MS3_06798 0.00000022 0.0000049 0.76 0.67 0.85 7.29 6.56 2.075083802 6 0 2.469135802 0 MS3_08903 0.0000003 0.0000064 0.67 0.59 0.75 7.16 6.48 1.973881184 8 0 3.29218107 0 MS3_01095 0.00000033 0.000007 0.78 0.69 0.86 8.85 7.65 3.320117607 40 0 16.46090535 0 MS3_01422 0.00000038 0.0000078 0.69 0.59 0.78 7.65 6.56 2.974279361 32 0 13.16872428 0 MS3_07406 0.00000041 0.0000083 0.64 0.56 0.72 7.23 6.59 1.896483464 7 0 2.880658436 0 MS3_02709 0.0000005 0.0000099 0.71 0.63 0.79 7.84 7.2 1.896481642 3 0 1.234567901 0 MS3_04617 0.00000053 0.00001 0.75 0.65 0.84 7.05 6.33 2.054438189 8 0 3.29218107 0 MS3_04267 0.00000054 0.00001 0.67 0.59 0.75 8.95 9.56 0.543350863 37 5 15.22633745 17.24137931 MS3_08094 0.0000006 0.000011 0.69 0.61 0.78 7.63 6.57 2.88637598 33 0 13.58024691 0 MS3_01899 0.00000063 0.000012 0.78 0.69 0.87 8.86 7.65 3.353485345 57 1 23.45679012 3.448275862 MS3_02802 0.00000065 0.000012 0.72 0.63 0.8 6.99 6.39 1.822122387 3 0 1.234567901 0 MS3_10956 0.00000067 0.000012 0.66 0.57 0.75 9.29 9.82 0.588604966 72 11 29.62962963 37.93103448 MS3_07390 0.00000068 0.000012 0.75 0.67 0.83 7.83 6.89 2.559983666 11 0 4.526748971 0 MS3_07411 0.00000086 0.000015 0.75 0.67 0.84 7.75 6.9 2.339648794 3 0 1.234567901 0 MS3_10288 0.00000095 0.000016 0.72 0.64 0.81 8.67 9.34 0.511708567 20 6 8.230452675 20.68965517 MS3_00004 0.00000097 0.000016 0.8 0.7 0.9 8.59 7.84 2.117000271 6 0 2.469135802 0 MS3_04526 0.0000013 0.000021 0.61 0.53 0.69 9.13 9.63 0.606530655 59 6 24.27983539 20.68965517 MS3_03424 0.0000017 0.000026 0.7 0.61 0.79 9.03 8.15 2.410899873 45 0 18.51851852 0 MS3_11103 0.0000019 0.00003 0.67 0.59 0.75 8.99 9.47 0.618783386 22 3 9.053497942 10.34482759 MS3_07045 0.000002 0.00003 0.72 0.63 0.82 8.6 7.6 2.718282417 37 0 15.22633745 0 MS3_11537 0.0000021 0.000031 0.73 0.65 0.81 8.82 9.42 0.548811628 21 6 8.641975309 20.68965517 MS3_04981 0.0000021 0.000031 0.71 0.63 0.8 8.98 9.57 0.554327279 26 7 10.69958848 24.13793103 MS3_03789 0.0000026 0.000039 0.63 0.54 0.71 7.68 6.86 2.270501851 32 0 13.16872428 0 MS3_04932 0.0000028 0.000041 0.69 0.61 0.78 8.91 9.54 0.532591794 36 8 14.81481481 27.5862069 41 MS3_02674 0.0000035 0.000051 0.73 0.64 0.81 8.36 7.45 2.484323237 35 1 14.40329218 3.448275862 MS3_10141 0.0000036 0.000052 0.72 0.63 0.81 7.91 7.2 2.033992118 10 0 4.115226337 0 MS3_08008 0.0000039 0.000054 0.65 0.57 0.74 9.35 9.84 0.612626391 78 12 32.09876543 41.37931034 MS3_02407 0.0000046 0.000064 0.67 0.59 0.76 8.52 9.26 0.477113901 15 1 6.172839506 3.448275862 MS3_03096 0.000005 0.000068 0.67 0.58 0.75 9.17 9.79 0.537944433 66 10 27.16049383 34.48275862 MS3_07994 0.0000057 0.000077 0.69 0.61 0.77 9.12 9.73 0.543350864 60 10 24.69135802 34.48275862 MS3_06167 0.0000093 0.00012 0.74 0.65 0.82 7.66 8.77 0.329558896 16 3 6.58436214 10.34482759 MS3_10816 0.000012 0.00015 0.68 0.59 0.76 9.4 9.89 0.612626392 81 10 33.33333333 34.48275862 MS3_11432 0.000012 0.00015 0.69 0.6 0.79 8.86 9.54 0.506616985 36 9 14.81481481 31.03448276 MS3_05837 0.000013 0.00016 0.7 0.62 0.78 8.97 9.46 0.612626388 29 4 11.93415638 13.79310345 MS3_09073 0.000013 0.00016 0.69 0.6 0.77 7.42 6.84 1.786039835 1 0 0.411522634 0 MS3_06608 0.000014 0.00017 0.75 0.66 0.85 8.53 7.39 3.126769435 21 0 8.641975309 0 MS3_09970 0.000015 0.00018 0.77 0.67 0.87 8.66 7.37 3.632787888 50 2 20.57613169 6.896551724 MS3_01016 0.000016 0.00019 0.71 0.62 0.79 8.52 9.27 0.472366538 28 3 11.52263374 10.34482759 MS3_06719 0.000016 0.00019 0.78 0.67 0.89 8.59 7.62 2.637945003 15 1 6.172839506 3.448275862 MS3_01337 0.000017 0.00019 0.75 0.67 0.84 8.83 7.77 2.886371442 27 0 11.11111111 0 MS3_07612 0.000017 0.00019 0.74 0.64 0.83 8.61 9.28 0.511708565 13 4 5.349794239 13.79310345 MS3_08808 0.000018 0.0002 0.67 0.58 0.76 8.75 9.4 0.522045767 30 7 12.34567901 24.13793103 MS3_01425 0.000022 0.00025 0.78 0.67 0.88 8.19 6.89 3.669300187 24 1 9.87654321 3.448275862 MS3_09692 0.000023 0.00026 0.73 0.63 0.83 7.46 6.83 1.877612151 2 0 0.823045267 0 MS3_05718 0.000029 0.00032 0.65 0.57 0.74 8.81 9.37 0.571209055 23 3 9.465020576 10.34482759 MS3_11411 0.00003 0.00033 0.74 0.67 0.81 9.95 8.93 2.773194806 124 1 51.02880658 3.448275862 MS3_04499 0.000031 0.00033 0.69 0.61 0.77 7.94 8.67 0.481908943 10 1 4.115226337 3.448275862 MS3_05170 0.000031 0.00033 0.68 0.59 0.77 9.24 9.79 0.576949807 68 11 27.98353909 37.93103448 MS3_04193 0.000032 0.00034 0.7 0.61 0.79 8.91 9.38 0.625002261 16 4 6.58436214 13.79310345 MS3_05000 0.000034 0.00036 0.69 0.59 0.79 7.26 6.69 1.768268911 6 0 2.469135802 0 MS3_04225 0.000039 0.0004 0.61 0.53 0.69 8.81 9.32 0.60049557 29 3 11.93415638 10.34482759 MS3_05034 0.00004 0.00041 0.66 0.57 0.75 9.15 9.72 0.565525434 60 10 24.69135802 34.48275862 MS3_05213 0.000041 0.00041 0.69 0.61 0.78 8.34 9.29 0.386741005 34 4 13.99176955 13.79310345 MS3_10305 0.000041 0.00041 0.71 0.62 0.8 8.65 9.15 0.606530648 6 0 2.469135802 0 MS3_07304 0.000043 0.00042 0.73 0.64 0.82 8.57 7.9 1.954237519 10 0 4.115226337 0 MS3_02999 0.000044 0.00043 0.61 0.53 0.7 8.94 9.42 0.618783385 39 4 16.04938272 13.79310345 MS3_06732 0.000045 0.00044 0.67 0.58 0.75 8.9 9.44 0.582748245 35 6 14.40329218 20.68965517 MS3_07823 0.000046 0.00044 0.72 0.62 0.82 8.52 7.67 2.339647268 29 1 11.93415638 3.448275862 MS3_05011 0.000048 0.00045 0.65 0.55 0.74 9.01 9.55 0.582748247 41 7 16.87242798 24.13793103 MS3_08954 0.000053 0.0005 0.71 0.63 0.8 7.99 8.68 0.501576026 4 1 1.646090535 3.448275862 MS3_07685 0.000055 0.00051 0.68 0.58 0.77 8.66 9.31 0.522045765 20 6 8.230452675 20.68965517 42 MS3_09958 0.000057 0.00053 0.65 0.57 0.73 8.93 9.43 0.606530653 43 3 17.69547325 10.34482759 MS3_03295 0.000062 0.00057 0.66 0.57 0.75 9.39 9.95 0.571209061 98 16 40.32921811 55.17241379 MS3_09276 0.000069 0.00061 0.68 0.59 0.77 8.61 9.09 0.618783379 8 1 3.29218107 3.448275862 MS3_07757 0.000069 0.00061 0.68 0.59 0.77 7.96 7.44 1.682028025 7 0 2.880658436 0 MS3_09521 0.000069 0.00061 0.75 0.65 0.86 8.45 7.62 2.293319187 24 1 9.87654321 3.448275862 MS3_10421 0.000069 0.00061 0.69 0.6 0.77 9 9.39 0.677056869 17 2 6.995884774 6.896551724 MS3_07763 0.000071 0.00062 0.69 0.6 0.78 8.05 7.43 1.858928507 6 0 2.469135802 0 MS3_04767 0.000073 0.00063 0.69 0.61 0.78 8.79 9.2 0.663650242 8 1 3.29218107 3.448275862 MS3_06125 0.00008 0.00069 0.71 0.61 0.8 8.85 7.86 2.691234818 59 2 24.27983539 6.896551724 MS3_05677 0.000085 0.00073 0.66 0.57 0.74 8.79 9.44 0.522045768 30 4 12.34567901 13.79310345 MS3_03301 0.000089 0.00075 0.64 0.56 0.73 8.98 9.51 0.588604964 46 5 18.93004115 17.24137931 MS3_09700 0.000089 0.00075 0.66 0.58 0.75 7.99 7.42 1.768267483 12 0 4.938271605 0 MS3_07178 0.000096 0.0008 0.75 0.64 0.85 8.44 6.9 4.664594791 65 2 26.74897119 6.896551724 MS3_09826 0.000099 0.00082 0.7 0.61 0.8 8.62 9.2 0.559898354 12 4 4.938271605 13.79310345 MS3_05595 0.0001 0.00082 0.7 0.61 0.79 7.28 6.75 1.698933831 1 0 0.411522634 0 MS3_10485 0.0001 0.00083 0.67 0.58 0.76 8.54 7.71 2.293319114 31 0 12.75720165 0 MS3_08723 0.00011 0.0009 0.72 0.62 0.82 8.27 7.35 2.509291262 27 1 11.11111111 3.448275862 MS3_09253 0.00011 0.00088 0.61 0.52 0.7 6.75 6.2 1.73325778 6 0 2.469135802 0 MS3_04279 0.00012 0.00093 0.61 0.53 0.7 8.12 7.47 1.915541282 30 0 12.34567901 0 MS3_05040 0.00012 0.00096 0.73 0.63 0.84 8.96 8.05 2.484322745 46 2 18.93004115 6.896551724 MS3_06009 0.00012 0.00092 0.72 0.63 0.81 8.22 7.14 2.944681188 47 1 19.34156379 3.448275862 MS3_08498 0.00012 0.00096 0.76 0.65 0.88 8.84 7.99 2.339647071 35 4 14.40329218 13.79310345 MS3_10772 0.00012 0.00093 0.74 0.64 0.85 7.65 6.98 1.954238569 4 0 1.646090535 0 MS3_02428 0.00013 0.00098 0.69 0.6 0.77 8.6 9.11 0.600495566 12 4 4.938271605 13.79310345 MS3_05391 0.00013 0.00098 0.71 0.62 0.8 8.24 7.7 1.716007095 2 0 0.823045267 0 MS3_07465 0.00013 0.00096 0.73 0.63 0.84 8.79 7.93 2.363160945 42 2 17.28395062 6.896551724 No hits 0.00013 0.00098 0.74 0.64 0.84 7.75 6.97 2.181473787 8 1 3.29218107 3.448275862 MS3_10002 0.00014 0.001 0.62 0.53 0.7 8.98 9.46 0.618783386 43 3 17.69547325 10.34482759 MS3_10184 0.00014 0.0011 0.66 0.57 0.76 7.99 7.3 1.993716214 21 0 8.641975309 0 MS3_03509 0.00015 0.0011 0.72 0.62 0.82 11.29 10.18 3.034358398 211 15 86.83127572 51.72413793 MS3_00880 0.00017 0.0012 0.66 0.57 0.76 8.53 9.13 0.548811621 16 3 6.58436214 10.34482759 MS3_03419 0.00017 0.0012 0.64 0.55 0.73 9.51 9.93 0.657046818 90 14 37.03703704 48.27586207 MS3_10138 0.00017 0.0012 0.72 0.62 0.82 10.04 8.97 2.915379542 121 5 49.79423868 17.24137931 MS3_01262 0.00018 0.0012 0.71 0.62 0.8 8.89 8.18 2.03399138 44 1 18.10699588 3.448275862 MS3_06539 0.00018 0.0012 0.68 0.58 0.78 7 6.4 1.822122316 6 0 2.469135802 0 MS3_06680 0.00018 0.0012 0.77 0.68 0.87 6.74 6.14 1.822124713 1 0 0.411522634 0 MS3_07363 0.00018 0.0013 0.64 0.55 0.73 8.54 9.09 0.576949796 18 1 7.407407407 3.448275862 43 MS3_04449 0.00021 0.0015 0.6 0.51 0.7 9.52 9.94 0.657046818 112 14 46.09053498 48.27586207 MS3_10345 0.00021 0.0015 0.57 0.49 0.66 9.58 9.94 0.697676324 123 14 50.61728395 48.27586207 MS3_00223 0.00024 0.0017 0.63 0.54 0.73 8.84 9.35 0.600495571 22 4 9.053497942 13.79310345 MS3_00996 0.00025 0.0017 0.64 0.56 0.73 10.34 9.78 1.750672504 130 8 53.49794239 27.5862069 MS3_01153 0.00025 0.0017 0.67 0.58 0.76 8.24 7.51 2.075081085 22 0 9.053497942 0 MS3_05639 0.00026 0.0017 0.69 0.59 0.79 8.58 9 0.657046807 3 1 1.234567901 3.448275862 MS3_08019 0.00026 0.0017 0.62 0.54 0.71 9.42 9.8 0.683861407 85 11 34.97942387 37.93103448 MS3_08161 0.00026 0.0017 0.66 0.57 0.75 8.89 9.45 0.571209057 38 6 15.63786008 20.68965517 MS3_10820 0.00028 0.0018 0.66 0.56 0.75 7.27 6.77 1.648722643 4 0 1.646090535 0 MS3_02343 0.00029 0.0019 0.68 0.59 0.78 8.06 7.51 1.733253365 8 0 3.29218107 0 MS3_03047 0.00029 0.0019 0.64 0.56 0.73 9.02 9.52 0.606530654 46 6 18.93004115 20.68965517 MS3_05586 0.00029 0.0019 0.68 0.59 0.77 8.39 7.84 1.733253197 15 0 6.172839506 0 MS3_03453 0.0003 0.0019 0.74 0.63 0.85 8.47 7.6 2.386911346 24 3 9.87654321 10.34482759 MS3_04827 0.0003 0.0019 0.71 0.61 0.81 8.7 8.18 1.682027735 5 0 2.057613169 0 MS3_02899 0.00031 0.0019 0.73 0.62 0.83 8.63 7.99 1.896481036 7 0 2.880658436 0 MS3_10590 0.00031 0.002 0.66 0.57 0.76 8.85 9.36 0.600495571 24 5 9.87654321 17.24137931 MS3_05496 0.00032 0.002 0.73 0.62 0.84 7.75 7.09 1.934793319 7 0 2.880658436 0 MS3_09810 0.00034 0.0021 0.64 0.56 0.72 10.33 9.73 1.822118805 148 11 60.90534979 37.93103448 MS3_01650 0.00037 0.0023 0.62 0.53 0.7 9.08 9.56 0.618783387 63 6 25.92592593 20.68965517 MS3_10221 0.00037 0.0023 0.62 0.54 0.7 8.09 7.69 1.491824869 9 0 3.703703704 0 MS3_05999 0.0004 0.0024 0.67 0.58 0.76 8.99 9.48 0.612626388 38 6 15.63786008 20.68965517 MS3_05387 0.00042 0.0025 0.68 0.59 0.78 8.21 7.62 1.803988716 9 0 3.703703704 0 MS3_10935 0.00043 0.0026 0.71 0.6 0.81 8.13 7.58 1.733253319 0 0 0 0 MS3_10591 0.00046 0.0027 0.64 0.55 0.73 6.81 6.41 1.491826921 0 0 0 0 MS3_07294 0.00048 0.0028 0.62 0.53 0.71 9.21 9.65 0.644036417 71 10 29.218107 34.48275862 MS3_00286 0.00055 0.0032 0.64 0.55 0.73 8.67 9.32 0.522045766 52 7 21.39917695 24.13793103 MS3_00604 0.00056 0.0033 0.63 0.54 0.73 9.2 9.71 0.600495575 67 9 27.57201646 31.03448276 MS3_01852 0.0006 0.0035 0.69 0.6 0.79 7.2 6.66 1.716008722 0 0 0 0 MS3_04375 0.00061 0.0035 0.67 0.57 0.77 7.87 7.32 1.733253525 7 0 2.880658436 0 MS3_08158 0.00061 0.0035 0.7 0.59 0.8 8.64 9.12 0.61878338 7 4 2.880658436 13.79310345 MS3_07702 0.00062 0.0036 0.69 0.59 0.79 10.88 9.83 2.857651125 179 10 73.66255144 34.48275862 MS3_06507 0.00063 0.0036 0.66 0.56 0.76 8.75 9.26 0.600495569 20 5 8.230452675 17.24137931 MS3_00625 0.00069 0.0039 0.74 0.63 0.86 7.83 7.05 2.181473562 5 0 2.057613169 0 MS3_07473 0.00072 0.0041 0.66 0.58 0.75 11.27 10.66 1.840431399 234 25 96.2962963 86.20689655 MS3_07569 0.00074 0.0041 0.7 0.61 0.79 9.69 8.9 2.203396459 96 2 39.50617284 6.896551724 MS3_01686 0.00075 0.0042 0.65 0.56 0.74 8.55 8.04 1.665291306 24 0 9.87654321 0 MS3_07795 0.00077 0.0042 0.65 0.56 0.74 7.41 6.97 1.552708021 2 0 0.823045267 0 44 MS3_07905 0.00077 0.0042 0.67 0.58 0.77 7.84 7.28 1.750673061 2 0 0.823045267 0 MS3_05539 0.00078 0.0042 0.72 0.6 0.83 8.44 7.67 2.159766623 8 1 3.29218107 3.448275862 MS3_03641 0.00081 0.0044 0.71 0.61 0.81 9.56 8.58 2.664456323 118 5 48.55967078 17.24137931 MS3_03776 0.00083 0.0045 0.77 0.67 0.88 8.75 7.77 2.66445665 35 2 14.40329218 6.896551724 MS3_02289 0.00084 0.0045 0.68 0.58 0.78 8.45 8.88 0.650509078 4 0 1.646090535 0 MS3_02690 0.00084 0.0045 0.56 0.47 0.66 6.79 6.29 1.648724856 10 0 4.115226337 0 MS3_02855 0.00085 0.0045 0.68 0.58 0.78 8.42 8.93 0.60049556 8 1 3.29218107 3.448275862 MS3_06918 0.00086 0.0046 0.62 0.53 0.71 9.28 9.65 0.690734327 66 9 27.16049383 31.03448276 No hits 0.0009 0.0047 0.59 0.5 0.68 9.38 9.77 0.677056872 95 12 39.09465021 41.37931034 MS3_02027 0.00091 0.0047 0.63 0.54 0.73 9.63 10.07 0.644036419 116 16 47.73662551 55.17241379 MS3_05050 0.00093 0.0048 0.72 0.63 0.82 8.44 9.09 0.522045759 11 2 4.526748971 6.896551724 MS3_02425 0.00094 0.0048 0.68 0.58 0.77 9.08 9.88 0.449328959 49 8 20.16460905 27.5862069 MS3_03977 0.00094 0.0048 0.63 0.54 0.72 9.18 9.63 0.637628148 69 8 28.39506173 27.5862069 MS3_03992 0.00094 0.0048 0.71 0.6 0.81 8.76 8.07 1.993715679 38 3 15.63786008 10.34482759 MS3_04311 0.00095 0.0048 0.67 0.57 0.77 8.49 7.85 1.896481087 20 0 8.230452675 0 No hits 0.00095 0.0048 0.66 0.56 0.75 8.74 9.27 0.58860496 27 3 11.11111111 10.34482759 MS3_01261 0.00096 0.0048 0.6 0.52 0.68 9.23 9.66 0.650509091 83 9 34.1563786 31.03448276 MS3_06979 0.00096 0.0048 0.7 0.59 0.81 7.8 7.19 1.840432136 1 0 0.411522634 0 MS3_01348 0.00097 0.0048 0.63 0.55 0.71 8.07 7.74 1.390968256 2 0 0.823045267 0 MS3_02681 0.00097 0.0048 0.65 0.56 0.73 8.03 8.43 0.670320007 3 0 1.234567901 0 MS3_01653 0.001 0.0051 0.67 0.58 0.77 8.88 9.36 0.618783384 17 4 6.995884774 13.79310345 MS3_08607 0.0011 0.0053 0.67 0.58 0.76 8.63 9.08 0.63762814 12 1 4.938271605 3.448275862 MS3_01710 0.0012 0.006 0.66 0.57 0.75 8.27 7.88 1.476980908 2 0 0.823045267 0 MS3_05516 0.0012 0.0057 0.61 0.52 0.7 9.09 9.54 0.637628147 59 7 24.27983539 24.13793103 MS3_06022 0.0012 0.0059 0.69 0.58 0.8 8.78 7.88 2.459603405 52 3 21.39917695 10.34482759 No hits 0.0012 0.006 0.66 0.56 0.77 7.53 7.09 1.55270785 1 0 0.411522634 0 MS3_01761 0.0013 0.0062 0.7 0.59 0.8 8.65 9.12 0.625002257 9 1 3.703703704 3.448275862 MS3_05945 0.0013 0.0061 0.68 0.58 0.77 8.52 7.92 1.822118969 24 1 9.87654321 3.448275862 MS3_02787 0.0014 0.0066 0.77 0.64 0.9 9.31 8.15 3.189933516 68 5 27.98353909 17.24137931 MS3_08059 0.0014 0.0066 0.68 0.58 0.79 7.25 6.81 1.552708323 1 0 0.411522634 0 MS3_09353 0.0015 0.0072 0.67 0.58 0.76 8.74 8.28 1.584074046 11 0 4.526748971 0 MS3_06126 0.0015 0.0072 0.68 0.58 0.78 8.74 8.27 1.599994257 7 0 2.880658436 0 MS3_10083 0.0015 0.0068 0.7 0.59 0.8 9.12 8.36 2.138276312 67 4 27.57201646 13.79310345 MS3_01365 0.0016 0.0073 0.74 0.63 0.85 10.13 9.16 2.637944484 132 6 54.32098765 20.68965517 MS3_05465 0.0016 0.0073 0.69 0.59 0.8 8.68 9.23 0.576949799 14 5 5.761316872 17.24137931 MS3_08398 0.0016 0.0075 0.63 0.54 0.73 8.85 9.21 0.697676319 14 3 5.761316872 10.34482759 MS3_00805 0.0017 0.0077 0.66 0.56 0.76 6.77 6.29 1.616077833 5 0 2.057613169 0 45 MS3_00900 0.0017 0.0077 0.64 0.53 0.74 8.98 9.49 0.600495573 39 8 16.04938272 27.5862069 MS3_01302 0.0017 0.0077 0.68 0.58 0.79 7.69 7.06 1.877611571 4 0 1.646090535 0 MS3_02157 0.0017 0.0077 0.71 0.59 0.82 9.05 8.38 1.954237397 43 3 17.69547325 10.34482759 No hits 0.0017 0.0078 0.65 0.56 0.75 7.76 7.26 1.648721786 2 0 0.823045267 0 MS3_01276 0.0018 0.0079 0.65 0.57 0.73 8.76 8.39 1.447734654 17 0 6.995884774 0 MS3_02856 0.0018 0.0079 0.58 0.5 0.67 9.18 9.59 0.663650246 67 7 27.57201646 24.13793103 MS3_05219 0.0018 0.0081 0.68 0.58 0.77 8.79 8.4 1.476980834 6 0 2.469135802 0 MS3_06898 0.0018 0.0079 0.67 0.57 0.78 8.51 7.99 1.682027775 12 0 4.938271605 0 MS3_08262 0.0018 0.0079 0.65 0.57 0.74 8.22 8.72 0.606530632 10 0 4.115226337 0 MS3_07944 0.0019 0.0082 0.67 0.57 0.77 9.09 8.47 1.8589281 58 3 23.86831276 10.34482759 MS3_07968 0.0019 0.0082 0.76 0.65 0.88 7.7 6.72 2.664459574 20 3 8.230452675 10.34482759 MS3_00048 0.0021 0.0089 0.59 0.51 0.68 9.09 8.62 1.599994225 43 0 17.69547325 0 MS3_00891 0.0021 0.009 0.73 0.62 0.85 7.67 7.14 1.698933006 2 0 0.823045267 0 MS3_03576 0.0024 0.01 0.65 0.56 0.74 8.42 7.96 1.584074101 9 0 3.703703704 0 MS3_05280 0.0024 0.01 0.64 0.54 0.74 9.15 9.51 0.697676322 40 7 16.46090535 24.13793103 MS3_05836 0.0024 0.01 0.62 0.53 0.72 7.27 6.9 1.447735383 2 0 0.823045267 0 MS3_00560 0.0025 0.011 0.7 0.59 0.82 8.1 7.43 1.954237828 10 0 4.115226337 0 MS3_01643 0.0025 0.01 0.64 0.54 0.73 8.62 8.2 1.521961621 16 0 6.58436214 0 MS3_07590 0.0025 0.01 0.64 0.56 0.73 9.01 9.57 0.571209058 55 5 22.63374486 17.24137931 MS3_09290 0.0025 0.011 0.64 0.53 0.74 7.85 7.33 1.682028117 9 0 3.703703704 0 MS3_09684 0.0025 0.01 0.58 0.48 0.69 8.16 7.61 1.733253302 25 0 10.28806584 0 MS3_06149 0.0027 0.011 0.63 0.54 0.72 9.19 9.62 0.650509091 65 10 26.74897119 34.48275862 MS3_02734 0.0027 0.011 0.65 0.56 0.75 7.88 7.44 1.552707532 2 0 0.823045267 0 MS3_04646 0.0027 0.011 0.71 0.59 0.83 9.94 9.09 2.339646876 134 7 55.14403292 24.13793103 MS3_01902 0.0028 0.011 0.65 0.55 0.74 8.59 8.96 0.690734318 4 0 1.646090535 0 MS3_11429 0.0028 0.011 0.65 0.57 0.74 8.39 8.82 0.650509075 8 1 3.29218107 3.448275862 MS3_00316 0.0029 0.012 0.64 0.55 0.73 7.42 7.09 1.390968595 1 0 0.411522634 0 MS3_03101 0.0029 0.012 0.64 0.54 0.74 9.14 9.64 0.606530655 55 10 22.63374486 34.48275862 MS3_09089 0.0029 0.012 0.7 0.59 0.81 7.44 6.9 1.716008013 2 0 0.823045267 0 MS3_05216 0.003 0.012 0.73 0.63 0.82 8.77 9.41 0.527292415 32 8 13.16872428 27.5862069 MS3_08975 0.003 0.012 0.67 0.57 0.77 8.46 7.5 2.611697155 59 2 24.27983539 6.896551724 MS3_10193 0.003 0.012 0.68 0.57 0.78 7.93 7.39 1.716007294 10 0 4.115226337 0 MS3_00196 0.0031 0.012 0.69 0.58 0.8 8.72 8.13 1.803988524 38 2 15.63786008 6.896551724 MS3_09662 0.0031 0.012 0.61 0.52 0.71 7.32 6.76 1.750674085 17 0 6.995884774 0 MS3_02234 0.0032 0.013 0.67 0.57 0.78 8.4 7.86 1.716007031 12 0 4.938271605 0 MS3_08160 0.0032 0.013 0.65 0.56 0.74 9.05 9.52 0.625002263 55 9 22.63374486 31.03448276 MS3_08737 0.0032 0.012 0.61 0.52 0.71 8.88 8.44 1.552707261 31 0 12.75720165 0 46 MS3_10729 0.0032 0.013 0.65 0.56 0.74 8.33 8.67 0.711770302 3 0 1.234567901 0 MS3_01516 0.0033 0.013 0.67 0.57 0.78 8.8 8.18 1.858928146 30 1 12.34567901 3.448275862 