1 Supplemental information Contents Supplemental Table S1. Proteins identified after comparing the proteome of human skin fibroblasts from an 8-year-old male HGPS patient (AG06297) versus cells from an 8-year-old male healthy control (GM08398). logFC: log fold change; RSD (we): relative standard deviation (within experiments); RSD (be): relative standard deviation (between experiments); Mw (Da): molecular weight (daltons); ID: identification; QT: quantification. Supplemental Table S2. Proteins identified after comparing the proteome of human skin fibroblasts from a 14-year-old female HGPS patient (AG01972) versus cells from a 13-year-old female healthy control (GM01651). logFC: log fold change; RSD (we): relative standard deviation (within experiments); RSD (be): relative standard deviation (between experiments); Mw (Da): molecular weight (daltons); ID: identification; QT: quantification. Supplemental Table S3. Proteins expressed at lower level in both male and female skin fibroblasts from HGPS patients compared with age-matched female and male healthy controls. RSD: relative standard deviation. Supplemental Table S4. Proteins expressed at higher level in both male and female skin fibroblasts from HGPS patients compared with age-matched female and male healthy controls. RSD: relative standard deviation. Supplementary Table S1. Proteins identified after comparing the proteome of human skin fibroblasts from an 8-year-old male HGPS patient (AG06297)   versus cells from an 8‐year‐old male healthy control (GM08398).  Accession Number (gi) Protein Name SILAC ratio logFC RSD (we) RSD (be) Mascot Score Mw (Da) Number of peptides Isoelectric point 4504301 histone cluster 1, H4a [Homo sapiens 13,951 3,802 19,315 …. 143 11360 7 11.36 5453543 aldo-keto reductase family 1, member C1 [Homo sapien 7,137 2,835 17,182 9,2933517 635 36765 15 8.02 4505467 5' nucleotidase, ecto [Homo sapiens 6,359 2,669 19,260 …. 526 63327 23 6.58 4504245 histone cluster 1, H2ac [Homo sapiens 5,793 2,534 18,332 2,1254495 121 14097 4 11.05 117189975 heterogeneous nuclear ribonucleoprotein C isoform a [Homo sapien 5,754 2,525 9,349 2,0930881 407 33650 16 4.95 4505415 NAD(P)H menadione oxidoreductase 1, dioxin-inducible isoform a [Homo sapien 5,721 2,516 0,210 3,6686881 1968 30848 14 8.91 6681764 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa [Homo sapien 5,664 2,502 19,949 …. 96 42483 11 9.81 31621303 sideroflexin 3 [Homo sapiens 5,287 2,402 17,128 …. 285 35956 11 9.25 6005854 prohibitin 2 isoform 2 [Homo sapiens 5,020 2,328 2,566 0,3031022 508 33276 15 9.83 27436946 lamin A/C isoform 1 precursor [Homo sapiens 4,839 2,275 18,199 12,458565 2288 74095 50 6.57 42476281 voltage-dependent anion channel 2 [Homo sapiens 4,790 2,260 0,618 …. 66 31547 4 7.49 55743098 alpha 3 type VI collagen isoform 1 precursor [Homo sapien 4,705 2,234 11,002 17,379812 211 343457 43 6.26 7657347 mitochondrial carrier 2 [Homo sapiens 4,626 2,210 12,849 …. 128 33309 4 8.25 34740329 heterogeneous nuclear ribonucleoprotein A3 [Homo sapien 4,577 2,194 5,055 …. 570 39571 10 9.10 7705618 mitochondrial ribosomal protein L11 isoform a [Homo sapien 4,454 2,155 9,855 …. 91 20670 7 9.91 17981856 cytochrome c oxidase subunit II [Homo sapiens 4,440 2,150 3,740 …. 69 25548 3 4.67 16751921 dermcidin preproprotein [Homo sapiens 4,427 2,146 1,573 …. 62 11277 2 6.08 4757834 BCL2-associated athanogene 2 [Homo sapiens 4,334 2,116 19,354 …. 142 23757 12 6.25 14141152 heterogeneous nuclear ribonucleoprotein M isoform a [Homo sapien 4,132 2,047 14,071 …. 167 77464 38 8.84 4506625 ribosomal protein L27a [Homo sapiens 3,871 1,953 4,719 …. 69 16551 4 11.00 157266300 membrane alanine aminopeptidase precursor [Homo sapien 3,787 1,921 19,478 …. 1335 109471 30 5.31 28178832 isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor [Homo sapien 3,678 1,879 4,238 …. 147 50877 11 8.88 21361565 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 precursor [Homo sapien 3,645 1,866 15,217 16,523041 577 28890 13 9.37 156766050 AHNAK nucleoprotein 2 [Homo sapiens 3,588 1,843 13,467 …. 256 616242 73 5.20 23308577 phosphoglycerate dehydrogenase [Homo sapiens 3,561 1,832 11,522 …. 327 56614 14 6.29 18104948 ribosomal protein L21 [Homo sapiens 3,514 1,813 17,127 …. 392 18553 7 10.49 13904870 ribosomal protein S5 [Homo sapiens 3,512 1,812 9,786 14,345127 638 22862 12 9.73 223555975 tropomyosin 4 isoform 1 [Homo sapiens 3,454 1,788 8,359 …. 634 32703 27 4.69 4504425 high-mobility group box 1 [Homo sapiens 3,387 1,760 16,004 19,551529 348 24878 7 5.62 5031875 lamin A/C isoform 2 [Homo sapiens 3,383 1,758 8,905 …. 394 65096 18 6.40 24797097 pyrroline-5-carboxylate reductase 1 isoform 1 [Homo sapien 3,378 1,756 6,922 …. 146 33340 6 7.18 41322923 plectin 1 isoform 11 [Homo sapiens 3,370 1,753 19,585 …. 3630 515884 215 5.64 4503151 cathepsin K preproprotein [Homo sapiens 3,336 1,738 2,725 …. 1423 36942 5 8.72 4758018 calponin 2 isoform a [Homo sapiens 3,248 1,700 19,539 …. 68 33675 3 6.95 15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo sapien 3,216 1,685 5,280 …. 76 118317 14 6.67 4507879 voltage-dependent anion channel 1 [Homo sapiens 3,186 1,672 15,917 …. 999 30754 16 8.62 17158044 ribosomal protein S6 [Homo sapiens 3,172 1,665 6,521 4,9367952 281 28663 13 10.85 19923362 Thy-1 cell surface antigen preproprotein [Homo sapiens 3,157 1,659 3,269 …. 138 17923 2 8.96 153070260 myristoylated alanine-rich protein kinase C substrate [Homo sapien 3,142 1,652 12,193 …. 290 31536 6 4.47 47607492 plectin 1 isoform 1 [Homo sapiens 3,067 1,617 18,889 …. 2264 518157 160 5.60 4503509 eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa [Homo sapien 3,028 1,599 14,529 …. 341 166468 46 6.38 169404009 signal sequence receptor, alpha [Homo sapiens 2,987 1,579 7,989 …. 197 32215 3 4.39 6912634 ribosomal protein L13a [Homo sapiens 2,983 1,577 5,043 …. 43 23562 4 10.94 15431295 ribosomal protein L13 [Homo sapiens 2,977 1,574 16,734 …. 427 24247 9 11.65 4503285 aldo-keto reductase family 1, member C2 [Homo sapien 2,954 1,562 4,174 …. 439 36712 13 7.13 70995211 peroxisomal enoyl-coenzyme A hydratase-like protein [Homo sapien 2,938 1,555 4,926 17,39213 929 35793 12 8.16 16933542 fibronectin 1 isoform 3 preproprotein [Homo sapiens 2,930 1,551 18,989 …. 426 259063 21 5.49 4506617 ribosomal protein L17 [Homo sapiens 2,928 1,550 15,153 4,8734277 527 21383 8 10.18 4507943 exportin 1 [Homo sapiens 2,909 1,540 17,459 …. 364 123306 20 5.71 4503155 cathepsin L1 preproprotein [Homo sapiens 2,891 1,531 19,614 …. 206 37540 6 5.31 4885079 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma subunit isoform H (heart) precursor [ 2,883 1,527 2,485 …. 162 32860 15 9.31 4507813 UDP-glucose dehydrogenase [Homo sapiens 2,839 1,505 17,436 9,7297862 472 54989 14 6.73 17105394 ribosomal protein L23a [Homo sapiens 2,815 1,493 16,506 4,0694269 288 17684 8 10.44 4502303 mitochondrial ATP synthase, O subunit precursor [Homo sapiens 2,796 1,483 9,282 9,6389203 339 23263 11 9.97 110349772 alpha 1 type I collagen preproprotein [Homo sapien 2,769 1,469 18,346 3,976412 370 138827 31 5.60 28626510 reticulocalbin 3, EF-hand calcium binding domain [Homo sapien 2,737 1,453 17,915 10,780951 272 37470 5 4.74 5453601 cartilage associated protein precursor [Homo sapien 2,707 1,436 16,889 …. 206 46532 8 5.50 4506661 ribosomal protein L7a [Homo sapiens 2,704 1,435 8,134 17,197753 581 29977 13 10.61 4504437 heme oxygenase (decyclizing) 1 [Homo sapiens 2,690 1,428 14,863 17,282402 504 32798 13 7.88 4885409 high density lipoprotein binding protein [Homo sapien 2,652 1,407 19,312 …. 709 141352 49 6.43 31621305 leucine-rich PPR motif-containing protein [Homo sapiens 2,650 1,406 4,097 …. 581 157805 29 5.81 21389433 heat shock protein, alpha-crystallin-related, B6 [Homo sapien 2,604 1,381 7,142 …. 146 17125 5 5.95 19923748 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) [Homo sapie 2,600 1,379 5,799 3,4448973 222 48724 5 9.11 50845388 annexin A2 isoform 1 [Homo sapiens 2,579 1,367 19,783 16,027155 5158 40386 35 8.53 4506723 ribosomal protein S3a [Homo sapiens 2,563 1,358 19,347 14,335989 375 29926 20 9.75 5453559 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d isoform a [Homo sapien 2,554 1,353 16,085 6,1619578 535 18480 10 5.21 15431293 ribosomal protein L15 [Homo sapiens 2,513 1,329 0,023 10,005164 243 24131 9 11.62 115527062 alpha 2 type VI collagen isoform 2C2 precursor [Homo sapien 2,499 1,321 12,770 16,423874 80 108512 18 5.85 4506787 IQ motif containing GTPase activating protein 1 [Homo sapien 2,477 1,308 1,309 19,236696 1958 189134 58 6.08 4757810 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit precursor [Homo sapien 2,454 1,295 17,655 …. 847 59714 20 9.16 223890243 ribosomal protein L10 [Homo sapiens 2,452 1,294 19,768 0,6672304 653 24588 7 10.11 15055539 ribosomal protein S2 [Homo sapiens 2,430 1,281 19,917 8,4388353 883 31305 14 10.25 5453880 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A [Homo sapien 2,411 1,270 6,464 …. 137 28568 9 3.99 20070197 dolichyl-diphosphooligosaccharide-protein glycosyltransferase precursor [Homo sapien 2,378 1,250 18,009 …. 597 50670 15 5.96 50592994 thioredoxin [Homo sapiens 2,376 1,248 12,252 9,2444228 47 11730 3 4.82 7019485 programmed cell death 6 [Homo sapiens 2,369 1,244 15,194 …. 282 21855 6 5.16 29789373 hypothetical protein LOC92689 [Homo sapiens 2,353 1,234 12,829 8,0794201 282 60787 14 4.63 24797067 major histocompatibility complex, class I, A precursor [Homo sapien 2,336 1,224 11,431 …. 126 40815 7 5.66 19920317 cytoskeleton-associated protein 4 [Homo sapiens 2,333 1,222 19,984 4,0681785 2823 65983 35 5.63 87196339 collagen, type VI, alpha 1 precursor [Homo sapiens 2,317 1,212 17,277 15,463841 489 108462 16 5.26 4506901 splicing factor, arginine/serine-rich 3 [Homo sapiens 2,305 1,205 19,588 …. 90 19318 7 11.64 48762934 alpha 2 type I collagen [Homo sapiens 2,302 1,203 19,970 6,8368661 488 129235 25 9.08 62414289 vimentin [Homo sapiens 2,281 1,189 19,510 4,4496513 1260 53619 37 5.06 4506725 ribosomal protein S4, X-linked X isoform [Homo sapien 2,275 1,186 14,640 6,4971401 584 29579 14 10.16 47132587 protein kinase C, delta binding protein [Homo sapien 2,275 1,186 15,255 …. 257 27685 8 6.05 24307969 cytoplasmic FMR1 interacting protein 1 isoform a [Homo sapien 2,271 1,183 7,145 …. 147 145089 29 6.46 21396489 mitochondrial lon peptidase 1 [Homo sapiens 2,266 1,180 9,724 …. 248 106422 24 6.01 4885425 v-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 1 [Homo sapien 2,265 1,179 19,090 …. 152 21285 8 5.16 4506713 ubiquitin and ribosomal protein S27a precursor [Homo sapien 2,259 1,176 8,067 …. 400 17953 6 9.68 7305503 stomatin (EPB72)-like 2 [Homo sapiens 2,259 1,175 17,954 …. 228 38510 5 6.88 4506607 ribosomal protein L18 [Homo sapiens 2,257 1,175 0,734 6,0314119 1000 21621 10 11.73 8922699 CNDP dipeptidase 2 [Homo sapiens 2,252 1,171 8,105 …. 328 52746 19 5.58 61743954 AHNAK nucleoprotein isoform 1 [Homo sapiens 2,248 1,169 18,552 9,2694454 3062 628699 184 5.80 14141193 ribosomal protein S9 [Homo sapiens 2,225 1,154 11,273 19,015823 345 22578 16 10.66 4502209 ADP-ribosylation factor 5 [Homo sapiens 2,221 1,151 18,580 …. 979 20517 12 6.30 29171736 phosphatidic acid phosphatase type 2A isoform 1 [Homo sapien 2,211 1,145 15,708 …. 401 32135 2 8.10 4506663 ribosomal protein L8 [Homo sapiens 2,205 1,141 17,465 1,8975587 397 28007 13 11.03 11559923 eukaryotic translation initiation factor 4H isoform 1 [Homo sapien 2,195 1,135 7,975 …. 270 27368 12 6.67 16753227 ribosomal protein L6 [Homo sapiens 2,189 1,130 6,382 16,013227 1120 32708 17 10.59 14165435 heterogeneous nuclear ribonucleoprotein K isoform b [Homo sapien 2,180 1,125 13,405 17,387913 211 50944 16 5.39 6005721 ER lipid raft associated 2 isoform 1 [Homo sapiens 2,180 1,125 16,197 …. 350 37815 11 5.47 4506699 ribosomal protein S21 [Homo sapiens 2,179 1,124 16,033 …. 142 9106 3 8.68 5902076 splicing factor, arginine/serine-rich 1 isoform 1 [Homo sapien 2,178 1,123 17,832 …. 69 27728 9 10.37 4758208 dual specificity phosphatase 3 [Homo sapiens 2,172 1,119 18,560 …. 399 20465 9 7.66 16579885 ribosomal protein L4 [Homo sapiens 2,167 1,116 4,386 19,264566 348 47667 18 11.07 18765694 dipeptidylpeptidase IV [Homo sapiens 2,165 1,114 15,584 …. 340 88222 14 5.67 4506741 ribosomal protein S7 [Homo sapiens 2,156 1,108 19,888 7,7378625 581 22113 9 10.09 66346721 mitochondrial phosphoenolpyruvate carboxykinase 2 isoform 1 precursor [Homo sapien 2,149 1,104 15,677 13,162268 432 70685 14 7.57 24234747 interleukin enhancer binding factor 2 [Homo sapiens 2,136 1,095 8,380 …. 284 43035 7 5.19 24233517 IKK interacting protein isoform 1 [Homo sapiens 2,133 1,093 8,211 …. 427 43057 16 4.86 4506685 ribosomal protein S13 [Homo sapiens 2,127 1,089 4,936 11,479289 264 17212 6 10.53 4504445 heterogeneous nuclear ribonucleoprotein A1 isoform a [Homo sapien 2,123 1,086 19,196 …. 904 34175 10 9.27 15431303 ribosomal protein L9 [Homo sapiens 2,123 1,086 14,344 1,0961462 745 21850 11 9.96 42491362 IKK interacting protein isoform 2 [Homo sapiens 2,122 1,085 7,316 …. 258 39285 15 9.21 33469985 FK506 binding protein 9 [Homo sapiens 2,116 1,082 19,959 …. 130 63044 12 4.91 5174447 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 [Homo sapie 2,108 1,076 19,860 3,1624548 890 35055 12 7.60 78000181 ribosomal protein L14 [Homo sapiens 2,102 1,072 17,233 11,03766 512 23417 7 10.94 4506407 RAN binding protein 1 [Homo sapiens 2,080 1,056 16,415 …. 