MS3_06877 0.0033 0.013 0.62 0.53 0.72 9.36 9.91 0.576949808 86 14 35.3909465 48.27586207 MS3_02141 0.0035 0.013 0.69 0.59 0.78 8.58 8.94 0.697676313 2 0 0.823045267 0 MS3_06538 0.0035 0.013 0.68 0.57 0.79 8.29 8.77 0.618783368 6 2 2.469135802 6.896551724 MS3_05953 0.0037 0.014 0.65 0.56 0.74 8.91 8.58 1.390968152 15 0 6.172839506 0 MS3_07010 0.0037 0.014 0.63 0.54 0.72 8.9 9.45 0.576949803 62 8 25.51440329 27.5862069 MS3_08776 0.0037 0.014 0.67 0.56 0.78 8.68 9.04 0.697676316 5 1 2.057613169 3.448275862 MS3_01611 0.004 0.015 0.68 0.58 0.78 8.26 8.75 0.612626369 9 3 3.703703704 10.34482759 MS3_01938 0.004 0.015 0.65 0.55 0.76 8.95 9.44 0.612626388 37 9 15.22633745 31.03448276 MS3_03979 0.004 0.015 0.65 0.54 0.75 8.11 7.62 1.632316465 13 0 5.349794239 0 MS3_06928 0.004 0.015 0.58 0.49 0.66 9.47 9.75 0.75578374 87 10 35.80246914 34.48275862 MS3_11250 0.004 0.015 0.6 0.51 0.7 9.14 9.51 0.690734326 51 7 20.98765432 24.13793103 MS3_03853 0.0042 0.016 0.64 0.54 0.73 7.18 6.82 1.433330291 0 0 0 0 MS3_08953 0.0044 0.016 0.65 0.54 0.75 8.27 7.6 1.954237682 33 1 13.58024691 3.448275862 MS3_09691 0.0044 0.016 0.62 0.51 0.72 9.84 10.23 0.677056873 156 22 64.19753086 75.86206897 MS3_06211 0.0045 0.016 0.63 0.54 0.72 8.9 9.26 0.697676319 25 2 10.28806584 6.896551724 MS3_04609 0.0046 0.017 0.69 0.57 0.8 8.43 7.91 1.682027796 5 1 2.057613169 3.448275862 MS3_07637 0.0047 0.017 0.63 0.53 0.72 7.58 7.27 1.363425419 1 0 0.411522634 0 MS3_03695 0.0048 0.017 0.67 0.56 0.78 6.23 6.95 0.486750815 1 0 0.411522634 0 MS3_00498 0.0049 0.018 0.65 0.54 0.75 9.63 9.07 1.750672516 88 5 36.21399177 17.24137931 MS3_03417 0.0051 0.018 0.67 0.55 0.79 9.03 8.56 1.599994229 24 2 9.87654321 6.896551724 MS3_02685 0.0052 0.019 0.55 0.46 0.64 9.46 9.79 0.718923731 106 11 43.62139918 37.93103448 MS3_06559 0.0052 0.018 0.67 0.55 0.79 8.15 7.62 1.698932576 0 0 0 0 MS3_08413 0.0052 0.018 0.63 0.54 0.72 8.49 8.87 0.683861394 10 0 4.115226337 0 MS3_08823 0.0054 0.019 0.64 0.54 0.74 8.46 8.02 1.552707317 18 1 7.407407407 3.448275862 MS3_05676 0.0055 0.019 0.66 0.56 0.77 8.77 8.32 1.568312241 7 0 2.880658436 0 MS3_07374 0.0055 0.019 0.61 0.51 0.72 9.06 9.54 0.618783387 51 10 20.98765432 34.48275862 MS3_08144 0.0055 0.019 0.64 0.55 0.72 7.81 7.29 1.682028156 8 1 3.29218107 3.448275862 MS3_10510 0.0055 0.019 0.66 0.56 0.76 8.86 9.51 0.522045769 61 9 25.10288066 31.03448276 MS3_10753 0.0055 0.019 0.62 0.52 0.72 9.16 9.51 0.704688086 44 6 18.10699588 20.68965517 MS3_09735 0.0056 0.019 0.62 0.52 0.71 9.18 9.56 0.683861405 53 6 21.81069959 20.68965517 MS3_03350 0.0057 0.019 0.68 0.57 0.79 8.52 7.73 2.203396764 43 3 17.69547325 10.34482759 MS3_07213 0.0057 0.02 0.7 0.59 0.81 8.32 7.38 2.559982262 47 2 19.34156379 6.896551724 MS3_07816 0.0057 0.02 0.66 0.57 0.75 7.46 8.15 0.501575945 18 2 7.407407407 6.896551724 MS3_02752 0.0059 0.02 0.58 0.49 0.68 9.22 9.6 0.683861406 64 6 26.33744856 20.68965517 MS3_00934 0.006 0.02 0.62 0.52 0.72 7.68 7.34 1.404947883 0 0 0 0 47 MS3_03618 0.006 0.02 0.63 0.53 0.72 7.61 7.16 1.568312747 1 0 0.411522634 0 MS3_02048 0.0062 0.021 0.65 0.55 0.76 7.74 8.19 0.63762808 1 0 0.411522634 0 MS3_03938 0.0062 0.021 0.63 0.52 0.74 7.24 6.78 1.584075215 5 0 2.057613169 0 MS3_09160 0.0062 0.021 0.62 0.53 0.71 7.87 7.5 1.447734846 5 0 2.057613169 0 MS3_09371 0.0065 0.022 0.64 0.54 0.74 8.58 8.07 1.665291299 30 1 12.34567901 3.448275862 MS3_07824 0.0066 0.022 0.67 0.57 0.78 9.58 9 1.786038449 79 4 32.51028807 13.79310345 MS3_05203 0.0067 0.022 0.66 0.56 0.76 8.24 8.64 0.67032002 2 1 0.823045267 3.448275862 MS3_06069 0.0067 0.022 0.69 0.58 0.79 8.95 9.57 0.537944431 41 8 16.87242798 27.5862069 MS3_06669 0.0067 0.022 0.56 0.47 0.65 9.1 9.4 0.740818217 37 4 15.22633745 13.79310345 MS3_10017 0.0068 0.022 0.67 0.55 0.79 8.24 7.69 1.73325326 8 1 3.29218107 3.448275862 MS3_09119 0.0071 0.023 0.62 0.52 0.72 8.69 8.03 1.934792485 48 1 19.75308642 3.448275862 MS3_02160 0.0072 0.023 0.66 0.55 0.77 7.9 7.44 1.584074314 2 0 0.823045267 0 MS3_02688 0.0074 0.024 0.63 0.54 0.73 10.73 10.3 1.537257525 206 17 84.77366255 58.62068966 MS3_04688 0.0074 0.024 0.42 0.32 0.52 9.28 8.67 1.840431437 70 2 28.80658436 6.896551724 MS3_05150 0.0075 0.024 0.66 0.56 0.76 7.87 7.39 1.616074782 5 0 2.057613169 0 MS3_01627 0.0076 0.025 0.45 0.35 0.55 9.61 9.96 0.704688088 118 11 48.55967078 37.93103448 MS3_10489 0.0076 0.024 0.64 0.56 0.73 8.05 8.45 0.670320008 6 1 2.469135802 3.448275862 MS3_09644 0.0078 0.025 0.67 0.56 0.78 8.22 7.63 1.80398871 25 1 10.28806584 3.448275862 MS3_04598 0.0083 0.027 0.67 0.55 0.78 8.71 8.13 1.786038537 29 4 11.93415638 13.79310345 MS3_08805 0.0083 0.027 0.64 0.54 0.74 8.71 9.03 0.726149028 5 3 2.057613169 10.34482759 MS3_01339 0.0084 0.027 0.64 0.54 0.75 8.66 9.11 0.63762814 16 4 6.58436214 13.79310345 MS3_03269 0.0085 0.027 0.64 0.54 0.74 9.27 9.73 0.631283642 64 10 26.33744856 34.48275862 MS3_05016 0.0085 0.027 0.68 0.57 0.8 8.47 7.94 1.69893245 4 1 1.646090535 3.448275862 MS3_09086 0.0086 0.027 0.62 0.52 0.72 7.66 7.31 1.419067868 0 0 0 0 MS3_02545 0.0087 0.027 0.67 0.55 0.78 8.97 8.42 1.733253074 38 2 15.63786008 6.896551724 MS3_11139 0.009 0.028 0.55 0.47 0.64 9.55 9.79 0.78662786 104 10 42.79835391 34.48275862 MS3_07337 0.0092 0.029 0.65 0.55 0.76 7.39 6.86 1.69893353 9 0 3.703703704 0 MS3_07158 0.0095 0.029 0.64 0.54 0.74 8.39 7.99 1.491824792 6 0 2.469135802 0 MS3_01141 0.0099 0.031 0.64 0.54 0.75 8.19 7.6 1.803988728 12 0 4.938271605 0 MS3_01922 0.01 0.032 0.6 0.51 0.69 8.84 9.2 0.697676319 22 2 9.053497942 6.896551724 MS3_07606 0.01 0.031 0.57 0.47 0.68 9.59 9.9 0.733446955 109 13 44.85596708 44.82758621 MS3_01777 0.011 0.035 0.66 0.57 0.76 8.7 9.03 0.718923724 9 0 3.703703704 0 MS3_01857 0.011 0.033 0.64 0.55 0.73 10.39 9.68 2.033991265 170 14 69.95884774 48.27586207 MS3_02393 0.011 0.033 0.63 0.53 0.72 8.48 8.1 1.462284661 14 0 5.761316872 0 MS3_03193 0.011 0.034 0.64 0.53 0.76 8.55 8.91 0.697676313 7 2 2.880658436 6.896551724 MS3_07372 0.011 0.033 0.63 0.54 0.72 9.11 9.77 0.51685133 82 10 33.74485597 34.48275862 MS3_09536 0.011 0.033 0.56 0.47 0.65 7 6.74 1.296930822 3 0 1.234567901 0 48 MS3_01597 0.012 0.037 0.63 0.52 0.75 7.26 6.89 1.447735399 3 0 1.234567901 0 MS3_07531 0.012 0.037 0.67 0.58 0.77 8.86 9.41 0.576949803 42 8 17.28395062 27.5862069 MS3_01049 0.013 0.039 0.65 0.54 0.77 9.32 8.45 2.386910944 95 6 39.09465021 20.68965517 MS3_01193 0.013 0.04 0.55 0.45 0.65 8.62 8.13 1.632316308 41 0 16.87242798 0 MS3_01668 0.013 0.038 0.67 0.56 0.78 9.4 8.7 2.01375275 67 3 27.57201646 10.34482759 MS3_02086 0.013 0.039 0.46 0.36 0.55 9.58 9.88 0.740818219 113 13 46.50205761 44.82758621 MS3_07345 0.013 0.039 0.55 0.46 0.64 8.85 9.17 0.72614903 30 1 12.34567901 3.448275862 MS3_08689 0.013 0.038 0.67 0.56 0.78 9.14 8.65 1.632316251 29 2 11.93415638 6.896551724 MS3_08943 0.013 0.038 0.65 0.55 0.76 8.42 8.78 0.697676309 2 0 0.823045267 0 MS3_00862 0.014 0.041 0.59 0.49 0.69 9 9.41 0.663650244 59 7 24.27983539 24.13793103 MS3_02044 0.014 0.041 0.7 0.58 0.82 8.92 8.24 1.973877834 49 3 20.16460905 10.34482759 MS3_06403 0.014 0.041 0.59 0.5 0.68 7.24 6.74 1.648722728 16 1 6.58436214 3.448275862 MS3_06834 0.014 0.041 0.63 0.52 0.74 7.31 6.9 1.506818641 1 0 0.411522634 0 MS3_09683 0.014 0.041 0.64 0.55 0.73 8.7 9.27 0.565525428 31 4 12.75720165 13.79310345 MS3_01983 0.015 0.043 0.64 0.53 0.74 8.87 9.22 0.704688083 23 4 9.465020576 13.79310345 MS3_04286 0.015 0.043 0.66 0.55 0.77 7.77 7.24 1.69893288 8 1 3.29218107 3.448275862 MS3_06243 0.015 0.043 0.64 0.53 0.75 7.86 7.49 1.447734851 4 0 1.646090535 0 MS3_08717 0.015 0.042 0.63 0.52 0.74 8.83 9.16 0.718923726 9 2 3.703703704 6.896551724 MS3_09070 0.015 0.043 0.65 0.53 0.78 6.36 6.99 0.53259066 2 1 0.823045267 3.448275862 No hits 0.015 0.042 0.61 0.52 0.71 8.33 8.86 0.588604947 25 2 10.28806584 6.896551724 MS3_01775 0.016 0.044 0.61 0.52 0.71 8.32 7.95 1.447734709 7 0 2.880658436 0 MS3_02176 0.016 0.044 0.67 0.54 0.79 8.86 9.25 0.677056867 12 5 4.938271605 17.24137931 MS3_02747 0.016 0.046 0.61 0.51 0.72 8.38 8.9 0.594520528 17 4 6.995884774 13.79310345 MS3_03603 0.016 0.045 0.63 0.52 0.73 8.47 8.79 0.726149022 4 0 1.646090535 0 MS3_06112 0.016 0.044 0.61 0.51 0.72 8.77 9.15 0.6838614 25 6 10.28806584 20.68965517 MS3_07594 0.016 0.044 0.63 0.53 0.74 7.81 7.44 1.447734876 1 0 0.411522634 0 MS3_08996 0.016 0.044 0.61 0.51 0.71 9.46 9.84 0.683861407 98 15 40.32921811 51.72413793 MS3_09865 0.016 0.044 0.7 0.6 0.81 9.65 9.27 1.462284596 69 3 28.39506173 10.34482759 MS3_00719 0.017 0.047 0.63 0.53 0.73 8.53 8.12 1.50681786 19 0 7.818930041 0 MS3_01445 0.017 0.047 0.55 0.45 0.65 7.1 6.72 1.462285723 12 0 4.938271605 0 MS3_02928 0.017 0.046 0.66 0.55 0.78 8.77 8.3 1.599994253 13 2 5.349794239 6.896551724 MS3_04178 0.017 0.046 0.65 0.54 0.76 7.38 6.91 1.599995164 9 1 3.703703704 3.448275862 MS3_05730 0.018 0.049 0.65 0.54 0.75 11.33 10.66 1.954237321 230 21 94.65020576 72.4137931 MS3_07126 0.018 0.049 0.62 0.53 0.72 8.06 8.35 0.748263535 3 0 1.234567901 0 MS3_08533 0.018 0.049 0.64 0.52 0.75 8.25 8.62 0.690734306 3 1 1.234567901 3.448275862 MS3_09274 0.018 0.049 0.54 0.45 0.63 9.09 9.38 0.748263563 56 4 23.04526749 13.79310345 MS3_10671 0.018 0.049 0.64 0.53 0.75 7.92 8.74 0.440431608 26 4 10.69958848 13.79310345 49 MS3_02944 0.019 0.051 0.63 0.53 0.73 8.74 9.03 0.748263559 5 1 2.057613169 3.448275862 MS3_10440 0.019 0.051 0.63 0.53 0.73 8.57 8.17 1.491824763 19 0 7.818930041 0 MS3_04158 0.02 0.054 0.59 0.49 0.69 8.78 8.37 1.50681783 30 0 12.34567901 0 MS3_05350 0.02 0.053 0.62 0.52 0.72 7.97 7.58 1.476981002 5 0 2.057613169 0 MS3_08891 0.02 0.053 0.6 0.49 0.71 7.43 7.11 1.377128199 2 0 0.823045267 0 MS3_09952 0.02 0.055 0.64 0.53 0.75 8.43 8.81 0.683861392 4 0 1.646090535 0 MS3_02356 0.021 0.055 0.63 0.53 0.74 8.76 9.08 0.726149029 15 2 6.172839506 6.896551724 MS3_03270 0.021 0.055 0.65 0.52 0.77 8.77 8.29 1.616074465 12 1 4.938271605 3.448275862 MS3_04025 0.021 0.055 0.63 0.52 0.74 8.31 8.64 0.718923712 1 0 0.411522634 0 MS3_06668 0.021 0.055 0.63 0.52 0.73 8.38 8.78 0.670320027 4 2 1.646090535 6.896551724 MS3_01001 0.023 0.061 0.62 0.53 0.71 7.97 8.22 0.778800746 0 0 0 0 MS3_05614 0.023 0.059 0.63 0.53 0.72 9.08 8.83 1.284025427 16 0 6.58436214 0 MS3_01905 0.024 0.062 0.64 0.53 0.75 8.44 8.78 0.711770306 7 1 2.880658436 3.448275862 MS3_04276 0.024 0.063 0.62 0.5 0.74 8.03 7.52 1.665291508 15 1 6.172839506 3.448275862 MS3_05646 0.024 0.064 0.61 0.51 0.71 7.93 7.6 1.390968297 4 0 1.646090535 0 MS3_02807 0.025 0.065 0.58 0.48 0.67 9.05 9.47 0.657046815 67 6 27.57201646 20.68965517 MS3_03775 0.025 0.065 0.59 0.5 0.68 9.26 9.56 0.740818218 58 7 23.86831276 24.13793103 MS3_04896 0.025 0.065 0.68 0.55 0.8 8.84 9.21 0.690734323 14 6 5.761316872 20.68965517 MS3_05370 0.025 0.064 0.57 0.48 0.66 7.79 7.48 1.363425315 6 0 2.469135802 0 MS3_11376 0.025 0.064 0.64 0.53 0.76 8.7 9.1 0.670320036 10 2 4.115226337 6.896551724 MS3_01771 0.026 0.066 0.66 0.54 0.77 8.91 9.29 0.683861403 24 7 9.87654321 24.13793103 MS3_02275 0.026 0.066 0.56 0.47 0.65 9.24 9.52 0.755783738 65 6 26.74897119 20.68965517 MS3_08366 0.026 0.066 0.61 0.51 0.71 8.21 7.9 1.363425201 6 0 2.469135802 0 MS3_09942 0.026 0.067 0.56 0.46 0.66 9.45 9.71 0.771051584 84 9 34.56790123 31.03448276 MS3_02346 0.027 0.068 0.59 0.49 0.68 7.73 7.42 1.36342534 4 0 1.646090535 0 MS3_03824 0.027 0.068 0.6 0.5 0.71 7.9 7.51 1.476981034 10 0 4.115226337 0 MS3_04261 0.027 0.068 0.6 0.49 0.71 7.71 7.33 1.462284924 9 0 3.703703704 0 MS3_06214 0.027 0.069 0.64 0.53 0.75 8.35 7.96 1.476980891 9 0 3.703703704 0 MS3_08000 0.027 0.068 0.59 0.5 0.67 8.33 8.06 1.309964505 6 0 2.469135802 0 MS3_10036 0.027 0.068 0.64 0.54 0.74 8.41 7.96 1.568312299 25 2 10.28806584 6.896551724 MS3_03655 0.028 0.07 0.62 0.53 0.71 9.1 8.74 1.433329433 69 2 28.39506173 6.896551724 MS3_05739 0.028 0.07 0.62 0.51 0.72 6.64 6.4 1.271250488 0 0 0 0 MS3_00569 0.029 0.072 0.63 0.51 0.74 8.98 8.53 1.568312222 47 2 19.34156379 6.896551724 MS3_10493 0.029 0.072 0.62 0.52 0.72 8.97 9.41 0.644036415 41 5 16.87242798 17.24137931 MS3_11247 0.029 0.073 0.62 0.52 0.73 8.55 8.94 0.677056861 6 2 2.469135802 6.896551724 MS3_02314 0.03 0.074 0.57 0.48 0.66 9.48 9.74 0.771051584 93 12 38.27160494 41.37931034 MS3_01114 0.03 0.075 0.59 0.49 0.68 7.33 7.05 1.323130239 3 0 1.234567901 0 50 MS3_06746 0.03 0.075 0.57 0.48 0.67 9.54 9.86 0.726149035 106 13 43.62139918 44.82758621 MS3_00670 0.031 0.075 0.62 0.51 0.74 8.79 8.38 1.506817829 12 1 4.938271605 3.448275862 MS3_03420 0.031 0.075 0.63 0.52 0.73 9.25 8.85 1.491824715 57 3 23.45679012 10.34482759 MS3_08169 0.031 0.075 0.66 0.55 0.76 8.58 9.05 0.625002255 18 2 7.407407407 6.896551724 MS3_10736 0.031 0.076 0.6 0.51 0.69 8.5 8.18 1.377127815 17 0 6.995884774 0 MS3_04437 0.032 0.078 0.61 0.51 0.7 8.59 8.84 0.778800772 5 0 2.057613169 0 MS3_10475 0.032 0.077 0.62 0.53 0.71 8.72 8.45 1.309964476 14 0 5.761316872 0 MS3_00440 0.033 0.079 0.62 0.51 0.73 7.51 7.16 1.41906798 0 0 0 0 MS3_08811 0.033 0.079 0.63 0.53 0.74 8.49 8.16 1.390968183 5 1 2.057613169 3.448275862 MS3_10022 0.033 0.079 0.62 0.52 0.73 7.8 7.52 1.323129979 0 0 0 0 MS3_01245 0.034 0.082 0.61 0.51 0.71 8.23 7.95 1.323129883 4 0 1.646090535 0 MS3_07422 0.034 0.081 0.65 0.52 0.77 8.5 8.91 0.663650235 9 4 3.703703704 13.79310345 MS3_06296 0.035 0.084 0.65 0.55 0.76 8.58 9.05 0.625002255 21 3 8.641975309 10.34482759 MS3_07370 0.035 0.084 0.6 0.5 0.7 8.34 8.6 0.771051568 3 0 1.234567901 0 MS3_03814 0.036 0.086 0.65 0.55 0.75 8.89 9.39 0.606530652 36 6 14.81481481 20.68965517 MS3_04262 0.036 0.086 0.62 0.51 0.73 8.52 8.16 1.433329475 5 0 2.057613169 0 MS3_06276 0.036 0.085 0.62 0.51 0.73 8.95 9.24 0.748263562 21 5 8.641975309 17.24137931 MS3_07105 0.036 0.086 0.59 0.5 0.69 8.39 8.04 1.419067623 20 2 8.230452675 6.896551724 MS3_07419 0.036 0.086 0.62 0.52 0.72 8.85 8.47 1.462284624 37 2 15.22633745 6.896551724 MS3_00452 0.037 0.086 0.61 0.51 0.71 8.36 8.1 1.296930135 2 0 0.823045267 0 MS3_01870 0.037 0.086 0.6 0.5 0.7 7.7 7.35 1.419067844 4 0 1.646090535 0 MS3_05252 0.037 0.086 0.63 0.52 0.73 8.06 8.38 0.726149003 0 0 0 0 MS3_08726 0.037 0.086 0.57 0.46 0.68 8.03 7.68 1.419067701 11 0 4.526748971 0 MS3_09427 0.037 0.086 0.58 0.48 0.69 7.93 7.66 1.309964572 8 0 3.29218107 0 MS3_00151 0.038 0.088 0.63 0.52 0.73 7.99 7.68 1.363425249 2 0 0.823045267 0 MS3_04227 0.038 0.089 0.64 0.53 0.75 8.75 9.07 0.726149028 17 1 6.995884774 3.448275862 MS3_05734 0.038 0.088 0.62 0.49 0.75 8.07 7.61 1.584074219 2 0 0.823045267 0 MS3_00412 0.039 0.09 0.61 0.51 0.7 8.67 8.9 0.794533594 8 1 3.29218107 3.448275862 MS3_10028 0.039 0.089 0.59 0.49 0.7 8.23 7.93 1.349858886 10 0 4.115226337 0 MS3_02653 0.04 0.091 0.62 0.5 0.73 8.12 8.51 0.677056842 5 2 2.057613169 6.896551724 MS3_03304 0.04 0.091 0.62 0.52 0.72 8.6 8.85 0.778800773 4 0 1.646090535 0 MS3_03768 0.04 0.091 0.63 0.52 0.73 7.42 7.87 0.637628016 7 1 2.880658436 3.448275862 MS3_06299 0.04 0.091 0.6 0.5 0.7 7.6 7.33 1.309964686 1 0 0.411522634 0 MS3_07509 0.04 0.091 0.63 0.52 0.74 8.32 8.62 0.740818201 4 1 1.646090535 3.448275862 MS3_10785 0.041 0.093 0.58 0.48 0.68 6.79 6.56 1.25860094 0 0 0 0 MS3_02474 0.042 0.095 0.63 0.51 0.75 8.65 8.92 0.763379485 4 1 1.646090535 3.448275862 MS3_04887 0.042 0.095 0.65 0.53 0.76 8.22 7.68 1.716007104 27 2 11.11111111 6.896551724 51 MS3_08692 0.042 0.096 0.61 0.5 0.71 8.96 9.41 0.637628145 55 9 22.63374486 31.03448276 MS3_00447 0.043 0.096 0.61 0.49 0.73 8.93 9.21 0.755783736 20 3 8.230452675 10.34482759 MS3_05352 0.043 0.096 0.59 0.48 0.69 8.61 9.02 0.663650238 33 6 13.58024691 20.68965517 MS3_08472 0.043 0.096 0.56 0.46 0.66 9.33 9.62 0.748263565 88 10 36.21399177 34.48275862 MS3_04342 0.044 0.098 0.56 0.47 0.65 8.77 9.11 0.711770314 35 2 14.40329218 6.896551724 MS3_06832 0.044 0.099 0.61 0.5 0.72 8.16 7.82 1.404947702 7 0 2.880658436 0 MS3_10177 0.044 0.097 0.6 0.5 0.71 8.19 7.92 1.309964523 2 0 0.823045267 0 MS3_11059 0.045 0.099 0.7 0.59 0.8 9.28 9.76 0.618783388 82 18 33.74485597 62.06896552 MS3_03400 0.047 0.1 0.58 0.49 0.68 8.71 8.89 0.835270205 3 0 1.234567901 0 MS3_06500 0.047 0.1 0.63 0.52 0.73 8.18 7.9 1.32312989 2 0 0.823045267 0 MS3_07481 0.047 0.1 0.57 0.47 0.66 9.9 9.29 1.84043141 122 10 50.20576132 34.48275862 MS3_01483 0.048 0.11 0.6 0.51 0.69 8.59 8.84 0.778800772 6 0 2.469135802 0 MS3_06380 0.048 0.1 0.65 0.53 0.76 8.65 8.23 1.521961617 18 1 7.407407407 3.448275862 MS3_08945 0.049 0.11 0.65 0.55 0.74 9.05 9.5 0.637628146 64 10 26.33744856 34.48275862 MS3_09510 0.049 0.11 0.57 0.47 0.66 8.79 9.12 0.718923725 29 3 11.93415638 10.34482759 MS3_01833 0.05 0.11 0.57 0.48 0.65 9.13 9.41 0.755783738 51 1 20.98765432 3.448275862 MS3_01871 0.05 0.11 0.62 0.49 0.74 8.43 8.05 1.462284669 9 0 3.703703704 0 MS3_07600 0.05 0.11 0.6 0.5 0.7 8.36 8.63 0.763379477 1 1 0.411522634 3.448275862 MS3_06748 0.051 0.11 0.67 0.58 0.77 9.19 9.77 0.559898363 57 10 23.45679012 34.48275862 MS3_06914 0.051 0.11 0.6 0.49 0.7 6.85 6.61 1.271250029 0 0 0 0 MS3_03427 0.052 0.11 0.64 0.53 0.75 8.43 8.84 0.663650232 5 0 2.057613169 0 MS3_01053 0.053 0.11 0.59 0.49 0.68 7.73 7.44 1.336427691 1 0 0.411522634 0 MS3_00812 0.054 0.12 0.58 0.48 0.68 9.34 9.6 0.771051583 74 9 30.4526749 31.03448276 MS3_02256 0.054 0.12 0.64 0.52 0.76 8.73 9.05 0.726149028 9 3 3.703703704 10.34482759 MS3_09229 0.055 0.12 0.6 0.49 0.71 9.12 8.81 1.363425128 37 1 15.22633745 3.448275862 MS3_09415 0.055 0.12 0.67 0.57 0.78 8.22 7.84 1.46228471 7 1 2.880658436 3.448275862 MS3_06327 0.057 0.12 0.59 0.48 0.7 6.86 6.59 1.309965483 1 0 0.411522634 0 MS3_08593 0.059 0.13 0.62 0.51 0.72 6.83 7.43 0.548811188 5 2 2.057613169 6.896551724 MS3_09426 0.059 0.13 0.61 0.5 0.72 6.72 7.08 0.697675805 1 0 0.411522634 0 MS3_06950 0.061 0.13 0.66 0.54 0.78 8.1 7.74 1.433329554 5 1 2.057613169 3.448275862 MS3_00076 0.062 0.13 0.6 0.5 0.7 8.43 8.66 0.794533589 2 0 0.823045267 0 MS3_06736 0.062 0.13 0.62 0.5 0.74 8.65 8.94 0.748263557 4 1 1.646090535 3.448275862 MS3_07686 0.064 0.13 0.61 0.51 0.7 9.55 9.85 0.740818219 106 13 43.62139918 44.82758621 MS3_00676 0.066 0.14 0.59 0.48 0.69 7.55 7.28 1.30996471 2 0 0.823045267 0 MS3_08220 0.066 0.14 0.58 0.48 0.69 10.19 10.61 0.657046819 186 22 76.54320988 75.86206897 MS3_11045 0.066 0.14 0.6 0.49 0.71 6.96 7.4 0.644036082 2 1 0.823045267 3.448275862 MS3_10148 0.067 0.14 0.6 0.49 0.7 8.55 8.81 0.771051574 8 0 3.29218107 0 52 MS3_01333 0.067 0.14 0.64 0.52 0.76 6.8 6.49 1.363426567 1 0 0.411522634 0 MS3_09744 0.067 0.14 0.62 0.52 0.72 10.24 9.53 2.033991267 174 16 71.60493827 55.17241379 MS3_01749 0.069 0.14 0.58 0.46 0.7 10.65 10.06 1.803988418 192 19 79.01234568 65.51724138 MS3_05077 0.07 0.14 0.56 0.45 0.68 9.33 8.9 1.53725754 58 5 23.86831276 17.24137931 MS3_05715 0.071 0.15 0.61 0.49 0.72 8.39 8 1.476980884 16 1 6.58436214 3.448275862 MS3_09296 0.071 0.15 0.61 0.5 0.72 9.33 9.66 0.718923731 65 12 26.74897119 41.37931034 MS3_00147 0.072 0.15 0.58 0.49 0.67 8.31 8.52 0.810584229 4 0 1.646090535 0 MS3_00148 0.072 0.15 0.57 0.47 0.67 10.04 10.31 0.763379494 160 18 65.8436214 62.06896552 MS3_04550 0.072 0.15 0.56 0.46 0.66 7.59 7.4 1.20924974 1 0 0.411522634 0 MS3_09287 0.072 0.15 0.59 0.48 0.69 9.08 8.79 1.336427502 40 2 16.46090535 6.896551724 MS3_08926 0.073 0.15 0.64 0.54 0.74 8.92 9.3 0.683861403 47 5 19.34156379 17.24137931 MS3_01289 0.074 0.15 0.56 0.45 0.67 9.62 9.82 0.818730752 103 13 42.38683128 44.82758621 MS3_08625 0.076 0.15 0.61 0.5 0.72 7.41 7.11 1.349859214 1 0 0.411522634 0 MS3_10292 0.076 0.15 0.61 0.5 0.73 8.32 8.63 0.733446936 7 2 2.880658436 6.896551724 MS3_01014 0.077 0.15 0.61 0.5 0.71 7.33 7.77 0.644036259 6 1 2.469135802 3.448275862 MS3_08178 0.077 0.16 0.58 0.47 0.68 7.82 7.6 1.246076842 5 0 2.057613169 0 MS3_06075 0.078 0.16 0.58 0.48 0.69 8.59 8.81 0.802518788 4 1 1.646090535 3.448275862 MS3_03461 0.079 0.16 0.65 0.53 0.77 8.63 9.12 0.612626382 18 6 7.407407407 20.68965517 MS3_08509 0.079 0.16 0.62 0.51 0.73 6.49 6.86 0.690733498 2 0 0.823045267 0 MS3_03054 0.084 0.17 0.6 0.48 0.71 8.82 8.52 1.349858832 13 0 5.349794239 0 MS3_03385 0.085 0.17 0.61 0.5 0.72 8.22 8.47 0.778800761 5 0 2.057613169 0 MS3_06080 0.085 0.17 0.58 0.47 0.7 8.58 8.28 1.349858847 12 0 4.938271605 0 MS3_08024 0.085 0.17 0.6 0.49 0.7 8.39 8.04 1.419067623 21 2 8.641975309 6.896551724 MS3_08907 0.086 0.17 0.57 0.46 0.67 7.13 6.92 1.233678473 1 0 0.411522634 0 MS3_02494 0.087 0.17 0.57 0.46 0.67 7.55 7.32 1.258600213 6 0 2.469135802 0 MS3_10209 0.087 0.17 0.64 0.55 0.74 9.14 9.52 0.683861405 68 9 27.98353909 31.03448276 MS3_00143 0.088 0.17 0.63 0.51 0.74 8.63 8.91 0.755783731 5 2 2.057613169 6.896551724 MS3_00703 0.089 0.17 0.57 0.47 0.67 7.67 7.42 1.284025598 2 0 0.823045267 0 MS3_07467 0.09 0.18 0.5 0.41 0.59 9.5 9.72 0.802518796 115 11 47.32510288 37.93103448 MS3_04063 0.091 0.18 0.59 0.47 0.71 8.51 9.08 0.565525423 34 7 13.99176955 24.13793103 MS3_07403 0.092 0.18 0.48 0.39 0.57 6.34 6.19 1.161835508 0 0 0 0 MS3_00257 0.093 0.18 0.6 0.49 0.7 8.25 8.59 0.711770299 2 1 0.823045267 3.448275862 MS3_03534 0.094 0.18 0.59 0.47 0.71 8.86 8.58 1.323129832 17 2 6.995884774 6.896551724 MS3_05748 0.094 0.18 0.6 0.49 0.71 8.74 8.98 0.786627853 14 1 5.761316872 3.448275862 MS3_02637 0.096 0.19 0.61 0.5 0.71 9.06 9.43 0.690734326 64 9 26.33744856 31.03448276 MS3_02838 0.097 0.19 0.58 0.47 0.69 8.84 9.09 0.778800777 20 3 8.230452675 10.34482759 MS3_04800 0.097 0.19 0.59 0.49 0.69 8.49 8.86 0.690734315 21 1 8.641975309 3.448275862 53 MS3_05337 0.097 0.19 0.59 0.47 0.71 8.36 8.02 1.404947666 13 1 5.349794239 3.448275862 MS3_10803 0.097 0.19 0.58 0.48 0.67 9.7 9.94 0.78662786 113 14 46.50205761 48.27586207 MS3_07737 0.098 0.19 0.51 0.42 0.61 9.68 9.95 0.763379493 135 14 55.55555556 48.27586207 MS3_02155 0.098 0.19 0.59 0.5 0.67 7.93 8.11 0.835270179 4 0 1.646090535 0 MS3_03625 0.098 0.19 0.59 0.48 0.71 8.14 8.42 0.755783714 1 1 0.411522634 3.448275862 MS3_04778 0.098 0.19 0.59 0.49 0.69 8.46 8.81 0.704688074 14 2 5.761316872 6.896551724 MS3_07273 0.098 0.19 0.56 0.46 0.66 8.67 8.37 1.34985884 22 1 9.053497942 3.448275862 MS3_09231 0.099 0.19 0.62 0.5 0.73 8.51 8.77 0.771051573 8 0 3.29218107 0 MS3_10187 0.099 0.19 0.6 0.51 0.68 9.85 9.5 1.419067553 139 10 57.20164609 34.48275862 MS3_00287 0.1 0.19 0.56 0.47 0.66 8.09 7.88 1.23367812 4 0 1.646090535 0 MS3_04307 0.1 0.19 0.5 0.42 0.58 9.82 9.51 1.363425118 99 6 40.74074074 20.68965517 MS3_06745 0.1 0.19 0.6 0.51 0.69 8.91 9.11 0.818730748 30 2 12.34567901 6.896551724 MS3_08999 0.1 0.2 0.57 0.46 0.67 8.98 8.71 1.309964466 32 2 13.16872428 6.896551724 MS3_10713 0.1 0.19 0.55 0.48 0.63 9.92 9.71 1.233678062 117 6 48.14814815 20.68965517 MS3_11509 0.1 0.19 0.6 0.49 0.71 8.58 8.83 0.778800772 7 1 2.880658436 3.448275862 MS3_00881 0.11 0.21 0.59 0.49 0.7 8.51 8.84 0.718923719 15 3 6.172839506 10.34482759 MS3_01328 0.11 0.21 0.54 0.43 0.64 9.73 9.94 0.810584245 137 16 56.37860082 55.17241379 MS3_01527 0.11 0.2 0.57 0.47 0.67 8.82 9.08 0.771051579 20 1 8.230452675 3.448275862 MS3_01764 0.11 0.2 0.54 0.44 0.63 10.18 10.57 0.677056874 170 20 69.95884774 68.96551724 MS3_04179 0.11 0.2 0.59 0.49 0.68 8.85 8.7 1.161834251 6 0 2.469135802 0 MS3_08663 0.11 0.21 0.54 0.44 0.65 8.63 8.38 1.284025443 21 0 8.641975309 0 MS3_09396 0.11 0.2 0.62 0.5 0.74 8.49 8.78 0.748263554 4 2 1.646090535 6.896551724 MS3_00785 0.12 0.22 0.55 0.46 0.65 9.43 9.66 0.794533601 88 11 36.21399177 37.93103448 MS3_01160 0.12 0.22 0.57 0.46 0.69 8.27 7.96 1.363425191 22 0 9.053497942 0 MS3_01937 0.12 0.21 0.6 0.48 0.73 8.64 8.94 0.74081821 15 3 6.172839506 10.34482759 MS3_04453 0.12 0.22 0.57 0.48 0.66 8.57 8.35 1.246076755 22 0 9.053497942 0 MS3_04564 0.12 0.22 0.63 0.5 0.76 7.01 6.72 1.336428344 1 0 0.411522634 0 MS3_05024 0.12 0.21 0.62 0.5 0.73 8.2 7.86 1.404947694 7 1 2.880658436 3.448275862 MS3_05038 0.12 0.22 0.64 0.53 0.75 9.05 9.39 0.711770318 48 9 19.75308642 31.03448276 MS3_06449 0.12 0.22 0.57 0.47 0.67 8.44 8.22 1.246076763 10 0 4.115226337 0 MS3_08613 0.12 0.22 0.61 0.49 0.73 8.97 9.22 0.778800778 23 4 9.465020576 13.79310345 MS3_10459 0.12 0.22 0.54 0.44 0.63 8.64 8.42 1.246076752 25 0 10.28806584 0 MS3_10943 0.12 0.22 0.52 0.43 0.62 7.97 7.74 1.258600098 8 0 3.29218107 0 MS3_01274 0.13 0.23 0.58 0.47 0.69 8.29 8.07 1.246076774 1 0 0.411522634 0 MS3_06424 0.13 0.24 0.62 0.48 0.75 8.82 9.09 0.763379487 12 4 4.938271605 13.79310345 MS3_06482 0.13 0.23 0.67 0.56 0.78 9.05 9.38 0.718923729 31 9 12.75720165 31.03448276 MS3_07854 0.13 0.24 0.59 0.48 0.7 7.98 8.32 0.711770282 1 1 0.411522634 3.448275862 54 MS3_09619 0.13 0.23 0.48 0.39 0.57 9.17 9.44 0.763379491 69 6 28.39506173 20.68965517 MS3_10499 0.13 0.23 0.57 0.46 0.67 8.7 8.86 0.852143782 2 0 0.823045267 0 MS3_10687 0.13 0.23 0.59 0.48 0.7 8.73 9.02 0.748263559 14 2 5.761316872 6.896551724 MS3_00494 0.14 0.24 0.68 0.57 0.79 7.26 6.9 1.433330162 1 1 0.411522634 3.448275862 MS3_00769 0.14 0.24 0.59 0.48 0.7 8.17 8.41 0.786627837 3 1 1.234567901 3.448275862 MS3_00939 0.14 0.25 0.55 0.45 0.66 7.33 7.15 1.197217586 0 0 0 0 MS3_06583 0.14 0.25 0.53 0.43 0.63 9.15 9.35 0.81873075 49 4 20.16460905 13.79310345 MS3_07487 0.14 0.26 0.6 0.49 0.7 8.25 8.45 0.818730735 4 0 1.646090535 0 MS3_08004 0.14 0.24 0.62 0.52 0.72 9.03 9.35 0.726149032 52 7 21.39917695 24.13793103 No hits 0.14 0.25 0.58 0.47 0.7 8.14 7.85 1.336427577 6 0 2.469135802 0 MS3_08460 0.15 0.27 0.57 0.49 0.66 9.62 9.33 1.336427493 84 4 34.56790123 13.79310345 MS3_01934 0.15 0.27 0.58 0.48 0.67 7.02 6.8 1.246077281 1 0 0.411522634 0 MS3_02050 0.15 0.27 0.58 0.47 0.69 8.36 8.61 0.778800766 7 2 2.880658436 6.896551724 MS3_05322 0.15 0.27 0.61 0.49 0.72 8.3 8.51 0.810584229 0 0 0 0 MS3_08210 0.15 0.27 0.56 0.47 0.65 8.08 7.93 1.161834282 0 0 0 0 MS3_08455 0.15 0.26 0.59 0.47 0.7 8.49 8.15 1.404947648 34 3 13.99176955 10.34482759 MS3_03171 0.16 0.28 0.59 0.48 0.69 8.41 8.65 0.786627846 10 1 4.115226337 3.448275862 MS3_06707 0.16 0.29 0.59 0.46 0.72 8.23 8.53 0.740818197 4 2 1.646090535 6.896551724 MS3_08176 0.16 0.27 0.55 0.46 0.64 8.4 8.23 1.185304876 11 0 4.526748971 0 MS3_09457 0.16 0.28 0.59 0.48 0.7 8.31 8.03 1.323129872 19 2 7.818930041 6.896551724 MS3_02805 0.17 0.29 0.58 0.47 0.7 8.67 8.95 0.755783732 27 5 11.11111111 17.24137931 MS3_03569 0.17 0.29 0.58 0.47 0.68 8.15 8.38 0.794533578 6 0 2.469135802 0 MS3_03976 0.17 0.29 0.59 0.48 0.69 7.93 8.26 0.718923688 21 0 8.641975309 0 MS3_05602 0.17 0.29 0.59 0.48 0.7 7.86 8.09 0.794533559 0 0 0 0 MS3_06161 0.17 0.29 0.6 0.5 0.7 9.26 9.45 0.826959132 56 6 23.04526749 20.68965517 MS3_07156 0.17 0.29 0.54 0.43 0.65 6.93 6.72 1.233678676 4 0 1.646090535 0 MS3_07395 0.17 0.29 0.59 0.48 0.7 8.99 8.74 1.28402543 43 4 17.69547325 13.79310345 MS3_10721 0.17 0.3 0.56 0.45 0.66 8.9 8.68 1.246076743 28 2 11.52263374 6.896551724 MS3_04347 0.18 0.3 0.57 0.46 0.68 9.49 9.22 1.309964456 81 8 33.33333333 27.5862069 MS3_05960 0.18 0.3 0.49 0.4 0.57 10.11 9.89 1.246076732 137 15 56.37860082 51.72413793 MS3_07593 0.18 0.31 0.54 0.44 0.64 9.63 9.82 0.826959133 113 13 46.50205761 44.82758621 MS3_09000 0.18 0.31 0.56 0.45 0.66 9.35 9.12 1.258600015 71 5 29.218107 17.24137931 MS3_09626 0.18 0.31 0.57 0.46 0.68 8.63 8.42 1.233678081 5 0 2.057613169 0 MS3_10471 0.18 0.31 0.58 0.46 0.7 8.55 8.32 1.258600037 6 0 2.469135802 0 MS3_10847 0.19 0.32 0.62 0.53 0.71 9.01 9.28 0.76337949 49 6 20.16460905 20.68965517 MS3_02538 0.19 0.31 0.45 0.33 0.56 8.16 7.94 1.246076787 3 0 1.234567901 0 MS3_04269 0.19 0.31 0.58 0.45 0.71 8.94 9.15 0.810584241 19 5 7.818930041 17.24137931 55 MS3_06947 0.19 0.32 0.57 0.46 0.68 8.61 8.78 0.843664809 8 1 3.29218107 3.448275862 MS3_08391 0.19 0.31 0.57 0.46 0.68 8.31 8.55 0.786627843 14 2 5.761316872 6.896551724 MS3_10378 0.19 0.31 0.44 0.34 0.55 8.2 7.98 1.246076783 3 0 1.234567901 0 MS3_10619 0.19 0.31 0.59 0.47 0.7 8.6 8.93 0.718923722 37 7 15.22633745 24.13793103 MS3_01504 0.2 0.33 0.57 0.45 0.68 8.55 8.32 1.258600037 26 2 10.69958848 6.896551724 MS3_02162 0.2 0.33 0.57 0.46 0.68 8.88 9.07 0.826959129 19 2 7.818930041 6.896551724 MS3_02499 0.2 0.33 0.56 0.46 0.66 8.53 8.71 0.835270202 8 1 3.29218107 3.448275862 MS3_03381 0.2 0.34 0.58 0.47 0.7 8.23 8.45 0.802518778 3 0 1.234567901 0 MS3_05289 0.2 0.33 0.55 0.45 0.65 8.72 8.53 1.209249613 27 1 11.11111111 3.448275862 MS3_06430 0.2 0.33 0.58 0.47 0.68 8.2 8 1.221402803 2 0 0.823045267 0 MS3_08727 0.2 0.33 0.6 0.49 0.7 7.44 7.16 1.323130155 6 1 2.469135802 3.448275862 MS3_00178 0.21 0.34 0.56 0.46 0.66 8.27 8.12 1.161834269 3 0 1.234567901 0 MS3_05910 0.21 0.34 0.57 0.44 0.69 7.84 8.09 0.778800736 1 1 0.411522634 3.448275862 MS3_05976 0.21 0.34 0.57 0.45 0.68 7.18 7.38 0.818730596 0 0 0 0 MS3_07061 0.21 0.35 0.56 0.45 0.67 8.06 7.88 1.197217415 5 0 2.057613169 0 MS3_07799 0.21 0.34 0.56 0.45 0.67 8.63 8.79 0.852143782 3 0 1.234567901 0 MS3_09271 0.21 0.35 0.59 0.49 0.7 6.75 6.99 0.78662745 1 0 0.411522634 0 MS3_00047 0.22 0.35 0.58 0.48 0.68 9.29 9.55 0.771051583 80 9 32.9218107 31.03448276 MS3_01313 0.22 0.36 0.47 0.34 0.6 9.48 9.21 1.309964456 77 9 31.6872428 31.03448276 MS3_02087 0.22 0.35 0.63 0.54 0.73 8.89 9.05 0.852143785 20 0 8.230452675 0 MS3_02804 0.22 0.36 0.56 0.47 0.66 9.69 9.52 1.185304853 94 5 38.68312757 17.24137931 MS3_05226 0.22 0.36 0.52 0.43 0.62 8.47 8.29 1.197217386 10 0 4.115226337 0 MS3_09846 0.22 0.36 0.64 0.52 0.76 8.55 8.87 0.726149024 16 4 6.58436214 13.79310345 MS3_01558 0.23 0.36 0.57 0.46 0.68 6.87 7.07 0.818730462 1 0 0.411522634 0 MS3_01636 0.23 0.37 0.59 0.47 0.71 7.81 7.58 1.258600131 6 1 2.469135802 3.448275862 MS3_02758 0.23 0.36 0.57 0.48 0.67 8.7 8.88 0.835270204 20 1 8.230452675 3.448275862 MS3_03091 0.23 0.36 0.54 0.44 0.64 8.45 8.27 1.197217387 11 0 4.526748971 0 MS3_05911 0.23 0.37 0.6 0.5 0.71 9.13 9.38 0.778800779 53 9 21.81069959 31.03448276 MS3_06223 0.23 0.37 0.56 0.45 0.66 6.62 6.46 1.173511658 0 0 0 0 MS3_08361 0.23 0.37 0.48 0.39 0.57 8.81 9 0.826959128 22 0 9.053497942 0 MS3_09634 0.23 0.37 0.56 0.45 0.67 8.57 8.73 0.852143781 1 1 0.411522634 3.448275862 MS3_10225 0.23 0.37 0.54 0.44 0.65 9.76 9.93 0.843664816 143 17 58.84773663 58.62068966 MS3_00066 0.24 0.38 0.58 0.45 0.7 8.4 8.6 0.818730739 5 2 2.057613169 6.896551724 MS3_01542 0.24 0.38 0.55 0.45 0.66 10.03 10.2 0.843664816 171 20 70.37037037 68.96551724 MS3_03429 0.24 0.38 0.46 0.36 0.57 9.01 8.72 1.336427504 64 3 26.33744856 10.34482759 MS3_06101 0.24 0.37 0.57 0.46 0.68 8.71 8.88 0.84366481 11 3 4.526748971 10.34482759 MS3_06471 0.24 0.38 0.61 0.5 0.72 8.67 8.86 0.826959126 12 0 4.938271605 0 56 MS3_08450 0.24 0.38 0.58 0.48 0.68 8.96 8.68 1.323129829 39 1 16.04938272 3.448275862 MS3_09283 0.24 0.37 0.57 0.46 0.68 8.05 8.21 0.852143765 1 0 0.411522634 0 MS3_02641 0.25 0.39 0.55 0.44 0.66 8.51 8.34 1.185304871 6 0 2.469135802 0 MS3_05026 0.25 0.39 0.51 0.4 0.62 9.6 9.74 0.869358234 103 10 42.38683128 34.48275862 MS3_06283 0.25 0.4 0.59 0.47 0.71 8.54 8.75 0.810584235 9 2 3.703703704 6.896551724 MS3_10423 0.25 0.39 0.48 0.36 0.59 9.49 9.28 1.233678064 67 5 27.57201646 17.24137931 MS3_10492 0.25 0.39 0.55 0.44 0.65 9.16 9.32 0.852143786 45 6 18.51851852 20.68965517 MS3_00187 0.26 0.41 0.58 0.47 0.68 8.39 8.56 0.843664804 12 0 4.938271605 0 MS3_05425 0.26 0.41 0.64 0.54 0.74 8.85 9.06 0.81058424 11 3 4.526748971 10.34482759 MS3_08157 0.26 0.4 0.56 0.45 0.67 8.59 8.42 1.185304868 11 0 4.526748971 0 MS3_08929 0.26 0.4 0.47 0.36 0.57 8.43 8.24 1.209249624 16 0 6.58436214 0 MS3_09110 0.26 0.4 0.59 0.48 0.7 8.42 8.58 0.852143778 1 0 0.411522634 0 MS3_00183 0.27 0.42 0.59 0.49 0.69 9.16 9.4 0.786627858 55 7 22.63374486 24.13793103 MS3_04083 0.27 0.42 0.58 0.47 0.69 11.55 11.16 1.476980794 228 23 93.82716049 79.31034483 MS3_05351 0.27 0.42 0.54 0.43 0.64 6.36 6.2 1.173512195 1 0 0.411522634 0 MS3_09190 0.27 0.42 0.56 0.44 0.67 8.3 8.47 0.843664802 6 0 2.469135802 0 MS3_03443 0.28 0.43 0.53 0.43 0.64 8.09 7.92 1.185304896 13 0 5.349794239 0 MS3_00702 0.28 0.43 0.56 0.46 0.66 8.53 8.68 0.860707968 10 1 4.115226337 3.448275862 MS3_05754 0.28 0.43 0.56 0.45 0.67 8 7.85 1.161834288 0 0 0 0 MS3_09690 0.28 0.43 0.57 0.46 0.68 8.85 9.03 0.835270206 33 4 13.58024691 13.79310345 MS3_02136 0.29 0.44 0.65 0.53 0.76 9.13 9.4 0.763379491 62 15 25.51440329 51.72413793 MS3_04386 0.29 0.44 0.47 0.37 0.57 8.01 7.85 1.17351092 9 0 3.703703704 0 MS3_04962 0.29 0.44 0.61 0.48 0.73 9.04 8.78 1.296930099 37 5 15.22633745 17.24137931 MS3_05735 0.29 0.44 0.55 0.45 0.64 9.08 9.25 0.843664813 41 3 16.87242798 10.34482759 MS3_06462 0.29 0.44 0.52 0.43 0.6 9.59 9.76 0.843664815 106 10 43.62139918 34.48275862 MS3_06825 0.29 0.44 0.55 0.44 0.67 8.6 8.45 1.161834257 7 0 2.880658436 0 MS3_07002 0.29 0.44 0.56 0.45 0.66 8.6 8.74 0.869358228 8 0 3.29218107 0 MS3_09305 0.29 0.44 0.55 0.46 0.65 8.57 8.66 0.91393118 2 0 0.823045267 0 MS3_09993 0.29 0.44 0.45 0.33 0.57 8.46 8.29 1.185304873 7 0 2.880658436 0 MS3_00403 0.3 0.44 0.55 0.44 0.66 8.5 8.35 1.16183426 8 0 3.29218107 0 MS3_00844 0.3 0.45 0.53 0.42 0.63 7.65 7.48 1.18530496 6 0 2.469135802 0 MS3_00876 0.3 0.45 0.58 0.48 0.69 8.5 8.34 1.173510889 11 2 4.526748971 6.896551724 MS3_02486 0.3 0.45 0.55 0.44 0.66 7.79 7.66 1.138828441 1 0 0.411522634 0 MS3_05142 0.3 0.45 0.56 0.45 0.66 8.76 8.89 0.878095426 9 1 3.703703704 3.448275862 MS3_09682 0.3 0.44 0.5 0.4 0.59 9.41 9.6 0.826959132 106 9 43.62139918 31.03448276 MS3_02375 0.31 0.47 0.54 0.43 0.65 8.71 8.57 1.150273809 2 0 0.823045267 0 MS3_02489 0.31 0.46 0.54 0.45 0.63 8.22 8.09 1.138828408 8 1 3.29218107 3.448275862 57 MS3_03818 0.31 0.46 0.52 0.42 0.63 6.38 6.27 1.11627886 1 0 0.411522634 0 MS3_06431 0.31 0.46 0.56 0.45 0.67 8.32 8.47 0.860707963 5 1 2.057613169 3.448275862 MS3_07716 0.31 0.46 0.55 0.43 0.67 7.93 7.76 1.185304913 8 0 3.29218107 0 MS3_00450 0.32 0.47 0.55 0.45 0.65 8.37 8.26 1.116278085 0 0 0 0 MS3_04493 0.32 0.47 0.58 0.46 0.7 7.91 8.08 0.843664784 2 0 0.823045267 0 MS3_05495 0.32 0.47 0.55 0.42 0.68 8.81 8.61 1.221402772 12 3 4.938271605 10.34482759 MS3_09076 0.32 0.47 0.54 0.43 0.64 8.06 7.88 1.197217415 12 0 4.938271605 0 MS3_09124 0.32 0.47 0.58 0.47 0.68 6.66 6.83 0.843664417 0 0 0 0 MS3_01218 0.33 0.49 0.54 0.43 0.65 8.87 8.72 1.161834251 13 1 5.349794239 3.448275862 MS3_01353 0.33 0.48 0.56 0.45 0.66 7.92 8.06 0.869358207 5 0 2.057613169 0 MS3_02539 0.33 0.48 0.53 0.41 0.65 8.61 8.4 1.233678081 12 0 4.938271605 0 MS3_03084 0.33 0.48 0.58 0.46 0.69 9.89 10.19 0.74081822 127 16 52.26337449 55.17241379 MS3_03405 0.33 0.49 0.55 0.44 0.66 8.46 8.6 0.869358226 4 0 1.646090535 0 MS3_03802 0.33 0.48 0.58 0.47 0.68 9.02 9.23 0.810584242 50 7 20.57613169 24.13793103 MS3_03918 0.33 0.48 0.55 0.43 0.67 8.05 8.21 0.852143765 3 0 1.234567901 0 MS3_08636 0.33 0.48 0.48 0.38 0.58 7.75 7.63 1.127496908 1 0 0.411522634 0 MS3_04053 0.34 0.49 0.44 0.34 0.55 8.98 8.77 1.23367807 48 3 19.75308642 10.34482759 MS3_09273 0.34 0.49 0.56 0.46 0.67 7.8 7.61 1.209249692 6 1 2.469135802 3.448275862 MS3_10600 0.34 0.49 0.55 0.46 0.65 7.46 7.62 0.852143712 2 1 0.823045267 3.448275862 MS3_00383 0.35 0.5 0.55 0.44 0.66 9.24 9.45 0.810584243 58 6 23.86831276 20.68965517 MS3_01104 0.35 0.5 0.52 0.43 0.62 9.5 9.62 0.886920436 104 10 42.79835391 34.48275862 MS3_01286 0.35 0.5 0.56 0.44 0.68 6.63 6.48 1.161834951 0 0 0 0 MS3_01898 0.35 0.5 0.55 0.42 0.68 9.14 8.93 1.233678067 44 6 18.10699588 20.68965517 MS3_05555 0.35 0.5 0.57 0.46 0.67 6.57 6.72 0.860707538 1 0 0.411522634 0 MS3_09406 0.35 0.5 0.54 0.44 0.65 8.4 8.26 1.150273818 14 1 5.761316872 3.448275862 MS3_09620 0.35 0.51 0.56 0.45 0.68 8.27 8.43 0.852143774 2 0 0.823045267 0 MS3_10297 0.35 0.5 0.55 0.44 0.66 7.56 7.74 0.835270143 3 0 1.234567901 0 MS3_10486 0.35 0.5 0.57 0.46 0.68 9.94 10.11 0.843664816 170 22 69.95884774 75.86206897 MS3_10607 0.35 0.5 0.5 0.41 0.6 6.67 6.55 1.127497344 4 0 1.646090535 0 MS3_11526 0.35 0.5 0.59 0.5 0.69 9.22 9.41 0.826959131 62 7 25.51440329 24.13793103 MS3_00850 0.37 0.53 0.59 0.48 0.71 8.44 8.61 0.843664805 20 2 8.230452675 6.896551724 MS3_02954 0.37 0.53 0.56 0.44 0.67 8.54 8.36 1.197217383 15 1 6.172839506 3.448275862 MS3_03558 0.37 0.53 0.48 0.38 0.58 8.23 8.36 0.878095417 2 1 0.823045267 3.448275862 MS3_05959 0.38 0.54 0.55 0.44 0.65 9.26 9.06 1.221402764 42 3 17.28395062 10.34482759 MS3_09546 0.38 0.53 0.49 0.38 0.6 8.9 8.76 1.150273806 27 1 11.11111111 3.448275862 MS3_10898 0.38 0.53 0.61 0.5 0.72 9.57 9.77 0.818730752 115 15 47.32510288 51.72413793 MS3_11161 0.38 0.54 0.56 0.45 0.66 7.44 7.31 1.1388285 1 0 0.411522634 0 58 MS3_00508 0.39 0.54 0.48 0.36 0.59 9.05 8.76 1.336427503 69 7 28.39506173 24.13793103 MS3_03513 0.39 0.55 0.57 0.45 0.69 6.76 6.61 1.161834789 4 0 1.646090535 0 MS3_06704 0.39 0.54 0.54 0.42 0.65 8.83 8.69 1.150273807 6 1 2.469135802 3.448275862 MS3_10900 0.39 0.55 0.57 0.46 0.68 7 7.17 0.843664614 3 1 1.234567901 3.448275862 MS3_03372 0.4 0.55 0.56 0.45 0.68 8.99 9.18 0.82695913 39 5 16.04938272 17.24137931 MS3_03571 0.4 0.56 0.58 