130 23296 6 5.19 15431288 ribosomal protein L10a [Homo sapiens 2,076 1,054 14,128 11,388413 518 24816 11 9.94 4506707 ribosomal protein S25 [Homo sapiens 2,075 1,053 8,198 7,0569687 178 13734 4 10.12 4506743 ribosomal protein S8 [Homo sapiens 2,068 1,048 19,110 14,234929 651 24190 10 10.32 4503525 eukaryotic translation initiation factor 3, subunit C [Homo sapien 2,064 1,045 11,576 …. 114 105278 17 5.48 119395729 cathepsin A isoform a precursor [Homo sapiens 2,063 1,045 0,723 …. 295 56197 5 6.17 4506695 ribosomal protein S19 [Homo sapiens 2,062 1,044 17,829 5,2926425 181 16051 11 10.31 15431290 ribosomal protein L11 [Homo sapiens 2,058 1,041 2,849 …. 353 20240 5 9.64 4506679 ribosomal protein S10 [Homo sapiens 2,052 1,037 18,791 10,311244 263 18886 9 10.15 4506649 ribosomal protein L3 isoform a [Homo sapiens 2,049 1,035 4,171 …. 150 46080 6 10.19 109148542 alanyl-tRNA synthetase [Homo sapiens 2,029 1,021 11,217 5,0783465 446 106743 18 5.34 17402893 phosphoserine aminotransferase 1 isoform 1 [Homo sapien 2,013 1,010 10,416 4,5561654 764 40397 19 7.56 4826686 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 [Homo sapiens 2,012 1,008 9,239 …. 136 82380 21 6.81 13236587 transmembrane protein 43 [Homo sapiens 2,011 1,008 19,079 2,5878512 531 44847 16 7.86 21361462 EH-domain containing 2 [Homo sapiens 2,008 1,006 12,198 15,755536 1142 61123 32 6.03 4502285 ATPase, Ca++ transporting, slow twitch 2 isoform 2 [Homo sapien 2,002 1,001 2,227 …. 114 109620 20 5.26 11415026 ribosomal protein L18a [Homo sapiens 1,997 0,998 16,650 6,9244527 53 20749 8 10.73 55749490 syntenin isoform 1 [Homo sapiens 1,982 0,987 7,962 3,950969 834 32424 7 7.05 14591909 ribosomal protein L5 [Homo sapiens 1,975 0,982 12,601 5,9108439 253 34341 12 9.73 5803187 transaldolase 1 [Homo sapiens 1,969 0,977 18,411 17,464557 844 37516 24 6.36 48255935 CD44 antigen isoform 1 precursor [Homo sapiens 1,959 0,970 6,909 5,7839123 311 81487 8 5.13 32454741 serine (or cysteine) proteinase inhibitor, clade H, member 1 precursor [Homo sapien 1,956 0,968 19,699 3,5424764 5072 46411 27 8.75 157168362 nucleoside phosphorylase [Homo sapiens 1,953 0,965 10,062 …. 247 32097 13 6.45 24497620 signal recognition particle 68kDa [Homo sapiens 1,949 0,963 13,386 …. 93 70686 13 8.75 23065552 glutathione S-transferase mu 3 [Homo sapiens 1,932 0,950 17,511 18,869252 908 26542 11 5.37 4506609 ribosomal protein L19 [Homo sapiens 1,928 0,947 19,727 11,451056 421 23451 12 11.48 41152086 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6 [Homo sapie 1,923 0,943 15,828 …. 733 42594 16 5.18 7705704 glutathione S-transferase kappa 1 isoform a [Homo sapien 1,916 0,938 13,953 4,5668741 647 25480 9 8.50 115430223 galectin 3 [Homo sapiens 1,915 0,937 19,286 17,244689 757 26136 7 8.57 26667180 calcium/calmodulin-dependent protein kinase II delta isoform 3 [Homo sapien 1,912 0,935 18,826 14,478932 249 56334 7 6.82 15431288 ribosomal protein L10a [Homo sapiens 1,909 0,933 16,137 …. 355 24816 12 9.94 52485853 integrin, alpha 11 precursor [Homo sapiens 1,908 0,932 13,988 …. 122 133386 13 6.24 7657441 PDGFA associated protein 1 [Homo sapiens 1,898 0,925 2,453 …. 181 20618 7 8.84 71565154 class III alcohol dehydrogenase, chi subunit [Homo sapien 1,897 0,924 0,133 8,6614374 24 39698 7 7.45 5174735 tubulin, beta, 2 [Homo sapiens 1,890 0,919 18,976 6,5230353 10395 49799 23 4.79 21361368 pyrroline-5-carboxylate synthetase isoform 1 [Homo sapien 1,885 0,915 18,298 …. 286 87248 20 6.66 32189394 mitochondrial ATP synthase beta subunit precursor [Homo sapien 1,883 0,913 15,101 2,7277226 3132 56525 27 5.26 4502105 annexin IV [Homo sapiens 1,875 0,907 13,862 1,6848842 1656 36062 25 5.84 13027378 glucosamine-6-phosphate deaminase 1 [Homo sapien 1,863 0,898 15,066 19,577031 482 32648 14 6.42 9845502 ribosomal protein SA [Homo sapiens 1,859 0,895 17,788 18,38469 959 32833 12 4.79 28178825 isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapien 1,854 0,891 2,235 …. 151 46630 8 6.53 40353734 nucleophosmin 1 isoform 2 [Homo sapiens 1,853 0,890 7,900 …. 498 29446 12 4.47 30240932 EH-domain containing 1 [Homo sapiens 1,845 0,883 15,963 …. 432 60589 21 6.35 40805868 tumor protein D52-like 2 isoform c [Homo sapiens 1,845 0,883 17,622 15,725704 562 23772 12 5.54 15431301 ribosomal protein L7 [Homo sapiens 1,831 0,873 16,115 3,4588952 338 29207 15 10.66 4502419 biliverdin reductase B (flavin reductase (NADPH)) [Homo sapiens 1,821 0,865 15,090 15,407087 758 22105 6 7.13 10190714 RAS-related protein RAB-22A [Homo sapiens 1,809 0,855 10,800 …. 110 21841 8 8.32 222352151 poly(rC) binding protein 1 [Homo sapiens 1,809 0,855 3,598 3,6881548 273 37474 9 6.66 94721252 vesicle-associated membrane protein-associated protein A isoform 2 [Homo sapien 1,804 0,852 14,646 11,593687 270 27875 11 8.80 4501853 acetyl-Coenzyme A acyltransferase 1 isoform a [Homo sapien 1,799 0,848 13,559 …. 583 44264 13 8.76 4826878 oxidative-stress responsive 1 [Homo sapiens] 1,797 0,846 19,157 …. 148 57986 10 6.03 15011936 ribosomal protein S26 [Homo sapiens] 1,796 0,845 12,267 …. 86 13007 6 11.01 4507951 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide [Homo sap 1,792 0,842 15,679 …. 992 28201 17 4.76 42734430 polymerase I and transcript release factor [Homo sapien 1,791 0,841 19,363 2,6484219 3259 43450 13 5.51 4506605 ribosomal protein L23 [Homo sapiens 1,783 0,834 8,262 …. 218 14856 5 10.51 4506667 ribosomal protein P0 [Homo sapiens 1,763 0,818 14,763 17,3671 403 34252 9 5.71 5453990 proteasome activator subunit 1 isoform 1 [Homo sapien 1,740 0,799 18,683 15,189472 401 28705 17 5.78 15718687 ribosomal protein S3 [Homo sapiens 1,738 0,798 11,944 4,236635 609 26671 17 9.68 14043072 heterogeneous nuclear ribonucleoprotein A2/B1 isoform B1 [Homo sapien 1,737 0,797 19,166 1,3960037 1860 37407 20 8.97 21361399 alpha isoform of regulatory subunit A, protein phosphatase 2 [Homo sapien 1,723 0,785 11,858 12,478124 128 65267 12 5.00 4503727 FK506 binding protein 3, 25kDa [Homo sapiens 1,721 0,783 18,227 15,080135 147 25161 7 9.29 4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sapiens 1,719 0,782 5,922 …. 191 56659 10 6.46 4504981 galectin-1 [Homo sapiens 1,719 0,782 10,220 …. 8114 14706 6 5.34 7706337 coatomer protein complex, subunit zeta 1 [Homo sapien 1,712 0,776 11,780 …. 274 20185 5 4.69 11345462 signal peptidase complex subunit 3 [Homo sapien 1,710 0,774 3,013 0,8673878 125 20301 4 8.67 4507947 tyrosyl-tRNA synthetase [Homo sapiens 1,709 0,773 12,835 …. 206 59106 26 6.61 7661714 family with sequence similarity 3, member C precursor [Homo sapien 1,706 0,770 12,713 2,1092174 525 24665 7 8.52 110611218 ribosome binding protein 1 [Homo sapiens 1,699 0,765 18,988 2,2533901 561 108589 34 5.45 5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens 1,688 0,755 10,077 …. 424 47337 16 5.09 7705813 ribosomal protein L26-like 1 [Homo sapiens 1,683 0,751 14,846 …. 141 17246 10 10.55 4507357 transgelin 2 [Homo sapiens 1,681 0,749 13,221 9,6730102 4263 22377 12 8.41 19923315 serine hydroxymethyltransferase 2 (mitochondrial) [Homo sapien 1,678 0,747 17,905 …. 335 55958 16 8.76 4502565 calpain, small subunit 1 [Homo sapiens 1,657 0,729 19,683 5,6051676 1957 28298 11 5.05 153945728 microtubule-associated protein 1B [Homo sapiens 1,656 0,727 19,876 7,3215053 223 270468 28 4.73 4504981 galectin-1 [Homo sapiens 1,655 0,727 19,580 5,4669162 3745 14706 4 5.34 13569879 acidic (leucine-rich) nuclear phosphoprotein 32 family, member E isoform 1 [Homo sapien 1,647 0,720 10,287 …. 137 30674 5 3.77 126012562 low density lipoprotein-related protein 1 [Homo sapien 1,636 0,710 18,706 7,7610861 507 504276 35 5.16 124494240 myosin IC isoform c [Homo sapiens 1,617 0,693 4,687 15,056872 279 117834 14 9.46 4758158 septin 2 [Homo sapiens 1,617 0,693 15,525 19,382583 793 41461 14 6.15 4506691 ribosomal protein S16 [Homo sapiens 1,606 0,683 11,438 2,070463 189 16435 11 10.21 110624774 mannose receptor, C type 2 [Homo sapiens 1,600 0,678 2,141 …. 140 166568 9 5.54 5803227 tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide [Homo sapie 1,597 0,675 17,318 6,6126314 1952 27747 18 4.68 170763498 SET translocation (myeloid leukemia-associated) isoform 2 [Homo sapien 1,592 0,671 18,130 …. 140 32084 7 4.12 21269877 cysteinyl-tRNA synthetase isoform a [Homo sapiens 1,590 0,669 9,505 …. 217 82794 12 6.59 224809468 retinoic acid induced 14 isoform a [Homo sapiens 1,576 0,657 9,164 …. 76 109973 27 5.87 4507115 fascin 1 [Homo sapiens 1,573 0,653 15,133 19,411421 712 54496 20 6.84 4504511 DnaJ (Hsp40) homolog, subfamily A, member 1 [Homo sapien 1,572 0,652 5,486 …. 140 44839 10 6.65 4758868 prolyl 4-hydroxylase, alpha II subunit isoform 1 precursor [Homo sapien 1,566 0,647 11,161 …. 225 60864 12 5.49 13027378 glucosamine-6-phosphate deaminase 1 [Homo sapien 1,566 0,647 8,975 …. 227 32648 9 6.42 33469966 vesicle transport-related protein isoform a [Homo sapien 1,563 0,644 9,184 …. 195 72334 18 5.89 4504041 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [Homo sapie 1,559 0,641 17,935 …. 1301 40425 11 5.34 21536286 brain creatine kinase [Homo sapiens 1,555 0,637 17,936 …. 395 42617 10 5.34 7657649 tropomodulin 3 (ubiquitous) [Homo sapiens 1,550 0,632 8,687 13,511774 516 39570 17 5.08 62241042 glutamyl-prolyl tRNA synthetase [Homo sapiens 1,547 0,629 13,222 0,1851182 615 170483 31 7.02 5901922 cell division cycle 37 protein [Homo sapiens 1,540 0,623 9,746 …. 177 44440 12 5.17 8923579 hypothetical protein LOC55004 [Homo sapiens 1,539 0,622 19,794 12,141141 99 17734 4 5.01 14251209 chloride intracellular channel 1 [Homo sapiens 1,536 0,619 12,198 3,6935026 855 26906 9 5.09 8922673 parvin, alpha [Homo sapiens 1,534 0,618 18,190 …. 411 42217 14 5.69 19923483 GTPase Rab14 [Homo sapiens 1,530 0,614 19,255 14,569642 899 23882 12 5.85 11321585 guanine nucleotide-binding protein, beta-1 subunit [Homo sapien 1,530 0,613 8,227 …. 162 37353 7 5.60 21361547 ribonuclease/angiogenin inhibitor [Homo sapiens 1,529 0,612 17,306 7,6618693 736 49941 10 4.71 4507143 sorting nexin 3 isoform a [Homo sapiens 1,526 0,609 19,366 …. 142 18751 9 8.71 116256327 membrane metallo-endopeptidase [Homo sapien 1,523 0,607 5,906 4,8544711 494 85460 18 5.54 20149594 heat shock 90kDa protein 1, beta [Homo sapiens 1,523 0,607 11,534 12,770122 2797 83212 43 4.97 4758762 asparaginyl-tRNA synthetase [Homo sapiens 1,517 0,601 15,976 …. 504 62903 5 5.90 5730023 RuvB-like 2 [Homo sapiens 1,517 0,601 17,926 …. 313 51125 21 5.49 15451856 caveolin 1 [Homo sapiens 1,515 0,600 16,844 1,920425 665 20458 13 5.65 10835063 nucleophosmin 1 isoform 1 [Homo sapiens 1,515 0,599 19,111 9,6748423 1068 32555 13 4.64 12025678 actinin, alpha 4 [Homo sapiens 1,514 0,599 14,513 2,8971162 3638 104788 58 5.27 4827050 ubiquitin specific protease 14 isoform a [Homo sapien 1,514 0,598 7,449 …. 175 56033 20 5.20 4757774 ADP-ribosylation factor-like 3 [Homo sapiens 1,512 0,596 10,965 …. 457 20443 6 6.74 19923233 sterol carrier protein 2 isoform 1 proprotein [Homo sapien 1,510 0,595 17,076 …. 32 100354 11 8.49 94721239 isoleucine tRNA synthetase [Homo sapiens 1,510 0,594 10,824 0,4263535 407 144406 24 5.82 47933379 N-ethylmaleimide-sensitive factor attachment protein, alpha [Homo sapien 1,502 0,587 16,676 15,872223 452 33211 13 5.23 23397427 synaptotagmin binding, cytoplasmic RNA interacting protein [Homo sapien 1,502 0,586 18,460 …. 449 69590 19 8.68 33356163 eukaryotic translation initiation factor 1A, Y chromosome [Homo sapien 1,498 0,583 8,039 …. 132 16432 5 5.07 4507729 tubulin, beta 2 [Homo sapiens 1,497 0,582 11,032 19,887795 2740 49875 22 4.78 5453555 ras-related nuclear protein [Homo sapiens 1,495 0,580 18,999 8,6297347 204 24408 6 7.01 4503471 eukaryotic translation elongation factor 1 alpha 1 [Homo sapien 1,494 0,579 19,926 9,0435044 2706 50109 12 9.10 5803013 endoplasmic reticulum protein 29 isoform 1 precursor [Homo sapien 1,491 0,576 16,899 …. 760 28975 13 6.77 4507789 ubiquitin-conjugating enzyme E2L 3 isoform 1 [Homo sapien 1,490 0,575 8,961 …. 283 17850 4 8.68 17986283 tubulin, alpha 1a [Homo sapiens 1,487 0,572 19,242 …. 2493 50104 14 4.94 8659555 aconitase 1 [Homo sapiens 1,485 0,571 15,589 …. 330 98337 16 6.23 21361091 ubiquitin carboxyl-terminal esterase L1 [Homo sapien 1,484 0,569 19,038 13,439852 1356 24808 11 5.33 169210992 PREDICTED: hypothetical protein LOC100131693 [Homo sapiens 1,483 0,568 10,272 …. 121 25111 4 6.00 13376181 tubulin, alpha-like 3 [Homo sapiens 1,482 0,568 3,422 …. 95 49877 8 5.68 4757838 BCL2-associated X protein isoform beta [Homo sapiens 1,480 0,565 15,029 …. 478 24204 9 7.74 4503583 epoxide hydrolase 1 [Homo sapiens 1,467 0,552 4,861 …. 305 52915 14 6.77 8923458 COMM domain containing 8 [Homo sapiens 1,466 0,552 18,405 …. 391 21077 7 5.29 22749479 canopy 4 homolog [Homo sapiens 1,462 0,548 12,702 …. 234 28292 6 4.60 4502049 aldo-keto reductase family 1, member B1 [Homo sapien 1,459 0,545 13,779 …. 364 35830 16 6.51 23397429 eukaryotic translation initiation factor 3, subunit M [Homo sapien 1,458 0,544 9,969 …. 343 42476 11 5.41 219555707 eukaryotic translation initiation factor 5A isoform A [Homo sapien 1,456 0,542 14,061 11,50446 506 24170 8 9.25 4506019 alpha isoform of regulatory subunit B55, protein phosphatase 2 [Homo sapien 1,455 0,541 18,108 …. 212 51659 10 5.82 4826960 glutaminyl-tRNA synthetase [Homo sapiens 1,452 0,538 18,251 …. 213 87743 20 6.71 4503515 eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa [Homo sapien 1,452 0,538 16,718 15,21209 279 39905 15 6.09 4757880 budding uninhibited by benzimidazoles 3 isoform a [Homo sapien 1,452 0,538 15,957 …. 257 37131 9 6.36 4557537 developmentally regulated GTP binding protein 2 [Homo sapien 1,448 0,534 18,241 …. 327 40720 12 9.02 33946329 ras related v-ral simian leukemia viral oncogene homolog A [Homo sapien 1,446 0,532 17,831 …. 514 23552 11 6.66 10864011 sulfide dehydrogenase like [Homo sapiens 1,445 0,531 15,494 7,6527933 281 49929 12 9.18 37594464 nudix-type motif 5 [Homo sapiens 1,443 0,529 15,098 …. 523 24312 4 4.87 29725611 protein phosphatase 2A, regulatory subunit B' isoform b [Homo sapien 1,438 0,524 1,855 …. 130 36752 6 5.89 23308579 prostaglandin-E synthase 3 [Homo sapiens 1,436 0,522 19,773 …. 180 18685 6 4.35 211904152 plasminogen activator inhibitor type 1, member 2 isoform b precursor [Homo sapie 1,428 0,514 19,783 …. 252 43972 10 9.42 25777602 proteasome 26S non-ATPase subunit 2 [Homo sapiens 1,425 0,511 12,809 …. 332 100136 23 5.08 5454028 related RAS viral (r-ras) oncogene homolog [Homo sapien 1,425 0,511 12,179 15,405436 777 23466 12 6.43 24497435 proteasome 26S ATPase subunit 5 [Homo sapiens 1,418 0,504 9,565 11,583319 277 45597 16 7.11 6274552 signal transducer and activator of transcription 1 isoform alpha [Homo sapien 1,415 0,500 18,559 12,493383 1081 87280 39 5.74 7524354 dimethylarginine dimethylaminohydrolase 2 [Homo sapien 1,411 0,497 12,713 16,40054 665 29625 7 5.66 10801345 eukaryotic translation initiation factor 3, subunit 12 [Homo sapien 1,410 0,495 18,474 7,8343272 274 25043 7 4.81 112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo sapien 1,409 0,494 14,642 17,109306 702 274439 63 5.39 7661568 phosphoglucomutase 3 [Homo sapiens 1,408 0,494 6,716 …. 106 59814 8 5.84 4826898 profilin 1 [Homo sapiens 1,404 0,489 7,251 7,1449569 3137 15045 12 8.44 4503097 casein kinase 2, alpha prime polypeptide [Homo sapien 1,403 0,489 4,006 …. 93 41187 7 8.65 4503095 casein kinase II alpha 1 subunit isoform a [Homo sapien 1,403 0,489 12,459 …. 211 45115 12 7.29 25777615 proteasome 26S non-ATPase subunit 7 [Homo sapiens 1,403 0,488 11,505 6,2059149 720 37002 14 6.29 223029410 talin 1 [Homo sapiens 1,402 0,488 19,049 4,2198786 2036 269599 80 5.77 4758086 cysteine and glycine-rich protein 1 isoform 1 [Homo sapien 1,400 0,485 17,225 …. 635 20554 6 8.90 47419914 tryptophanyl-tRNA synthetase isoform a [Homo sapiens 1,399 0,484 13,915 15,988344 327 53132 13 5.83 11968182 ribosomal protein S18 [Homo sapiens 1,399 0,484 7,927 17,608838 114 17708 10 10.99 4557839 phosphomannomutase 2 [Homo sapiens 1,398 0,483 12,919 …. 72 28064 10 6.35 28872725 proteasome 26S non-ATPase subunit 11 [Homo sapiens 1,397 0,483 18,949 16,046513 502 47434 18 6.08 38027923 COP9 signalosome subunit 5 [Homo sapiens 1,397 0,483 15,173 …. 162 37555 8 6.10 6912594 phosphatidylinositol transfer protein, beta [Homo sapien 1,397 0,482 10,015 …. 144 31520 14 6.41 4759034 eukaryotic translation termination factor 1 [Homo sapien 1,392 0,477 17,804 …. 256 49000 14 5.51 148536855 coatomer protein complex, subunit alpha isoform 1 [Homo sapien 1,391 0,476 18,308 19,258717 469 139235 33 7.53 23110942 proteasome alpha 5 subunit [Homo sapiens 1,390 0,475 11,987 13,269471 870 26394 7 4.74 38373690 COP9 signalosome subunit 4 [Homo sapiens 1,388 0,473 18,783 …. 367 46240 18 5.57 13775198 SH3 domain binding glutamic acid-rich protein like 3 [Homo sapien 1,388 0,473 12,276 …. 194 10431 5 4.82 7705885 vacuolar protein sorting 28 isoform 1 [Homo sapiens 1,388 0,473 14,578 …. 252 25409 7 5.37 22027538 programmed cell death 6 interacting protein isoform 1 [Homo sapien 1,381 0,466 16,730 12,197621 675 95963 30 6.13 4506005 protein phosphatase 1, catalytic subunit, beta isoform 1 [Homo sapien 1,377 0,462 18,384 …. 778 37163 14 5.84 33620775 kinectin 1 isoform a [Homo sapiens 1,375 0,460 0,792 11,036593 350 156179 30 5.52 24797086 importin 5 [Homo sapiens 1,374 0,459 15,636 4,8449553 1252 125464 34 4.80 4506455 reticulocalbin 1 precursor [Homo sapiens 1,374 0,458 5,556 …. 159 38866 11 4.86 9910280 UDP-glucose ceramide glucosyltransferase-like 1 [Homo sapien 1,373 0,457 19,621 2,5493972 953 177078 37 5.42 28416940 Shwachman-Bodian-Diamond syndrome protein [Homo sapien 1,372 0,457 17,558 17,237951 193 28745 11 8.91 5031635 cofilin 1 (non-muscle) [Homo sapiens 1,367 0,451 16,609 …. 1194 18491 7 8.22 6996014 histidyl-tRNA synthetase [Homo sapiens 1,362 0,446 16,983 …. 263 57374 23 5.72 4758950 peptidylprolyl isomerase B precursor [Homo sapien 1,360 0,444 18,079 16,252594 2184 23728 14 9.42 4502599 carbonyl reductase 1 [Homo sapiens 1,356 0,439 17,944 2,2048262 1648 30356 13 8.55 19923142 karyopherin beta 1 [Homo sapiens 1,355 0,439 5,052 6,1653035 779 97108 27 4.68 21040371 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 [Homo sapiens 1,354 0,437 14,208 …. 171 49098 11 5.46 55770888 early endosome antigen 1, 162kD [Homo sapiens 1,349 0,432 14,346 …. 1504 162367 66 5.53 48762932 chaperonin containing TCP1, subunit 8 (theta) [Homo sapiens 1,348 0,431 19,225 6,1058264 253 59583 10 5.42 4557541 torsin A [Homo sapiens 1,346 0,429 4,199 …. 184 37784 10 6.51 4506181 proteasome subunit alpha type 2 [Homo sapiens 1,344 0,427 15,409 1,5951832 1668 25882 12 6.92 4503165 cullin 3 [Homo sapiens 1,342 0,424 7,058 …. 101 88873 20 8.68 4502201 ADP-ribosylation factor 1 [Homo sapiens 1,341 0,423 15,224 5,4365427 1788 20684 10 6.32 21361370 brain glycogen phosphorylase [Homo sapiens 1,340 0,422 16,935 13,481228 592 96635 34 6.40 40068518 phosphogluconate dehydrogenase [Homo sapiens 1,340 0,422 15,131 18,867227 874 53106 17 6.80 4503117 cystatin B [Homo sapiens 1,333 0,415 3,729 2,4358405 294 11133 5 6.96 41872631 fatty acid synthase [Homo sapiens 1,331 0,413 17,562 …. 808 273254 44 6.01 4505621 prostatic binding protein [Homo sapiens 1,329 0,410 19,784 …. 1722 21044 10 7.01 23110944 proteasome alpha 6 subunit [Homo sapiens 1,328 0,409 16,582 15,440126 1157 27382 10 6.34 4503377 dihydropyrimidinase-like 2 [Homo sapiens 1,327 0,408 19,967 …. 1997 62255 24 5.95 4759270 translin [Homo sapiens 1,325 0,406 18,943 …. 338 26167 8 6.01 5803013 endoplasmic reticulum protein 29 isoform 1 precursor [Homo sapien 1,323 0,404 15,666 17,873291 780 28975 10 6.77 4502643 chaperonin containing TCP1, subunit 6A isoform a [Homo sapiens 1,322 0,403 19,611 …. 837 57988 23 6.23 6912238 peroxiredoxin 5 isoform a precursor [Homo sapien 1,321 0,401 16,631 1,8447888 579 22012 10 8.85 5454090 signal sequence receptor, delta [Homo sapiens 1,319 0,400 6,698 …. 73 43916 5 6.06 38202255 threonyl-tRNA synthetase [Homo sapiens 1,317 0,397 19,215 14,953806 294 83382 13 6.23 4503507 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa [Homo sapien 1,316 0,397 19,316 …. 92 51077 11 8.66 4758988 RAB1A, member RAS oncogene family isoform 1 [Homo sapiens 1,311 0,390 9,113 …. 2788 22663 13 5.93 157389005 calpain 2 isoform 1 [Homo sapiens 1,310 0,390 12,046 5,0352012 229 79959 6 4.88 4506055 cAMP-dependent protein kinase catalytic subunit alpha isoform 1 [Homo sapien 1,309 0,388 17,926 …. 287 40564 18 8.84 4885539 protein-L-isoaspartate (D-aspartate) O-methyltransferase [Homo sapien 1,306 0,385 19,473 14,709777 663 24621 12 6.70 25777612 proteasome 26S non-ATPase subunit 3 [Homo sapiens 1,306 0,385 11,066 3,3719905 396 60939 24 8.47 33519426 thioredoxin reductase 1 isoform 2 [Homo sapiens 1,295 0,373 17,743 …. 306 54720 12 6.07 25777600 proteasome 26S non-ATPase subunit 1 [Homo sapiens 1,294 0,372 11,446 …. 410 105769 23 5.25 83700235 eukaryotic translation initiation factor 4A2 [Homo sapiens 1,293 0,371 2,584 2,4701723 129 46373 4 5.33 4557237 acetyl-Coenzyme A acetyltransferase 1 precursor [Homo sapien 1,293 0,371 16,616 2,8330865 319 45171 10 8.98 29029559 CSE1 chromosome segregation 1-like protein [Homo sapien 1,292 0,370 5,637 …. 403 110346 21 5.51 4502551 calumenin isoform a precursor [Homo sapiens 1,292 0,369 18,718 …. 474 37084 17 4.47 67782305 manganese superoxide dismutase isoform A precursor [Homo sapien 1,291 0,368 19,376 6,836533 2252 24735 11 8.35 109148508 otubain 1 [Homo sapiens 1,289 0,367 11,272 16,885449 194 31264 5 4.85 13259510 dynactin 1 isoform 1 [Homo sapiens 1,288 0,365 3,895 …. 351 141607 43 5.61 4506013 protein phosphatase 1, regulatory subunit 7 [Homo sapien 1,288 0,365 18,595 …. 369 41539 14 4.84 34147513 RAB7, member RAS oncogene family [Homo sapiens 1,285 0,361 19,675 13,363547 1705 23475 17 6.40 39725636 transmembrane emp24 protein transport domain containing 9 [Homo sapien 1,284 0,360 10,936 8,4029605 365 27260 10 7.82 4758516 hepatoma-derived growth factor isoform a [Homo sapien 1,281 0,357 7,875 …. 145 26772 12 4.70 34147630 Tu translation elongation factor, mitochondrial precursor [Homo sapien 1,279 0,355 7,811 18,022244 394 49843 16 7.26 4506243 polypyrimidine tract-binding protein 1 isoform a [Homo sapien 1,276 0,352 17,450 …. 679 59596 12 9.21 4506221 proteasome 26S non-ATPase subunit 12 isoform 1 [Homo sapiens 1,276 0,352 17,450 …. 765 52871 20 7.53 8392875 transcription factor IIB [Homo sapiens 1,275 0,350 0,046 …. 184 22760 4 9.78 4505591 peroxiredoxin 1 [Homo sapiens 1,273 0,348 19,757 5,3789217 1968 22096 18 8.27 4507761 ubiquitin and ribosomal protein L40 precursor [Homo sapien 1,271 0,346 17,938 …. 184 14719 5 9.87 14210536 tubulin, beta 6 [Homo sapiens 1,270 0,344 12,984 3,3515809 3895 49825 22 4.77 41349439 SEC31 homolog A isoform 1 [Homo sapiens 1,267 0,342 13,895 …. 218 132931 20 6.43 19913410 major vault protein [Homo sapiens 1,265 0,339 1,399 12,065369 1192 99266 42 5.34 4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapien 1,263 0,337 18,930 5,4282407 338 79636 24 8.96 156564401 vesicle-fusing ATPase [Homo sapiens 1,262 0,335 12,935 2,5843977 182 82542 11 6.52 13569962 RAB1B, member RAS oncogene family [Homo sapiens 1,261 0,335 16,084 4,9853268 2664 22157 15 5.55 4504067 aspartate aminotransferase 1 [Homo sapiens 1,261 0,335 16,339 11,78235 665 46219 22 6.52 4557469 adaptor-related protein complex 2, beta 1 subunit isoform b [Homo sapien 1,257 0,330 17,691 13,182934 524 104486 21 5.22 14043022 methionyl-tRNA synthetase [Homo sapiens 1,251 0,323 19,109 2,7798182 224 101052 11 5.82 30410792 proteasome activator subunit 2 [Homo sapiens 1,251 0,323 10,465 5,6560911 661 27384 7 5.54 28570172 NADP-dependent leukotriene B4 12-hydroxydehydrogenase [Homo sapien 1,250 0,322 6,949 3,8147615 362 35863 12 8.45 4503895 galactokinase 1 [Homo sapiens 1,250 0,322 19,702 8,5712864 203 42246 12 6.04 41327764 aldo-keto reductase family 7, member A2 [Homo sapien 1,247 0,318 15,458 16,349277 327 39564 11 6.70 7305053 myoferlin isoform a [Homo sapiens 1,247 0,318 19,527 8,6172742 3064 234561 84 5.84 5802966 destrin isoform a [Homo sapiens 1,246 0,317 10,707 1,7022503 1325 47239 10 4.91 4505257 moesin [Homo sapiens 1,246 0,317 19,636 0,0424246 1826 67778 51 6.08 19913414 adaptor-related protein complex 2, alpha 1 subunit isoform 1 [Homo sapien 1,244 0,315 17,771 14,503931 397 107478 29 6.63 15149476 arginyl-tRNA synthetase [Homo sapiens 1,243 0,314 8,946 15,829452 272 75331 26 6.26 4759264 COP9 constitutive photomorphogenic homolog subunit 2 isoform 1 [Homo sapien 1,243 0,314 19,304 0,4327804 359 51564 18 5.36 12408656 calpain 1, large subunit [Homo sapiens 1,241 0,311 18,782 …. 502 81838 25 5.49 7657603 heme binding protein 2 [Homo sapiens 1,239 0,309 8,690 …. 350 22861 6 4.58 24430151 proteasome 26S ATPase subunit 1 [Homo sapiens 1,236 0,306 5,226 8,5210932 501 49154 16 5.87 116805340 glycyl-tRNA synthetase [Homo sapiens 1,236 0,306 13,967 5,4632323 309 83113 19 6.61 91199540 dihydrolipoamide dehydrogenase precursor [Homo sapien 1,235 0,304 7,638 10,437393 229 54143 11 7.95 17978519 vacuolar protein sorting 26 A isoform 1 [Homo sapiens 1,234 0,304 13,449 5,9204271 294 38146 11 6.13 38569423 ATP citrate lyase isoform 2 [Homo sapiens 1,232 0,301 8,265 …. 476 119695 25 6.95 5802966 destrin isoform a [Homo sapiens 1,231 0,300 13,244 …. 293 18493 7 8.06 38569421 ATP citrate lyase isoform 1 [Homo sapiens 1,230 0,299 18,549 …. 1020 120762 42 6.95 148727341 serine/threonine kinase receptor associated protein [Homo sapien 1,229 0,298 17,403 2,643195 610 38414 13 4.98 22538465 proteasome beta 3 subunit [Homo sapiens 1,226 0,294 17,760 12,969033 1523 22933 12 6.14 158937236 aminopeptidase puromycin sensitive [Homo sapien 1,225 0,293 5,729 2,7501997 343 103211 20 5.49 4758256 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [Homo sapien 1,223 0,291 12,590 …. 413 36089 15 5.02 20357529 guanine nucleotide-binding protein, beta-2 subunit [Homo sapien 1,223 0,290 6,231 …. 317 37307 11 5.60 19913432 ATPase, H+ transporting, lysosomal, V0 subunit d1 [Homo sapiens 1,222 0,289 5,229 2,0824764 177 40303 10 4.89 4507953 tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide [Homo sapie 1,221 0,289 19,301 11,548273 4120 27728 24 4.73 4758648 kinesin family member 5B [Homo sapiens 1,218 0,284 11,520 …. 588 109617 38 6.12 4759270 translin [Homo sapiens 1,216 0,283 10,340 12,636285 611 26167 9 6.01 11125770 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 [Homo sapien 1,216 0,283 18,667 …. 