0.47 0.69 7.79 7.92 0.878095396 2 0 0.823045267 0 MS3_05952 0.4 0.55 0.51 0.41 0.61 9.14 8.96 1.197217369 38 1 15.63786008 3.448275862 MS3_06488 0.4 0.56 0.56 0.45 0.66 8.89 9.17 0.755783735 67 5 27.57201646 17.24137931 MS3_08415 0.4 0.56 0.49 0.39 0.58 7.8 7.71 1.09417432 3 0 1.234567901 0 MS3_09128 0.4 0.56 0.57 0.46 0.69 8.67 8.87 0.818730745 35 6 14.40329218 20.68965517 MS3_01030 0.41 0.57 0.55 0.44 0.66 8.73 8.91 0.835270205 24 1 9.87654321 3.448275862 MS3_03206 0.41 0.56 0.55 0.45 0.66 8.92 9.09 0.843664812 37 6 15.22633745 20.68965517 MS3_07918 0.41 0.57 0.54 0.44 0.65 8.69 8.85 0.852143782 33 2 13.58024691 6.896551724 MS3_09443 0.41 0.56 0.55 0.45 0.65 8.35 8.24 1.116278086 1 0 0.411522634 0 MS3_10513 0.41 0.57 0.48 0.39 0.58 8.62 8.7 0.923116342 2 0 0.823045267 0 MS3_11544 0.41 0.57 0.52 0.42 0.62 9.57 9.68 0.895834134 97 11 39.91769547 37.93103448 MS3_01693 0.42 0.58 0.55 0.45 0.65 7.66 7.79 0.878095386 0 0 0 0 MS3_06889 0.42 0.58 0.55 0.44 0.65 9.05 8.88 1.185304858 43 2 17.69547325 6.896551724 MS3_05908 0.43 0.59 0.53 0.42 0.64 8.78 8.66 1.127496859 20 1 8.230452675 3.448275862 MS3_10397 0.43 0.59 0.55 0.45 0.65 7.71 7.88 0.843664768 8 1 3.29218107 3.448275862 MS3_03973 0.44 0.6 0.56 0.44 0.67 7.34 7.46 0.886920357 0 0 0 0 MS3_04559 0.44 0.6 0.49 0.38 0.61 8.69 8.55 1.150273809 17 0 6.995884774 0 MS3_04820 0.44 0.6 0.51 0.42 0.61 9.66 9.47 1.2092496 102 7 41.97530864 24.13793103 MS3_06677 0.44 0.6 0.55 0.42 0.67 7.91 8.06 0.860707946 1 0 0.411522634 0 MS3_06789 0.44 0.6 0.54 0.43 0.65 8.61 8.72 0.895834129 7 0 2.880658436 0 MS3_11484 0.45 0.61 0.56 0.45 0.67 9.16 9.32 0.852143786 67 6 27.57201646 20.68965517 MS3_02368 0.45 0.61 0.54 0.43 0.64 8.03 8.13 0.904837401 3 0 1.234567901 0 MS3_02442 0.45 0.61 0.53 0.42 0.64 9.68 9.79 0.895834135 117 12 48.14814815 41.37931034 MS3_04268 0.45 0.61 0.54 0.43 0.66 7.21 7.12 1.094174402 0 0 0 0 MS3_04285 0.45 0.61 0.5 0.42 0.59 9.7 9.79 0.913931185 117 8 48.14814815 27.5862069 MS3_04781 0.45 0.61 0.53 0.42 0.64 8.79 8.91 0.886920432 17 3 6.995884774 10.34482759 MS3_05520 0.45 0.61 0.54 0.44 0.64 8.48 8.57 0.913931179 3 0 1.234567901 0 MS3_10998 0.45 0.61 0.56 0.45 0.66 9.29 9.43 0.869358234 79 10 32.51028807 34.48275862 MS3_03988 0.46 0.62 0.53 0.41 0.64 7.31 7.21 1.105171028 0 0 0 0 MS3_08480 0.46 0.61 0.56 0.45 0.66 10.35 10.12 1.258600011 194 21 79.83539095 72.4137931 MS3_09879 0.46 0.61 0.52 0.41 0.63 7.31 7.21 1.105171028 0 0 0 0 MS3_00808 0.47 0.63 0.54 0.44 0.64 9 9.1 0.904837416 26 2 10.69958848 6.896551724 59 MS3_01051 0.47 0.63 0.48 0.39 0.57 8.67 8.59 1.083287073 14 0 5.761316872 0 MS3_03119 0.47 0.62 0.54 0.42 0.65 7.89 8.01 0.88692041 2 0 0.823045267 0 MS3_08725 0.47 0.62 0.53 0.44 0.63 8.87 8.99 0.886920433 49 2 20.16460905 6.896551724 MS3_09961 0.47 0.63 0.55 0.44 0.65 9.54 9.39 1.161834245 107 10 44.03292181 34.48275862 MS3_11280 0.47 0.63 0.48 0.39 0.58 8.07 7.97 1.105170942 9 0 3.703703704 0 MS3_01096 0.48 0.63 0.49 0.39 0.6 8.05 7.93 1.127496883 21 0 8.641975309 0 MS3_04147 0.48 0.63 0.54 0.42 0.66 7.74 7.6 1.150273869 6 0 2.469135802 0 MS3_05284 0.48 0.63 0.55 0.42 0.67 8.29 8.4 0.895834124 1 0 0.411522634 0 MS3_05389 0.48 0.63 0.52 0.41 0.63 7.37 7.25 1.127496973 2 0 0.823045267 0 MS3_06258 0.48 0.63 0.56 0.44 0.68 8.66 8.51 1.161834255 16 4 6.58436214 13.79310345 MS3_10188 0.48 0.63 0.51 0.39 0.63 7.12 6.96 1.17351116 10 0 4.115226337 0 MS3_00242 0.49 0.63 0.55 0.45 0.65 9.02 9.18 0.852143786 50 4 20.57613169 13.79310345 MS3_01004 0.49 0.63 0.53 0.41 0.64 9.74 9.94 0.818730752 131 16 53.90946502 55.17241379 MS3_01705 0.49 0.63 0.52 0.42 0.62 6.06 5.99 1.07250906 0 0 0 0 MS3_05896 0.49 0.64 0.48 0.38 0.58 8.16 8.24 0.923116335 0 0 0 0 MS3_06347 0.49 0.63 0.56 0.45 0.67 8.71 8.61 1.105170925 10 1 4.115226337 3.448275862 MS3_07693 0.49 0.64 0.52 0.42 0.63 10.47 10.31 1.173510871 193 21 79.42386831 72.4137931 MS3_07874 0.49 0.63 0.59 0.48 0.71 9.18 9.33 0.860707974 53 8 21.81069959 27.5862069 MS3_09698 0.49 0.63 0.54 0.43 0.65 8.1 8.01 1.094174304 1 0 0.411522634 0 MS3_00663 0.5 0.65 0.55 0.45 0.66 7.6 7.5 1.105170979 2 1 0.823045267 3.448275862 MS3_03130 0.5 0.65 0.59 0.48 0.7 7.75 7.62 1.138828446 2 1 0.823045267 3.448275862 MS3_08283 0.5 0.65 0.52 0.41 0.64 7.86 7.75 1.116278111 4 0 1.646090535 0 MS3_05484 0.51 0.66 0.53 0.41 0.64 7.62 7.51 1.116278137 6 0 2.469135802 0 MS3_09829 0.51 0.66 0.5 0.39 0.6 6.5 6.42 1.083287493 1 0 0.411522634 0 MS3_01318 0.52 0.66 0.56 0.45 0.67 9.04 9.25 0.810584242 79 11 32.51028807 37.93103448 MS3_04595 0.52 0.67 0.57 0.47 0.68 7.77 7.94 0.843664773 29 0 11.93415638 0 MS3_04642 0.52 0.67 0.49 0.39 0.6 9.08 9.18 0.904837416 45 5 18.51851852 17.24137931 MS3_07096 0.52 0.67 0.55 0.44 0.66 7.8 7.89 0.91393116 3 0 1.234567901 0 MS3_08037 0.52 0.67 0.53 0.42 0.64 8.62 8.53 1.094174291 3 0 1.234567901 0 MS3_00610 0.53 0.67 0.54 0.44 0.64 8.85 8.98 0.878095427 25 2 10.28806584 6.896551724 MS3_01105 0.53 0.68 0.51 0.4 0.61 7.54 7.44 1.105170987 1 0 0.411522634 0 MS3_03937 0.53 0.68 0.57 0.48 0.66 9.13 9 1.138828387 55 1 22.63374486 3.448275862 MS3_06807 0.53 0.67 0.55 0.43 0.66 7.67 7.8 0.878095387 5 0 2.057613169 0 MS3_07738 0.53 0.68 0.5 0.39 0.61 8.36 8.24 1.127496868 17 0 6.995884774 0 MS3_08840 0.53 0.67 0.55 0.44 0.66 8.25 8.35 0.904837407 5 0 2.057613169 0 MS3_10811 0.53 0.67 0.54 0.44 0.65 8.49 8.37 1.127496864 20 2 8.230452675 6.896551724 MS3_10931 0.53 0.68 0.54 0.42 0.65 7.94 8.03 0.913931166 2 0 0.823045267 0 60 MS3_00756 0.54 0.68 0.5 0.4 0.6 9.47 9.6 0.87809543 98 9 40.32921811 31.03448276 MS3_03599 0.54 0.69 0.59 0.48 0.69 10.11 10.01 1.105170918 191 17 78.60082305 58.62068966 MS3_10249 0.54 0.68 0.54 0.43 0.64 8.59 8.67 0.923116342 11 0 4.526748971 0 MS3_00277 0.55 0.69 0.53 0.44 0.63 10.73 10.51 1.246076731 160 15 65.8436214 51.72413793 MS3_00312 0.55 0.69 0.49 0.37 0.61 9.57 9.42 1.161834245 96 12 39.50617284 41.37931034 MS3_01840 0.55 0.69 0.51 0.41 0.6 9.46 9.53 0.932393819 80 7 32.9218107 24.13793103 MS3_05126 0.55 0.69 0.51 0.39 0.63 8.98 9.17 0.82695913 36 4 14.81481481 13.79310345 MS3_11077 0.55 0.69 0.52 0.41 0.63 7.8 7.72 1.083287099 1 0 0.411522634 0 MS3_01257 0.56 0.7 0.54 0.45 0.64 7.82 7.98 0.852143751 33 2 13.58024691 6.896551724 MS3_02041 0.56 0.7 0.52 0.43 0.61 8.16 8.23 0.93239381 0 0 0 0 MS3_03872 0.56 0.7 0.54 0.45 0.62 9.5 9.38 1.127496853 93 4 38.27160494 13.79310345 MS3_09739 0.56 0.7 0.53 0.42 0.64 8.2 8.29 0.913931174 4 1 1.646090535 3.448275862 MS3_00054 0.57 0.71 0.56 0.47 0.66 8.1 8.16 0.941764524 6 0 2.469135802 0 MS3_00449 0.57 0.71 0.54 0.43 0.66 7.82 7.91 0.913931161 2 0 0.823045267 0 MS3_00504 0.57 0.71 0.5 0.4 0.6 8.56 8.48 1.083287075 17 0 6.995884774 0 MS3_03963 0.57 0.71 0.5 0.39 0.6 7.18 7.11 1.072508275 2 0 0.823045267 0 MS3_11226 0.57 0.71 0.57 0.45 0.68 7.99 8.08 0.913931168 0 0 0 0 MS3_00405 0.58 0.72 0.53 0.42 0.63 8.37 8.29 1.083287078 3 0 1.234567901 0 MS3_01386 0.58 0.72 0.46 0.34 0.57 8.25 8.36 0.895834123 11 1 4.526748971 3.448275862 MS3_03041 0.58 0.72 0.49 0.39 0.59 6.67 6.59 1.08328737 1 0 0.411522634 0 MS3_05002 0.58 0.71 0.54 0.43 0.66 8.38 8.46 0.923116339 1 0 0.411522634 0 MS3_05230 0.58 0.72 0.51 0.42 0.59 8.44 8.39 1.051271102 4 0 1.646090535 0 MS3_06994 0.58 0.72 0.57 0.49 0.66 9.45 9.39 1.061836547 69 3 28.39506173 10.34482759 MS3_11293 0.58 0.72 0.55 0.45 0.65 9.45 9.57 0.886920436 95 10 39.09465021 34.48275862 MS3_02172 0.59 0.72 0.52 0.42 0.63 10.02 10.09 0.93239382 152 18 62.55144033 62.06896552 MS3_05447 0.59 0.72 0.59 0.47 0.7 7.58 7.45 1.138828471 7 1 2.880658436 3.448275862 MS3_07037 0.59 0.72 0.51 0.38 0.64 8.49 8.39 1.105170928 2 0 0.823045267 0 MS3_00413 0.6 0.73 0.55 0.44 0.66 7.84 7.76 1.083287097 1 1 0.411522634 3.448275862 MS3_04717 0.6 0.73 0.55 0.46 0.64 7.41 7.49 0.923116296 4 0 1.646090535 0 MS3_05631 0.6 0.73 0.56 0.47 0.64 9.83 9.74 1.094174284 129 8 53.08641975 27.5862069 MS3_09161 0.6 0.73 0.51 0.4 0.62 9.12 9.05 1.072508183 28 0 11.52263374 0 MS3_00787 0.61 0.74 0.51 0.41 0.62 10.67 10.76 0.913931185 233 26 95.88477366 89.65517241 MS3_02476 0.61 0.74 0.55 0.44 0.66 8.38 8.28 1.105170931 9 2 3.703703704 6.896551724 MS3_02504 0.61 0.74 0.52 0.4 0.64 8.44 8.35 1.094174294 9 1 3.703703704 3.448275862 MS3_05761 0.61 0.74 0.56 0.46 0.67 6.26 6.31 0.951229094 0 0 0 0 MS3_06468 0.61 0.74 0.52 0.42 0.61 7.8 7.73 1.072508208 1 0 0.411522634 0 MS3_06769 0.61 0.74 0.53 0.43 0.63 7.91 7.84 1.072508203 2 1 0.823045267 3.448275862 61 MS3_00361 0.62 0.74 0.51 0.41 0.61 8.87 8.99 0.886920433 55 5 22.63374486 17.24137931 MS3_01435 0.63 0.76 0.51 0.4 0.62 8.14 8.07 1.072508195 4 0 1.646090535 0 MS3_02359 0.63 0.76 0.54 0.43 0.66 7.46 7.53 0.93239378 3 0 1.234567901 0 MS3_02951 0.63 0.76 0.48 0.37 0.58 10.59 10.53 1.061836547 237 25 97.5308642 86.20689655 MS3_03406 0.63 0.76 0.55 0.44 0.65 8.19 8.27 0.923116336 5 0 2.057613169 0 MS3_07587 0.63 0.76 0.52 0.41 0.62 9.84 9.91 0.93239382 133 16 54.73251029 55.17241379 MS3_00665 0.64 0.76 0.53 0.42 0.65 7.08 7.16 0.92311625 2 0 0.823045267 0 MS3_00404 0.65 0.78 0.51 0.41 0.62 8.86 8.91 0.951229423 8 1 3.29218107 3.448275862 MS3_02991 0.65 0.77 0.52 0.42 0.63 9.19 9.09 1.105170921 61 6 25.10288066 20.68965517 MS3_10085 0.65 0.78 0.55 0.45 0.64 9.68 9.59 1.094174285 105 7 43.20987654 24.13793103 MS3_01406 0.66 0.79 0.51 0.41 0.62 9.17 9.1 1.072508183 50 5 20.57613169 17.24137931 MS3_04117 0.66 0.79 0.5 0.4 0.6 6.22 6.16 1.061837082 2 0 0.823045267 0 MS3_05157 0.66 0.79 0.47 0.36 0.58 7.93 7.86 1.072508202 1 0 0.411522634 0 MS3_09233 0.66 0.79 0.52 0.42 0.61 8.83 8.9 0.932393817 18 0 7.407407407 0 MS3_08446 0.67 0.79 0.48 0.37 0.6 8.25 8.19 1.061836556 1 0 0.411522634 0 MS3_04873 0.67 0.79 0.54 0.42 0.66 8.83 8.93 0.904837415 28 4 11.52263374 13.79310345 MS3_05360 0.67 0.79 0.53 0.41 0.64 8.13 8.2 0.932393809 0 0 0 0 MS3_07565 0.67 0.79 0.54 0.44 0.64 8.35 8.29 1.061836554 2 0 0.823045267 0 MS3_08432 0.67 0.79 0.52 0.42 0.63 9.16 9.26 0.904837416 50 5 20.57613169 17.24137931 MS3_08871 0.67 0.79 0.52 0.43 0.61 8.9 8.86 1.040810776 18 0 7.407407407 0 MS3_04817 0.68 0.79 0.56 0.45 0.66 8.01 8.07 0.941764522 3 0 1.234567901 0 MS3_05958 0.68 0.8 0.53 0.43 0.63 8.79 8.87 0.923116343 30 2 12.34567901 6.896551724 MS3_04355 0.69 0.8 0.49 0.39 0.59 8.32 8.38 0.941764527 2 0 0.823045267 0 MS3_04584 0.69 0.81 0.55 0.44 0.65 10.33 10.39 0.941764533 204 25 83.95061728 86.20689655 MS3_04799 0.69 0.8 0.5 0.39 0.62 7.13 7.26 0.878095302 14 2 5.761316872 6.896551724 MS3_01600 0.7 0.82 0.53 0.43 0.63 8.48 8.54 0.941764529 9 0 3.703703704 0 MS3_03079 0.7 0.82 0.51 0.4 0.62 9.29 9.17 1.127496854 105 12 43.20987654 41.37931034 MS3_05332 0.7 0.81 0.58 0.48 0.69 9.27 9.34 0.932393819 50 5 20.57613169 17.24137931 MS3_08162 0.7 0.81 0.53 0.43 0.62 9.14 9.22 0.923116345 57 6 23.45679012 20.68965517 MS3_11076 0.7 0.82 0.49 0.38 0.6 8.92 8.86 1.061836549 30 0 12.34567901 0 MS3_02396 0.71 0.82 0.52 0.41 0.63 8.83 8.88 0.951229423 13 0 5.349794239 0 MS3_06257 0.71 0.83 0.54 0.41 0.66 8.19 8.3 0.895834122 9 2 3.703703704 6.896551724 MS3_06690 0.71 0.82 0.49 0.38 0.61 10.72 10.82 0.904837418 214 23 88.06584362 79.31034483 MS3_07420 0.71 0.82 0.5 0.37 0.62 7.14 7.22 0.923116261 1 1 0.411522634 3.448275862 MS3_09793 0.71 0.83 0.53 0.41 0.64 8.49 8.44 1.051271101 2 0 0.823045267 0 MS3_10588 0.71 0.82 0.58 0.46 0.7 8.36 8.52 0.852143776 42 7 17.28395062 24.13793103 MS3_01964 0.72 0.83 0.48 0.37 0.6 8.21 8.27 0.941764526 0 0 0 0 62 MS3_06108 0.72 0.83 0.52 0.42 0.63 8.47 8.56 0.913931179 35 1 14.40329218 3.448275862 MS3_08618 0.72 0.83 0.5 0.39 0.61 8.8 8.75 1.051271099 12 0 4.938271605 0 MS3_09188 0.72 0.83 0.51 0.4 0.62 10.75 10.65 1.105170918 239 26 98.35390947 89.65517241 MS3_01780 0.73 0.84 0.52 0.42 0.62 6.17 6.14 1.030454813 0 0 0 0 MS3_04100 0.73 0.84 0.52 0.4 0.64 8.11 8.06 1.051271106 2 0 0.823045267 0 MS3_05427 0.73 0.84 0.54 0.44 0.64 8.3 8.35 0.951229419 7 1 2.880658436 3.448275862 MS3_05437 0.73 0.84 0.54 0.43 0.65 7.85 7.89 0.960789428 2 0 0.823045267 0 MS3_07617 0.73 0.84 0.52 0.39 0.65 8.39 8.32 1.07250819 3 0 1.234567901 0 MS3_07988 0.73 0.84 0.5 0.4 0.6 10.35 10.44 0.913931185 162 20 66.66666667 68.96551724 MS3_08539 0.73 0.84 0.49 0.38 0.6 8.18 8.13 1.051271105 0 0 0 0 MS3_00294 0.74 0.84 0.52 0.42 0.63 8.43 8.47 0.960789436 3 0 1.234567901 0 MS3_02318 0.74 0.84 0.51 0.4 0.62 9.25 9.14 1.116278073 102 11 41.97530864 37.93103448 MS3_03817 0.74 0.85 0.55 0.45 0.64 9.24 9.15 1.094174286 104 7 42.79835391 24.13793103 MS3_07280 0.74 0.85 0.51 0.4 0.63 8.11 8.06 1.051271106 0 0 0 0 MS3_01952 0.75 0.85 0.5 0.39 0.61 8.5 8.46 1.040810778 11 1 4.526748971 3.448275862 MS3_04582 0.75 0.85 0.48 0.35 0.61 8.87 8.92 0.951229423 12 4 4.938271605 13.79310345 MS3_05283 0.75 0.85 0.52 0.42 0.62 8.45 8.4 1.051271101 19 0 7.818930041 0 MS3_06592 0.75 0.85 0.53 0.43 0.64 7.05 6.99 1.061836648 5 1 2.057613169 3.448275862 MS3_00668 0.76 0.86 0.49 0.38 0.6 10.35 10.27 1.083287068 185 22 76.13168724 75.86206897 MS3_02085 0.76 0.86 0.52 0.41 0.63 9.86 9.78 1.083287068 171 18 70.37037037 62.06896552 MS3_04206 0.76 0.86 0.51 0.41 0.6 8.41 8.44 0.970445531 2 0 0.823045267 0 MS3_06868 0.76 0.86 0.5 0.4 0.61 9.75 9.82 0.932393819 125 12 51.44032922 41.37931034 MS3_07195 0.76 0.86 0.51 0.41 0.61 7.84 7.79 1.051271114 2 0 0.823045267 0 MS3_09240 0.76 0.86 0.5 0.41 0.6 8.39 8.36 1.030454537 11 0 4.526748971 0 MS3_09434 0.76 0.86 0.49 0.39 0.6 8.86 8.93 0.932393817 23 1 9.465020576 3.448275862 MS3_11074 0.76 0.85 0.5 0.41 0.6 7.96 7.92 1.040810785 4 0 1.646090535 0 MS3_01664 0.77 0.86 0.51 0.4 0.63 8.12 8.17 0.951229416 5 1 2.057613169 3.448275862 MS3_05587 0.77 0.86 0.53 0.4 0.66 7 7.07 0.932393719 3 1 1.234567901 3.448275862 MS3_06944 0.77 0.86 0.55 0.45 0.64 9.56 9.59 0.970445533 87 6 35.80246914 20.68965517 MS3_07520 0.77 0.86 0.53 0.41 0.65 8.18 8.23 0.951229417 5 1 2.057613169 3.448275862 MS3_08440 0.77 0.86 0.55 0.43 0.67 8.86 8.92 0.941764531 28 3 11.52263374 10.34482759 MS3_08479 0.77 0.86 0.51 0.43 0.6 9.48 9.44 1.040810775 82 5 33.74485597 17.24137931 MS3_07831 0.78 0.87 0.5 0.38 0.61 8.6 8.64 0.960789437 6 1 2.469135802 3.448275862 MS3_09613 0.78 0.87 0.5 0.41 0.59 9.6 9.57 1.030454534 83 4 34.1563786 13.79310345 MS3_10194 0.78 0.87 0.54 0.42 0.66 8.35 8.26 1.094174296 32 4 13.16872428 13.79310345 MS3_10472 0.78 0.87 0.49 0.37 0.6 8.53 8.57 0.960789436 4 0 1.646090535 0 MS3_02453 0.79 0.88 0.53 0.42 0.64 7.76 7.8 0.960789426 1 0 0.411522634 0 63 MS3_07405 0.79 0.88 0.53 0.4 0.65 8.33 8.27 1.061836554 15 3 6.172839506 10.34482759 MS3_00859 0.8 0.88 0.53 0.41 0.65 6.39 6.34 1.051271408 4 0 1.646090535 0 MS3_02465 0.8 0.88 0.51 0.39 0.62 7.4 7.44 0.960789412 0 0 0 0 MS3_03192 0.8 0.88 0.53 0.43 0.62 8.21 8.24 0.970445529 13 0 5.349794239 0 MS3_08444 0.8 0.88 0.5 0.41 0.59 8.92 8.89 1.030454535 25 0 10.28806584 0 MS3_08504 0.8 0.88 0.53 0.41 0.64 8.18 8.22 0.960789433 4 0 1.646090535 0 MS3_03856 0.81 0.89 0.5 0.41 0.6 8.45 8.48 0.970445531 1 0 0.411522634 0 MS3_04221 0.81 0.89 0.53 0.42 0.64 8.71 8.67 1.040810777 5 1 2.057613169 3.448275862 MS3_08337 0.81 0.89 0.5 0.4 0.61 7.46 7.5 0.960789415 1 1 0.411522634 3.448275862 MS3_08503 0.81 0.89 0.5 0.4 0.61 7.48 7.45 1.030454554 0 0 0 0 MS3_00203 0.82 0.89 0.5 0.38 0.61 8.67 8.63 1.040810777 9 1 3.703703704 3.448275862 MS3_00353 0.82 0.89 0.57 0.47 0.68 9.79 9.85 0.941764533 136 19 55.96707819 65.51724138 MS3_01972 0.82 0.89 0.52 0.38 0.65 8.17 8.22 0.951229417 4 0 1.646090535 0 MS3_01988 0.82 0.89 0.54 0.41 0.67 9.62 9.53 1.094174285 96 11 39.50617284 37.93103448 MS3_02237 0.82 0.89 0.52 0.43 0.61 8.64 8.61 1.030454536 21 1 8.641975309 3.448275862 MS3_07650 0.82 0.89 0.51 0.41 0.6 10.29 10.24 1.051271097 160 19 65.8436214 65.51724138 MS3_07822 0.82 0.89 0.5 0.38 0.61 7.47 7.51 0.960789415 1 0 0.411522634 0 MS3_07885 0.82 0.89 0.5 0.39 0.61 8.17 8.14 1.030454539 2 0 0.823045267 0 MS3_05939 0.83 0.9 0.52 0.41 0.63 8.09 8.12 0.970445528 0 0 0 0 MS3_08159 0.83 0.9 0.54 0.44 0.64 8.22 8.25 0.970445529 7 0 2.880658436 0 MS3_01240 0.84 0.91 0.5 0.4 0.6 8.59 8.62 0.970445532 19 1 7.818930041 3.448275862 MS3_02088 0.84 0.9 0.47 0.35 0.58 8.11 8.14 0.970445528 3 0 1.234567901 0 MS3_07464 0.84 0.9 0.51 0.4 0.63 8.88 8.83 1.051271099 26 1 10.69958848 3.448275862 MS3_07729 0.84 0.9 0.5 0.37 0.63 8.28 8.24 1.04081078 8 0 3.29218107 0 MS3_10116 0.84 0.91 0.5 0.38 0.62 8.87 8.83 1.040810776 24 3 9.87654321 10.34482759 MS3_10572 0.84 0.91 0.53 0.42 0.63 9.35 9.4 0.951229424 81 10 33.33333333 34.48275862 MS3_04266 0.85 0.91 0.54 0.43 0.64 8.96 8.94 1.020201341 16 1 6.58436214 3.448275862 MS3_05125 0.85 0.91 0.47 0.35 0.59 8.02 7.95 1.072508199 34 6 13.99176955 20.68965517 MS3_06147 0.85 0.91 0.5 0.39 0.62 7.79 7.76 1.030454545 0 0 0 0 MS3_07651 0.85 0.91 0.51 0.41 0.61 8.61 8.65 0.960789437 30 2 12.34567901 6.896551724 MS3_10161 0.85 0.91 0.5 0.4 0.61 8.4 8.38 1.020201342 3 0 1.234567901 0 MS3_01124 0.86 0.92 0.49 0.39 0.58 8.66 8.64 1.020201341 5 0 2.057613169 0 MS3_05222 0.86 0.92 0.5 0.39 0.6 9.79 9.81 0.980198673 130 14 53.49794239 48.27586207 MS3_06248 0.86 0.91 0.48 0.39 0.58 8.81 8.85 0.960789438 29 1 11.93415638 3.448275862 MS3_08276 0.86 0.91 0.51 0.4 0.63 8.95 8.91 1.040810776 48 5 19.75308642 17.24137931 MS3_10044 0.86 0.92 0.55 0.45 0.66 6.35 6.38 0.970445361 1 0 0.411522634 0 MS3_03726 0.87 0.92 0.5 0.39 0.62 8.69 8.67 1.020201341 14 2 5.761316872 6.896551724 64 MS3_03800 0.87 0.92 0.48 0.36 0.6 7.59 7.64 0.951229401 1 1 0.411522634 3.448275862 MS3_05192 0.87 0.92 0.5 0.38 0.63 8.61 8.57 1.040810777 11 2 4.526748971 6.896551724 MS3_06348 0.87 0.92 0.54 0.43 0.66 9.17 9.2 0.970445533 64 10 26.33744856 34.48275862 MS3_09489 0.87 0.92 0.5 0.39 0.61 8.98 8.93 1.051271098 55 5 22.63374486 17.24137931 MS3_02307 0.88 0.93 0.52 0.42 0.62 9.22 9.19 1.030454535 62 4 25.51440329 13.79310345 MS3_03140 0.88 0.93 0.52 0.4 0.63 9.61 9.59 1.02020134 81 11 33.33333333 37.93103448 MS3_03226 0.88 0.93 0.51 0.4 0.63 8.22 8.2 1.020201343 0 0 0 0 MS3_03577 0.88 0.93 0.52 0.4 0.65 8.25 8.22 1.030454538 1 0 0.411522634 0 MS3_00800 0.89 0.93 0.5 0.39 0.61 7.68 7.66 1.020201349 2 0 0.823045267 0 MS3_07347 0.89 0.93 0.54 0.42 0.65 8.67 8.7 0.970445532 15 2 6.172839506 6.896551724 MS3_09569 0.89 0.93 0.53 0.4 0.65 8.73 8.75 0.980198672 11 1 4.526748971 3.448275862 MS3_09652 0.89 0.93 0.52 0.42 0.62 8.07 8.08 0.990049832 1 0 0.411522634 0 MS3_11428 0.89 0.93 0.53 0.42 0.65 9.06 9.08 0.980198673 19 2 7.818930041 6.896551724 MS3_01364 0.9 