63 35326 4 8.45 21361794 TIP120 protein [Homo sapiens 1,215 0,281 13,858 5,6426702 839 136289 30 5.52 11055992 serine carboxypeptidase 1 precursor [Homo sapien 1,215 0,281 3,755 11,167096 371 50798 7 5.61 31542319 epsilon subunit of coatomer protein complex isoform a [Homo sapien 1,214 0,280 19,578 …. 1210 34460 10 4.97 5032117 sigma non-opioid intracellular receptor 1 isoform 1 [Homo sapien 1,213 0,279 12,616 4,8570224 198 25112 3 5.61 4826659 F-actin capping protein beta subunit [Homo sapiens 1,212 0,277 19,291 6,6227211 1084 30609 13 5.69 157502193 proteasome 26S non-ATPase subunit 13 isoform 1 [Homo sapiens 1,207 0,271 12,817 1,0614791 331 42918 13 5.53 4506365 RAB2A, member RAS oncogene family [Homo sapiens 1,204 0,268 17,944 …. 61 23531 2 6.08 4506183 proteasome alpha 3 subunit isoform 1 [Homo sapien 1,201 0,264 17,061 0,9015937 357 28415 9 5.19 48255957 plasma membrane calcium ATPase 4 isoform 4b [Homo sapien 1,195 0,257 17,630 …. 299 133846 13 6.04 4507949 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [Homo sa 1,192 0,254 17,205 …. 1968 28065 18 4.76 7705369 coatomer protein complex, subunit beta 1 [Homo sapien 1,192 0,254 17,977 11,866934 532 107074 32 5.72 5032007 purine-rich element binding protein A [Homo sapien 1,191 0,252 6,922 …. 191 34889 7 6.07 38455427 chaperonin containing TCP1, subunit 4 (delta) [Homo sapiens 1,191 0,252 13,446 6,0668053 631 57888 23 7.96 4506189 proteasome alpha 7 subunit [Homo sapiens 1,187 0,248 17,701 0,6944624 1025 27870 12 8.60 5453603 chaperonin containing TCP1, subunit 2 [Homo sapiens 1,186 0,246 19,599 6,2795197 1293 57452 25 6.01 4506179 proteasome alpha 1 subunit isoform 2 [Homo sapien 1,183 0,243 11,326 …. 227 29537 13 6.15 17999541 vacuolar protein sorting 35 [Homo sapiens 1,183 0,243 7,857 11,297946 684 91649 27 5.32 55956788 nucleolin [Homo sapiens 1,181 0,240 16,710 6,3071636 445 76568 16 4.60 5803225 tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide [Homo sapie 1,177 0,236 19,647 1,1389787 4222 29155 24 4.63 215490011 small inducible cytokine subfamily E, member 1 isoform b precursor [Homo sapien 1,177 0,235 12,350 …. 108 37016 7 8.83 11559929 coatomer protein complex, subunit gamma 1 [Homo sapien 1,177 0,235 14,194 1,0529457 734 97655 31 5.32 37594471 3-hydroxyisobutyryl-Coenzyme A hydrolase isoform 1 [Homo sapien 1,176 0,234 15,152 14,444751 282 43454 12 8.38 42734438 hypothetical protein LOC51571 [Homo sapiens 1,174 0,231 9,286 8,6642342 183 36725 11 5.76 4758484 glutathione-S-transferase omega 1 [Homo sapiens 1,173 0,230 18,097 …. 410 27548 14 6.23 116256489 septin 9 isoform c [Homo sapiens 1,170 0,227 0,230 …. 149 63626 9 8.56 5454158 valyl-tRNA synthetase [Homo sapiens 1,170 0,226 10,719 18,347155 459 140387 21 7.53 4503529 eukaryotic translation initiation factor 4A isoform 1 [Homo sapien 1,168 0,224 18,130 5,2640339 1296 46125 20 5.32 71773329 annexin VI isoform 1 [Homo sapiens 1,168 0,224 18,209 12,731418 3100 75826 38 5.42 4503379 dihydropyrimidinase-like 3 [Homo sapiens 1,166 0,221 17,973 15,797221 870 61924 19 6.04 19923231 RAB6A, member RAS oncogene family isoform a [Homo sapien 1,157 0,211 19,660 9,4380437 967 23534 13 5.42 154146191 heat shock 90kDa protein 1, alpha isoform 2 [Homo sapiens 1,157 0,211 19,163 1,0091803 2295 84607 39 4.94 31542319 epsilon subunit of coatomer protein complex isoform a [Homo sapien 1,155 0,208 17,632 …. 509 34460 16 4.97 4758582 isocitrate dehydrogenase 3 (NAD+) gamma isoform a precursor [Homo sapien 1,155 0,207 15,932 …. 122 42767 8 8.75 38327039 heat shock 70kDa protein 4 [Homo sapiens 1,152 0,205 18,392 …. 1109 94271 37 5.11 24307939 chaperonin containing TCP1, subunit 5 (epsilon) [Homo sapiens 1,149 0,201 17,220 18,327877 909 59633 22 5.45 4758952 protein phosphatase 2, catalytic subunit, beta isoform [Homo sapien 1,149 0,201 17,005 …. 203 35552 10 5.21 5174419 caseinolytic peptidase, ATP-dependent, proteolytic subunit precursor [Homo sapien 1,148 0,200 1,230 …. 289 30161 6 8.26 4504169 glutathione synthetase [Homo sapiens 1,148 0,199 14,031 …. 363 52352 15 5.67 5453607 chaperonin containing TCP1, subunit 7 isoform a [Homo sapiens 1,147 0,198 13,930 11,837337 880 59329 19 7.55 5453908 phosphatidylinositol transfer protein, alpha [Homo sapien 1,144 0,195 15,434 11,816191 428 31786 11 6.11 208973246 quinoid dihydropteridine reductase [Homo sapien 1,144 0,194 8,540 …. 281 25773 10 6.90 4503483 eukaryotic translation elongation factor 2 [Homo sapien 1,143 0,193 19,346 2,5438427 1903 95277 44 6.41 4503519 eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa [Homo sapien 1,139 0,187 18,512 18,641334 686 37540 8 5.24 61742819 dCMP deaminase isoform b [Homo sapiens 1,133 0,180 18,126 …. 46 55047 3 6.57 4759274 thioredoxin-like 1 [Homo sapiens 1,126 0,171 11,135 …. 322 32231 10 4.84 4757900 calreticulin precursor [Homo sapiens 1,126 0,171 13,194 17,092975 1577 48112 17 4.29 4826952 proteasome 26S non-ATPase subunit 5 [Homo sapiens 1,121 0,165 18,955 17,68185 544 56160 15 5.35 205277386 glucosamine-fructose-6-phosphate aminotransferase [Homo sapien 1,120 0,163 17,305 1,5533185 548 76710 22 6.39 4502899 clathrin, light polypeptide A isoform a [Homo sapien 1,120 0,163 13,126 …. 173 23647 9 4.45 19923262 RAB5A, member RAS oncogene family [Homo sapiens 1,119 0,163 9,647 …. 535 23644 13 8.32 190358517 RAB11B, member RAS oncogene family [Homo sapiens 1,117 0,160 17,966 2,880425 1620 24473 14 5.64 33695095 ras-related GTP-binding protein RAB10 [Homo sapiens 1,116 0,159 17,886 2,4282641 433 22455 8 8.80 4508047 zyxin [Homo sapiens 1,116 0,158 17,303 …. 258 61238 7 6.22 4503521 eukaryotic translation initiation factor 3, subunit 6 48kDa [Homo sapien 1,112 0,153 4,370 …. 260 52187 13 5.71 5729877 heat shock 70kDa protein 8 isoform 1 [Homo sapiens 1,109 0,150 18,295 …. 3004 70854 32 5.37 7019323 dolichyl-phosphate beta-glucosyltransferase isoform 1 [Homo sapien 1,109 0,150 8,125 …. 103 36922 10 9.34 4759300 vesicle-associated membrane protein 3 [Homo sapien 1,107 0,147 12,721 …. 556 11302 4 8.89 4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo sapiens 1,107 0,146 19,061 …. 216 24412 7 5.71 4506209 proteasome 26S ATPase subunit 2 [Homo sapiens 1,106 0,146 16,064 4,9903888 440 48603 12 5.71 4506467 radixin [Homo sapiens 1,106 0,146 8,118 …. 583 68521 24 6.03 5729779 COP9 signalosome subunit 8 isoform 1 [Homo sapiens 1,106 0,146 16,334 …. 475 23211 6 5.25 4758340 phenylalanyl-tRNA synthetase, alpha subunit [Homo sapiens 1,106 0,145 17,892 …. 189 57528 12 7.31 34485714 Ras-related protein Rab-23 [Homo sapiens 1,106 0,145 9,542 6,7890133 237 26643 12 6.22 4506193 proteasome beta 1 subunit [Homo sapiens 1,105 0,144 19,487 16,828517 1386 26472 11 8.27 24234688 heat shock 70kDa protein 9 precursor [Homo sapiens 1,104 0,143 19,761 5,3513234 1923 73635 32 5.87 4885417 ubiquitin-conjugating enzyme E2-25K isoform 1 [Homo sapien 1,103 0,141 10,586 …. 130 22393 9 5.33 20127486 mannose 6 phosphate receptor binding protein 1 [Homo sapien 1,102 0,141 19,947 13,675478 3255 47018 23 5.30 58761486 chaperonin containing TCP1, subunit 3 isoform b [Homo sapiens 1,102 0,141 16,826 5,0750475 418 60424 18 6.10 19923973 potassium channel tetramerisation domain containing 12 [Homo sapien 1,100 0,138 5,331 …. 241 35679 13 5.51 4758516 hepatoma-derived growth factor isoform a [Homo sapien 1,100 0,138 13,957 …. 210 26772 19 4.70 20127454 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [Homo sapie 1,100 0,138 11,670 2,7410863 1142 64575 27 6.27 18375501 APEX nuclease 1 [Homo sapiens 1,099 0,136 18,687 …. 176 35532 7 8.33 25777713 S-phase kinase-associated protein 1 isoform b [Homo sapien 1,094 0,129 0,338 …. 151 18646 3 4.40 21361361 ilvB (bacterial acetolactate synthase)-like [Homo sapien 1,093 0,128 7,813 …. 176 67825 4 8.43 5729877 heat shock 70kDa protein 8 isoform 1 [Homo sapiens 1,092 0,127 19,380 2,2167054 3797 70854 31 5.37 5729850 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [Homo sapie 1,091 0,126 13,363 …. 710 40506 9 5.50 4505331 N-ethylmaleimide-sensitive factor attachment protein, gamma [Homo sapien 1,089 0,122 17,522 15,556377 212 34724 8 5.30 19743875 fumarate hydratase precursor [Homo sapiens 1,088 0,122 13,070 …. 231 54602 13 8.85 27735029 MOB1, Mps One Binder kinase activator-like 1A [Homo sapiens 1,088 0,121 9,965 …. 64 25075 6 6.24 21614499 ezrin [Homo sapiens 1,086 0,119 3,076 3,2037328 589 69370 26 5.94 167466173 heat shock 70kDa protein 1B [Homo sapiens 1,080 0,111 16,226 4,8813066 1270 70009 21 5.48 29501813 ubiquitin fusion degradation 1-like isoform A [Homo sapien 1,078 0,109 13,962 …. 113 34478 11 6.27 98986464 transmembrane emp24 domain-containing protein 10 precursor [Homo sapien 1,078 0,108 18,282 15,772054 211 24960 4 6.97 7661678 RAP1B, member of RAS oncogene family [Homo sapiens 1,076 0,105 19,798 1,1524693 2045 20812 10 5.65 27501446 density-regulated protein [Homo sapiens 1,074 0,103 0,036 3,3564802 155 22078 5 5.21 48255966 UDP-glucose pyrophosphorylase 2 isoform a [Homo sapiens 1,072 0,101 18,548 7,7853945 374 56905 19 8.16 25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens 1,072 0,100 15,560 …. 299 57213 13 6.55 10880989 RAB18, member RAS oncogene family [Homo sapiens 1,070 0,097 6,975 19,929909 616 22963 8 5.11 13654237 protein kinase, DNA-activated, catalytic polypeptide isoform 1 [Homo sapien 1,069 0,096 19,957 …. 387 468788 72 6.75 41393561 leucine aminopeptidase 3 [Homo sapiens 1,069 0,096 17,684 …. 320 56131 23 8.03 41393545 RAB5C, member RAS oncogene family isoform b [Homo sapien 1,068 0,094 19,735 8,5882577 1536 23468 9 8.64 4506209 proteasome 26S ATPase subunit 2 [Homo sapiens 1,067 0,094 5,868 …. 339 48603 19 5.71 7706481 calcium binding protein 39 [Homo sapiens 1,067 0,094 3,837 …. 159 39844 10 6.43 6912280 activator of heat shock 90kDa protein ATPase homolog 1 [Homo sapien 1,066 0,093 19,346 …. 185 38250 8 5.41 9910542 SAR1a gene homolog 1 [Homo sapiens 1,066 0,092 19,919 13,903492 1139 22353 13 6.21 41393599 coproporphyrinogen oxidase [Homo sapiens 1,063 0,088 7,327 …. 206 50120 12 8.59 30410796 proteasome activator subunit 3 isoform 2 [Homo sapien 1,062 0,086 8,417 …. 313 30867 5 5.79 4503609 electron-transfer-flavoprotein, beta polypeptide isoform 1 [Homo sapien 1,061 0,086 18,405 …. 250 27826 14 8.24 4505701 pyridoxal kinase [Homo sapiens 1,059 0,083 3,789 …. 388 35080 12 5.75 4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo sapiens 1,059 0,083 17,553 …. 254 38426 6 5.17 42794771 thioredoxin domain containing 5 isoform 1 precursor [Homo sapien 1,059 0,082 8,164 …. 229 47599 11 5.63 13489054 mitogen-activated protein kinase kinase 2 [Homo sapien 1,057 0,080 11,680 …. 83 44396 6 6.12 13376840 WD repeat domain 61 [Homo sapiens 1,056 0,079 19,027 18,56218 563 33560 7 5.16 38202214 SEC23-related protein A [Homo sapiens 1,056 0,079 15,289 13,218093 399 86105 16 6.64 4885583 Rho-associated, coiled-coil containing protein kinase 1 [Homo sapien 1,054 0,076 13,321 …. 107 158076 36 5.66 40316915 arginyl aminopeptidase [Homo sapiens 1,053 0,075 11,764 …. 134 72549 11 5.51 22538467 proteasome beta 4 subunit [Homo sapiens 1,052 0,073 18,963 0,341718 2617 29185 8 5.72 48255889 protein kinase C substrate 80K-H isoform 1 [Homo sapiens 1,052 0,073 18,366 19,37958 619 59388 10 4.33 6005942 valosin-containing protein [Homo sapiens 1,048 0,068 19,395 …. 615 89266 24 5.14 19923193 heat shock 70kD protein binding protein [Homo sapiens 1,047 0,067 7,990 5,7376434 350 41305 12 5.18 4758304 protein disulfide isomerase A4 [Homo sapiens 1,047 0,066 12,590 18,801357 862 72887 34 4.96 4505705 phosphoprotein enriched in astrocytes 15 [Homo sapiens 1,046 0,065 15,692 …. 397 15031 6 4.93 5803149 coated vesicle membrane protein [Homo sapien 1,044 0,062 10,424 …. 474 22746 7 5.08 21361619 toll interacting protein [Homo sapiens 1,044 0,062 0,368 …. 91 30262 6 5.68 4758442 glia maturation factor, beta [Homo sapiens 1,044 0,062 5,626 …. 163 16702 6 5.19 5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) [Homo sapien 1,043 0,060 17,600 8,4155715 277 62599 29 6.40 4506203 proteasome beta 7 subunit proprotein [Homo sapien 1,034 0,048 6,777 1,4359182 558 29946 6 7.57 5031753 heterogeneous nuclear ribonucleoprotein H1 [Homo sapien 1,032 0,046 13,994 …. 357 49198 10 5.89 4505029 leukotriene A4 hydrolase [Homo sapiens 1,032 0,046 15,956 …. 450 69241 17 5.80 4505541 USO1 homolog, vesicle docking protein [Homo sapien 1,030 0,043 19,229 …. 607 107840 23 4.85 4503131 catenin (cadherin-associated protein), beta 1, 88kDa [Homo sapien 1,029 0,041 1,672 …. 84 85442 13 5.53 47519639 microtubule-associated protein 4 isoform 1 [Homo sapien 1,023 0,033 16,120 …. 95 120930 32 5.32 14917113 signal recognition particle receptor, beta subunit [Homo sapien 1,023 0,032 0,937 …. 275 29633 11 9.16 4506597 ribosomal protein L12 [Homo sapiens 1,021 0,030 14,301 …. 533 17808 6 9.48 8923001 abhydrolase domain containing 10 [Homo sapiens 1,021 0,030 13,669 …. 422 33911 8 8.80 5729980 phosphomevalonate kinase [Homo sapiens 1,020 0,029 9,749 …. 113 21981 9 5.56 10863927 peptidylprolyl isomerase A [Homo sapiens 1,017 0,024 16,802 7,0828197 1820 18001 9 7.68 4557032 L-lactate dehydrogenase B [Homo sapiens 1,017 0,024 19,259 16,389201 2260 36615 20 5.71 40254924 leucine rich repeat containing 59 [Homo sapiens 1,015 0,022 13,296 0,8877661 940 34909 12 9.61 38202257 neutral alpha-glucosidase AB isoform 2 [Homo sapiens 1,015 0,022 13,534 …. 545 106807 29 5.74 4757766 Rho GTPase activating protein 1 [Homo sapiens 1,012 0,018 14,971 8,2676897 245 50404 19 5.85 13994151 PDZ and LIM domain 1 [Homo sapiens 1,012 0,017 7,737 …. 95 36049 12 6.56 49574508 N-Acetylglucosamine kinase [Homo sapiens 1,011 0,016 11,589 5,9711251 359 37352 11 5.81 4501867 aconitase 2, mitochondrial precursor [Homo sapiens 1,008 0,012 19,834 3,4573583 413 85372 22 7.36 14110417 heterogeneous nuclear ribonucleoprotein D isoform b [Homo sapien 1,007 0,009 17,217 …. 421 36249 10 8.14 41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a [Homo sapien 1,006 0,009 14,164 …. 370 33810 13 5.38 14149680 extended synaptotagmin-like protein 1 [Homo sapien 1,006 0,009 11,105 15,69451 591 122780 27 5.57 18379349 vesicle amine transport protein 1 [Homo sapiens 1,006 0,009 18,447 19,203887 1463 41893 19 5.88 22267436 nipsnap homolog 3A [Homo sapiens 1,005 0,007 5,332 15,550578 229 28449 8 9.21 41349456 prolyl endopeptidase [Homo sapiens 1,001 0,002 18,151 …. 323 80648 16 5.53 11321601 phosphofructokinase, platelet [Homo sapiens 1,000 0,000 14,295 2,6293982 580 85542 22 7.50 7661914 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [Homo sapien 0,997 -0,004 17,554 14,055438 251 45502 14 5.45 4502491 complement component 1, q subcomponent binding protein precursor [Homo sapien 0,995 -0,007 15,354 …. 694 31343 8 4.74 5453629 dynactin 2 [Homo sapiens 0,995 -0,008 15,917 …. 296 44792 16 5.06 34577063 adenylosuccinate synthase [Homo sapiens 0,994 -0,008 13,363 …. 184 50066 13 6.13 7706757 H(+)-transporting two-sector ATPase [Homo sapiens 0,994 -0,008 16,047 …. 421 28245 13 9.36 21361144 proteasome 26S ATPase subunit 3 [Homo sapiens 0,994 -0,009 12,945 17,28996 630 49172 21 5.13 4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [Homo sapien 0,992 -0,011 16,699 5,7587796 1399 26906 14 7.66 31542947 chaperonin [Homo sapiens 0,992 -0,011 91,367 …. 682 61016 22 5.70 41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapien 0,992 -0,012 18,070 …. 2069 228858 86 5.44 13562090 apolipoprotein L2 [Homo sapiens 0,992 -0,012 12,998 …. 198 37069 9 6.28 20986531 mitogen-activated protein kinase 1 [Homo sapien 0,991 -0,012 18,837 8,2270741 251 41363 21 6.50 23510338 ubiquitin-activating enzyme E1 [Homo sapiens 0,991 -0,013 19,424 2,9537974 1833 117774 37 5.49 8923812 acyl-CoA thioesterase 13 isoform 1 [Homo sapiens 0,989 -0,016 11,636 …. 66 29932 3 6.33 7706495 DnaJ (Hsp40) homolog, subfamily B, member 11 precursor [Homo sapien 0,989 -0,017 17,080 …. 502 40489 12 5.81 4503607 electron transfer flavoprotein, alpha polypeptide isoform a [Homo sapien 0,985 -0,021 17,744 7,1956026 1748 35058 15 8.62 118402586 glyoxalase I [Homo sapiens 0,985 -0,022 12,762 …. 570 20764 10 5.12 5174529 methionine adenosyltransferase II, alpha [Homo sapien 0,984 -0,023 7,786 16,363024 267 43633 6 6.02 5031595 actin related protein 2/3 complex subunit 4 isoform a [Homo sapien 0,984 -0,024 19,433 7,1978093 253 19654 9 8.53 5031973 protein disulfide isomerase A6 [Homo sapiens 0,983 -0,024 11,585 8,5975501 1333 48091 23 4.95 11034825 methionine adenosyltransferase II, beta isoform 1 [Homo sapien 0,983 -0,024 1,342 …. 172 37528 6 6.90 224465187 secernin 1 isoform a [Homo sapiens 0,983 -0,025 9,627 10,866909 134 46353 9 4.66 23110925 proteasome beta 6 subunit [Homo sapiens 0,982 -0,027 19,772 …. 342 25341 5 4.80 7661910 tetratricopeptide repeat domain 35 [Homo sapien 0,981 -0,027 11,998 …. 295 34811 9 6.15 25453474 eukaryotic translation elongation factor 1 delta isoform 1 [Homo sapien 0,979 -0,031 17,955 4,4516765 915 71364 16 6.02 11863154 archain isoform 1 [Homo sapiens 0,974 -0,038 20,935 8,7389127 133 57174 22 5.89 94429050 SEC22 vesicle trafficking protein homolog B [Homo sapiens 0,974 -0,039 19,629 0,6042003 1294 24578 11 6.43 5453597 F-actin capping protein alpha-1 subunit [Homo sapiens 0,973 -0,040 19,496 9,2003187 1655 32902 11 5.45 6005846 twinfilin-like protein [Homo sapiens 0,971 -0,042 19,361 …. 252 39523 9 6.37 21735621 mitochondrial malate dehydrogenase precursor [Homo sapien 0,971 -0,043 18,509 17,576547 2079 35481 17 8.92 20127408 mitochondrial trifunctional protein, alpha subunit precursor [Homo sapien 0,971 -0,043 4,248 0,621357 1678 82947 38 9.16 9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens 0,970 -0,043 9,280 5,1830803 247 66152 16 6.17 48255905 transgelin [Homo sapiens 0,969 -0,045 19,951 …. 4817 22596 16 8.87 38016911 stomatin isoform a [Homo sapiens 0,969 -0,046 17,797 9,7489562 103 31711 10 7.71 10835049 ras homolog gene family, member A [Homo sapien 0,966 -0,051 14,842 2,9173157 863 21754 9 5.83 4506201 proteasome beta 5 subunit isoform 1 [Homo sapien 0,964 -0,053 13,003 1,154956 890 28462 15 6.43 33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens 0,963 -0,055 17,794 4,5039053 4934 532072 176 6.01 4506195 proteasome beta 2 subunit [Homo sapiens 0,961 -0,057 17,343 4,6326119 400 22822 8 6.51 41406084 glutathione peroxidase 1 isoform 1 [Homo sapien 0,961 -0,058 6,732 …. 217 22075 6 6.15 9845297 diablo isoform 1 precursor [Homo sapiens 0,959 -0,060 14,947 13,739797 320 27114 8 5.68 4504183 glutathione transferase [Homo sapiens 0,959 -0,060 19,637 5,4015358 6964 23341 13 5.43 24119203 tropomyosin 3 isoform 2 [Homo sapiens 0,956 -0,065 18,381 10,447234 1667 29015 28 4.75 4504763 integrin alpha-V isoform 1 precursor [Homo sapiens 0,955 -0,067 10,404 …. 245 115978 30 5.45 4502013 adenylate kinase 2 isoform a [Homo sapiens 0,954 -0,068 10,694 …. 393 26461 7 7.67 7656991 coronin, actin binding protein, 1C isoform 1 [Homo sapien 0,953 -0,070 14,772 …. 251 53215 11 6.65 5729730 apoptosis inhibitor 5 isoform b [Homo sapiens 0,950 -0,073 10,841 …. 229 56735 13 5.72 23097250 TIP41, TOR signalling pathway regulator-like isoform 1 [Homo sapien 0,950 -0,074 7,000 …. 87 31424 13 5.60 7657015 hypothetical protein LOC51493 [Homo sapiens 0,950 -0,074 16,207 …. 248 55175 21 6.77 38327625 citrate synthase precursor [Homo sapiens 0,948 -0,076 15,591 …. 299 51680 14 8.45 41872583 Rho-associated, coiled-coil containing protein kinase 2 [Homo sapien 0,947 -0,079 10,123 …. 132 160799 28 5.75 4506063 cAMP-dependent protein kinase, regulatory subunit alpha 1 [Homo sapien 0,944 -0,083 15,624 1,6734824 236 42955 9 5.27 4885281 glutamate dehydrogenase 1 [Homo sapiens 0,944 -0,083 18,871 13,113298 372 61359 15 7.66 4504327 mitochondrial trifunctional protein, beta subunit precursor [Homo sapien 0,943 -0,084 13,563 6,7226001 341 51262 20 9.45 7705827 SAR1a gene homolog 2 [Homo sapiens 0,936 -0,095 14,227 …. 420 22396 8 5.76 134142815 es1 protein isoform Ia precursor [Homo sapiens 0,936 -0,096 8,719 2,3570203 147 28153 7 8.50 5803023 lectin, mannose-binding 2 precursor [Homo sapiens 0,933 -0,100 14,815 …. 520 40203 11 6.46 28178821 isocitrate dehydrogenase 3, beta subunit isoform a precursor [Homo sapien 0,930 -0,104 12,745 …. 223 42157 13 8.64 4506127 phosphoribosyl pyrophosphate synthetase 1 [Homo sapien 0,927 -0,109 18,051 …. 574 34812 9 6.51 16933540 fibroblast activation protein, alpha subunit [Homo sapien 0,925 -0,112 16,962 …. 829 87657 21 6.21 91984773 apolipoprotein A-I binding protein precursor [Homo sapien 0,925 -0,112 12,194 17,432826 239 31654 8 7.56 188497754 hexokinase 1 isoform HKI [Homo sapiens 0,923 -0,116 14,621 11,391045 520 102420 17 6.36 4758606 integrin-linked kinase [Homo sapiens 0,922 -0,118 14,498 10,016593 165 51386 21 8.30 4506057 cAMP-dependent protein kinase catalytic subunit beta isoform 2 [Homo sapien 0,921 -0,119 19,038 …. 179 40597 14 8.84 4758012 clathrin heavy chain 1 [Homo sapiens 0,921 -0,119 19,634 18,394649 2605 191493 44 5.48 4506371 RAB5B, member RAS oncogene family [Homo sapiens 0,920 -0,121 10,745 …. 353 23692 10 8.29 16507237 heat shock 70kDa protein 5 [Homo sapiens 0,915 -0,127 16,566 3,607444 6324 72288 52 5.07 18491024 dipeptidyl peptidase III [Homo sapiens 0,911 -0,134 18,013 …. 371 82538 16 5.02 4507651 tropomyosin 4 isoform 2 [Homo sapiens 0,911 -0,134 19,738 11,714771 787 28504 24 4.67 4503503 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa [Homo sapien 0,911 -0,135 19,150 …. 87 33691 5 6.90 5453634 dynein, cytoplasmic, light intermediate polypeptide 2 [Homo sapien 0,909 -0,137 14,164 5,5951235 250 54066 13 5.97 4501891 actinin, alpha 1 isoform b [Homo sapiens 0,905 -0,144 18,893 6,7158548 5768 102993 54 5.25 5453832 hypoxia up-regulated 1 precursor [Homo sapiens 0,904 -0,145 19,812 13,205607 1387 111266 37 5.16 4557809 ornithine aminotransferase precursor [Homo sapiens 0,903 -0,147 16,992 …. 380 48504 18 6.57 4502211 ADP-ribosylation factor 6 [Homo sapiens 0,902 -0,149 4,984 …. 156 31492 6 8.58 4557817 3-oxoacid CoA transferase 1 precursor [Homo sapiens 0,901 -0,150 17,080 …. 261 56122 11 7.14 4502205 ADP-ribosylation factor 4 [Homo sapiens 0,898 -0,155 12,424 7,7663639 1626 20498 10 6.59 7705983 coatomer protein complex, subunit zeta 2 [Homo sapien 0,897 -0,157 10,389 …. 145 23533 7 5.08 4504771 eukaryotic translation initiation factor 6 isoform a [Homo sapien 0,897 -0,157 13,924 1,3469789 353 26582 5 4.56 4503771 farnesyltransferase, CAAX box, alpha isoform a [Homo sapien 0,897 -0,157 19,462 …. 302 44381 5 4.96 50428925 cytoskeleton associated protein 1 [Homo sapiens 0,897 -0,157 19,942 …. 163 27308 4 5.06 5174539 cytosolic malate dehydrogenase [Homo sapiens 0,894 -0,161 17,602 14,874768 1000 36403 16 6.91 112380628 lysosomal-associated membrane protein 1 [Homo sapien 0,891 -0,167 18,502 15,987843 193 44854 6 9.00 8923417 ADP-ribosylhydrolase like 2 [Homo sapiens 0,891 -0,167 15,184 1,7678631 370 38922 10 4.95 33620730 kinesin light chain 1 isoform 1 [Homo sapiens 0,890 -0,167 5,979 …. 210 63776 21 5.62 24308201 chromosome 20 open reading frame 3 [Homo sapien 0,890 -0,169 14,448 …. 375 46451 15 5.82 6912396 glyoxylate reductase/hydroxypyruvate reductase [Homo sapien 0,889 -0,170 13,976 12,688558 333 35646 14 7.01 11995472 Ras-related GTP binding C [Homo sapiens 0,887 -0,173 10,555 …. 282 44196 6 4.94 5453599 capping protein (actin filament) muscle Z-line, alpha 2 [Homo sapien 0,883 -0,179 16,157 …. 757 32929 11 5.57 224496106 small fragment nuclease [Homo sapiens 0,883 -0,180 16,963 5,5575214 513 26816 10 6.41 19923750 RAB3B, member RAS oncogene family [Homo sapiens 0,883 -0,180 9,810 …. 120 24742 4 4.85 16306548 seryl-tRNA synthetase [Homo sapiens 0,880 -0,184 19,340 18,547701 348 58740 14 6.05 7705773 SH3-containing protein SH3GLB1 [Homo sapiens 0,877 -0,189 16,449 …. 136 40771 8 5.78 5031599 actin related protein 2/3 complex subunit 2 [Homo sapien 0,877 -0,190 18,252 15,139553 1240 34311 24 6.84 33286418 pyruvate kinase, muscle isoform M2 [Homo sapiens 0,877 -0,190 18,511 …. 1899 57900 27 7.96 7706322 homeobox prox 1 [Homo sapiens 0,871 -0,200 19,874 3,2500637 900 28051 13 6.19 21359929 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble [Homo sapien 0,870 -0,201 11,899 …. 142 69873 15 5.42 6912586 6-phosphogluconolactonase [Homo sapiens 0,869 -0,203 17,852 10,578202 777 27530 8 5.70 71037379 liver glycogen phosphorylase [Homo sapiens 0,868 -0,204 7,790 12,380394 356 97087 20 6.71 15626999 inosine triphosphatase isoform a [Homo sapiens 0,868 -0,205 2,549 …. 169 21432 5 5.50 4504175 glutathione S-transferase mu 2 isoform 1 [Homo sapiens 0,867 -0,205 16,622 12,361229 760 25728 18 6.00 4507669 tumor protein, translationally-controlled 1 [Homo sapien 0,866 -0,208 11,613 7,3035459 766 19583 8 4.84 14210504 adaptor-related protein complex 1, mu 1 subunit isoform 2 [Homo sapien 0,866 -0,208 6,204 …. 79 48556 6 6.82 5031981 proteasome 26S subunit, non-ATPase 14 [Homo sapiens 0,864 -0,210 19,444 …. 601 34555 15 6.06 4503685 farnesyl diphosphate synthase isoform a [Homo sapiens 0,863 -0,213 15,992 12,360125 209 48245 6 5.83 155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [Homo sapiens 0,862 -0,215 13,205 …. 131 66275 10 5.17 5453998 importin 7 [Homo sapiens 0,860 -0,217 3,789 12,152574 606 119440 21 4.70 4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens 0,860 -0,217 17,309 15,384972 224 36045 18 9.35 21361657 protein disulfide-isomerase A3 precursor [Homo sapien 0,860 -0,218 18,878 9,9402309 1750 56747 34 5.98 11386147 prosaposin isoform a preproprotein [Homo sapien 0,860 -0,218 18,804 1,2133641 252 58074 11 5.06 5031573 ARP3 actin-related protein 3 homolog [Homo sapiens 0,857 -0,223 19,104 …. 988 47341 18 5.61 7706441 vacuolar protein sorting 29 isoform 1 [Homo sapiens 0,857 -0,223 9,164 …. 285 20493 4 6.29 28933465 syntaxin 12 [Homo sapiens 0,857 -0,223 17,636 8,7892994 248 31622 7 5.45 32171186 B-cell receptor-associated protein 31 isoform b [Homo sapien 0,857 -0,223 16,712 …. 577 27974 11 8.44 14249382 abhydrolase domain containing 14B [Homo sapiens 0,857 -0,223 12,927 9,2759607 566 22332 5 5.94 5453710 LIM and SH3 protein 1 [Homo sapiens 0,856 -0,224 13,849 14,263947 580 29698 14 6.61 12056473 N-acetylneuraminic acid phosphate synthase [Homo sapien 0,856 -0,224 16,853 7,5803659 491 40281 8 6.29 4503729 FK506 binding protein 52 [Homo sapiens 0,853 -0,230 1,297 …. 129 51772 9 5.35 7661922 RAB21, member RAS oncogene family [Homo sapiens 0,851 -0,233 4,999 19,407088 469 24332 11 8.11 4503571 enolase 1 [Homo sapiens 0,850 -0,235 18,537 1,7917252 12893 47139 30 7.01 192448443 FK506 binding protein 10 [Homo sapiens 0,849 -0,237 10,203 …. 306 64204 16 5.36 45827806 atlastin 3 [Homo sapiens 0,848 -0,238 3,572 6,594124 153 60503 11 5.43 4504221 guanylate kinase 1 isoform b [Homo sapiens 0,847 -0,240 11,057 …. 