0.94 0.5 0.39 0.61 10.19 10.23 0.960789439 151 16 62.1399177 55.17241379 MS3_04540 0.9 0.94 0.52 0.41 0.62 6.65 6.64 1.010050201 3 0 1.234567901 0 MS3_05326 0.9 0.94 0.5 0.39 0.61 7.87 7.89 0.980198668 1 0 0.411522634 0 MS3_03863 0.91 0.95 0.52 0.44 0.61 7.65 7.64 1.010050172 0 0 0 0 MS3_04680 0.91 0.95 0.49 0.4 0.58 7.92 7.94 0.980198668 23 1 9.465020576 3.448275862 MS3_09778 0.91 0.95 0.51 0.41 0.61 8.03 8.01 1.020201344 2 0 0.823045267 0 MS3_02202 0.92 0.96 0.51 0.41 0.61 9.09 9.08 1.010050167 30 1 12.34567901 3.448275862 MS3_03933 0.92 0.96 0.49 0.37 0.62 8.7 8.69 1.010050168 11 1 4.526748971 3.448275862 MS3_06649 0.92 0.95 0.53 0.42 0.64 8.66 8.68 0.980198672 23 2 9.465020576 6.896551724 MS3_11273 0.92 0.95 0.5 0.4 0.6 8.65 8.64 1.010050168 7 0 2.880658436 0 MS3_03231 0.93 0.96 0.51 0.41 0.61 7.98 7.97 1.010050169 2 0 0.823045267 0 MS3_04364 0.93 0.96 0.54 0.43 0.65 9.35 9.33 1.02020134 77 9 31.6872428 31.03448276 MS3_05913 0.93 0.96 0.52 0.41 0.63 8.83 8.85 0.980198672 29 3 11.93415638 10.34482759 MS3_08042 0.93 0.96 0.52 0.39 0.64 8.74 8.76 0.980198672 18 4 7.407407407 13.79310345 MS3_09465 0.93 0.96 0.48 0.38 0.59 7.64 7.63 1.010050172 1 0 0.411522634 0 MS3_11239 0.93 0.96 0.51 0.41 0.61 7.79 7.8 0.99004983 1 0 0.411522634 0 MS3_00931 0.94 0.96 0.5 0.42 0.58 9.79 9.8 0.990049834 111 9 45.67901235 31.03448276 MS3_04275 0.94 0.96 0.48 0.38 0.58 8.76 8.76 1 10 0 4.115226337 0 MS3_06551 0.94 0.96 0.51 0.39 0.62 8.66 8.65 1.010050168 14 3 5.761316872 10.34482759 MS3_07125 0.94 0.96 0.51 0.41 0.6 8.42 8.42 1 4 0 1.646090535 0 MS3_08839 0.94 0.96 0.52 0.42 0.61 8.43 8.42 1.010050168 12 0 4.938271605 0 MS3_09640 0.94 0.96 0.53 0.44 0.62 9.12 9.1 1.020201341 61 4 25.10288066 13.79310345 MS3_01585 0.95 0.97 0.52 0.41 0.62 8.52 8.52 1 1 0 0.411522634 0 MS3_04011 0.95 0.97 0.54 0.41 0.66 7.84 7.86 0.980198667 14 4 5.761316872 13.79310345 65 MS3_05047 0.95 0.97 0.51 0.41 0.61 9.16 9.17 0.990049834 59 5 24.27983539 17.24137931 MS3_06400 0.95 0.97 0.52 0.39 0.64 8.17 8.18 0.990049832 2 0 0.823045267 0 MS3_00006 0.96 0.97 0.51 0.4 0.63 7.9 7.9 1 1 0 0.411522634 0 MS3_02952 0.96 0.97 0.53 0.42 0.63 7.04 7.04 1 1 1 0.411522634 3.448275862 MS3_04474 0.96 0.97 0.51 0.38 0.63 8.5 8.5 1 5 0 2.057613169 0 MS3_06729 0.96 0.97 0.51 0.39 0.62 8.27 8.27 1 7 0 2.880658436 0 MS3_07299 0.96 0.98 0.51 0.39 0.63 7.76 7.77 0.99004983 3 1 1.234567901 3.448275862 MS3_03615 0.97 0.98 0.57 0.44 0.7 7.56 7.57 0.990049828 27 3 11.11111111 10.34482759 MS3_06740 0.97 0.98 0.5 0.39 0.62 8.06 8.06 1 0 0 0 0 MS3_08655 0.97 0.98 0.55 0.42 0.69 7.65 7.66 0.990049829 13 3 5.349794239 10.34482759 MS3_09333 0.97 0.98 0.52 0.41 0.64 8.62 8.63 0.990049833 9 0 3.703703704 0 MS3_02460 0.98 0.98 0.51 0.4 0.62 8.71 8.72 0.990049833 4 0 1.646090535 0 MS3_08216 0.98 0.99 0.54 0.44 0.64 7.27 7.27 1 0 0 0 0 MS3_09473 0.98 0.98 0.51 0.41 0.61 9.26 9.27 0.990049834 67 8 27.57201646 27.5862069 MS3_02593 0.99 0.99 0.5 0.39 0.62 7.97 7.97 1 2 0 0.823045267 0 MS3_05686 0.99 0.99 0.51 0.41 0.62 9.59 9.58 1.010050167 84 8 34.56790123 27.5862069 MS3_00499 1 1 0.52 0.41 0.63 8.51 8.51 1 37 3 15.22633745 10.34482759 MS3_03511 1 1 0.5 0.41 0.6 8.22 8.22 1 2 0 0.823045267 0 *WormBase ParaSite online database, version 14 https://parasite.wormbase.org/Schistosoma_haematobium_prjna78265/Info/Index/ 66 Table S3. Fold change of IgG responses between infected and non-infected (S. haematobium-endemic) populations resulting from urine sample probing of S. haematobium protein arrays. Antigen P value FDR AUC AUC AUC Mean Mean Fold Positive Positive Positive Positive (WBPS14* Lower Upper infected non Change infected non infected non accession) CI CI infected infected (%) infected (%) MS3_10385 4.20E-14 4.20E-11 0.93 0.85 1 12 7.5 90.01716 103 2 91.15044 8.33333333 MS3_06193 4.30E-10 1.8E-07 0.83 0.75 0.91 11.14 7.75 29.66596 90 7 79.64602 29.1666667 MS3_10186 5.40E-10 1.8E-07 0.88 0.8 0.97 11.68 7.73 51.93538 99 6 87.61062 25 MS3_02553 0.000000017 0.0000043 0.86 0.77 0.94 10.79 8.87 6.820959 107 18 94.69027 75 MS3_01466 0.000000096 0.000019 0.75 0.66 0.84 9.46 6.96 12.1825 59 7 52.21239 29.1666667 MS3_07702 0.00000012 0.00002 0.76 0.67 0.85 8.94 7.43 4.526732 57 3 50.44248 12.5 MS3_04688 0.00000054 0.000077 0.76 0.66 0.86 8.38 6.96 4.137124 46 2 40.70796 8.33333333 MS3_00996 0.00000075 0.000086 0.7 0.61 0.78 9.62 8.87 2.117 98 22 86.72566 91.6666667 MS3_09198 0.00000078 0.000086 0.83 0.73 0.92 10.65 8.65 7.389056 103 11 91.15044 45.8333333 MS3_01597 0.0000056 0.00056 0.78 0.69 0.86 6.94 7.71 0.463013 5 5 4.424779 20.8333333 MS3_07968 0.0000094 0.00084 0.78 0.69 0.87 7.02 8.41 0.249075 19 13 16.81416 54.1666667 MS3_07481 0.000014 0.0012 0.74 0.63 0.85 9.43 7.82 5.002812 77 9 68.14159 37.5 MS3_09207 0.000018 0.0013 0.68 0.57 0.78 8.11 7.02 2.974276 39 2 34.51327 8.33333333 MS3_00805 0.000028 0.002 0.77 0.68 0.86 7.01 8.58 0.208045 23 15 20.35398 62.5 MS3_07178 0.000032 0.0021 0.66 0.57 0.76 7.35 6.33 2.773202 32 0 28.31858 0 MS3_07693 0.000043 0.0027 0.7 0.6 0.81 10.11 10.98 0.418952 99 24 87.61062 100 MS3_05950 0.000064 0.0036 0.72 0.62 0.82 9.04 7.31 5.640656 64 7 56.63717 29.1666667 MS3_02428 0.000065 0.0036 0.75 0.66 0.85 7.92 7.26 1.934793 33 1 29.20354 4.16666667 MS3_05350 0.000073 0.0036 0.77 0.66 0.89 7.23 8.19 0.382893 13 13 11.50442 54.1666667 MS3_07037 0.000074 0.0036 0.74 0.63 0.85 7.58 8.33 0.472366 19 12 16.81416 50 MS3_05192 0.00008 0.0036 0.73 0.63 0.83 7.7 8.39 0.501576 24 10 21.23894 41.6666667 MS3_08283 0.00008 0.0036 0.76 0.66 0.86 7.63 8.85 0.29523 29 15 25.66372 62.5 MS3_05024 0.000084 0.0036 0.77 0.66 0.87 7.44 8.45 0.364219 20 13 17.69912 54.1666667 MS3_00180 0.000089 0.0037 0.68 0.58 0.79 8.24 7.27 2.637946 42 2 37.16814 8.33333333 MS3_01257 0.0001 0.0041 0.7 0.6 0.81 6.74 5.98 2.138287 13 0 11.50442 0 MS3_04820 0.00012 0.0045 0.77 0.66 0.88 8.86 7.81 2.857652 83 7 73.45133 29.1666667 MS3_05739 0.00012 0.0045 0.77 0.67 0.87 6.31 7.1 0.453844 1 2 0.884956 8.33333333 MS3_01857 0.00013 0.0045 0.75 0.65 0.84 9.57 8.36 3.353485 96 14 84.95575 58.3333333 MS3_08087 0.00013 0.0045 0.77 0.65 0.89 7.66 8.71 0.349938 26 17 23.00885 70.8333333 MS3_07405 0.00014 0.0045 0.73 0.62 0.83 7.61 8.43 0.440432 23 13 20.35398 54.1666667 MS3_03509 0.00015 0.0049 0.74 0.64 0.84 9.44 8.38 2.886371 90 13 79.64602 54.1666667 67 MS3_09779 0.00017 0.0051 0.66 0.55 0.76 7.49 6.55 2.559986 30 0 26.54867 0 MS3_01365 0.00019 0.0057 0.69 0.59 0.79 8.5 7.73 2.159767 57 6 50.44248 25 MS3_05676 0.0002 0.0059 0.74 0.63 0.85 7.8 8.44 0.527292 25 13 22.12389 54.1666667 MS3_00670 0.00021 0.0059 0.73 0.62 0.84 7.79 8.54 0.472366 33 13 29.20354 54.1666667 MS3_02343 0.00024 0.0067 0.74 0.64 0.84 7.04 7.63 0.554327 5 4 4.424779 16.6666667 MS3_00886 0.00028 0.0074 0.7 0.59 0.8 8.66 7.82 2.316367 63 8 55.75221 33.3333333 MS3_03988 0.00041 0.01 0.75 0.64 0.86 7.02 7.78 0.467666 11 6 9.734513 25 MS3_06551 0.00041 0.01 0.72 0.61 0.83 7.77 8.45 0.506617 26 13 23.00885 54.1666667 MS3_01364 0.00052 0.013 0.66 0.57 0.76 7.67 6.77 2.459606 38 2 33.62832 8.33333333 MS3_01749 0.00053 0.013 0.74 0.65 0.83 9.85 8.95 2.459603 105 19 92.92035 79.1666667 MS3_02688 0.0006 0.014 0.74 0.62 0.86 9.35 8.22 3.095657 96 12 84.95575 50 MS3_10485 0.00078 0.018 0.74 0.62 0.87 7.28 8.38 0.332871 16 14 14.15929 58.3333333 MS3_00203 0.0008 0.018 0.71 0.6 0.82 7.65 8.32 0.511708 21 11 18.58407 45.8333333 MS3_03140 0.0008 0.018 0.74 0.63 0.85 8.84 8.23 1.840431 89 9 78.76106 37.5 MS3_09744 0.00085 0.018 0.72 0.61 0.83 8.99 7.93 2.886371 81 9 71.68142 37.5 MS3_07988 0.00097 0.021 0.7 0.59 0.8 9.56 8.56 2.718282 94 16 83.18584 66.6666667 MS3_07617 0.001 0.021 0.71 0.59 0.82 7.71 8.3 0.554327 24 11 21.23894 45.8333333 MS3_08220 0.0011 0.021 0.73 0.61 0.86 9.06 7.99 2.91538 85 9 75.22124 37.5 MS3_05959 0.0012 0.023 0.65 0.56 0.75 8.52 7.81 2.033992 52 4 46.0177 16.6666667 MS3_06608 0.0012 0.023 0.71 0.6 0.83 7.5 8.31 0.444858 24 11 21.23894 45.8333333 MS3_03603 0.0014 0.027 0.72 0.6 0.84 8.18 7.5 1.973878 50 4 44.24779 16.6666667 MS3_09536 0.0014 0.027 0.72 0.59 0.85 6.63 7.39 0.467666 1 3 0.884956 12.5 MS3_04827 0.0015 0.028 0.72 0.6 0.84 7.97 8.57 0.548812 33 16 29.20354 66.6666667 MS3_07158 0.0015 0.027 0.7 0.59 0.81 7.89 8.48 0.554327 29 12 25.66372 50 MS3_08094 0.0017 0.029 0.71 0.59 0.84 8.18 7.61 1.768267 39 3 34.51327 12.5 MS3_04307 0.0017 0.029 0.65 0.54 0.76 8.18 7.11 2.915381 47 4 41.59292 16.6666667 MS3_05952 0.0017 0.029 0.66 0.56 0.77 8.46 7.72 2.095936 56 4 49.55752 16.6666667 MS3_06258 0.0017 0.029 0.71 0.59 0.83 7.55 8.28 0.481909 21 10 18.58407 41.6666667 MS3_09521 0.0018 0.029 0.71 0.6 0.82 7.44 8.24 0.449329 17 11 15.04425 45.8333333 MS3_01852 0.0019 0.031 0.71 0.62 0.81 6.5 7.05 0.576949 3 2 2.654867 8.33333333 MS3_07972 0.0019 0.031 0.65 0.54 0.76 8.31 7.45 2.363161 51 7 45.13274 29.1666667 MS3_06532 0.002 0.031 0.63 0.52 0.75 8.64 7.85 2.203397 56 7 49.55752 29.1666667 MS3_09690 0.002 0.031 0.69 0.59 0.79 8.23 7.76 1.599994 54 3 47.78761 12.5 MS3_01370 0.0021 0.031 0.66 0.56 0.77 8.11 7.31 2.225542 43 3 38.0531 12.5 MS3_02314 0.0022 0.032 0.69 0.57 0.81 8.01 8.51 0.606531 37 15 32.74336 62.5 MS3_00850 0.0022 0.032 0.7 0.58 0.82 7.74 8.27 0.588605 22 12 19.46903 50 MS3_06825 0.0022 0.032 0.69 0.58 0.8 7.58 8.12 0.582748 19 8 16.81416 33.3333333 68 MS3_07612 0.0022 0.032 0.71 0.62 0.81 8.42 7.81 1.840432 67 7 59.29204 29.1666667 MS3_10017 0.0022 0.032 0.73 0.61 0.85 7.63 8.4 0.463013 28 14 24.77876 58.3333333 MS3_00277 0.0023 0.033 0.68 0.57 0.79 8.45 7.11 3.819046 52 5 46.0177 20.8333333 MS3_08413 0.0026 0.036 0.68 0.57 0.78 7.86 7.34 1.682028 26 1 23.00885 4.16666667 MS3_05002 0.0028 0.038 0.7 0.58 0.82 7.62 8.2 0.559898 23 11 20.35398 45.8333333 MS3_10378 0.0029 0.038 0.7 0.58 0.81 7.48 8.06 0.559898 15 8 13.27434 33.3333333 MS3_06898 0.0031 0.041 0.67 0.57 0.77 7.69 7.2 1.632317 25 0 22.12389 0 MS3_06944 0.0032 0.042 0.71 0.59 0.84 8.34 7.42 2.509291 65 6 57.52212 25 MS3_05913 0.0033 0.042 0.7 0.59 0.81 7.72 7.03 1.993717 29 2 25.66372 8.33333333 MS3_08432 0.0035 0.044 0.7 0.58 0.82 8.16 7.35 2.247909 52 4 46.0177 16.6666667 MS3_08811 0.0038 0.047 0.7 0.57 0.83 7.81 8.4 0.554327 21 12 18.58407 50 MS3_05976 0.004 0.049 0.68 0.56 0.81 6.95 7.56 0.543351 3 4 2.654867 16.6666667 MS3_09070 0.0045 0.055 0.64 0.54 0.75 6.73 6.14 1.803994 9 0 7.964602 0 MS3_07594 0.0047 0.057 0.66 0.56 0.76 7.3 7.69 0.677057 11 1 9.734513 4.16666667 MS3_10785 0.0048 0.058 0.71 0.58 0.83 6.66 7.27 0.54335 3 2 2.654867 8.33333333 MS3_07763 0.0051 0.06 0.68 0.56 0.8 7.5 8.13 0.532592 17 9 15.04425 37.5 MS3_01030 0.0052 0.061 0.67 0.56 0.78 7.58 6.91 1.954239 35 1 30.97345 4.16666667 MS3_00361 0.0053 0.061 0.7 0.58 0.82 8.26 7.37 2.43513 58 4 51.32743 16.6666667 MS3_01870 0.0053 0.061 0.69 0.56 0.82 7 7.71 0.491644 11 8 9.734513 33.3333333 MS3_02256 0.0054 0.061 0.69 0.57 0.81 7.99 7.51 1.616075 31 4 27.43363 16.6666667 MS3_01193 0.0055 0.061 0.65 0.53 0.78 7.65 7.04 1.840432 26 2 23.00885 8.33333333 MS3_05425 0.0057 0.063 0.7 0.58 0.82 8.56 7.94 1.858928 74 8 65.48673 33.3333333 MS3_05730 0.006 0.066 0.67 0.57 0.78 9.58 8.87 2.033991 95 17 84.0708 70.8333333 No hits 0.0061 0.066 0.67 0.56 0.78 7.03 7.5 0.625002 7 2 6.19469 8.33333333 MS3_05718 0.0063 0.067 0.67 0.57 0.78 7.12 6.38 2.09594 18 1 15.9292 4.16666667 MS3_09700 0.0063 0.067 0.69 0.58 0.8 7.45 7.96 0.600495 16 9 14.15929 37.5 MS3_05539 0.0065 0.068 0.68 0.57 0.8 7.49 8.17 0.506617 18 10 15.9292 41.6666667 MS3_10083 0.0067 0.069 0.66 0.55 0.77 7.8 8.36 0.571209 35 11 30.97345 45.8333333 MS3_01780 0.0068 0.069 0.69 0.58 0.8 6.04 6.49 0.637626 1 0 0.884956 0 MS3_03041 0.0068 0.069 0.68 0.56 0.79 6.43 6.89 0.631283 1 0 0.884956 0 MS3_01585 0.007 0.07 0.67 0.55 0.78 7.82 8.17 0.704688 20 8 17.69912 33.3333333 MS3_02805 0.0071 0.07 0.68 0.56 0.8 8.12 7.48 1.896481 49 5 43.36283 20.8333333 MS3_10184 0.0071 0.07 0.66 0.55 0.77 7.56 6.75 2.24791 36 3 31.85841 12.5 MS3_01337 0.0072 0.07 0.67 0.55 0.78 8.02 7.44 1.786039 39 4 34.51327 16.6666667 MS3_07347 0.0073 0.07 0.67 0.55 0.79 7.64 8.16 0.59452 19 9 16.81416 37.5 MS3_02539 0.0077 0.073 0.67 0.55 0.78 7.66 8.19 0.588605 29 9 25.66372 37.5 MS3_06736 0.0078 0.073 0.67 0.55 0.8 8.12 7.52 1.822119 42 5 37.16814 20.8333333 69 MS3_05222 0.0079 0.073 0.69 0.58 0.8 8.43 7.58 2.339647 65 8 57.52212 33.3333333 MS3_05496 0.0079 0.073 0.68 0.57 0.79 7.05 7.62 0.565525 9 6 7.964602 25 MS3_03429 0.008 0.073 0.66 0.55 0.77 8.21 7.66 1.733253 53 5 46.90265 20.8333333 MS3_07650 0.008 0.073 0.68 0.56 0.8 8.71 7.88 2.293319 76 9 67.25664 37.5 MS3_06868 0.0085 0.077 0.69 0.55 0.82 8.98 8.21 2.159766 82 11 72.56637 45.8333333 MS3_08455 0.0086 0.077 0.6 0.49 0.72 8.06 7.48 1.786039 34 5 30.0885 20.8333333 MS3_01938 0.0089 0.079 0.69 0.57 0.8 8.94 8.45 1.632316 86 13 76.10619 54.1666667 MS3_04083 0.0097 0.085 0.66 0.56 0.77 10.93 10.5 1.537258 112 24 99.11504 100 MS3_04193 0.0099 0.085 0.69 0.58 0.79 8.29 7.79 1.648721 61 5 53.9823 20.8333333 MS3_04437 0.0099 0.085 0.68 0.56 0.8 7.86 7.45 1.506818 26 2 23.00885 8.33333333 MS3_08618 0.0099 0.085 0.68 0.55 0.8 7.83 8.25 0.657047 24 11 21.23894 45.8333333 MS3_00498 0.01 0.085 0.68 0.57 0.79 8.86 8.17 1.993716 81 11 71.68142 45.8333333 MS3_01141 0.01 0.085 0.67 0.54 0.8 7.06 7.87 0.444858 13 11 11.50442 45.8333333 MS3_02162 0.01 0.085 0.67 0.55 0.78 8.05 7.53 1.682028 43 5 38.0531 20.8333333 MS3_05283 0.01 0.085 0.66 0.55 0.78 7.18 7.74 0.571209 13 6 11.50442 25 MS3_08954 0.01 0.085 0.66 0.53 0.78 7.11 6.46 1.915544 18 2 15.9292 8.33333333 MS3_00808 0.011 0.086 0.68 0.58 0.79 8.75 8.28 1.599994 78 10 69.02655 41.6666667 MS3_04262 0.011 0.086 0.67 0.56 0.78 8.28 7.72 1.750673 59 4 52.21239 16.6666667 MS3_08840 0.011 0.086 0.67 0.56 0.78 8.15 7.71 1.552707 51 5 45.13274 20.8333333 MS3_08975 0.011 0.086 0.58 0.48 0.68 7.83 7.28 1.733254 35 1 30.97345 4.16666667 MS3_09000 0.011 0.086 0.65 0.53 0.76 8.48 7.95 1.698932 54 10 47.78761 41.6666667 MS3_09287 0.011 0.086 0.66 0.55 0.77 8.03 7.47 1.750673 44 3 38.93805 12.5 MS3_10729 0.011 0.086 0.66 0.54 0.78 7.71 8.16 0.637628 19 9 16.81416 37.5 MS3_09396 0.012 0.089 0.66 0.55 0.76 7.87 7.38 1.632317 36 3 31.85841 12.5 MS3_09632 0.012 0.089 0.61 0.51 0.72 7.05 6.64 1.506819 11 1 9.734513 4.16666667 MS3_09692 0.012 0.092 0.69 0.55 0.82 6.44 7.08 0.527291 3 2 2.654867 8.33333333 MS3_00812 0.013 0.094 0.68 0.56 0.79 8.39 7.77 1.858928 63 6 55.75221 25 MS3_02442 0.013 0.095 0.66 0.54 0.79 8.33 7.6 2.075081 56 9 49.55752 37.5 MS3_04117 0.013 0.098 0.67 0.53 0.81 6.3 7.16 0.423161 6 6 5.309735 25 MS3_05322 0.013 0.096 0.67 0.55 0.8 7.91 7.46 1.568312 22 3 19.46903 12.5 MS3_01840 0.014 0.1 0.67 0.55 0.78 8.87 8.25 1.858928 81 13 71.68142 54.1666667 MS3_02758 0.014 0.1 0.67 0.55 0.79 7.79 8.27 0.618783 26 11 23.00885 45.8333333 MS3_05734 0.014 0.1 0.66 0.55 0.77 7.25 7.69 0.644036 16 4 14.15929 16.6666667 MS3_00257 0.015 0.1 0.66 0.54 0.77 7.68 7.2 1.616075 24 2 21.23894 8.33333333 MS3_01483 0.015 0.1 0.64 0.53 0.76 7.72 8.13 0.66365 31 9 27.43363 37.5 MS3_04962 0.015 0.1 0.63 0.52 0.74 7.86 8.23 0.690734 27 10 23.89381 41.6666667 MS3_03372 0.016 0.11 0.66 0.54 0.78 8.07 7.42 1.915541 51 5 45.13274 20.8333333 70 MS3_09846 0.016 0.11 0.68 0.55 0.81 7.62 6.72 2.459606 38 4 33.62832 16.6666667 MS3_11293 0.016 0.11 0.67 0.55 0.8 8.14 7.37 2.159767 53 7 46.90265 29.1666667 MS3_00859 0.017 0.11 0.66 0.53 0.78 6.04 6.5 0.631281 0 0 0 0 MS3_01339 0.017 0.11 0.66 0.55 0.76 8.18 7.68 1.648721 54 4 47.78761 16.6666667 MS3_04800 0.017 0.11 0.68 0.56 0.8 7.98 7.34 1.896481 42 3 37.16814 12.5 MS3_07422 0.017 0.11 0.65 0.53 0.77 7.57 7.96 0.677057 14 6 12.38938 25 MS3_09089 0.017 0.11 0.67 0.54 0.79 6.5 6.95 0.637627 3 0 2.654867 0 MS3_00756 0.018 0.12 0.65 0.53 0.77 8.32 7.61 2.033992 64 9 56.63717 37.5 MS3_05280 0.018 0.12 0.65 0.53 0.76 8.39 7.98 1.506818 61 8 53.9823 33.3333333 MS3_06147 0.018 0.12 0.67 0.56 0.78 7.04 7.41 0.690734 6 2 5.309735 8.33333333 MS3_10440 0.018 0.12 0.66 0.54 0.78 7.45 8.02 0.565525 24 8 21.23894 33.3333333 MS3_10772 0.018 0.12 0.67 0.55 0.79 6.94 7.47 0.588605 9 3 7.964602 12.5 MS3_00151 0.019 0.12 0.64 0.52 0.75 7.17 7.64 0.625002 6 3 5.309735 12.5 MS3_01542 0.019 0.12 0.65 0.52 0.78 9.15 8.46 1.993716 86 13 76.10619 54.1666667 MS3_02593 0.019 0.12 0.66 0.53 0.79 7.34 7.83 0.612626 10 6 8.849558 25 MS3_03872 0.019 0.12 0.66 0.55 0.77 8.12 7.45 1.954238 56 6 49.55752 25 MS3_05284 0.019 0.12 0.66 0.54 0.78 7.48 7.93 0.637628 17 8 15.04425 33.3333333 MS3_08144 0.019 0.12 0.66 0.54 0.78 6.8 7.27 0.625002 3 2 2.654867 8.33333333 MS3_09233 0.019 0.12 0.65 0.54 0.75 7.88 7.43 1.568313 36 2 31.85841 8.33333333 MS3_05677 0.02 0.12 0.65 0.51 0.79 8.63 7.85 2.181473 64 10 56.63717 41.6666667 MS3_00934 0.021 0.12 0.66 0.54 0.79 6.27 6.8 0.588604 1 2 0.884956 8.33333333 MS3_00006 0.021 0.12 0.66 0.53 0.78 7.31 7.82 0.600495 11 7 9.734513 29.1666667 MS3_04053 0.021 0.12 0.65 0.53 0.76 8 8.43 0.650509 38 14 33.62832 58.3333333 MS3_09684 0.021 0.12 0.56 0.44 0.68 7.9 7.38 1.682028 31 2 27.43363 8.33333333 MS3_09829 0.021 0.12 0.66 0.54 0.78 6.21 6.68 0.625001 2 1 1.769912 4.16666667 MS3_01871 0.022 0.13 0.65 0.52 0.78 7.58 8.03 0.637628 17 9 15.04425 37.5 MS3_01937 0.022 0.13 0.65 0.52 0.77 7.82 7.37 1.568313 29 4 25.66372 16.6666667 MS3_03569 0.022 0.13 0.65 0.53 0.77 7.84 8.27 0.650509 30 12 26.54867 50 MS3_05050 0.022 0.13 0.64 0.52 0.75 7.05 6.53 1.68203 11 1 9.734513 4.16666667 MS3_07918 0.022 0.13 0.66 0.53 0.79 8.5 7.81 1.993716 65 9 57.52212 37.5 MS3_09489 0.023 0.13 0.65 0.53 0.76 7.65 7.06 1.803989 34 5 30.0885 20.8333333 MS3_09942 0.023 0.13 0.65 0.51 0.79 8.38 7.64 2.095936 59 10 52.21239 41.6666667 MS3_00779 0.024 0.13 0.66 0.54 0.78 8.26 7.82 1.552707 61 6 53.9823 25 MS3_06877 0.024 0.13 0.65 0.53 0.76 8.34 7.72 1.858928 62 8 54.86726 33.3333333 MS3_10459 0.024 0.13 0.62 0.48 0.75 7.91 7.33 1.786039 28 4 24.77876 16.6666667 MS3_11526 0.024 0.13 0.66 0.53 0.78 7.81 7.09 2.054434 46 4 40.70796 16.6666667 MS3_00880 0.025 0.14 0.65 0.53 0.77 7.03 6.48 1.733256 10 1 8.849558 4.16666667 71 MS3_08162 0.025 0.14 0.65 0.53 0.77 7.43 6.79 1.896483 28 2 24.77876 8.33333333 MS3_00844 0.026 0.14 0.71 0.59 0.83 7.24 7.74 0.60653 8 5 7.079646 20.8333333 MS3_03576 0.026 0.14 0.66 0.53 0.78 7.61 8.12 0.600495 22 9 19.46903 37.5 MS3_04025 0.026 0.14 0.65 0.53 0.77 7.7 8.03 0.718924 21 7 18.58407 29.1666667 MS3_06283 0.027 0.14 0.65 0.53 0.77 7.84 8.25 0.66365 30 11 26.54867 45.8333333 MS3_00569 