105 21712 9 6.11 4502107 annexin 5 [Homo sapiens 0,846 -0,241 19,680 5,8184832 10596 35914 27 4.94 4503513 eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa [Homo sapien 0,844 -0,245 11,441 6,7877464 221 36479 11 5.38 10863945 ATP-dependent DNA helicase II [Homo sapiens 0,844 -0,245 17,423 13,062138 547 82652 17 5.55 4757732 programmed cell death 8 isoform 1 [Homo sapien 0,843 -0,246 12,832 …. 118 66859 11 9.04 4757756 annexin A2 isoform 2 [Homo sapiens 0,843 -0,246 12,832 …. 368 38580 13 7.57 40068475 twinfilin 1 [Homo sapiens 0,842 -0,248 9,421 …. 207 43891 12 8.64 4503481 eukaryotic translation elongation factor 1 gamma [Homo sapien 0,841 -0,249 19,499 2,7138797 830 50087 21 6.25 4503327 cytochrome b5 reductase 3 isoform m [Homo sapiens 0,840 -0,251 19,720 0,8975483 2939 34213 15 7.18 26667183 calcium/calmodulin-dependent protein kinase II delta isoform 1 [Homo sapien 0,840 -0,252 5,778 19,708923 278 54093 14 6.82 19424132 NIMA-related kinase 7 [Homo sapiens 0,838 -0,256 18,185 …. 242 34528 13 8.49 119372308 galactosidase, beta 1 isoform a preproprotein [Homo sapien 0,835 -0,260 11,642 14,646911 225 76027 11 6.10 19743813 integrin beta 1 isoform 1A precursor [Homo sapiens 0,832 -0,265 15,057 13,960185 924 88357 18 5.27 13129092 transmembrane protein 109 [Homo sapiens 0,831 -0,267 16,497 …. 274 26194 7 10.48 5031593 actin related protein 2/3 complex subunit 5 [Homo sapien 0,831 -0,268 19,335 0,0840666 219 16310 6 5.47 14249348 thioredoxin-like 5 [Homo sapiens 0,830 -0,269 10,345 11,819277 139 13932 5 5.40 170932494 syntaxin 7 [Homo sapiens 0,828 -0,273 17,755 15,348345 258 29797 6 5.41 4503915 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylam 0,825 -0,277 3,475 …. 38 107699 9 6.26 4503477 eukaryotic translation elongation factor 1 beta 2 [Homo sapien 0,824 -0,280 7,651 3,2463663 1012 24748 7 4.50 4504523 heat shock 10kDa protein 1 [Homo sapiens 0,822 -0,283 14,069 16,41719 296 10925 6 8.89 21618349 mitogen-activated protein kinase kinase 3 isoform B [Homo sapien 0,820 -0,286 2,630 …. 212 39293 9 7.05 32483377 peroxiredoxin 3 isoform b [Homo sapiens 0,818 -0,290 19,290 4,828178 1855 25822 11 7.04 73486658 aspartate aminotransferase 2 precursor [Homo sapien 0,817 -0,291 10,340 7,0045268 270 47487 13 9.14 13654274 fumarylacetoacetate hydrolase domain containing 1 isoform 2 [Homo sapien 0,817 -0,292 8,928 …. 264 24827 8 6.96 4505021 low density lipoprotein receptor-related protein associated protein 1 precursor [Homo sapie 0,811 -0,303 19,291 …. 266 41441 14 8.73 7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapien 0,807 -0,309 19,542 …. 692 34302 18 9.34 44680105 caldesmon 1 isoform 1 [Homo sapiens 0,807 -0,309 17,129 …. 3034 93175 40 5.62 6912586 6-phosphogluconolactonase [Homo sapiens 0,804 -0,315 17,477 …. 769 27530 11 5.70 4502315 ATPase, H+ transporting, lysosomal V1 subunit C1 [Homo sapiens 0,803 -0,317 17,461 0,9893912 491 43914 18 7.02 4758220 XAP-5 protein [Homo sapiens 0,802 -0,318 18,719 …. 79 40216 11 6.39 14141195 stromal cell-derived factor 2 precursor [Homo sapien 0,799 -0,324 6,929 …. 331 23011 5 6.83 20336761 heme binding protein 1 [Homo sapiens 0,799 -0,325 19,061 …. 667 21084 9 5.71 4507877 vinculin isoform VCL [Homo sapiens 0,796 -0,328 12,443 1,9546793 2137 116649 59 5.83 5031571 actin-related protein 2 isoform b [Homo sapiens 0,794 -0,333 13,929 …. 486 44732 16 6.30 4505753 bisphosphoglycerate mutase 1 [Homo sapiens 0,794 -0,333 19,913 19,285465 3426 28786 15 6.67 20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo sapien 0,791 -0,339 16,639 6,6923851 2461 57081 34 4.76 4502923 calponin 3 [Homo sapiens 0,789 -0,341 16,609 …. 48 36391 5 5.69 4826760 heterogeneous nuclear ribonucleoprotein F [Homo sapien 0,789 -0,342 3,989 …. 420 45643 5 5.38 8922712 septin 11 [Homo sapiens 0,789 -0,343 18,893 3,1626923 557 49367 22 6.36 5453958 protein phosphatase 5, catalytic subunit [Homo sapiens 0,788 -0,344 13,735 …. 128 56842 8 5.88 5031597 actin related protein 2/3 complex subunit 3 [Homo sapien 0,787 -0,346 12,668 11,338125 553 20533 9 8.78 105990514 filamin B, beta (actin binding protein 278) [Homo sapien 0,785 -0,349 18,929 10,035923 1189 277990 64 5.47 4503841 ATP-dependent DNA helicase II, 70 kDa subunit [Homo sapiens 0,779 -0,360 0,958 …. 223 69799 14 6.23 40317626 thrombospondin 1 precursor [Homo sapiens 0,775 -0,368 4,701 …. 305 129300 18 4.71 4502227 ADP-ribosylation factor-like 1 [Homo sapiens 0,774 -0,369 19,045 …. 366 20404 7 5.63 7706318 dehydrogenase/reductase (SDR family) member 7 [Homo sapien 0,770 -0,377 14,932 12,646588 370 38274 12 8.59 5453790 nicotinamide N-methyltransferase [Homo sapiens 0,768 -0,381 18,847 4,8026637 1351 29555 7 5.56 34147637 COP9 signalosome subunit 6 [Homo sapiens 0,767 -0,383 8,324 …. 122 36140 8 5.47 188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sapien 0,766 -0,384 16,078 14,990251 403 58450 13 8.21 6598323 GDP dissociation inhibitor 2 isoform 1 [Homo sapiens 0,765 -0,387 12,401 5,228469 1920 50631 28 6.11 77404397 staphylococcal nuclease domain containing 1 [Homo sapien 0,764 -0,388 10,706 17,647647 611 101934 22 6.74 4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sapien 0,760 -0,395 19,875 …. 428 62042 13 8.60 19923881 glucosamine-6-phosphate deaminase 2 [Homo sapien 0,759 -0,397 9,127 …. 207 31065 11 6.45 19913428 vacuolar H+ATPase B2 [Homo sapiens 0,759 -0,398 12,638 5,3092263 846 56465 19 5.57 4505641 proliferating cell nuclear antigen [Homo sapiens 0,757 -0,401 19,867 …. 193 28750 13 4.57 4885049 cardiac muscle alpha actin 1 proprotein [Homo sapien 0,756 -0,403 10,895 …. 9296 41992 31 5.23 31543380 Parkinson disease protein 7 [Homo sapiens 0,756 -0,404 19,333 9,9888939 709 19878 12 6.33 32307144 lysyl hydroxylase 1 precursor [Homo sapiens 0,755 -0,405 5,388 …. 289 83497 17 6.47 9951915 adenosylhomocysteinase isoform 1 [Homo sapiens 0,752 -0,411 14,356 9,8799172 689 47685 14 5.92 4502011 adenylate kinase 1 [Homo sapiens 0,751 -0,414 16,461 15,299509 1149 21621 15 8.73 4507677 heat shock protein 90kDa beta, member 1 [Homo sapien 0,742 -0,431 13,548 10,676703 4010 92411 52 4.76 5174391 aldo-keto reductase family 1, member A1 [Homo sapien 0,740 -0,434 18,246 12,919722 641 36550 14 6.32 6912638 ras suppressor protein 1 isoform 1 [Homo sapiens 0,740 -0,434 19,828 4,1013712 380 31521 10 8.57 21361621 phosphoglucomutase 1 [Homo sapiens 0,737 -0,439 17,234 6,9007852 762 61411 27 6.30 21956645 myotrophin [Homo sapiens 0,735 -0,445 18,534 …. 61 40015 5 5.40 4502101 annexin I [Homo sapiens 0,732 -0,450 19,851 4,053532 7409 38690 26 6.57 4507231 single-stranded DNA binding protein 1 [Homo sapiens 0,732 -0,450 15,658 …. 335 17249 7 9.59 6912328 dimethylarginine dimethylaminohydrolase 1 isoform 1 [Homo sapien 0,731 -0,452 14,037 …. 118 31102 14 5.53 7669492 glyceraldehyde-3-phosphate dehydrogenase [Homo sapien 0,730 -0,453 18,448 0,2671332 42753 36030 27 8.57 4501887 actin, gamma 1 propeptide [Homo sapiens 0,728 -0,458 18,675 …. 4959 41766 27 5.31 4502679 CD63 antigen isoform A [Homo sapiens 0,725 -0,464 15,278 10,825243 962 25619 5 8.14 4502549 calmodulin 2 [Homo sapiens 0,719 -0,476 10,158 …. 396 16827 5 4.09 61744475 solute carrier family 3, member 2 isoform a [Homo sapien 0,719 -0,477 18,058 12,045711 339 71079 13 4.84 4501885 beta actin [Homo sapiens 0,718 -0,479 19,999 0,2356882 16912 41710 33 5.29 4506061 AMP-activated protein kinase, noncatalytic gamma-1 subunit isoform 1 [Homo sapien 0,716 -0,481 6,231 …. 249 37556 10 6.42 7549809 plastin 3 [Homo sapiens 0,712 -0,490 19,472 0,9055261 1177 70766 33 5.41 116805322 gamma filamin isoform a [Homo sapiens 0,711 -0,492 18,257 19,748325 2770 290841 72 5.65 4885063 fructose-bisphosphate aldolase C [Homo sapiens 0,711 -0,493 19,395 …. 1173 39431 15 6.41 18201905 glucose phosphate isomerase [Homo sapiens 0,707 -0,501 8,770 8,284852 1519 63107 26 8.43 32189392 peroxiredoxin 2 isoform a [Homo sapiens 0,704 -0,507 18,269 …. 1992 21878 11 5.66 33589854 biliverdin reductase A [Homo sapiens 0,703 -0,508 18,005 7,5486662 287 33407 9 6.06 49574502 cytochrome b5 reductase 1 [Homo sapiens 0,701 -0,513 17,146 1,1142607 453 34073 11 9.41 66392203 NME1-NME2 protein [Homo sapiens 0,701 -0,513 19,731 5,5096405 295 30118 9 9.06 11128019 cytochrome c [Homo sapiens 0,698 -0,520 12,764 3,5640027 220 11741 7 9.59 4502317 vacuolar H+ ATPase E1 isoform a [Homo sapiens 0,697 -0,521 19,444 6,3191884 575 26129 18 7.71 5031569 ARP1 actin-related protein 1 homolog A, centractin alpha [Homo sapien 0,697 -0,521 18,812 …. 690 42587 15 6.19 41393608 reticulon 3 isoform b [Homo sapiens 0,696 -0,522 13,507 10,208914 114 110584 8 4.86 4557797 non-metastatic cells 1, protein (NM23A) expressed in isoform b [Homo sapien 0,687 -0,542 4,017 …. 355 17138 6 5.83 38044288 gelsolin isoform b [Homo sapiens 0,685 -0,546 17,252 16,559872 2072 80591 35 5.58 4557235 acyl-Coenzyme A dehydrogenase, very long chain isoform 1 precursor [Homo sapien 0,683 -0,550 18,064 9,2588342 481 70345 23 8.92 4507149 superoxide dismutase 1, soluble [Homo sapiens 0,682 -0,552 8,685 …. 525 15926 3 5.70 4507645 triosephosphate isomerase 1 isoform 1 [Homo sapien 0,681 -0,555 19,093 16,568119 5508 26653 14 6.45 4758958 cAMP-dependent protein kinase, regulatory subunit alpha 2 [Homo sapien 0,679 -0,558 19,855 …. 417 45490 10 4.96 19913424 ATPase, H+ transporting, lysosomal V1 subunit A [Homo sapiens 0,679 -0,559 18,570 15,447948 1268 68260 32 5.35 4507791 ubiquitin-conjugating enzyme E2M [Homo sapiens 0,677 -0,563 12,318 …. 61 20887 6 7.57 11056044 pyrophosphatase 1 [Homo sapiens 0,676 -0,564 19,380 …. 859 32639 19 5.54 4502011 adenylate kinase 1 [Homo sapiens 0,670 -0,579 17,700 …. 986 21621 11 8.73 148352329 cell division cycle 10 isoform 2 [Homo sapiens 0,662 -0,596 15,375 3,8301719 359 50549 22 8.76 4501883 alpha 2 actin [Homo sapiens 0,661 -0,597 13,199 …. 2826 41982 22 5.23 4758032 coatomer protein complex, subunit beta 2 (beta prime) [Homo sapien 0,658 -0,603 16,638 …. 180 102422 18 5.15 5453595 adenylyl cyclase-associated protein [Homo sapiens 0,657 -0,605 17,730 …. 416 51641 15 8.07 116063573 filamin A, alpha isoform 1 [Homo sapiens 0,656 -0,608 18,848 5,1313426 12591 279843 103 5.69 56682959 ferritin, heavy polypeptide 1 [Homo sapiens 0,654 -0,613 17,114 2,5996286 551 21212 6 5.30 14141166 poly(rC) binding protein 2 isoform b [Homo sapiens 0,654 -0,614 8,922 …. 243 38197 5 6.33 20270343 ADP-ribosylation factor-like 8A [Homo sapiens 0,651 -0,620 9,460 …. 425 21402 10 7.63 5174741 ubiquitin carboxyl-terminal esterase L3 [Homo sapien 0,648 -0,626 4,910 0,4248035 259 26166 7 4.84 17986258 myosin, light chain 6, alkali, smooth muscle and non-muscle isoform 1 [Homo sapien 0,648 -0,627 13,578 10,126235 670 16919 9 4.56 33286420 pyruvate kinase, muscle isoform M1 [Homo sapiens 0,647 -0,627 18,841 4,0180995 9242 58025 34 7.60 47933395 lanosterol synthase isoform 1 [Homo sapiens 0,645 -0,633 1,270 …. 115 83255 9 6.16 33413400 esterase D/formylglutathione hydrolase [Homo sapien 0,642 -0,639 19,052 …. 367 31442 11 6.54 4505763 phosphoglycerate kinase 1 [Homo sapiens 0,641 -0,642 16,476 …. 2287 44586 28 8.30 4502171 adenine phosphoribosyltransferase isoform a [Homo sapien 0,640 -0,643 19,627 …. 409 19595 8 5.78 8922601 ADP-ribosylation factor-like 10C [Homo sapiens 0,636 -0,652 17,512 …. 602 21525 10 8.67 4757952 cell division cycle 42 isoform 1 [Homo sapiens 0,635 -0,654 13,545 …. 546 21245 4 6.15 29568111 myosin regulatory light chain 9 isoform a [Homo sapien 0,633 -0,659 18,607 …. 2258 19814 8 4.80 10716563 calnexin precursor [Homo sapiens 0,627 -0,672 18,241 15,234162 900 67526 18 4.47 7657069 ERO1-like [Homo sapiens 0,626 -0,676 16,275 8,2398414 262 54358 8 5.48 4758756 nucleosome assembly protein 1-like 1 [Homo sapien 0,623 -0,683 7,526 …. 345 45346 6 4.36 194097323 mitochondrial short-chain enoyl-coenzyme A hydratase 1 precursor [Homo sapien 0,622 -0,684 19,814 10,000925 708 31367 13 8.34 33457348 hypothetical protein LOC56005 [Homo sapiens 0,619 -0,692 18,301 …. 92 72334 9 5.89 23308751 3-hydroxyisobutyrate dehydrogenase [Homo sapiens 0,619 -0,693 17,410 1,8023049 896 35306 16 8.38 5453916 progesterone receptor membrane component 2 [Homo sapien 0,618 -0,694 18,732 6,9164544 1156 23804 9 4.76 4557305 fructose-bisphosphate aldolase A [Homo sapiens 0,617 -0,696 19,174 …. 3906 39395 22 8.30 4557317 annexin A11 [Homo sapiens 0,615 -0,701 19,343 5,9879897 154 54355 11 7.53 20149498 ferritin, light polypeptide [Homo sapiens 0,614 -0,704 17,440 6,5848796 1114 20007 10 5.51 21464101 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide [Homo 0,605 -0,726 17,356 14,146894 1654 28285 17 4.80 4506925 SH3 domain binding glutamic acid-rich protein like [Homo sapien 0,600 -0,736 17,606 …. 188 12766 5 5.22 4503971 GDP dissociation inhibitor 1 [Homo sapiens 0,599 -0,739 7,887 10,073593 765 50550 19 5.00 40806164 ubiquitin-conjugating enzyme E2 variant 1 isoform a [Homo sapien 0,596 -0,748 16,707 …. 213 19295 8 8.73 4504011 glutamate-cysteine ligase regulatory protein [Homo sapien 0,587 -0,767 6,046 …. 233 30708 6 5.69 5453740 myosin, light chain 12A, regulatory, non-sarcomeric [Homo sapien 0,576 -0,795 19,106 5,5520031 2416 19781 8 4.67 4507513 tissue inhibitor of metalloproteinase 3 precursor [Homo sapien 0,576 -0,796 18,367 …. 144 24129 4 9.00 12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapien 0,575 -0,798 16,828 2,2888144 21906 226392 168 5.50 41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b [Homo sapien 0,574 -0,802 29,840 …. 