0.028 0.15 0.65 0.53 0.77 7.59 8.09 0.606531 25 10 22.12389 41.6666667 MS3_03818 0.028 0.15 0.66 0.55 0.77 6.28 6.68 0.670319 1 1 0.884956 4.16666667 MS3_04598 0.028 0.15 0.66 0.53 0.8 7.56 8.13 0.565525 20 12 17.69912 50 MS3_09283 0.028 0.15 0.67 0.55 0.79 7.54 8.17 0.532592 15 8 13.27434 33.3333333 MS3_08636 0.029 0.15 0.63 0.51 0.75 7.44 7.06 1.462285 15 0 13.27434 0 MS3_10900 0.029 0.15 0.65 0.52 0.79 6.66 7.05 0.677056 0 1 0 4.16666667 MS3_09276 0.03 0.15 0.64 0.53 0.76 8.11 7.68 1.537258 47 5 41.59292 20.8333333 MS3_00499 0.03 0.16 0.66 0.52 0.8 8.14 7.47 1.954238 49 7 43.36283 29.1666667 MS3_03571 0.03 0.15 0.64 0.51 0.76 6.98 7.39 0.66365 5 2 4.424779 8.33333333 MS3_01705 0.031 0.16 0.66 0.52 0.8 6.11 6.58 0.625 1 1 0.884956 4.16666667 MS3_06223 0.031 0.16 0.65 0.52 0.78 6.36 6.77 0.663649 1 0 0.884956 0 MS3_06276 0.031 0.16 0.66 0.54 0.79 8.51 8.08 1.537258 66 6 58.40708 25 MS3_09903 0.031 0.16 0.65 0.53 0.77 7.43 6.83 1.82212 24 2 21.23894 8.33333333 MS3_02202 0.032 0.16 0.63 0.51 0.76 8.28 7.87 1.506818 51 7 45.13274 29.1666667 MS3_05516 0.032 0.16 0.64 0.52 0.75 7.17 6.54 1.877613 19 2 16.81416 8.33333333 MS3_08024 0.032 0.16 0.64 0.52 0.76 7.33 7.74 0.66365 15 6 13.27434 25 MS3_09626 0.032 0.16 0.64 0.52 0.76 7.81 8.21 0.67032 28 12 24.77876 50 MS3_10956 0.032 0.16 0.65 0.53 0.77 7.96 7.36 1.822119 45 4 39.82301 16.6666667 MS3_06380 0.033 0.16 0.66 0.55 0.77 7.7 8.13 0.650509 23 8 20.35398 33.3333333 MS3_06488 0.033 0.16 0.66 0.52 0.79 8.08 7.45 1.877611 45 5 39.82301 20.8333333 MS3_07337 0.033 0.16 0.64 0.53 0.76 6.51 6.97 0.631283 4 3 3.539823 12.5 MS3_08613 0.033 0.16 0.64 0.51 0.77 8.07 8.53 0.631284 43 14 38.0531 58.3333333 MS3_11103 0.033 0.16 0.66 0.53 0.79 7.49 6.82 1.954239 25 3 22.12389 12.5 MS3_00663 0.034 0.16 0.65 0.52 0.78 7.16 7.56 0.67032 8 2 7.079646 8.33333333 MS3_07994 0.034 0.16 0.64 0.49 0.78 7.95 7.24 2.033992 40 8 35.39823 33.3333333 MS3_08004 0.034 0.16 0.65 0.53 0.77 7.87 7.38 1.632317 39 4 34.51327 16.6666667 MS3_11280 0.034 0.16 0.64 0.52 0.77 7.11 7.45 0.71177 7 2 6.19469 8.33333333 MS3_06914 0.035 0.16 0.65 0.53 0.76 6.46 6.9 0.644035 3 2 2.654867 8.33333333 MS3_07273 0.035 0.16 0.67 0.53 0.81 7.58 8.11 0.588605 18 11 15.9292 45.8333333 MS3_00223 0.037 0.17 0.64 0.51 0.76 7.79 7.3 1.632317 30 5 26.54867 20.8333333 MS3_03863 0.037 0.17 0.66 0.52 0.79 7.19 7.59 0.67032 5 4 4.424779 16.6666667 MS3_09993 0.037 0.17 0.67 0.54 0.79 7.71 8.19 0.618783 24 10 21.23894 41.6666667 72 MS3_05910 0.038 0.17 0.65 0.55 0.76 7.41 7.81 0.67032 18 7 15.9292 29.1666667 MS3_10044 0.038 0.17 0.65 0.54 0.75 6.31 6.61 0.740817 3 0 2.654867 0 MS3_11076 0.038 0.17 0.63 0.51 0.75 8.48 8.02 1.584074 66 9 58.40708 37.5 MS3_10671 0.039 0.18 0.64 0.5 0.77 7.35 6.79 1.750674 23 3 20.35398 12.5 MS3_01761 0.04 0.18 0.63 0.52 0.75 8.01 7.67 1.404948 41 5 36.28319 20.8333333 MS3_05389 0.04 0.18 0.61 0.47 0.76 6.78 7.26 0.618783 4 6 3.539823 25 MS3_07403 0.04 0.18 0.66 0.55 0.77 6.37 6.73 0.697675 3 0 2.654867 0 MS3_05495 0.041 0.18 0.63 0.51 0.75 7.98 8.35 0.690734 32 11 28.31858 45.8333333 MS3_02928 0.042 0.18 0.63 0.51 0.76 8.18 8.51 0.718924 45 14 39.82301 58.3333333 MS3_06211 0.042 0.18 0.65 0.51 0.79 7.52 6.93 1.80399 16 4 14.15929 16.6666667 MS3_06719 0.042 0.18 0.65 0.53 0.78 7.57 8.05 0.618783 23 8 20.35398 33.3333333 MS3_00891 0.043 0.19 0.63 0.52 0.75 6.78 7.14 0.697676 2 2 1.769912 8.33333333 MS3_02356 0.044 0.19 0.61 0.49 0.74 8.37 7.97 1.491825 54 8 47.78761 33.3333333 MS3_05939 0.044 0.19 0.65 0.52 0.78 7.53 7.93 0.67032 13 7 11.50442 29.1666667 MS3_06101 0.044 0.19 0.65 0.51 0.78 7.99 7.58 1.506818 40 5 35.39823 20.8333333 MS3_06500 0.044 0.19 0.64 0.53 0.76 7.39 7.78 0.677057 16 5 14.15929 20.8333333 MS3_09333 0.044 0.19 0.63 0.52 0.75 7.77 7.42 1.419068 24 1 21.23894 4.16666667 MS3_00787 0.045 0.19 0.62 0.5 0.74 9.61 9.92 0.733447 105 24 92.92035 100 MS3_03269 0.046 0.19 0.63 0.52 0.74 7.72 7.23 1.632317 42 2 37.16814 8.33333333 MS3_06431 0.046 0.19 0.63 0.5 0.75 7.58 7.92 0.71177 12 5 10.61947 20.8333333 MS3_07411 0.046 0.19 0.64 0.51 0.77 6.66 7.12 0.631283 3 3 2.654867 12.5 MS3_08907 0.046 0.19 0.62 0.5 0.75 7.23 6.79 1.552708 15 1 13.27434 4.16666667 MS3_02637 0.047 0.2 0.65 0.51 0.78 7.61 7.03 1.786039 27 5 23.89381 20.8333333 MS3_05047 0.048 0.2 0.63 0.51 0.75 7.18 6.67 1.665293 21 1 18.58407 4.16666667 MS3_00702 0.049 0.2 0.64 0.5 0.77 7.76 7.33 1.537258 27 3 23.89381 12.5 MS3_06680 0.049 0.2 0.65 0.53 0.77 6.07 6.57 0.606529 2 1 1.769912 4.16666667 MS3_06707 0.049 0.2 0.62 0.49 0.75 7.56 7.98 0.657047 23 8 20.35398 33.3333333 MS3_07885 0.049 0.2 0.63 0.51 0.75 7.52 7.82 0.740818 14 5 12.38938 20.8333333 MS3_11411 0.05 0.2 0.66 0.53 0.78 8.33 7.49 2.316368 51 7 45.13274 29.1666667 MS3_03963 0.051 0.2 0.65 0.52 0.78 6.67 7.08 0.66365 2 3 1.769912 12.5 MS3_04493 0.051 0.2 0.63 0.49 0.76 7.31 7.69 0.683861 10 7 8.849558 29.1666667 MS3_08533 0.051 0.2 0.64 0.52 0.76 7.4 7.72 0.726149 12 7 10.61947 29.1666667 MS3_04896 0.053 0.21 0.64 0.51 0.77 8.17 7.78 1.476981 47 6 41.59292 25 MS3_10305 0.053 0.21 0.62 0.51 0.74 8.1 7.78 1.377128 46 6 40.70796 25 MS3_05125 0.054 0.21 0.45 0.32 0.57 7.18 6.72 1.584075 18 0 15.9292 0 MS3_09443 0.054 0.21 0.64 0.52 0.76 7.48 7.81 0.718924 16 4 14.15929 16.6666667 MS3_04221 0.055 0.21 0.61 0.48 0.74 7.7 8.07 0.690734 26 8 23.00885 33.3333333 73 MS3_05484 0.055 0.21 0.65 0.52 0.78 6.88 7.26 0.683861 2 3 1.769912 12.5 MS3_10292 0.055 0.21 0.61 0.49 0.73 7.75 8.06 0.733447 27 7 23.89381 29.1666667 MS3_02176 0.056 0.21 0.63 0.51 0.75 8.31 7.99 1.377128 57 7 50.44248 29.1666667 MS3_06690 0.056 0.21 0.61 0.48 0.75 9.42 8.87 1.733253 98 15 86.72566 62.5 MS3_09952 0.056 0.21 0.63 0.52 0.75 7.48 7.85 0.690734 15 5 13.27434 20.8333333 MS3_05602 0.057 0.22 0.6 0.49 0.72 7.54 7.21 1.390968 19 2 16.81416 8.33333333 MS3_08903 0.057 0.22 0.64 0.52 0.76 6.6 7.02 0.657046 6 1 5.309735 4.16666667 MS3_03091 0.06 0.23 0.64 0.52 0.77 7.47 7.86 0.677057 17 7 15.04425 29.1666667 MS3_02157 0.061 0.23 0.58 0.47 0.69 7.87 8.17 0.740818 35 6 30.97345 25 MS3_02807 0.061 0.23 0.62 0.51 0.74 7.58 7.05 1.698933 36 4 31.85841 16.6666667 MS3_06748 0.061 0.23 0.63 0.51 0.75 7.48 6.98 1.648722 32 2 28.31858 8.33333333 MS3_08216 0.061 0.23 0.62 0.5 0.74 6.86 7.22 0.697676 3 5 2.654867 20.8333333 MS3_10931 0.061 0.23 0.65 0.5 0.79 7.25 7.66 0.66365 5 6 4.424779 25 MS3_05908 0.062 0.23 0.63 0.5 0.76 7.86 7.47 1.476981 29 4 25.66372 16.6666667 MS3_09961 0.062 0.23 0.62 0.49 0.74 8.43 7.9 1.698932 68 9 60.17699 37.5 MS3_05600 0.063 0.23 0.63 0.5 0.76 6.41 6.88 0.625001 3 1 2.654867 4.16666667 MS3_08169 0.063 0.23 0.61 0.49 0.73 7.11 6.65 1.584076 16 1 14.15929 4.16666667 MS3_07737 0.065 0.24 0.64 0.52 0.76 9 8.6 1.491825 86 13 76.10619 54.1666667 MS3_01777 0.065 0.24 0.63 0.52 0.74 7.93 7.61 1.377128 41 4 36.28319 16.6666667 MS3_07854 0.065 0.24 0.62 0.49 0.75 7.17 7.54 0.690734 9 4 7.964602 16.6666667 MS3_10486 0.065 0.24 0.63 0.5 0.76 8.55 8.04 1.665291 74 8 65.48673 33.3333333 MS3_01348 0.066 0.24 0.6 0.48 0.71 7.42 7.67 0.778801 7 3 6.19469 12.5 MS3_00383 0.067 0.24 0.62 0.5 0.74 7.85 7.37 1.616075 37 5 32.74336 20.8333333 MS3_05631 0.067 0.24 0.62 0.5 0.73 8.15 7.55 1.822119 54 6 47.78761 25 MS3_06462 0.067 0.24 0.62 0.49 0.75 8.79 8.18 1.840432 76 12 67.25664 50 MS3_02172 0.068 0.24 0.6 0.48 0.73 9.23 8.72 1.665291 93 14 82.30088 58.3333333 MS3_02375 0.068 0.24 0.61 0.49 0.73 8.36 7.99 1.447735 59 12 52.21239 50 MS3_02393 0.068 0.24 0.64 0.51 0.77 7.19 7.57 0.683861 9 4 7.964602 16.6666667 MS3_11139 0.069 0.24 0.65 0.53 0.77 8.02 7.54 1.616075 53 4 46.90265 16.6666667 MS3_00800 0.071 0.25 0.62 0.49 0.75 7.1 7.58 0.618783 14 8 12.38938 33.3333333 MS3_03726 0.071 0.25 0.63 0.49 0.76 7.76 8.12 0.697676 25 9 22.12389 37.5 MS3_08042 0.072 0.25 0.6 0.48 0.73 7.83 8.17 0.71177 33 10 29.20354 41.6666667 MS3_03304 0.074 0.25 0.61 0.49 0.72 8.06 7.75 1.363425 41 7 36.28319 29.1666667 MS3_02991 0.075 0.26 0.63 0.51 0.75 8.3 7.88 1.521962 60 8 53.09735 33.3333333 MS3_07125 0.075 0.26 0.61 0.48 0.73 7.52 7.89 0.690734 22 7 19.46903 29.1666667 MS3_10194 0.075 0.26 0.56 0.45 0.67 7.82 7.41 1.506818 34 5 30.0885 20.8333333 MS3_05960 0.076 0.26 0.63 0.51 0.75 8.01 7.41 1.822119 39 4 34.51327 16.6666667 74 MS3_09161 0.076 0.26 0.58 0.47 0.7 8.42 8.14 1.32313 52 9 46.0177 37.5 MS3_00939 0.077 0.26 0.62 0.5 0.74 6.78 7.08 0.740818 3 1 2.654867 4.16666667 MS3_02499 0.077 0.26 0.62 0.48 0.76 7.57 7.19 1.462285 15 1 13.27434 4.16666667 MS3_07824 0.078 0.26 0.6 0.47 0.72 8.65 8.33 1.377128 71 13 62.83186 54.1666667 MS3_09190 0.078 0.26 0.61 0.49 0.74 7.64 7.3 1.404948 23 2 20.35398 8.33333333 MS3_06918 0.079 0.26 0.62 0.5 0.75 7.47 7 1.599995 27 3 23.89381 12.5 MS3_06928 0.08 0.26 0.62 0.49 0.74 8.16 7.75 1.506818 46 6 40.70796 25 MS3_07874 0.08 0.26 0.61 0.48 0.74 8.08 7.57 1.665291 49 7 43.36283 29.1666667 MS3_08037 0.08 0.26 0.61 0.49 0.73 8 7.68 1.377128 32 3 28.31858 12.5 MS3_08725 0.08 0.26 0.62 0.5 0.74 7.58 7.13 1.568313 27 5 23.89381 20.8333333 MS3_10713 0.08 0.26 0.62 0.49 0.75 7.68 7.1 1.786039 36 4 31.85841 16.6666667 MS3_02041 0.081 0.26 0.61 0.49 0.72 7.4 7.08 1.377128 16 1 14.15929 4.16666667 MS3_02346 0.081 0.26 0.64 0.53 0.75 6.73 7.04 0.733446 3 0 2.654867 0 MS3_03096 0.083 0.27 0.61 0.48 0.73 7.55 8.04 0.612626 35 11 30.97345 45.8333333 MS3_04261 0.083 0.27 0.6 0.49 0.72 7.43 7.05 1.462285 25 2 22.12389 8.33333333 MS3_04158 0.084 0.27 0.64 0.51 0.77 7.83 8.22 0.677057 33 14 29.20354 58.3333333 MS3_09644 0.084 0.27 0.62 0.5 0.74 7.18 7.52 0.71177 15 3 13.27434 12.5 MS3_06257 0.085 0.27 0.64 0.5 0.79 7.26 6.76 1.648723 15 4 13.27434 16.6666667 MS3_01302 0.086 0.27 0.63 0.51 0.75 6.73 7.08 0.704688 8 2 7.079646 8.33333333 MS3_03206 0.086 0.27 0.64 0.5 0.77 7.04 6.54 1.648723 12 2 10.61947 8.33333333 MS3_05150 0.086 0.27 0.62 0.5 0.74 6.89 7.21 0.726149 3 1 2.654867 4.16666667 MS3_08398 0.086 0.27 0.61 0.48 0.73 8.35 8.03 1.377128 56 8 49.55752 33.3333333 MS3_08996 0.086 0.27 0.63 0.5 0.77 7.22 7.84 0.537944 28 12 24.77876 50 MS3_10499 0.086 0.27 0.61 0.48 0.73 8.08 7.76 1.377128 42 5 37.16814 20.8333333 MS3_05686 0.087 0.27 0.59 0.46 0.71 8.19 7.84 1.419068 39 5 34.51327 20.8333333 MS3_09253 0.087 0.27 0.54 0.43 0.65 6.68 6.35 1.39097 13 0 11.50442 0 MS3_09229 0.088 0.27 0.6 0.48 0.72 8.62 8.31 1.363425 74 14 65.48673 58.3333333 MS3_07395 0.089 0.27 0.61 0.48 0.74 7.75 8.12 0.690734 33 10 29.20354 41.6666667 MS3_08689 0.089 0.27 0.62 0.5 0.74 8.36 8.61 0.778801 54 15 47.78761 62.5 MS3_08391 0.09 0.28 0.58 0.47 0.7 7.8 8.11 0.733447 35 8 30.97345 33.3333333 MS3_11059 0.091 0.28 0.62 0.5 0.74 7.95 7.42 1.698933 51 6 45.13274 25 MS3_04157 0.092 0.28 0.62 0.49 0.75 7.83 7.43 1.491825 37 5 32.74336 20.8333333 MS3_10591 0.094 0.29 0.61 0.47 0.74 6.14 6.42 0.755782 0 0 0 0 No hits 0.095 0.29 0.61 0.49 0.74 6.62 6.19 1.537261 4 1 3.539823 4.16666667 MS3_00178 0.095 0.29 0.6 0.48 0.72 7.5 7.18 1.377128 15 2 13.27434 8.33333333 MS3_07757 0.095 0.29 0.62 0.5 0.75 7.16 7.48 0.726149 9 2 7.964602 8.33333333 MS3_01771 0.096 0.29 0.63 0.51 0.75 8.4 8.09 1.363425 61 11 53.9823 45.8333333 75 MS3_10811 0.096 0.29 0.63 0.5 0.76 7.4 7.75 0.704688 12 7 10.61947 29.1666667 MS3_08663 0.097 0.29 0.59 0.47 0.71 7.83 7.55 1.32313 22 3 19.46903 12.5 MS3_02538 0.098 0.29 0.63 0.5 0.75 7.66 8.09 0.650509 28 9 24.77876 37.5 MS3_04564 0.099 0.29 0.61 0.48 0.73 6.46 6.91 0.637627 3 2 2.654867 8.33333333 No hits 0.1 0.3 0.6 0.48 0.71 6.96 6.53 1.537259 15 2 13.27434 8.33333333 MS3_00508 0.1 0.3 0.6 0.47 0.72 7.9 7.4 1.648722 39 6 34.51327 25 MS3_06126 0.1 0.3 0.61 0.48 0.74 8 8.3 0.740818 37 10 32.74336 41.6666667 MS3_07096 0.1 0.3 0.6 0.49 0.71 7.11 6.73 1.462286 15 1 13.27434 4.16666667 MS3_08625 0.1 0.3 0.61 0.49 0.72 7.02 6.71 1.363426 6 0 5.309735 0 MS3_10036 0.1 0.3 0.62 0.5 0.75 7.23 7.61 0.683861 18 6 15.9292 25 MS3_02486 0.11 0.32 0.61 0.48 0.74 7.03 7.3 0.763379 4 2 3.539823 8.33333333 MS3_02641 0.11 0.31 0.59 0.48 0.71 7.71 7.49 1.246077 20 0 17.69912 0 MS3_03461 0.11 0.32 0.6 0.47 0.73 7.41 7.01 1.491825 21 3 18.58407 12.5 MS3_03534 0.11 0.31 0.6 0.47 0.74 8.37 8.67 0.740818 53 14 46.90265 58.3333333 MS3_03768 0.11 0.31 0.5 0.35 0.64 6.92 8.15 0.292292 8 6 7.079646 25 MS3_04540 0.11 0.32 0.63 0.51 0.75 6.41 6.7 0.748263 2 2 1.769912 8.33333333 MS3_05520 0.11 0.32 0.63 0.49 0.77 7.5 7.81 0.733447 13 6 11.50442 25 MS3_06112 0.11 0.32 0.63 0.48 0.77 7.6 7.08 1.682028 26 4 23.00885 16.6666667 MS3_06559 0.11 0.31 0.6 0.48 0.73 7.25 7.56 0.733447 10 5 8.849558 20.8333333 MS3_06994 0.11 0.31 0.62 0.48 0.76 8.31 7.84 1.599994 59 7 52.21239 29.1666667 MS3_08479 0.11 0.31 0.58 0.47 0.7 7.78 7.27 1.665292 38 3 33.62832 12.5 MS3_02899 0.12 0.33 0.59 0.45 0.72 7.79 8.06 0.763379 19 8 16.81416 33.3333333 MS3_00447 0.12 0.33 0.61 0.48 0.75 8.17 7.91 1.29693 45 6 39.82301 25 MS3_02085 0.12 0.33 0.6 0.47 0.73 9.22 8.84 1.462285 95 16 84.0708 66.6666667 MS3_05219 0.12 0.33 0.62 0.49 0.75 7.92 7.63 1.336428 29 4 25.66372 16.6666667 MS3_05761 0.12 0.33 0.61 0.48 0.73 6.22 6.52 0.740817 1 1 0.884956 4.16666667 MS3_09086 0.12 0.34 0.61 0.48 0.74 6.88 7.17 0.748263 3 2 2.654867 8.33333333 MS3_10161 0.12 0.34 0.59 0.46 0.73 7.78 7.4 1.462285 29 4 25.66372 16.6666667 MS3_10820 0.12 0.34 0.62 0.5 0.74 7.07 7.36 0.748263 10 2 8.849558 8.33333333 MS3_00242 0.13 0.35 0.62 0.49 0.75 7.97 7.49 1.616075 48 7 42.47788 29.1666667 MS3_00412 0.13 0.35 0.61 0.48 0.73 8.12 7.86 1.29693 43 6 38.0531 25 MS3_01964 0.13 0.36 0.6 0.48 0.71 7.2 7.48 0.755784 11 3 9.734513 12.5 MS3_02289 0.13 0.35 0.61 0.48 0.75 7.87 8.13 0.771052 24 11 21.23894 45.8333333 MS3_03400 0.13 0.36 0.6 0.48 0.73 8.14 7.91 1.2586 38 5 33.62832 20.8333333 MS3_03992 0.13 0.36 0.62 0.49 0.76 7.62 7.97 0.704688 20 11 17.69912 45.8333333 MS3_05351 0.13 0.35 0.6 0.49 0.71 6.52 6.8 0.755783 3 1 2.654867 4.16666667 MS3_06167 0.13 0.36 0.42 0.3 0.55 6.88 6.49 1.476983 14 1 12.38938 4.16666667 76 MS3_06740 0.13 0.35 0.59 0.46 0.72 7.92 7.65 1.309965 34 6 30.0885 25 MS3_07419 0.13 0.36 0.6 0.49 0.72 7.69 8.04 0.704688 25 8 22.12389 33.3333333 MS3_08399 0.13 0.36 0.6 0.47 0.72 7.44 6.97 1.599995 38 4 33.62832 16.6666667 MS3_08891 0.13 0.36 0.61 0.49 0.74 7.03 7.34 0.733447 8 4 7.079646 16.6666667 MS3_09175 0.13 0.36 0.61 0.48 0.74 6.71 7.05 0.71177 5 4 4.424779 16.6666667 MS3_09426 0.13 0.36 0.6 0.48 0.71 6.77 7.07 0.740818 5 3 4.424779 12.5 MS3_02838 0.14 0.37 0.6 0.48 0.72 8.02 7.8 1.246077 36 5 31.85841 20.8333333 MS3_03119 0.14 0.37 0.59 0.47 0.72 7.53 7.23 1.349859 15 2 13.27434 8.33333333 MS3_03625 0.14 0.37 0.59 0.47 0.71 7.73 7.48 1.284026 23 2 20.35398 8.33333333 MS3_04268 0.14 0.37 0.61 0.48 0.73 6.99 7.27 0.755783 7 1 6.19469 4.16666667 MS3_04799 0.14 0.37 0.63 0.51 0.76 6.78 7.1 0.726149 9 1 7.964602 4.16666667 MS3_05142 0.14 0.36 0.62 0.48 0.76 7.89 8.19 0.740818 31 10 27.43363 41.6666667 MS3_06080 0.14 0.38 0.6 0.47 0.73 7.59 7.9 0.733447 21 7 18.58407 29.1666667 MS3_06649 0.14 0.38 0.64 0.51 0.78 8.38 7.87 1.665291 57 7 50.44248 29.1666667 MS3_06745 0.14 0.37 0.56 0.43 0.69 7.96 7.73 1.2586 28 4 24.77876 16.6666667 No hits 0.15 0.39 0.59 0.45 0.73 7.8 7.35 1.568313 33 6 29.20354 25 MS3_01218 0.15 0.38 0.61 0.49 0.74 7.99 8.23 0.786628 34 10 30.0885 41.6666667 MS3_01318 0.15 0.39 0.59 0.46 0.73 8.35 7.91 1.552707 58 11 51.32743 45.8333333 MS3_01504 0.15 0.39 0.6 0.48 0.72 7.56 7.81 0.778801 22 5 19.46903 20.8333333 MS3_01600 0.15 0.39 0.59 0.46 0.71 8.29 7.92 1.447735 57 9 50.44248 37.5 MS3_01972 0.15 0.39 0.6 0.49 0.71 7.88 7.59 1.336428 40 3 35.39823 12.5 MS3_02681 0.15 0.38 0.58 0.45 0.71 7.87 7.57 1.349859 31 6 27.43363 25 MS3_03054 0.15 0.39 0.6 0.46 0.75 8.36 8.68 0.726149 62 14 54.86726 58.3333333 MS3_04227 0.15 0.38 0.59 0.47 0.71 8.06 7.82 1.271249 43 5 38.0531 20.8333333 MS3_06161 0.15 0.38 0.58 0.46 0.71 8.1 7.8 1.349859 49 6 43.36283 25 MS3_08440 0.15 0.38 0.6 0.47 0.73 7.76 8.08 0.726149 24 10 21.23894 41.6666667 MS3_09415 0.15 0.38 0.62 0.49 0.74 7.54 7.82 0.755784 18 6 15.9292 25 MS3_00785 0.16 0.39 0.6 0.47 0.73 7.22 6.79 1.537259 22 3 19.46903 12.5 MS3_02460 0.16 0.4 0.59 0.46 0.72 8 7.73 1.309965 31 4 27.43363 16.6666667 MS3_03127 0.16 0.39 0.61 0.49 0.73 6.93 7.2 0.763379 7 0 6.19469 0 MS3_03270 0.16 0.39 0.61 0.48 0.73 7.79 8.03 0.786628 24 8 21.23894 33.3333333 MS3_05370 0.16 0.4 0.61 0.49 0.74 7.04 7.29 0.778801 7 1 6.19469 4.16666667 MS3_05391 0.16 0.4 0.6 0.46 0.74 7.32 7.64 0.726149 12 8 10.61947 33.3333333 MS3_06769 0.16 0.4 0.59 0.47 0.7 7.39 7.15 1.271249 14 2 12.38938 8.33333333 MS3_08655 0.16 0.4 0.59 0.46 0.72 7.05 7.37 0.726149 9 5 7.964602 20.8333333 MS3_09569 0.16 0.4 0.58 0.47 0.69 7.84 8.05 0.810584 30 7 26.54867 29.1666667 MS3_09620 0.16 0.4 0.59 0.48 0.7 7.93 7.71 1.246077 39 4 34.51327 16.6666667 77 MS3_09739 0.16 0.39 0.62 0.48 0.75 7.42 7.67 0.778801 9 5 7.964602 20.8333333 MS3_10116 0.16 0.39 0.6 0.48 0.71 8.42 8.15 1.309964 64 9 56.63717 37.5 MS3_10513 0.16 0.4 0.59 0.45 0.73 7.53 7.28 1.284026 14 3 12.38938 12.5 MS3_10588 0.16 0.4 0.61 0.49 0.73 6.71 6.18 1.698937 26 3 23.00885 12.5 MS3_10590 0.16 0.4 0.6 0.46 0.73 7.22 6.86 1.43333 13 3 11.50442 12.5 MS3_11376 0.16 0.39 0.6 0.46 0.73 7.82 8.07 0.778801 24 9 21.23894 37.5 MS3_00316 0.17 0.4 0.59 0.44 0.73 6.79 7.1 0.733447 3 2 2.654867 8.33333333 MS3_02999 0.17 0.4 0.61 0.48 0.73 7.08 6.71 1.447736 18 3 15.9292 12.5 MS3_03641 0.17 0.41 0.55 0.43 0.67 8.82 9.1 0.755784 77 17 68.14159 70.8333333 MS3_03695 0.17 0.4 0.6 0.47 0.72 6.26 5.93 1.390973 9 0 7.964602 0 MS3_04279 0.17 0.4 0.56 0.45 0.68 7.52 7.21 1.363425 27 3 23.89381 12.5 MS3_04347 0.17 0.4 0.6 0.48 0.72 8.38 8.61 0.794534 58 17 51.32743 70.8333333 MS3_09231 0.17 0.4 0.59 0.44 0.74 7.6 7.9 0.740818 20 10 17.69912 41.6666667 MS3_10803 0.17 0.4 0.61 0.47 0.76 8.55 8.92 0.690734 76 16 67.25664 66.6666667 MS3_11544 0.17 0.4 0.59 0.47 0.71 7.95 7.62 1.390968 42 6 37.16814 25 MS3_10847 0.18 0.42 0.58 0.44 0.72 8.51 8.11 1.491825 70 11 61.9469 45.8333333 MS3_01328 0.18 0.42 0.58 0.44 0.72 8.4 8.02 1.462285 67 12 59.29204 50 MS3_01516 0.18 0.42 0.6 0.47 0.72 7.49 7.79 0.740818 25 7 22.12389 29.1666667 MS3_01527 0.18 0.41 0.6 0.47 0.74 7.24 7.64 0.67032 18 8 15.9292 33.3333333 MS3_01833 0.18 0.42 0.57 0.45 0.69 7.23 7.59 0.697676 26 8 23.00885 33.3333333 MS3_01952 0.18 0.42 0.56 0.43 0.68 7.65 7.86 0.810584 12 6 10.61947 25 MS3_02136 0.18 0.42 0.59 0.46 0.72 7.69 7.26 1.537258 38 7 33.62832 29.1666667 MS3_02489 0.18 0.42 0.59 0.47 0.72 7.36 7.63 