266 22892 6 5.33 4505585 platelet-activating factor acetylhydrolase, isoform Ib, beta subunit [Homo sapien 0,571 -0,808 16,775 …. 513 25553 6 5.57 22538444 tumor protein p53 inducible protein 3 [Homo sapien 0,570 -0,812 14,906 …. 108 35514 9 6.67 13236495 crystallin, zeta isoform a [Homo sapiens 0,566 -0,821 17,204 …. 177 35185 14 8.56 7706497 UMP-CMP kinase 1 isoform a [Homo sapiens 0,566 -0,821 18,646 5,6844876 917 25838 10 8.14 156564357 NAD(P)H dehydrogenase, quinone 2 [Homo sapiens 0,558 -0,841 6,406 …. 127 25902 8 5.88 11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens 0,556 -0,847 12,685 …. 189 49813 11 8.76 4503139 cathepsin B preproprotein [Homo sapiens 0,556 -0,848 19,747 2,191872 5497 37797 8 5.88 93141047 collagen, type XII, alpha 1 long isoform precursor [Homo sapien 0,552 -0,856 16,644 18,432905 426 332941 43 5.38 7706497 UMP-CMP kinase 1 isoform a [Homo sapiens 0,543 -0,880 16,454 …. 879 25838 16 8.14 72534712 endoplasmic reticulum-golgi intermediate compartment 32 kDa protein [Homo sapie 0,542 -0,883 19,401 19,361827 113 32571 7 6.59 5453549 peroxiredoxin 4 [Homo sapiens 0,533 -0,909 19,428 2,6570858 1121 30521 12 5.86 5032051 ribosomal protein S14 [Homo sapiens 0,530 -0,915 8,747 …. 41 16263 6 10.07 5729770 tripeptidyl-peptidase I preproprotein [Homo sapien 0,528 -0,921 19,261 …. 535 61210 8 6.01 14589866 aspartate beta-hydroxylase isoform a [Homo sapien 0,516 -0,955 1,425 17,82057 155 85809 15 4.92 14389309 tubulin alpha 6 [Homo sapiens 0,506 -0,982 18,000 8,563229 121 49863 6 4.96 24431933 reticulon 4 isoform B [Homo sapiens 0,503 -0,992 17,842 …. 396 40293 10 4.71 153791352 prostate, ovary, testis expressed protein on chromosome 2 [Homo sapien 0,497 -1,010 13,110 …. 130 121367 19 5.83 39777597 transglutaminase 2 isoform a [Homo sapiens 0,494 -1,017 19,823 …. 881 77280 26 5.11 4503143 cathepsin D preproprotein [Homo sapiens 0,489 -1,033 19,678 1,4067284 1872 44524 13 6.10 5031777 isocitrate dehydrogenase 3 (NAD+) alpha precursor [Homo sapien 0,484 -1,046 16,976 …. 940 39566 13 6.47 33598968 LIM domain only 7 isoform 1 [Homo sapiens 0,476 -1,070 17,310 …. 455 153575 18 7.90 4503057 crystallin, alpha B [Homo sapiens 0,473 -1,081 18,048 …. 1018 20146 12 6.76 94557308 L-3-hydroxyacyl-Coenzyme A dehydrogenase precursor [Homo sapien 0,457 -1,131 2,320 0,3972 549 34272 12 8.88 166795301 prenylcysteine oxidase 1 [Homo sapiens 0,456 -1,133 19,240 5,6882285 383 56604 9 5.80 7330335 chloride intracellular channel 4 [Homo sapiens 0,447 -1,163 19,236 5,4798696 1161 28754 15 5.45 5031873 lectin, mannose-binding, 1 precursor [Homo sapiens 0,438 -1,189 19,973 …. 134 57513 12 6.30 47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens 0,436 -1,198 19,573 17,479819 1938 32970 35 4.63 4504517 heat shock protein beta-1 [Homo sapiens 0,430 -1,218 19,699 4,0738691 3581 22768 14 5.98 189181666 hexosaminidase A preproprotein [Homo sapien 0,420 -1,250 10,547 19,80826 138 60664 9 5.04 15149465 caldesmon 1 isoform 5 [Homo sapiens 0,419 -1,255 18,996 0,8319837 3068 61176 40 6.40 5031857 L-lactate dehydrogenase A isoform 1 [Homo sapiens 0,403 -1,310 19,593 …. 130 36665 6 8.44 4504373 hexosaminidase B preproprotein [Homo sapien 0,402 -1,315 19,596 9,1126106 1344 63071 24 6.29 4758638 peroxiredoxin 6 [Homo sapiens 0,383 -1,386 17,257 …. 5573 25019 19 6.00 21361120 calponin 1, basic, smooth muscle [Homo sapiens 0,383 -1,386 13,122 …. 211 33150 9 9.14 19923437 adenylate kinase 3 [Homo sapiens 0,367 -1,445 15,674 9,6800219 753 25550 19 9.15 37655183 N-myc downstream regulated 1 [Homo sapiens 0,361 -1,469 1,935 …. 259 42808 7 5.49 63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens 0,347 -1,526 8,174 16,164111 1912 32856 35 4.72 29788785 tubulin, beta [Homo sapiens 0,346 -1,532 18,916 …. 38 49639 7 4.78 156104878 glutaminase [Homo sapiens 0,346 -1,532 18,897 9,7612704 263 73414 12 7.85 17738302 alpha 1 type VIII collagen precursor [Homo sapiens 0,337 -1,570 2,791 8,9814839 217 73317 5 9.62 5803011 enolase 2 [Homo sapiens 0,335 -1,576 0,142 …. 2414 47239 13 4.91 39995109 GM2 ganglioside activator precursor [Homo sapiens 0,333 -1,587 2,718 …. 114 20825 5 5.17 119393891 acid alpha-glucosidase preproprotein [Homo sapien 0,320 -1,643 3,079 17,742462 119 105257 6 5.62 160420317 filamin A, alpha isoform 2 [Homo sapiens 0,313 -1,676 4,240 …. 216 280564 29 5.70 34098946 nuclease sensitive element binding protein 1 [Homo sapien 0,310 -1,691 39,232 …. 420 35903 9 9.87 66932947 alpha-2-macroglobulin precursor [Homo sapiens 0,292 -1,778 12,087 …. 281 163189 8 6.00 5031631 scavenger receptor class B, member 2 [Homo sapien 0,290 -1,785 16,933 …. 480 54255 8 5.00 27734917 phospholipase B domain containing 2 [Homo sapiens 0,288 -1,793 18,411 19,45091 470 65430 15 6.53 24475586 ependymin related protein 1 precursor [Homo sapien 0,268 -1,897 14,524 …. 400 38126 9 9.66 7657309 LIM and cysteine-rich domains 1 [Homo sapiens 0,266 -1,910 3,926 …. 115 40806 4 8.27 6005990 arylsulfatase A isoform a precursor [Homo sapiens 0,207 -2,275 11,597 …. 577 53554 9 5.65 4758112 HLA-B associated transcript 1 [Homo sapiens] 0,204 -2,293 6,753 …. 245 48960 16 5.44 33636742 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 isoform a precursor [Homo sapiens] 0,162 -2,622 14,995 …. 280 87043 24 6.24 8051579 adenylate kinase 3-like 1 isoform 6 [Homo sapiens] 0,157 -2,669 10,060 …. 106 25252 8 8.47 54607043 glucocerebrosidase precursor [Homo sapiens] 0,134 -2,897 19,245 19,356126 62 59678 4 7.29 Supplementary Table S2. Proteins identified after comparing the proteome of human skin fibroblasts from a 14-year-old female HGPS patient (AG01972) versus cells from a 13-year-old female healthy control (GM01651). Accession Number (gi) Protein Name SILAC ratio logFC RSD (we) RSD (be) Mascot Score Mw (Da) Number of peptides Isoelectric point 124494247 myosin IC isoform b [Homo sapiens] 6,111 2,611 19,753 … 468 119554 21 5,5 44680105 caldesmon 1 isoform 1 [Homo sapiens] 5,992 2,583 12,885 9,341 920 93175 32 8,57 5453710 LIM and SH3 protein 1 [Homo sapiens] 5,781 2,531 16,117 … 329 29698 8 6,84 32454741 serine (or cysteine) proteinase inhibitor, clade H, member 1 precursor [Homo sa 5,604 2,486 19,994 8,053 2396 46411 26 5,49 108773793 glucose-6-phosphate dehydrogenase isoform b [Homo sapiens] 5,102 2,351 15,833 … 267 59219 25 6,1 31542947 chaperonin [Homo sapiens] 5,062 2,340 18,712 … 2733 61016 34 8,02 56237029 integrin alpha 5 precursor [Homo sapiens] 4,726 2,241 11,579 … 48 114465 10 7,96 163965366 nascent polypeptide-associated complex alpha subunit isoform a [Homo sapien 4,269 2,094 19,012 … 455 205295 22 5,25 47519639 microtubule-associated protein 4 isoform 1 [Homo sapiens] 3,827 1,936 6,016 … 112 120930 19 7,66 15149465 caldesmon 1 isoform 5 [Homo sapiens] 3,767 1,914 10,143 … 920 61176 33 8,54 4505415 NAD(P)H menadione oxidoreductase 1, dioxin-inducible isoform a [Homo sapie 3,705 1,890 19,916 18,794 2735 30848 13 4,77 6912582 penta-EF-hand domain containing 1 [Homo sapiens] 3,682 1,881 5,662 … 100 30361 4 5,95 4758868 prolyl 4-hydroxylase, alpha II subunit isoform 1 precursor [Homo sapiens] 3,652 1,869 16,200 … 401 60864 11 5,69 4758950 peptidylprolyl isomerase B precursor [Homo sapiens] 3,619 1,856 18,066 17,524 1073 23728 15 10,21 4885409 high density lipoprotein binding protein [Homo sapiens] 3,457 1,789 18,688 13,645 314 141352 41 6,23 4557469 adaptor-related protein complex 2, beta 1 subunit isoform b [Homo sapiens] 3,409 1,769 19,665 19,659 837 104486 32 5,96 46367787 poly(A) binding protein, cytoplasmic 1 [Homo sapiens] 3,343 1,741 2,328 … 200 70626 22 5,5 40805868 tumor protein D52-like 2 isoform c [Homo sapiens] 3,277 1,713 18,043 … 557 23772 14 9,59 11559929 coatomer protein complex, subunit gamma 1 [Homo sapiens] 3,277 1,712 12,833 9,733 554 97655 21 6,54 13904870 ribosomal protein S5 [Homo sapiens] 3,265 1,707 8,310 … 297 22862 9 4,64 124494238 myosin IC isoform a [Homo sapiens] 3,231 1,692 17,334 … 1667 121606 43 9,66 186928835 leprecan 1 isoform 1 [Homo sapiens] 3,204 1,680 10,724 … 110 83341 13 6,08 21361091 ubiquitin carboxyl-terminal esterase L1 [Homo sapiens] 3,194 1,676 18,911 … 321 24808 11 9,81 7305053 myoferlin isoform a [Homo sapiens] 3,107 1,636 19,406 4,985 2757 234561 72 5,57 148727247 ubiquitin specific peptidase 5 isoform 2 [Homo sapiens] 3,060 1,614 2,489 … 173 93248 14 8,23 110349772 alpha 1 type I collagen preproprotein [Homo sapiens] 2,967 1,569 17,806 10,858 397 138827 28 8,5 48762934 alpha 2 type I collagen [Homo sapiens] 2,953 1,562 8,730 … 288 129235 15 4,56 23065552 glutathione S-transferase mu 3 [Homo sapiens] 2,945 1,558 17,031 … 534 26542 11 6,67 4757838 BCL2-associated X protein isoform beta [Homo sapiens] 2,900 1,536 18,221 … 746 24204 7 9,68 7705369 coatomer protein complex, subunit beta 1 [Homo sapiens] 2,808 1,489 9,336 8,129 274 107074 26 5,45 110624774 mannose receptor, C type 2 [Homo sapiens] 2,779 1,475 18,723 … 184 166568 8 6,36 4503483 eukaryotic translation elongation factor 2 [Homo sapiens] 2,772 1,471 17,782 18,366 2560 95277 40 11,65 55956788 nucleolin [Homo sapiens] 2,758 1,464 2,687 … 641 76568 20 7,18 166235148 osteoclast stimulating factor 1 [Homo sapiens] 2,739 1,454 19,637 … 197 23772 6 6,53 31621305 leucine-rich PPR motif-containing protein [Homo sapiens] 2,000 1,000 13,870 … 248 157805 25 5,67 10801345 eukaryotic translation initiation factor 3, subunit 12 [Homo sapiens] 2,649 1,406 16,762 … 383 25043 6 6,84 15431295 ribosomal protein L13 [Homo sapiens] 2,639 1,400 7,827 1,452 232 24247 11 6,78 78000181 ribosomal protein L14 [Homo sapiens] 2,601 1,379 18,577 … 640 23417 7 4,87 38569423 ATP citrate lyase isoform 2 [Homo sapiens] 2,594 1,375 6,225 … 811 119695 39 4,47 29826335 eukaryotic translation initiation factor 2 beta [Homo sapiens] 2,566 1,360 0,228 … 129 38364 9 7,95 14141161 heterogeneous nuclear ribonucleoprotein U isoform b [Homo sapiens] 2,551 1,351 7,761 … 106 88924 7 6,13 48255937 CD44 antigen isoform 2 precursor [Homo sapiens] 2,536 1,343 4,441 … 68 76565 6 5,12 116256489 septin 9 isoform c [Homo sapiens] 2,518 1,332 15,378 … 220 63626 14 8,76 4758304 protein disulfide isomerase A4 [Homo sapiens] 2,504 1,324 18,565 8,636 612 72887 27 5,79 42491362 IKK interacting protein isoform 2 [Homo sapiens] 2,494 1,319 14,391 … 744 39285 19 5,58 110611218 ribosome binding protein 1 [Homo sapiens] 2,429 1,280 19,740 12,716 626 108589 27 8,44 4557317 annexin A11 [Homo sapiens] 2,414 1,271 18,119 12,303 137 54355 12 9,48 4506667 ribosomal protein P0 [Homo sapiens] 2,411 1,270 13,178 2,431 678 34252 10 9,71 40254924 leucine rich repeat containing 59 [Homo sapiens] 2,400 1,263 18,628 2,696 581 34909 8 9,18 4506723 ribosomal protein S3a [Homo sapiens] 2,399 1,262 17,598 15,822 441 29926 12 5,68 47717100 ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H isoform 2 [Homo s 2,395 1,260 18,449 … 247 54116 9 4,7 4506127 phosphoribosyl pyrophosphate synthetase 1 [Homo sapiens] 2,379 1,251 18,601 … 385 34812 11 5,06 5031873 lectin, mannose-binding, 1 precursor [Homo sapiens] 2,378 1,250 0,467 … 109 57513 13 4,76 79750824 hypothetical protein LOC64855 isoform 2 [Homo sapiens] 2,346 1,230 16,338 … 442 82631 16 4,8 14141193 ribosomal protein S9 [Homo sapiens] 2,329 1,220 19,630 … 260 22578 17 5,47 71773415 annexin VI isoform 2 [Homo sapiens] 2,326 1,218 19,177 … 3128 75229 42 8,73 38569421 ATP citrate lyase isoform 1 [Homo sapiens] 2,285 1,192 16,078 … 462 120762 21 5,27 21361322 tubulin, beta 4 [Homo sapiens] 2,272 1,184 0,353 … 4245 49554 18 5,61 63252891 prolyl 4-hydroxylase, alpha II subunit isoform 2 precursor [Homo sapiens] 2,263 1,178 13,323 … 523 60595 19 6,13 4758158 septin 2 [Homo sapiens] 2,247 1,168 12,634 … 515 41461 14 5,96 5453832 hypoxia up-regulated 1 precursor [Homo sapiens] 2,222 1,152 8,707 6,533 707 111266 40 6,11 4507357 transgelin 2 [Homo sapiens] 2,219 1,150 16,200 … 3350 22377 16 10,61 24431935 reticulon 4 isoform A [Homo sapiens] 2,212 1,146 19,222 … 749 129851 18 8,78 4506707 ribosomal protein S25 [Homo sapiens] 2,209 1,143 13,081 … 129 13734 7 6,89 156564401 vesicle-fusing ATPase [Homo sapiens] 2,204 1,140 12,621 … 102 82542 20 5,2 4506365 RAB2A, member RAS oncogene family [Homo sapiens] 2,182 1,125 19,707 2,219 1114 23531 11 7,26 4506661 ribosomal protein L7a [Homo sapiens] 2,174 1,121 18,977 13,201 940 29977 12 10,17 47132587 protein kinase C, delta binding protein [Homo sapiens] 2,168 1,116 19,251 18,001 738 27685 12 6,77 156104878 glutaminase [Homo sapiens] 2,168 1,116 12,885 8,401 192 73414 14 5,18 71773329 annexin VI isoform 1 [Homo sapiens] 2,168 1,116 17,758 … 3804 75826 45 6,25 223890243 ribosomal protein L10 [Homo sapiens] 2,167 1,116 18,616 … 417 24588 9 7 4501853 acetyl-Coenzyme A acyltransferase 1 isoform a [Homo sapiens] 2,161 1,112 14,151 … 116 44264 5 6 21614499 ezrin [Homo sapiens] 2,158 1,110 18,359 17,664 1479 69370 32 6,36 14210536 tubulin, beta 6 [Homo sapiens] 2,149 1,104 17,866 … 3713 49825 20 9,43 33620775 kinectin 1 isoform a [Homo sapiens] 2,149 1,103 7,934 … 519 156179 36 8,87 4758256 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [Homo sapiens] 2,132 1,093 9,902 … 251 36089 11 9,37 14165469 ribosomal protein S15a [Homo sapiens] 2,112 1,079 17,723 … 237 14830 7 6,9 20149594 heat shock 90kDa protein 1, beta [Homo sapiens] 2,107 1,075 17,710 12,943 3133 83212 47 8,16 4504763 integrin alpha-V isoform 1 precursor [Homo