0.763379 10 3 8.849558 12.5 MS3_03789 0.18 0.42 0.54 0.43 0.64 7.42 7.1 1.377128 24 1 21.23894 4.16666667 MS3_05038 0.18 0.42 0.6 0.47 0.73 7.4 7.04 1.43333 27 3 23.89381 12.5 MS3_05203 0.18 0.42 0.6 0.48 0.72 7.58 7.32 1.29693 25 4 22.12389 16.6666667 MS3_05216 0.18 0.42 0.61 0.47 0.75 7.77 7.36 1.506818 40 6 35.39823 25 MS3_07487 0.18 0.42 0.61 0.48 0.74 7.82 7.55 1.309965 27 4 23.89381 16.6666667 MS3_07905 0.18 0.42 0.43 0.31 0.56 6.73 7.06 0.718923 10 2 8.849558 8.33333333 MS3_09640 0.18 0.42 0.57 0.44 0.71 7.69 7.29 1.491825 26 6 23.00885 25 MS3_00196 0.19 0.43 0.59 0.46 0.72 7.73 8.23 0.606531 28 10 24.77876 41.6666667 MS3_01004 0.19 0.43 0.59 0.45 0.72 8.82 9.12 0.740818 79 19 69.9115 79.1666667 MS3_01686 0.19 0.43 0.58 0.45 0.7 7.46 7.24 1.246077 7 2 6.19469 8.33333333 MS3_01898 0.19 0.43 0.58 0.46 0.71 8.33 8.58 0.778801 58 18 51.32743 75 MS3_04550 0.19 0.43 0.58 0.45 0.7 7.33 7.58 0.778801 11 5 9.734513 20.8333333 MS3_05040 0.19 0.43 0.59 0.45 0.73 7.59 7.89 0.740818 22 8 19.46903 33.3333333 MS3_05465 0.19 0.43 0.57 0.42 0.72 8.09 7.8 1.336428 39 9 34.51327 37.5 78 MS3_08059 0.19 0.43 0.58 0.45 0.71 6.67 6.94 0.763379 4 2 3.539823 8.33333333 MS3_08361 0.19 0.43 0.6 0.47 0.73 6.97 6.62 1.419069 14 2 12.38938 8.33333333 MS3_08480 0.19 0.43 0.58 0.45 0.72 9.6 9.23 1.447735 104 18 92.0354 75 MS3_09290 0.19 0.43 0.59 0.45 0.73 6.74 7.1 0.697676 8 4 7.079646 16.6666667 MS3_09662 0.19 0.43 0.6 0.47 0.73 6.61 6.88 0.763379 7 2 6.19469 8.33333333 MS3_09810 0.19 0.43 0.6 0.48 0.72 8.83 8.48 1.419068 80 12 70.79646 50 MS3_10600 0.19 0.43 0.58 0.47 0.7 6.96 6.66 1.34986 15 2 13.27434 8.33333333 MS3_11509 0.19 0.43 0.59 0.46 0.72 7.89 7.64 1.284026 34 6 30.0885 25 MS3_00668 0.2 0.43 0.58 0.46 0.7 8.31 7.97 1.404948 57 10 50.44248 41.6666667 MS3_01014 0.2 0.44 0.59 0.46 0.71 6.85 6.56 1.336429 10 1 8.849558 4.16666667 MS3_02155 0.2 0.44 0.57 0.43 0.7 7.57 7.77 0.818731 13 6 11.50442 25 MS3_05387 0.2 0.44 0.58 0.45 0.71 6.89 7.17 0.755783 6 3 5.309735 12.5 MS3_06327 0.2 0.44 0.59 0.47 0.71 6.6 6.87 0.763379 4 2 3.539823 8.33333333 MS3_06583 0.2 0.44 0.57 0.45 0.7 7.27 6.92 1.419068 21 3 18.58407 12.5 MS3_08504 0.2 0.44 0.57 0.45 0.68 7.47 7.7 0.794534 23 4 20.35398 16.6666667 MS3_09119 0.2 0.44 0.63 0.52 0.74 7.74 8.02 0.755784 24 8 21.23894 33.3333333 MS3_01051 0.21 0.45 0.6 0.47 0.74 7.88 8.1 0.802519 26 12 23.00885 50 MS3_01153 0.21 0.45 0.6 0.47 0.73 7.21 7.5 0.748263 11 4 9.734513 16.6666667 MS3_01333 0.21 0.46 0.57 0.43 0.71 6.05 6.35 0.740816 0 1 0 4.16666667 MS3_01710 0.21 0.45 0.6 0.47 0.73 7.69 7.92 0.794534 18 6 15.9292 25 MS3_04011 0.21 0.45 0.58 0.45 0.71 6.68 6.34 1.40495 4 2 3.539823 8.33333333 MS3_04375 0.21 0.46 0.58 0.46 0.71 7.17 7.46 0.748263 13 4 11.50442 16.6666667 MS3_07105 0.21 0.45 0.6 0.46 0.73 7.2 7.5 0.740818 14 5 12.38938 20.8333333 MS3_09510 0.21 0.45 0.6 0.48 0.71 7.36 7.01 1.419068 33 3 29.20354 12.5 MS3_10148 0.22 0.46 0.59 0.47 0.71 8.3 8.02 1.32313 61 12 53.9823 50 MS3_01611 0.22 0.46 0.58 0.46 0.7 7.83 8.04 0.810584 32 9 28.31858 37.5 MS3_04526 0.22 0.47 0.56 0.42 0.7 7.08 7.47 0.677057 16 6 14.15929 25 MS3_04595 0.22 0.46 0.59 0.47 0.71 7.55 7.24 1.363425 26 3 23.00885 12.5 MS3_04932 0.22 0.47 0.56 0.44 0.69 7.12 7.44 0.726149 20 5 17.69912 20.8333333 MS3_05289 0.22 0.47 0.58 0.45 0.72 7.75 7.96 0.810584 20 8 17.69912 33.3333333 MS3_08539 0.22 0.46 0.56 0.43 0.68 7.53 7.77 0.786628 15 6 13.27434 25 MS3_03817 0.23 0.47 0.59 0.46 0.72 8.09 7.73 1.43333 51 7 45.13274 29.1666667 MS3_04355 0.23 0.48 0.58 0.44 0.73 7.67 7.44 1.2586 17 3 15.04425 12.5 MS3_04873 0.23 0.47 0.57 0.44 0.71 8.19 7.92 1.309965 50 9 44.24779 37.5 MS3_05337 0.23 0.47 0.59 0.47 0.71 7.54 7.75 0.810584 19 5 16.81416 20.8333333 MS3_06248 0.23 0.47 0.59 0.47 0.72 8.22 7.92 1.349859 57 8 50.44248 33.3333333 MS3_09160 0.23 0.49 0.58 0.44 0.73 7.03 7.25 0.802519 6 1 5.309735 4.16666667 79 MS3_09828 0.23 0.48 0.61 0.51 0.72 7.42 7.61 0.826959 17 3 15.04425 12.5 MS3_11484 0.24 0.49 0.59 0.46 0.71 7.18 6.85 1.390969 23 3 20.35398 12.5 MS3_00452 0.24 0.49 0.58 0.45 0.71 7.82 8.01 0.826959 24 6 21.23894 25 MS3_01016 0.24 0.49 0.6 0.48 0.72 7.69 7.37 1.377128 37 3 32.74336 12.5 MS3_01114 0.24 0.49 0.59 0.46 0.72 7.12 7.36 0.786628 6 3 5.309735 12.5 MS3_01245 0.24 0.49 0.57 0.45 0.69 7.55 7.74 0.826959 15 4 13.27434 16.6666667 MS3_03933 0.24 0.49 0.57 0.42 0.73 7.67 7.94 0.763379 19 10 16.81416 41.6666667 MS3_04063 0.24 0.49 0.6 0.46 0.74 7.18 7.46 0.755784 8 3 7.079646 12.5 MS3_06108 0.24 0.49 0.57 0.44 0.7 7.59 7.23 1.43333 33 5 29.20354 20.8333333 MS3_06449 0.24 0.49 0.58 0.45 0.7 7.91 7.69 1.246077 32 5 28.31858 20.8333333 MS3_06828 0.24 0.49 0.6 0.47 0.72 6.9 7.21 0.733447 13 3 11.50442 12.5 MS3_06832 0.24 0.49 0.58 0.45 0.7 7.07 7.29 0.802519 8 3 7.079646 12.5 MS3_09473 0.24 0.49 0.58 0.45 0.71 7.06 6.73 1.390969 17 2 15.04425 8.33333333 No hits 0.25 0.49 0.58 0.45 0.71 7.75 7.42 1.390968 40 6 35.39823 25 MS3_01105 0.25 0.49 0.58 0.46 0.7 6.94 6.68 1.296931 14 1 12.38938 4.16666667 MS3_01286 0.25 0.49 0.6 0.49 0.71 6.48 6.68 0.81873 5 0 4.424779 0 MS3_02234 0.25 0.5 0.58 0.46 0.71 7.3 7.56 0.771051 18 6 15.9292 25 MS3_03381 0.25 0.49 0.59 0.46 0.72 7.45 7.68 0.794534 12 6 10.61947 25 MS3_04285 0.25 0.49 0.58 0.45 0.7 7.6 7.19 1.506818 31 5 27.43363 20.8333333 MS3_04767 0.25 0.5 0.59 0.45 0.73 7.96 7.75 1.233678 31 5 27.43363 20.8333333 MS3_05000 0.25 0.49 0.44 0.3 0.59 6.89 7.14 0.7788 5 5 4.424779 20.8333333 MS3_05230 0.25 0.5 0.6 0.44 0.75 7.79 8.03 0.786628 15 9 13.27434 37.5 MS3_08509 0.25 0.5 0.62 0.49 0.74 6.24 5.95 1.336431 4 1 3.539823 4.16666667 MS3_00900 0.26 0.51 0.58 0.45 0.72 7.29 6.93 1.43333 24 4 21.23894 16.6666667 MS3_03824 0.26 0.51 0.56 0.45 0.68 7.17 6.98 1.20925 12 1 10.61947 4.16666667 MS3_04147 0.26 0.52 0.58 0.46 0.7 6.8 7.01 0.810584 6 0 5.309735 0 MS3_07213 0.26 0.51 0.6 0.48 0.71 6.98 7.29 0.733447 15 2 13.27434 8.33333333 MS3_07729 0.26 0.51 0.58 0.47 0.7 7.58 7.79 0.810584 24 7 21.23894 29.1666667 MS3_08000 0.26 0.5 0.58 0.46 0.7 7.21 7.43 0.802519 6 1 5.309735 4.16666667 MS3_09958 0.26 0.5 0.58 0.46 0.69 7.2 6.89 1.363426 24 2 21.23894 8.33333333 MS3_08446 0.27 0.52 0.58 0.46 0.7 7.58 7.38 1.221403 18 3 15.9292 12.5 MS3_00312 0.27 0.53 0.45 0.31 0.59 8.87 8.56 1.363425 86 15 76.10619 62.5 MS3_03577 0.27 0.53 0.57 0.44 0.69 7.79 7.55 1.271249 35 4 30.97345 16.6666667 MS3_03599 0.27 0.52 0.58 0.46 0.71 8.38 8.61 0.794534 59 17 52.21239 70.8333333 MS3_04774 0.27 0.52 0.58 0.44 0.72 6.72 6.49 1.258601 6 1 5.309735 4.16666667 MS3_11226 0.27 0.52 0.56 0.42 0.71 7.23 7.46 0.794533 9 4 7.964602 16.6666667 MS3_00054 0.28 0.53 0.56 0.43 0.69 7.38 7.57 0.826959 7 4 6.19469 16.6666667 80 MS3_02087 0.28 0.53 0.53 0.41 0.66 8.03 7.81 1.246077 34 4 30.0885 16.6666667 MS3_02160 0.28 0.53 0.55 0.41 0.68 7.06 7.27 0.810584 7 3 6.19469 12.5 MS3_03775 0.28 0.53 0.58 0.44 0.71 7.81 7.51 1.349859 43 7 38.0531 29.1666667 MS3_05735 0.28 0.53 0.56 0.45 0.67 7.98 7.77 1.233678 47 5 41.59292 20.8333333 MS3_06592 0.28 0.53 0.57 0.44 0.71 6.63 6.84 0.810584 5 0 4.424779 0 MS3_09073 0.28 0.53 0.57 0.44 0.71 6.72 6.92 0.81873 5 0 4.424779 0 MS3_09427 0.28 0.53 0.58 0.44 0.71 7.19 7.38 0.826959 5 2 4.424779 8.33333333 MS3_09638 0.28 0.53 0.57 0.44 0.7 6.75 7.01 0.771051 5 3 4.424779 12.5 MS3_10489 0.28 0.53 0.57 0.43 0.71 7.25 7.45 0.818731 9 2 7.964602 8.33333333 MS3_11074 0.28 0.53 0.58 0.43 0.73 7.39 7.61 0.802519 10 6 8.849558 25 MS3_00294 0.29 0.55 0.56 0.42 0.7 7.85 7.64 1.233678 28 6 24.77876 25 MS3_01934 0.29 0.54 0.57 0.44 0.7 6.51 6.71 0.81873 5 1 4.424779 4.16666667 MS3_02494 0.29 0.54 0.57 0.44 0.71 7.23 7.4 0.843665 6 2 5.309735 8.33333333 MS3_05586 0.29 0.55 0.55 0.44 0.66 7.64 7.84 0.818731 29 7 25.66372 29.1666667 MS3_07944 0.29 0.54 0.58 0.46 0.7 7.6 7.83 0.794534 26 8 23.00885 33.3333333 MS3_11537 0.3 0.55 0.58 0.46 0.7 8.38 8.22 1.173511 60 9 53.09735 37.5 MS3_00440 0.3 0.55 0.56 0.45 0.67 7.31 7.49 0.83527 14 2 12.38938 8.33333333 MS3_00931 0.3 0.55 0.47 0.34 0.6 8.02 7.66 1.43333 40 7 35.39823 29.1666667 MS3_01386 0.3 0.56 0.58 0.46 0.71 7.7 7.9 0.818731 23 7 20.35398 29.1666667 MS3_01406 0.3 0.55 0.55 0.42 0.67 8.41 8.23 1.197217 60 11 53.09735 45.8333333 MS3_02545 0.3 0.55 0.57 0.46 0.68 7.49 7.68 0.826959 22 5 19.46903 20.8333333 MS3_03776 0.3 0.55 0.56 0.42 0.7 7.04 7.32 0.755783 11 6 9.734513 25 MS3_04981 0.3 0.55 0.57 0.45 0.7 7.33 7.05 1.32313 23 3 20.35398 12.5 MS3_05945 0.3 0.55 0.57 0.44 0.7 7.35 7.58 0.794533 16 4 14.15929 16.6666667 MS3_06539 0.3 0.56 0.56 0.43 0.69 6.04 6.27 0.794532 1 1 0.884956 4.16666667 MS3_07390 0.3 0.55 0.57 0.44 0.71 6.86 6.5 1.433331 17 3 15.04425 12.5 MS3_08262 0.3 0.55 0.55 0.44 0.66 7.48 7.3 1.197218 24 1 21.23894 4.16666667 MS3_10736 0.3 0.55 0.53 0.42 0.64 7.59 7.39 1.221403 22 3 19.46903 12.5 MS3_01049 0.31 0.56 0.57 0.46 0.68 7.82 8.01 0.826959 32 7 28.31858 29.1666667 MS3_01988 0.31 0.56 0.57 0.44 0.7 7.66 7.38 1.32313 32 5 28.31858 20.8333333 MS3_02504 0.31 0.56 0.48 0.35 0.6 7.96 8.14 0.83527 41 7 36.28319 29.1666667 MS3_06214 0.31 0.57 0.57 0.44 0.69 7.78 7.59 1.20925 26 2 23.00885 8.33333333 MS3_06348 0.31 0.56 0.59 0.47 0.7 7.27 7 1.309965 21 2 18.58407 8.33333333 MS3_06471 0.31 0.56 0.55 0.42 0.68 7.79 7.59 1.221403 23 5 20.35398 20.8333333 MS3_10187 0.31 0.56 0.57 0.46 0.68 7.86 7.59 1.309965 47 8 41.59292 33.3333333 MS3_09353 0.32 0.57 0.6 0.45 0.74 7.79 7.97 0.83527 19 10 16.81416 41.6666667 MS3_00143 0.32 0.57 0.58 0.44 0.71 8.04 8.21 0.843665 29 13 25.66372 54.1666667 81 MS3_00148 0.32 0.57 0.57 0.46 0.69 8.91 8.68 1.2586 76 16 67.25664 66.6666667 MS3_00403 0.32 0.57 0.58 0.45 0.72 7.89 8.07 0.83527 27 10 23.89381 41.6666667 MS3_01478 0.32 0.57 0.56 0.43 0.68 7.01 6.77 1.27125 13 2 11.50442 8.33333333 MS3_02318 0.32 0.57 0.45 0.31 0.6 8.44 8.09 1.419068 63 13 55.75221 54.1666667 MS3_03453 0.32 0.57 0.56 0.43 0.69 7.18 7.39 0.810584 13 4 11.50442 16.6666667 MS3_04364 0.32 0.57 0.59 0.47 0.7 8.15 7.97 1.197217 52 6 46.0177 25 MS3_04920 0.32 0.57 0.6 0.49 0.71 7.74 7.94 0.818731 26 6 23.00885 25 MS3_06243 0.32 0.57 0.54 0.41 0.67 7.03 7.25 0.802519 9 4 7.964602 16.6666667 MS3_07061 0.32 0.57 0.56 0.43 0.7 7.29 7.47 0.83527 8 2 7.079646 8.33333333 MS3_09188 0.32 0.57 0.62 0.49 0.76 9.82 10.13 0.733447 101 23 89.38053 95.8333333 MS3_10002 0.32 0.57 0.58 0.46 0.71 7.59 7.33 1.29693 35 4 30.97345 16.6666667 MS3_01425 0.33 0.57 0.54 0.41 0.67 6.92 7.23 0.733447 14 4 12.38938 16.6666667 MS3_03350 0.33 0.58 0.58 0.45 0.71 6.99 7.19 0.818731 8 2 7.079646 8.33333333 MS3_04609 0.33 0.58 0.55 0.41 0.7 7.63 7.83 0.818731 18 7 15.9292 29.1666667 MS3_09273 0.33 0.57 0.56 0.43 0.69 6.85 7.01 0.852144 2 1 1.769912 4.16666667 MS3_09286 0.33 0.57 0.58 0.46 0.7 7.39 7.1 1.336428 34 2 30.0885 8.33333333 MS3_11428 0.33 0.57 0.54 0.41 0.66 8.19 8.36 0.843665 50 10 44.24779 41.6666667 MS3_00286 0.34 0.59 0.56 0.44 0.68 7.56 7.3 1.29693 40 4 35.39823 16.6666667 MS3_00769 0.34 0.58 0.55 0.43 0.67 7.3 7.13 1.185305 13 1 11.50442 4.16666667 MS3_01650 0.34 0.58 0.56 0.44 0.68 7.36 7.07 1.336428 37 5 32.74336 20.8333333 MS3_01668 0.34 0.58 0.54 0.43 0.66 8.17 7.95 1.246077 52 8 46.0177 33.3333333 MS3_03856 0.34 0.58 0.59 0.47 0.72 7.5 7.33 1.185305 8 2 7.079646 8.33333333 MS3_05427 0.34 0.58 0.57 0.43 0.7 7.62 7.79 0.843665 15 5 13.27434 20.8333333 MS3_07520 0.34 0.58 0.58 0.45 0.7 7.66 7.84 0.83527 24 6 21.23894 25 MS3_07565 0.34 0.58 0.58 0.45 0.72 7.54 7.74 0.818731 12 5 10.61947 20.8333333 MS3_07685 0.34 0.58 0.56 0.43 0.68 7.13 7.38 0.778801 17 6 15.04425 25 MS3_09465 0.34 0.59 0.57 0.44 0.7 7.15 7.32 0.843665 5 2 4.424779 8.33333333 MS3_01124 0.35 0.6 0.58 0.44 0.73 7.83 8.04 0.810584 26 10 23.00885 41.6666667 MS3_05587 0.35 0.6 0.57 0.44 0.69 6.73 6.94 0.810584 7 2 6.19469 8.33333333 MS3_08503 0.35 0.59 0.54 0.42 0.65 7.27 7.43 0.852144 9 2 7.964602 8.33333333 MS3_09110 0.35 0.59 0.57 0.44 0.7 7.8 7.62 1.197217 29 4 25.66372 16.6666667 MS3_09457 0.35 0.59 0.55 0.4 0.7 7.24 7.48 0.786628 11 7 9.734513 29.1666667 MS3_09619 0.35 0.59 0.57 0.45 0.69 8.08 7.8 1.32313 54 9 47.78761 37.5 MS3_00560 0.36 0.6 0.59 0.47 0.71 6.94 7.14 0.818731 12 2 10.61947 8.33333333 MS3_01313 0.36 0.6 0.54 0.43 0.65 8.53 8.67 0.869358 62 17 54.86726 70.8333333 MS3_03427 0.36 0.6 0.55 0.43 0.67 6.98 6.79 1.20925 10 1 8.849558 4.16666667 MS3_05715 0.36 0.6 0.57 0.43 0.72 7.4 7.62 0.802519 13 6 11.50442 25 82 MS3_06704 0.36 0.6 0.57 0.44 0.7 8.06 8.22 0.852144 37 11 32.74336 45.8333333 MS3_09652 0.36 0.6 0.56 0.42 0.69 7.6 7.44 1.173511 10 3 8.849558 12.5 MS3_09793 0.36 0.6 0.57 0.42 0.71 7.81 8 0.826959 31 11 27.43363 45.8333333 MS3_00353 0.37 0.61 0.57 0.44 0.7 8.4 8.12 1.32313 68 10 60.17699 41.6666667 MS3_01261 0.37 0.61 0.56 0.45 0.67 7.67 7.41 1.29693 44 7 38.93805 29.1666667 MS3_01905 0.37 0.61 0.55 0.4 0.7 7.62 7.81 0.826959 16 8 14.15929 33.3333333 MS3_04559 0.37 0.61 0.46 0.33 0.59 7.65 7.83 0.83527 17 5 15.04425 20.8333333 MS3_05836 0.37 0.61 0.54 0.41 0.68 6.74 6.92 0.83527 3 2 2.654867 8.33333333 MS3_06430 0.37 0.61 0.56 0.42 0.69 7.42 7.62 0.818731 15 6 13.27434 25 MS3_07738 0.37 0.61 0.55 0.43 0.68 7.28 7.05 1.2586 19 2 16.81416 8.33333333 MS3_08530 0.37 0.61 0.56 0.42 0.7 7.03 7.28 0.778801 15 6 13.27434 25 MS3_08805 0.37 0.61 0.56 0.41 0.7 7.89 8.07 0.83527 25 8 22.12389 33.3333333 MS3_09271 0.37 0.61 0.51 0.41 0.61 6.59 6.45 1.150275 6 0 5.309735 0 MS3_01658 0.38 0.62 0.57 0.45 0.69 6.48 6.66 0.83527 7 1 6.19469 4.16666667 MS3_04269 0.38 0.62 0.57 0.45 0.7 8.23 8.04 1.20925 55 8 48.67257 33.3333333 MS3_04778 0.38 0.62 0.57 0.44 0.7 7.29 7.05 1.27125 18 3 15.9292 12.5 MS3_05595 0.38 0.61 0.57 0.44 0.7 6.18 5.97 1.233681 1 0 0.884956 0 MS3_06299 0.38 0.61 0.56 0.42 0.71 6.8 6.98 0.83527 4 1 3.539823 4.16666667 MS3_06889 0.38 0.62 0.55 0.41 0.69 7.31 7.55 0.786628 17 6 15.04425 25 MS3_08161 0.38 0.62 0.57 0.44 0.7 7.93 7.67 1.29693 45 7 39.82301 29.1666667 MS3_08498 0.38 0.62 0.56 0.43 0.7 7.87 8.05 0.83527 28 8 24.77876 33.3333333 No hits 0.39 0.62 0.55 0.41 0.7 7.39 7.13 1.29693 20 6 17.69912 25 No hits 0.39 0.62 0.56 0.44 0.68 7.47 7.26 1.233678 26 3 23.00885 12.5 MS3_02653 0.39 0.62 0.55 0.43 0.67 7.26 7.11 1.161834 15 1 13.27434 4.16666667 MS3_02709 0.39 0.62 0.56 0.42 0.69 6.97 7.16 0.826959 7 3 6.19469 12.5 MS3_05326 0.39 0.62 0.58 0.44 0.72 7.37 7.18 1.20925 11 4 9.734513 16.6666667 MS3_05958 0.39 0.62 0.56 0.43 0.69 7.07 6.82 1.284026 22 3 19.46903 12.5 MS3_07420 0.39 0.62 0.55 0.43 0.67 7.05 6.9 1.161835 7 1 6.19469 4.16666667 MS3_07569 0.39 0.62 0.47 0.34 0.6 8.4 8.19 1.233678 50 11 44.24779 45.8333333 MS3_07593 0.39 0.63 0.53 0.38 0.68 8.47 8.22 1.284025 75 12 66.37168 50 MS3_08943 0.39 0.62 0.47 0.35 0.59 7.86 7.71 1.161834 31 5 27.43363 20.8333333 MS3_09735 0.39 0.62 0.55 0.43 0.66 7.14 6.9 1.27125 21 1 18.58407 4.16666667 MS3_10177 0.39 0.62 0.56 0.44 0.68 7.65 7.51 1.150274 18 2 15.9292 8.33333333 MS3_03295 0.4 0.63 0.56 0.43 0.7 7.48 7.21 1.309965 31 6 27.43363 25 MS3_07473 0.4 0.64 0.47 0.35 0.6 9.57 9.29 1.32313 99 18 87.61062 75 MS3_07831 0.4 0.63 0.55 0.4 0.7 7.68 7.88 0.818731 25 8 22.12389 33.3333333 MS3_08999 0.4 0.63 0.56 0.43 0.7 7.99 7.84 1.161834 35 8 30.97345 33.3333333 83 MS3_01289 0.41 0.64 0.57 0.43 0.7 7.62 7.37 1.284026 34 6 30.0885 25 MS3_01899 0.41 0.65 0.56 0.44 0.68 7.36 7.54 0.83527 23 5 20.35398 20.8333333 MS3_09778 0.41 0.64 0.56 0.43 0.68 7.38 7.54 0.852144 18 3 15.9292 12.5 MS3_10471 0.41 0.64 0.57 0.44 0.69 7.54 7.67 0.878095 13 4 11.50442 16.6666667 MS3_05754 0.42 0.66 0.54 0.4 0.67 7.06 7.23 0.843665 6 3 5.309735 12.5 MS3_07294 0.42 0.66 0.56 0.42 0.69 7.47 7.23 1.271249 36 6 31.85841 25 MS3_10209 0.42 0.66 0.47 0.35 0.6 7.03 7.31 0.755783 18 5 15.9292 20.8333333 MS3_10493 0.42 0.65 0.55 0.42 0.69 7.51 7.74 0.794534 26 8 23.00885 33.3333333 MS3_10619 0.42 0.65 0.55 0.42 0.68 7.43 7.21 1.246077 22 3 19.46903 12.5 MS3_00048 0.43 0.66 0.51 0.38 0.64 7.91 7.75 1.173511 26 6 23.00885 25 MS3_03193 0.43 0.66 0.56 0.43 0.68 7.79 7.64 1.161834 31 4 27.43363 16.6666667 MS3_05447 0.43 0.66 0.55 0.43 0.68 7.18 7.32 0.869358 6 1 5.309735 4.16666667 MS3_06069 0.43 0.66 0.59 0.45 0.72 8.18 8.36 0.83527 50 13 44.24779 54.1666667 MS3_06400 0.43 0.66 0.55 0.42 0.68 7.54 7.34 1.221403 31 7 27.43363 29.1666667 MS3_07280 0.43 0.66 0.55 0.43 0.67 7.65 7.49 1.173511 30 4 26.54867 16.6666667 MS3_07531 0.43 0.66 0.55 0.41 0.7 7.49 7.24 1.284026 33 7 29.20354 29.1666667 MS3_08808 0.43 0.66 0.56 0.42 0.7 7.28 7.03 1.284026 23 4 20.35398 16.6666667 MS3_10472 0.43 0.66 0.57 0.43 0.71 7.92 7.77 1.161834 26 5 23.00885 20.8333333 MS3_00703 0.44 0.67 0.55 0.42 0.68 7.02 7.18 0.852144 4 2 3.539823 8.33333333 MS3_04100 0.44 0.67 0.55 0.42 0.67 7.2 7.36 0.852144 10 3 8.849558 12.5 MS3_05530 0.44 0.67 0.54 0.41 0.68 6.74 6.98 0.786627 10 5 8.849558 20.8333333 MS3_06482 0.44 0.67 0.55 0.42 0.68 7.92 8.17 0.778801 47 13 41.59292 54.1666667 MS3_06732 0.44 0.67 0.54 0.42 0.67 7.45 7.2 1.284026 31 6 27.43363 25 MS3_06950 0.44 0.67 0.56 0.43 0.7 7.12 7.3 0.83527 8 4 7.079646 16.6666667 MS3_09128 0.44 0.67 0.56 0.42 0.7 7.26 7.47 0.810584 18 7 15.9292 29.1666667 MS3_10510 0.44 0.67 0.56 0.44 0.68 7.77 7.55 1.246077 38 7 33.62832 29.1666667 MS3_02674 0.45 0.67 0.58 0.46 0.7 6.81 6.94 0.878095 8 1 7.079646 4.16666667 MS3_02734 0.45 0.67 0.55 0.42 0.68 7 6.79 1.233679 16 3 14.15929 12.5 MS3_03084 0.45 0.67 0.58 0.44 0.71 8.57 8.75 0.83527 73 17 64.60177 70.8333333 MS3_04887 0.45 0.68 0.47 0.33 0.6 7.22 7.39 0.843665 12 3 10.61947 12.5 MS3_06979 0.45 0.67 0.53 0.4 0.66 6.74 6.9 0.852143 2 1 1.769912 4.16666667 MS3_07370 0.45 0.67 0.55 0.42 0.68 7.4 7.25 1.161834 16 3 14.15929 12.5 MS3_07467 0.45 0.68 0.57 0.45 0.7 7.79 7.58 1.233678 47 8 41.59292 33.3333333 MS3_07637 0.45 0.67 0.56 0.42 0.7 7.22 7.38 0.852144 9 4 7.964602 16.6666667 MS3_08472 0.45 0.67 0.52 0.4 0.64 7.91 8.15 0.786628 50 13 44.24779 54.1666667 MS3_02856 0.46 0.68 0.56 0.44 0.68 7.51 7.3 1.233678 42 6 37.16814 25 MS3_04179 0.46 0.69 0.55 0.42 0.69 8.1 8.21 0.895834 39 10 34.51327 41.6666667 84 MS3_05614 0.46 0.68 0.57 0.44 0.7 8.35 8.25 1.105171 57 10 50.44248 41.6666667 MS3_09683 0.46 0.68 0.61 0.48 0.74 7.48 7.17 1.363425 34 5 30.0885 20.8333333 MS3_10492 0.46 0.68 0.55 0.41 0.68 7.79 7.6 1.20925 36 7 31.85841 29.1666667 MS3_05213 0.47 0.69 0.54 0.42 0.66 6.99 7.18 0.826959 14 2 12.38938 8.33333333 MS3_07195 0.47 0.69 0.55 0.42 0.68 7.33 7.12 1.233678 25 5 22.12389 20.8333333 MS3_09406 0.47 0.69 0.56 0.44 0.69 7.76 7.63 1.138828 24 4 21.23894 16.6666667 MS3_10397 0.47 0.7 0.56 0.43 0.7 7.2 7.05 1.161834 10 2 8.849558 8.33333333 MS3_10607 0.47 0.7 0.53 0.4 0.66 6.4 6.61 0.810583 4 1 3.539823 4.16666667 MS3_00676 0.48 0.7 0.53 0.38 0.69 6.51 6.72 0.810584 2 5 1.769912 20.8333333 MS3_02804 0.48 0.7 0.53 0.39 0.66 8.05 7.86 1.20925 46 7 40.70796 29.1666667 MS3_03615 0.48 0.7 0.49 0.37 0.61 6.69 6.48 1.233679 16 3 14.15929 12.5 MS3_04453 0.48 0.7 0.53 0.4 0.67 7.8 7.64 1.173511 29 6 25.66372 25 MS3_05639 0.48 0.7 0.54 0.42 0.67 8.1 8.2 0.904837 40 8 35.39823 33.3333333 MS3_07716 0.48 0.7 0.56 0.43 0.69 7.18 7.07 1.116278 7 1 6.19469 4.16666667 MS3_07795 0.48 0.7 0.54 0.41 0.67 6.62 6.85 0.794533 7 1 6.19469 4.16666667 MS3_08692 0.48 0.7 0.55 0.42 0.68 7.5 7.29 1.233678 27 4 23.89381 16.6666667 MS3_10297 0.48 0.7 0.46 0.35 0.58 7.26 7.11 1.161834 21 2 18.58407 8.33333333 MS3_10753 0.48 0.7 0.55 0.42 0.67 7.46 7.26 1.221403 32 6 28.31858 25 MS3_05252 0.49 0.71 0.63 0.52 0.75 7.79 7.57 1.246077 28 2 24.77876 8.33333333 MS3_06075 0.49 0.71 0.55 0.41 0.69 7.68 7.81 0.878095 17 6 15.04425 25 MS3_08826 0.49 0.71 0.47 0.34 0.6 6.86 6.72 1.150274 10 2 8.849558 8.33333333 MS3_10225 0.49 0.71 0.55 0.43 0.67 8.2 8.02 1.197217 56 8 49.55752 33.3333333 MS3_04311 0.5 0.71 0.55 0.42 0.68 6.75 6.58 1.185306 8 2 7.079646 8.33333333 MS3_08460 0.5 0.71 0.57 0.44 0.7 7.33 7.11 1.246077 27 4 23.89381 16.6666667 MS3_10141 0.5 0.71 0.55 0.41 0.68 7.18 7.32 0.869358 10 2 8.849558 8.33333333 MS3_01001 0.5 0.71 0.47 0.34 0.6 7.52 7.39 1.138828 20 1 17.69912 4.16666667 MS3_02855 0.5 0.71 0.53 0.41 0.65 7.46 7.58 0.88692 15 3 13.27434 12.5 MS3_03405 0.5 0.71 0.57 0.43 0.71 7.65 7.78 0.878095 17 5 15.04425 20.8333333 MS3_05437 0.5 0.71 0.55 0.4 0.7 7.61 7.47 1.150274 12 7 10.61947 29.1666667 MS3_06507 0.5 0.71 0.56 0.43 0.69 7.12 6.92 1.221403 16 3 14.15929 12.5 MS3_07822 0.5 0.71 0.56 0.43 0.68 7.17 7.05 1.127497 10 3 8.849558 12.5 MS3_10943 0.5 0.71 0.58 0.46 0.71 7.31 7.45 0.869358 13 2 11.50442 8.33333333 MS3_11429 0.5 0.71 0.56 0.43 0.7 7.95 7.83 1.127497 30 4 26.54867 16.6666667 MS3_01664 0.51 0.72 0.55 0.42 0.68 7.47 7.61 0.869358 19 6 16.81416 25 MS3_02453 0.51 0.72 0.54 0.4 0.67 6.79 6.93 0.869358 2 2 1.769912 8.33333333 MS3_02474 0.51 0.72 0.53 0.41 0.66 7.87 7.78 1.094174 24 5 21.23894 20.8333333 MS3_04286 0.51 0.71 0.56 0.42 0.7 6.38 6.16 1.246079 6 4 5.309735 16.6666667 85 MS3_10249 0.51 0.72 0.56 0.43 0.69 7.93 8.06 0.878095 32 11 28.31858 45.8333333 MS3_10721 0.51 0.72 0.58 0.45 0.71 7.84 7.96 0.88692 24 8 21.23894 33.3333333 MS3_00719 0.52 0.73 0.55 0.42 0.69 7.41 7.55 0.869358 16 6 14.15929 25 MS3_00404 0.53 0.74 0.53 0.38 0.68 7.8 7.91 0.895834 22 6 19.46903 25 MS3_00876 0.53 0.74 0.56 0.43 0.69 7.54 7.44 1.105171 14 2 12.38938 8.33333333 MS3_05157 0.53 0.74 0.52 0.39 0.65 7.33 7.2 1.138829 12 3 10.61947 12.5 MS3_07600 0.53 0.74 0.56 0.42 0.69 7.68 7.56 1.127497 15 4 13.27434 16.6666667 MS3_08737 0.53 0.74 0.54 0.41 0.66 7.79 7.94 0.860708 21 6 18.58407 25 MS3_09305 0.53 0.74 0.53 0.38 0.67 8.03 7.92 1.116278 38 9 33.62832 37.5 MS3_02044 0.54 0.74 0.57 0.43 0.7 7.95 8.11 0.852144 40 10 35.39823 41.6666667 MS3_06022 0.54 0.74 0.57 0.46 0.68 7.48 7.59 0.895834 21 4 18.58407 16.6666667 MS3_08726 0.54 0.74 0.53 0.4 0.66 7.28 7.14 1.150274 13 4 11.50442 16.6666667 MS3_09970 0.54 0.74 0.58 0.46 0.7 7.28 7.42 0.869358 19 3 16.81416 12.5 MS3_10998 0.54 0.75 0.55 0.41 0.69 7.24 7.46 0.802519 22 8 19.46903 33.3333333 MS3_11432 0.54 0.75 0.53 0.4 0.67 7.07 7.25 0.83527 19 5 16.81416 20.8333333 MS3_07465 0.55 0.75 0.52 0.38 0.66 7.6 7.48 1.127497 18 5 15.9292 20.8333333 MS3_10188 0.55 0.76 0.61 0.49 0.72 6.89 7.01 0.88692 13 0 11.50442 0 MS3_02685 0.56 0.76 0.56 0.43 0.68 8.27 8.1 1.185305 64 11 56.63717 45.8333333 MS3_03192 0.56 0.76 0.48 0.34 0.62 7.28 7.42 0.869358 13 5 11.50442 20.8333333 MS3_03417 0.56 0.77 0.55 0.43 0.66 8.19 8.28 0.913931 48 13 42.47788 54.1666667 MS3_06468 0.56 0.77 0.54 0.41 0.66 7.08 6.98 1.105171 7 1 6.19469 4.16666667 MS3_06677 0.56 0.77 0.54 0.41 0.67 7.42 7.53 0.895834 16 5 14.15929 20.8333333 MS3_08159 0.56 0.76 0.52 0.39 0.65 7.34 7.49 0.860708 17 5 15.04425 20.8333333 MS3_05011 0.57 0.77 0.55 0.41 0.69 7.58 7.4 1.197217 33 6 29.20354 25 MS3_05126 0.57 0.77 0.56 0.43 0.68 7.78 7.61 1.185305 24 4 21.23894 16.6666667 MS3_10085 0.57 0.77 0.55 0.42 0.68 7.36 7.54 0.83527 24 8 21.23894 33.3333333 MS3_00449 0.58 0.78 0.52 0.4 0.65 7.44 7.57 0.878095 23 5 20.35398 20.8333333 MS3_00625 0.58 0.78 0.56 0.43 0.7 6.71 6.82 0.895834 5 2 4.424779 8.33333333 MS3_05646 0.58 0.78 0.48 0.34 0.61 7.05 7.16 0.895834 6 2 5.309735 8.33333333 MS3_05748 0.58 0.78 0.52 0.39 0.66 7.91 8 0.913931 22 8 19.46903 33.3333333 MS3_07606 0.58 0.78 0.49 0.37 0.61 7.84 7.99 0.860708 44 10 38.93805 41.6666667 MS3_08157 0.58 0.78 0.56 0.42 0.7 7.76 7.87 0.895834 18 7 15.9292 29.1666667 MS3_08276 0.58 0.78 0.54 0.41 0.67 7.61 7.46 1.161834 36 7 31.85841 29.1666667 MS3_11247 0.58 0.78 0.55 0.41 0.69 7.75 7.64 1.116278 22 5 19.46903 20.8333333 MS3_03171 0.59 0.78 0.54 0.41 0.67 7.68 7.57 1.116278 19 4 16.81416 16.6666667 MS3_05026 0.59 0.79 0.54 0.4 0.68 7.78 7.61 1.185305 40 7 35.39823 29.1666667 MS3_06668 0.59 0.78 0.56 0.44 0.67 8.14 8.05 1.094174 52 8 46.0177 33.3333333 86 MS3_08925 0.59 0.79 0.54 0.41 0.66 7.13 6.98 1.161835 19 4 16.81416 16.6666667 MS3_10423 0.59 0.78 0.56 0.42 0.7 8.39 8.51 0.88692 52 17 46.0177 70.8333333 MS3_11273 0.59 0.79 0.55 0.41 0.69 7.81 7.7 1.116278 29 6 25.66372 25 MS3_02237 0.6 0.79 0.51 0.38 0.64 7.68 7.58 1.105171 25 3 22.12389 12.5 MS3_02396 0.6 0.79 0.53 0.39 0.68 7.72 7.82 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0.51 0.39 0.63 6.91 6.86 1.051271 14 1 12.38938 4.16666667 MS3_01764 0.84 0.92 0.51 0.4 0.62 7.73 7.68 1.051271 44 8 38.93805 33.3333333 MS3_02747 0.84 0.92 0.53 0.39 0.67 6.69 6.62 1.072508 12 3 10.61947 12.5 MS3_04646 0.84 0.92 0.52 0.41 0.64 8.41 8.45 0.960789 54 14 47.78761 58.3333333 MS3_06009 0.84 0.92 0.53 0.4 0.66 6.91 6.96 0.951229 12 1 10.61947 4.16666667 MS3_07299 0.84 0.92 0.5 0.39 0.6 7.57 7.6 0.970446 21 1 18.58407 4.16666667 MS3_07464 0.84 0.92 0.53 0.4 0.65 6.92 6.87 1.051271 14 3 12.38938 12.5 MS3_00604 0.85 0.92 0.53 0.4 0.66 7.66 7.61 1.051271 33 6 29.20354 25 MS3_02954 0.85 0.92 0.5 0.36 0.64 7.46 7.5 0.960789 10 5 8.849558 20.8333333 MS3_03853 0.85 0.92 0.53 0.39 0.67 6.48 6.51 0.970445 2 0 1.769912 0 MS3_04817 0.85 0.92 0.53 0.39 0.67 7.48 7.51 0.970446 13 4 11.50442 16.6666667 MS3_07406 0.85 0.92 0.53 0.4 0.66 6.42 6.46 0.960789 5 1 4.424779 4.16666667 MS3_08929 0.85 0.93 0.48 0.35 0.62 7.49 7.52 0.970446 16 5 14.15929 20.8333333 MS3_08945 0.85 0.92 0.53 0.4 0.65 7.25 7.2 1.051271 28 3 24.77876 12.5 MS3_10816 0.85 0.92 0.49 0.35 0.63 7.37 7.31 1.061837 18 6 15.9292 25 MS3_01276 0.86 0.93 0.52 0.38 0.66 7.41 7.38 1.030455 13 4 11.50442 16.6666667 MS3_03420 0.86 0.93 0.53 0.41 0.64 7.97 8 0.970446 39 9 34.51327 37.5 MS3_07799 0.86 0.93 0.49 0.36 0.62 7.89 7.92 0.970446 28 7 24.77876 29.1666667 MS3_08176 0.86 0.93 0.48 0.35 0.62 7.64 7.61 1.030455 12 3 10.61947 12.5 MS3_09691 0.86 0.93 0.5 0.37 0.63 8.55 8.5 1.051271 72 15 63.71681 62.5 MS3_01653 0.87 0.93 0.51 0.38 0.64 7.58 7.54 1.040811 26 7 23.00885 29.1666667 MS3_02275 0.87 0.93 0.53 0.4 0.66 7.29 7.24 1.051271 24 4 21.23894 16.6666667 MS3_02752 0.87 0.93 0.52 0.39 0.66 7.21 7.16 1.051271 24 6 21.23894 25 MS3_02951 0.87 0.93 0.52 0.39 0.65 9.1 9.07 1.030455 87 17 76.99115 70.8333333 MS3_03419 0.87 0.93 0.53 0.39 0.67 8.5 8.46 1.040811 71 12 62.83186 50 MS3_03979 0.87 0.94 0.48 0.36 0.61 7.17 7.2 0.970446 7 0 6.19469 0 MS3_08105 0.87 0.93 0.5 0.36 0.64 6.8 6.84 0.960789 11 3 9.734513 12.5 MS3_00494 0.88 0.94 0.52 0.38 0.66 6.46 6.42 1.040811 5 2 4.424779 8.33333333 MS3_02088 0.88 0.94 0.49 0.36 0.62 7.46 7.48 0.980199 12 3 10.61947 12.5 MS3_03385 0.88 0.94 0.53 0.42 0.63 7.45 7.47 0.980199 16 1 14.15929 4.16666667 MS3_03918 0.88 0.94 0.48 0.35 0.62 7.55 7.52 1.030455 17 4 15.04425 16.6666667 MS3_03976 0.88 0.94 0.49 0.36 0.62 7.91 7.87 1.040811 38 11 33.62832 45.8333333 MS3_09634 0.88 0.94 0.51 0.36 0.66 8.09 8.05 1.040811 37 10 32.74336 41.6666667 MS3_09698 0.88 0.94 0.52 0.39 0.66 7.24 7.22 1.020201 7 3 6.19469 12.5 MS3_00610 0.89 0.94 0.52 0.4 0.65 7.5 7.54 0.960789 28 6 24.77876 25 91 MS3_04206 0.89 0.95 0.5 0.39 0.62 7.77 7.75 1.020201 25 6 22.12389 25 MS3_04584 0.89 0.94 0.5 0.36 0.63 9.15 9.11 1.040811 93 19 82.30088 79.1666667 MS3_09865 0.89 0.94 0.49 0.36 0.63 8.53 8.57 0.960789 59 14 52.21239 58.3333333 MS3_04266 0.9 0.95 0.52 0.37 0.67 8.05 8.07 0.980199 34 10 30.0885 41.6666667 MS3_07816 0.9 0.95 0.51 0.38 0.64 7.3 7.27 1.030455 25 6 22.12389 25 MS3_10252 0.9 0.95 0.52 0.39 0.65 7.43 7.46 0.970446 23 6 20.35398 25 MS3_03406 0.91 0.95 0.49 0.37 0.61 7.47 7.44 1.030455 22 2 19.46903 8.33333333 MS3_03513 0.91 0.95 0.49 0.37 0.61 6.29 6.27 1.020201 5 0 4.424779 0 MS3_04225 0.91 0.95 0.49 0.36 0.62 7.26 7.29 0.970446 24 7 21.23894 29.1666667 MS3_07587 0.91 0.95 0.5 0.37 0.62 8.92 8.95 0.970446 87 20 76.99115 83.3333333 MS3_01636 0.92 0.96 0.5 0.36 0.63 7.48 7.5 0.980199 16 5 14.15929 20.8333333 MS3_02465 0.92 0.96 0.5 0.37 0.63 6.73 6.7 1.030455 5 2 4.424779 8.33333333 MS3_03800 0.92 0.96 0.57 0.45 0.69 7.16 7.11 1.051271 25 2 22.12389 8.33333333 MS3_03802 0.92 0.96 0.54 0.38 0.69 6.7 6.67 1.030455 8 3 7.079646 12.5 MS3_03977 0.92 0.96 0.5 0.37 0.63 7.44 7.47 0.970446 33 7 29.20354 29.1666667 MS3_04474 0.92 0.96 0.5 0.36 0.64 7.84 7.82 1.020201 32 6 28.31858 25 MS3_07372 0.92 0.96 0.51 0.38 0.65 7.31 7.36 0.951229 28 7 24.77876 29.1666667 MS3_07823 0.92 0.96 0.54 0.42 0.66 7.72 7.7 1.020201 26 5 23.00885 20.8333333 MS3_01095 0.93 0.96 0.5 0.38 0.61 7.47 7.45 1.020201 25 2 22.12389 8.33333333 MS3_05332 0.93 0.97 0.5 0.37 0.62 8.01 7.99 1.020201 44 7 38.93805 29.1666667 MS3_05911 0.93 0.96 0.51 0.38 0.64 7.11 7.09 1.020201 18 5 15.9292 20.8333333 MS3_00665 0.94 0.97 0.5 0.37 0.63 7.28 7.26 1.020201 14 2 12.38938 8.33333333 MS3_02141 0.94 0.97 0.51 0.36 0.66 8.02 8.04 0.980199 31 8 27.43363 33.3333333 MS3_02368 0.94 0.97 0.49 0.36 0.63 7.31 7.29 1.020201 10 4 8.849558 16.6666667 MS3_02690 0.94 0.97 0.59 0.48 0.69 6.98 6.96 1.020201 16 1 14.15929 4.16666667 MS3_04449 0.94 0.97 0.54 0.42 0.65 7.71 7.7 1.01005 48 5 42.47788 20.8333333 MS3_00287 0.95 0.97 0.51 0.38 0.65 7.55 7.54 1.01005 21 6 18.58407 25 MS3_00413 0.95 0.98 0.52 0.39 0.65 7.22 7.23 0.99005 13 3 11.50442 12.5 MS3_03618 0.95 0.97 0.53 0.38 0.68 6.27 6.29 0.980199 3 1 2.654867 4.16666667 MS3_06538 0.95 0.97 0.51 0.39 0.63 8.09 8.08 1.01005 44 9 38.93805 37.5 MS3_06807 0.96 0.98 0.54 0.42 0.66 7.27 7.28 0.99005 17 1 15.04425 4.16666667 MS3_07651 0.96 0.99 0.51 0.38 0.64 7.17 7.16 1.01005 13 3 11.50442 12.5 MS3_09076 0.96 0.98 0.53 0.4 0.65 7.12 7.13 0.99005 10 2 8.849558 8.33333333 MS3_01445 0.97 0.99 0.54 0.43 0.64 6.87 6.87 1 13 1 11.50442 4.16666667 MS3_05077 0.97 0.99 0.54 0.41 0.66 8.3 8.29 1.01005 47 15 41.59292 62.5 MS3_06729 0.97 0.99 0.49 0.38 0.6 7.63 7.64 0.99005 27 2 23.89381 8.33333333 MS3_07010 0.97 0.99 0.5 0.37 0.64 7.74 7.75 0.99005 39 7 34.51327 29.1666667 92 MS3_08415 0.97 0.99 0.5 0.39 0.61 7.61 7.61 1 23 3 20.35398 12.5 MS3_09371 0.97 0.99 0.51 0.36 0.65 7.53 7.54 0.99005 17 5 15.04425 20.8333333 MS3_09434 0.97 0.99 0.52 0.38 0.66 7.5 7.49 1.01005 25 7 22.12389 29.1666667 MS3_07231 0.98 0.99 0.52 0.39 0.65 7.48 7.48 1 27 6 23.89381 25 MS3_08723 0.98 0.99 0.5 0.38 0.62 7.43 7.43 1 15 2 13.27434 8.33333333 MS3_00187 0.99 1 0.51 0.37 0.65 7.61 7.61 1 16 4 14.15929 16.6666667 MS3_01160 0.99 1 0.51 0.37 0.65 7.55 7.55 1 23 5 20.35398 20.8333333 MS3_01274 0.99 1 0.51 0.38 0.65 7.85 7.85 1 35 8 30.97345 33.3333333 MS3_03101 0.99 1 0.48 0.36 0.6 7.57 7.58 0.99005 34 4 30.0885 16.6666667 MS3_05226 0.99 1 0.53 0.41 0.65 7.84 7.84 1 26 4 23.00885 16.6666667 MS3_05953 0.99 1 0.5 0.37 0.63 8.17 8.17 1 38 9 33.62832 37.5 MS3_04499 1 1 0.51 0.38 0.63 7.46 7.46 1 23 2 20.35398 8.33333333 MS3_05837 1 1 0.49 0.37 0.6 8.4 8.4 1 65 17 57.52212 70.8333333 MS3_09124 1 1 0.48 0.35 0.6 6.78 6.79 0.99005 5 2 4.424779 8.33333333 MS3_10193 1 1 0.5 0.37 0.63 7.2 7.2 1 5 1 4.424779 4.16666667 MS3_10345 1 1 0.49 0.36 0.62 8.14 8.14 1 59 13 52.21239 54.1666667 *WormBase ParaSite online database, version 14 https://parasite.wormbase.org/Schistosoma_haematobium_prjna78265/Info/Index/ 93 Figure S1: Schematic of PoC-ICT design. The conjugate pad (orange) was coated with 10 OD of gold-conjugated mouse anti-human IgG (to capture any human IgG present in the applied serum), 1.0 mg/ml of recombinant antigen (Sh-TSP-2 in this example) was sprayed at the test line (to capture any anti- Sh-TSP-2 human IgG/anti-human IgG gold-conjugate complex) and 1.0 mg/ml anti-mouse IgG was sprayed at the control line (to capture anti-human IgG gold-conjugate and serve as an internal validation). For each strip, a band at the test and control lines was considered a positive result, a band at the control line only was considered a negative result and a test was considered invalid if there was no band at the control line. 94 log2 egg burden m ea n SI b y sa m pl e (A) log2 egg burden m ea n SI b y sa m pl e (B) Figure S2. Scatterplot showing correlation of S. haematobium infection intensity (urine egg burden) with individual mean SI of all spots resulting from probing of S. haematobium protein arrays with different diagnostic fluids. (A) Serum. (B) Urine. 95 Accuracy= 0.98 Accuracy= 0.98 Accuracy= 0.98 (A) (B) Figure S3. Receiver operating characteristic curve showing diagnostic performance (area under the curve - AUC) of the minimal antibody signature in each diagnostic fluid. (A) Serum. (B) Urine. 96 (A) (B) Figure S4. (A) Amino acid alignment of S. haematobium TSPs and (B) percent identity matrix showing level of identity between S. haematobium TSPs . 97 (A) (B) (C) (D) hig h low eg g - ve /C AA +v e eg g - ve /C AA -v e no n-e nd . -v e 0 1 2 3 4 O D 40 5n m **** * **** hig h low eg g - ve /C AA +v e eg g - ve /C AA -v e no n-e nd . -v e 0.0 0.5 1.0 2 4 O D 40 5n m *** * * hig h low eg g - ve /C AA +v e eg g - ve /C AA -v e no n-e nd . -v e 0.0 0.5 1.0 2 4 O D 40 5n m **** * *** hig h low eg g - ve /C AA +v e eg g - ve /C AA -v e no n-e nd . -v e 0.0 0.5 1.0 2 4 O D 40 5n m *** * * Figure S5. Antibody responses to combinations of cell-based recombinant versions of top-ranked proteins generated by ELISA with human urine from S. haematobium- endemic populations. (A) anti-MS3_10385 + anti-MS3_10186 + anti-MS3_09198 IgG response. (B) anti-MS3_10385 + anti-MS3_09198 + anti-MS3_01370 + anti-Sh-TSP-2 IgG response. (C) anti-MS3_09198 + anti-MS3_01370 + anti Sh-TSP-2 IgG response. (D) anti- MS3_01370 IgG response + anti-Sh-TSP-2 IgG response. Egg-positive subjects were characterized (WHO stratification) as either having a high (≥50 eggs per 10 ml urine) or low (1-49 eggs per 10 ml urine) infection. “egg -ve/CAA +ve” = egg negative subjects who are classified as positive (infected) by the more sensitive circulating anodic antigen (CAA) detection test. “egg -ve/CAA -ve” = egg negative subjects who are confirmed as antigen negative by the CAA detection test. “non-end. -ve” = subjects from a non-endemic area. Plotted data represent the responses of both the Zimbabwe (black symbols) and Zanzibar (red symbols) cohorts. Reactivity cutoffs were determined as the average plus 3SD of the values of the non-endemic negative group (red dotted line). Significance of responses between each infected group and the non-infected group were analysed by Student’s t test *p≤0.05, **p≤0.01, ***p≤0.001, ****p≤0.0001. 98 Table S4: Diagnostic accuracy of antigen combinations using urine of individuals from Schistosoma haematobium-endemic populations determined by ELISA. Antigen combination AUC in cohort (95% CI) Zimbabwe Zanzibar All MS3_10385 + MS3_10186 + MS3_09198 0×94 (0×89-0×98) 0×63 (0×48-0×80) 0×70 (0×61-0×79) MS3_10385 + MS3_09198 + MS3_01370 + Sh-TSP2 0×93 (0×87-0×98) 0×79 (0×70-0×88) 0×88 (0×83-0×93) MS3_09198 + MS3_01370 + Sh-TSP2 0×94 (0×89-1×00) 0×92 (0×85-0×99) 0×93 (0×87-0×98) MS3_01370 + Sh-TSP2 0×97 (0×93-1×00) 0×92 (0×86-0×98) 0×95 (0×91-0×99) 99 Zim 70 78 70 86 Zan 14 61 59 72 all 43 70 65 79 combination 1 combination 2 combination 3 combination 4 FoR (sensitivity) (%) high egg neg. CAA +ve low Figure S6. Frequency of recognition (FoR) patterns based on IgG ELISA responses to combinations of cell-based recombinant versions of top-ranked proteins and Sh-SEA using urine from infected individuals in S. haematobium-endemic populations. Samples have been sorted from left to right by decreasing egg burden. For each antigen, black bars represent recognition by a sample from the Zimbabwe cohort, red bars represent recognition by a sample from the Zanzibar cohort and white bars denote no recognition (below the cutoff determined by ELISA), regardless of cohort. “Combination 1” = MS3_10385 + MS3_10186 + MS3_09198, “combination 2” = MS3_10385 + MS3_09198 + MS3_01370 + Sh-TSP-2, “combination 3” = MS3_09198 + MS3_01370 + Sh-TSP-2, “combination 4” = MS3_01370 + Sh-TSP-2. FoR percentages among the infected populations (sensitivity) are displayed on the right-hand side of the pattern. “Zim” = Zimbabwe cohort, “Zan” = Zanzibar cohort, “all” = samples from both cohorts combined. To facilitate proper comparison, the dataset has been trimmed to exclude any samples not assayed for all four recombinant antigen combinations (n=148). 100 Sh Sm S j no n-e nd . -v e 0.0 0.5 1.0 2 4 O D 40 5n m **** 58% **** 69% (A) Sh Sm S j no n-e nd . -v e 0.0 0.5 1.0 2 4 O D 40 5n m **** 61% 80% (B) Figure S7. Serum IgG ELISAs showing recognition of S. haematobium diagnostic antigens by other schistosome species. (A) Sh-TSP2. (B) MS3_01370. “Sh” = S. haematobium-infected serum samples from the Gabon cohort used previously in this study. “Sm” = S. mansoni-infected serum samples. “Sj” = S. japonicum- infected serum samples. “non-end. -ve” = serum samples from a non-endemic area used previously in this study. 101 Figure S8. Amino acid alignment of S. haematobium diagnostic antigens and homologs from S. mansoni, S. japonicum and H. sapiens. (A) Sh-TSP2. (B) MS3_01370. (C) MS3_09198. (D) MS3_10186. (E) MS3_10385. (F) Percent homology table of the diagnostic antigens and their homologs. “Sh” = S. haematobium, “Sm” = S. mansoni, “Sj” = S. japonicum and “Hs” = Homo sapiens. 102