sapiens] 2,093 1,065 13,189 5,058 329 115978 21 6,52 9845502 ribosomal protein SA [Homo sapiens] 2,091 1,064 16,620 2,857 407 32833 13 9,44 17105394 ribosomal protein L23a [Homo sapiens] 2,076 1,054 8,955 … 135 17684 9 5,34 155969707 insulin-degrading enzyme [Homo sapiens] 2,067 1,048 12,674 … 46 117893 6 5,66 4758516 hepatoma-derived growth factor isoform a [Homo sapiens] 2,063 1,045 7,499 … 225 26772 12 5,27 23308577 phosphoglycerate dehydrogenase [Homo sapiens] 2,061 1,043 5,859 8,283 304 56614 15 8,92 17402893 phosphoserine aminotransferase 1 isoform 1 [Homo sapiens] 2,036 1,026 18,372 7,239 165 40397 13 8,29 94429050 SEC22 vesicle trafficking protein homolog B [Homo sapiens] 2,035 1,025 19,809 4,815 1230 24578 10 6 7705704 glutathione S-transferase kappa 1 isoform a [Homo sapiens] 2,033 1,023 18,824 … 677 25480 11 5,09 17158044 ribosomal protein S6 [Homo sapiens] 2,022 1,015 19,840 … 285 28663 13 4,71 5453629 dynactin 2 [Homo sapiens] 2,014 1,010 19,831 … 353 44792 11 9,76 4757756 annexin A2 isoform 2 [Homo sapiens] 2,009 1,006 19,910 1,844 13013 38580 33 5,38 4506609 ribosomal protein L19 [Homo sapiens] 2,008 1,006 19,433 … 337 23451 11 5,22 162951877 scinderin isoform 1 [Homo sapiens] 2,006 1,004 16,471 14,780 703 80438 29 5,66 4506467 radixin [Homo sapiens] 2,003 1,002 16,263 … 577 68521 22 6,32 4502101 annexin I [Homo sapiens] 2,002 1,002 19,568 19,358 4808 38690 23 5,5 15431293 ribosomal protein L15 [Homo sapiens] 1,990 0,993 15,651 … 232 24247 11 8,11 50428925 cytoskeleton associated protein 1 [Homo sapiens] 1,986 0,990 15,118 … 159 27308 12 4,56 15055539 ribosomal protein S2 [Homo sapiens] 1,975 0,982 18,040 7,375 770 31305 13 5,96 4885079 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma subunit isofo 1,969 0,978 17,640 9,493 171 32860 10 7,6 5454090 signal sequence receptor, delta [Homo sapiens] 1,959 0,970 5,246 … 152 18987 4 8,69 19920317 cytoskeleton-associated protein 4 [Homo sapiens] 1,954 0,967 18,963 18,270 2281 65983 37 7,01 4507651 tropomyosin 4 isoform 2 [Homo sapiens] 1,940 0,956 19,614 18,254 1555 28504 22 11,03 157168362 nucleoside phosphorylase [Homo sapiens] 1,939 0,955 8,296 … 323 32097 15 6,7 34147630 Tu translation elongation factor, mitochondrial precursor [Homo sapiens] 1,936 0,953 5,817 … 159 49843 7 5,56 116256327 membrane metallo-endopeptidase [Homo sapiens] 1,932 0,950 18,242 4,336 1568 85460 25 5,68 4504747 integrin alpha 3 isoform a precursor [Homo sapiens] 1,931 0,949 10,888 … 137 116538 7 10,12 47933379 N-ethylmaleimide-sensitive factor attachment protein, alpha [Homo sapiens] 1,931 0,949 9,420 5,197 1155 33211 16 5,48 61743954 AHNAK nucleoprotein isoform 1 [Homo sapiens] 1,929 0,948 19,169 3,615 3409 628699 166 5,49 4507115 fascin 1 [Homo sapiens] 1,927 0,947 19,041 19,588 447 54496 16 4,94 34335134 SEC13 protein isoform 1 [Homo sapiens] 1,923 0,943 18,284 … 83 35518 2 5,71 50592996 tubulin, beta, 4 [Homo sapiens] 1,915 0,937 19,328 5,538 5041 50400 22 4,46 4826960 glutaminyl-tRNA synthetase [Homo sapiens] 1,908 0,932 11,335 … 271 87743 21 5,78 214010226 ribosomal protein S24 isoform d [Homo sapiens] 1,903 0,928 13,576 … 133 32410 7 5,3 22267436 nipsnap homolog 3A [Homo sapiens] 1,900 0,926 10,352 … 274 28449 12 5,34 156071459 solute carrier family 25, member 5 [Homo sapiens] 1,896 0,923 14,141 … 240 32831 17 8,67 4506743 ribosomal protein S8 [Homo sapiens] 1,895 0,922 18,639 5,561 587 24190 11 4,85 4557014 catalase [Homo sapiens] 1,889 0,918 18,927 … 137 59719 5 6,25 41872631 fatty acid synthase [Homo sapiens] 1,886 0,916 18,258 13,076 757 273254 40 6,27 11968182 ribosomal protein S18 [Homo sapiens] 1,877 0,909 12,477 12,239 71 17708 4 4,74 222136639 methylenetetrahydrofolate dehydrogenase 1 [Homo sapiens] 1,869 0,902 9,416 … 213 101467 16 5,06 21361619 toll interacting protein [Homo sapiens] 1,852 0,889 15,785 … 131 30262 11 5,9 13259508 dynactin 1 isoform 2 [Homo sapiens] 1,844 0,883 15,176 … 405 127325 21 5,36 16753227 ribosomal protein L6 [Homo sapiens] 1,832 0,873 16,742 7,898 912 32708 14 5,09 4505541 USO1 homolog, vesicle docking protein [Homo sapiens] 1,821 0,865 11,600 11,447 395 107840 13 5,02 4506623 ribosomal protein L27 [Homo sapiens] 1,815 0,860 17,510 … 68 15788 8 4,83 42734430 polymerase I and transcript release factor [Homo sapiens] 1,815 0,860 15,038 15,550 3236 43450 13 8,24 4506649 ribosomal protein L3 isoform a [Homo sapiens] 1,815 0,860 9,793 … 110 46080 9 6,71 154146191 heat shock 90kDa protein 1, alpha isoform 2 [Homo sapiens] 1,812 0,857 19,246 2,696 3140 84607 45 5,69 4503727 FK506 binding protein 3, 25kDa [Homo sapiens] 1,808 0,854 16,244 … 111 11943 3 9,21 87196339 collagen, type VI, alpha 1 precursor [Homo sapiens] 1,807 0,854 19,296 18,063 2167 108462 29 5,86 4757774 ADP-ribosylation factor-like 3 [Homo sapiens] 1,802 0,850 3,459 … 234 20443 9 10,66 4506725 ribosomal protein S4, X-linked X isoform [Homo sapiens] 1,801 0,848 15,860 … 575 29579 16 5,31 115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 1,783 0,835 18,043 … 238 56255 10 5,87 219555707 eukaryotic translation initiation factor 5A isoform A [Homo sapiens] 1,777 0,829 15,268 … 452 20157 7 5,65 4506663 ribosomal protein L8 [Homo sapiens] 1,777 0,829 12,758 … 146 28007 12 9,21 4758648 kinesin family member 5B [Homo sapiens] 1,776 0,829 19,917 17,690 611 109617 33 4,73 4757810 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit precu 1,775 0,828 15,495 13,225 2415 59714 27 5,09 4506607 ribosomal protein L18 [Homo sapiens] 1,774 0,827 19,837 … 1054 21621 9 9,75 28872725 proteasome 26S non-ATPase subunit 11 [Homo sapiens] 1,771 0,824 12,964 … 314 47434 11 4,36 4503513 eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa [Homo sapiens] 1,767 0,821 12,110 15,507 123 36479 8 10,94 15431303 ribosomal protein L9 [Homo sapiens] 1,766 0,820 14,522 … 468 21850 9 5,55 15431288 ribosomal protein L10a [Homo sapiens] 1,765 0,820 12,956 3,841 321 24816 10 5,35 5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) [Homo sap 1,765 0,819 10,624 … 152 62599 22 7,29 23110942 proteasome alpha 5 subunit [Homo sapiens] 1,760 0,816 4,167 … 366 26394 7 8,57 5453555 ras-related nuclear protein [Homo sapiens] 1,760 0,816 13,671 … 172 24408 8 5,7 4503519 eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa [Homo sapien 1,758 0,814 3,431 … 727 37540 8 6,95 4503481 eukaryotic translation elongation factor 1 gamma [Homo sapiens] 1,758 0,814 15,134 15,862 456 50087 19 4,81 7661714 family with sequence similarity 3, member C precursor [Homo sapiens] 1,757 0,813 19,814 … 376 24665 8 8,75 14389309 tubulin alpha 6 [Homo sapiens] 1,751 0,808 19,739 … 11073 49863 20 7,09 4506741 ribosomal protein S7 [Homo sapiens] 1,748 0,806 18,911 … 508 22113 12 10,59 4507729 tubulin, beta 2 [Homo sapiens] 1,748 0,805 3,792 … 5840 49875 21 11,73 4506597 ribosomal protein L12 [Homo sapiens] 1,739 0,798 7,928 … 325 17808 7 5,23 4506675 ribophorin I precursor [Homo sapiens] 1,739 0,798 19,537 8,090 896 68527 31 10,32 127139033 cytochrome P450 reductase [Homo sapiens] 1,732 0,792 8,959 … 227 76999 11 5,78 4758958 cAMP-dependent protein kinase, regulatory subunit alpha 2 [Homo sapiens] 1,731 0,792 11,146 … 312 45490 14 4,39 4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 1,726 0,788 18,125 19,972 505 79636 14 8,41 14251209 chloride intracellular channel 1 [Homo sapiens] 1,718 0,781 18,494 15,329 649 26906 8 5,81 4506605 ribosomal protein L23 [Homo sapiens] 1,717 0,780 13,314 … 224 14856 5 5,8 15718687 ribosomal protein S3 [Homo sapiens] 1,715 0,778 15,799 11,182 645 26671 15 6,43 5031601 actin related protein 2/3 complex subunit 1B [Homo sapiens] 1,704 0,769 11,136 … 118 40923 6 5,83 109148508 otubain 1 [Homo sapiens] 1,696 0,762 10,286 … 162 31264 5 9,61 38202214 SEC23-related protein A [Homo sapiens] 1,679 0,747 18,735 16,727 505 86105 14 5,31 50845388 annexin A2 isoform 1 [Homo sapiens] 1,675 0,744 19,007 … 3158 40386 33 5,45 23397427 synaptotagmin binding, cytoplasmic RNA interacting protein [Homo sapiens] 1,674 0,744 4,022 18,598 257 69590 13 5,85 21361462 EH-domain containing 2 [Homo sapiens] 1,671 0,740 17,958 10,004 761 61123 25 8,62 20070197 dolichyl-diphosphooligosaccharide-protein glycosyltransferase precursor [Homo 1,667 0,737 16,096 6,149 740 50670 13 6,29 15149476 arginyl-tRNA synthetase [Homo sapiens] 1,665 0,736 9,087 17,731 372 75331 28 5,49 21361565 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 precurso 1,663 0,734 19,430 6,621 835 28890 13 5,32 4505143 cytosolic malic enzyme 1 [Homo sapiens] 1,659 0,730 8,801 … 560 64109 13 5,42 19923231 RAB6A, member RAS oncogene family isoform a [Homo sapiens] 1,656 0,727 12,069 … 760 23534 15 8,97 5803187 transaldolase 1 [Homo sapiens] 1,654 0,726 19,724 1,464 439 37516 24 4,97 19743813 integrin beta 1 isoform 1A precursor [Homo sapiens] 1,653 0,725 19,007 16,619 825 88357 18 4,88 96975097 RAB6B, member RAS oncogene family [Homo sapiens] 1,651 0,723 7,736 … 318 23447 6 6,24 153945728 microtubule-associated protein 1B [Homo sapiens] 1,648 0,721 19,980 … 180 270468 16 6,67 19743875 fumarate hydratase precursor [Homo sapiens] 1,645 0,718 19,714 … 322 54602 13 7,02 19923315 serine hydroxymethyltransferase 2 (mitochondrial) [Homo sapiens] 1,639 0,713 19,553 … 348 55958 16 6,35 4505891 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 precursor [Homo sapiens] 1,636 0,710 18,992 13,648 321 84731 24 6,16 4506691 ribosomal protein S16 [Homo sapiens] 1,634 0,708 17,124 … 162 16435 8 6,9 169404009 signal sequence receptor, alpha [Homo sapiens] 1,626 0,701 4,142 4,148 354 32215 3 5,51 93141047 collagen, type XII, alpha 1 long isoform precursor [Homo sapiens] 1,625 0,700 19,575 1,594 221 332941 42 8,85 4503471 eukaryotic translation elongation factor 1 alpha 1 [Homo sapiens] 1,620 0,696 18,409 6,684 1480 50109 14 5,46 11415026 ribosomal protein L18a [Homo sapiens] 1,603 0,681 16,356 … 88 20749 10 5,02 32307144 lysyl hydroxylase 1 precursor [Homo sapiens] 1,596 0,675 19,420 14,346 574 83497 33 6,46 7705885 vacuolar protein sorting 28 isoform 1 [Homo sapiens] 1,595 0,674 12,910 … 147 25409 11 8,45 4502303 mitochondrial ATP synthase, O subunit precursor [Homo sapiens] 1,593 0,672 16,489 … 524 23263 13 9,42 19557691 surfeit 4 [Homo sapiens] 1,580 0,660 11,600 … 671 30374 7 6,46 7705827 SAR1a gene homolog 2 [Homo sapiens] 1,578 0,658 3,827 … 343 22396 9 5,84 4506003 protein phosphatase 1, catalytic subunit, alpha isoform 1 [Homo sapiens] 1,561 0,643 19,052 … 694 37488 11 6,29 5453990 proteasome activator subunit 1 isoform 1 [Homo sapiens] 1,555 0,637 19,702 … 592 28705 17 6,15 22749197 motile sperm domain containing 2 [Homo sapiens] 1,554 0,636 3,412 … 77 59708 15 6,53 4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [Homo sapiens] 1,550 0,633 16,741 … 798 26906 10 6,36 25777612 proteasome 26S non-ATPase subunit 3 [Homo sapiens] 1,547 0,629 15,204 8,436 454 60939 21 6,41 5174447 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 [Homo 1,546 0,628 16,595 4,041 745 35055 10 6,98 5453998 importin 7 [Homo sapiens] 1,541 0,624 17,060 2,341 570 119440 24 6,95 90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 1,538 0,621 11,322 … 205 85611 11 6,15 4507947 tyrosyl-tRNA synthetase [Homo sapiens] 1,535 0,618 19,369 10,017 177 59106 22 6,4 38455427 chaperonin containing TCP1, subunit 4 (delta) [Homo sapiens] 1,534 0,617 19,786 4,425 618 57888 13 7,53 133925811 transportin 1 isoform 1 [Homo sapiens] 1,525 0,609 7,893 … 102 102289 10 6,18 190358517 RAB11B, member RAS oncogene family [Homo sapiens] 1,525 0,609 18,522 … 1209 24473 14 5,69 14141195 stromal cell-derived factor 2 precursor [Homo sapiens] 1,524 0,608 14,596 … 189 23011 5 5,72 11345462 signal peptidase complex subunit 3 [Homo sapiens] 1,522 0,606 7,894 … 175 20301 7 6,14 9910542 SAR1a gene homolog 1 [Homo sapiens] 1,517 0,602 19,651 … 970 22353 11 7,7 32189394 mitochondrial ATP synthase beta subunit precursor [Homo sapiens] 1,516 0,600 19,630 7,253 3067 56525 27 5,49 57863257 T-complex protein 1 isoform a [Homo sapiens] 1,512 0,597 18,969 … 1117 60306 27 8,71 33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens] 1,511 0,596 19,367 … 3601 532072 151 6,03 4503685 farnesyl diphosphate synthase isoform a [Homo sapiens] 1,506 0,590 9,636 12,266 137 48245 11 8,56 48255959 plasma membrane calcium ATPase 4 isoform 4a [Homo sapiens] 1,505 0,589 13,457 … 275 129321 16 6,46 19923973 potassium channel tetramerisation domain containing 12 [Homo sapiens] 1,504 0,589 14,387 … 142 35679 11 5,13 4758762 asparaginyl-tRNA synthetase [Homo sapiens] 1,504 0,589 17,580 5,440 726 62903 15 8,76 4507951 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 1,501 0,586 17,847 … 726 28201 16 7,01 31621303 sideroflexin 3 [Homo sapiens] 1,498 0,583 15,274 … 683 35956 14 6,06 21361399 alpha isoform of regulatory subunit A, protein phosphatase 2 [Homo sapiens] 1,494 0,579 19,997 15,857 736 65267 23 4,63 25453474 eukaryotic translation elongation factor 1 delta isoform 1 [Homo sapiens] 1,492 0,577 19,325 12,331 893 71364 13 8,16 55743106 alpha 3 type VI collagen isoform 5 precursor [Homo sapiens] 1,492 0,577 15,473 … 1933 321156 70 5,53 156564357 NAD(P)H dehydrogenase, quinone 2 [Homo sapiens] 1,489 0,574 15,103 … 273 25902 7 5,91 5031569 ARP1 actin-related protein 1 homolog A, centractin alpha [Homo sapiens] 1,483 0,568 9,138 6,270 625 42587 11 5,64 4504517 heat shock protein beta-1 [Homo sapiens] 1,482 0,567 17,547 … 1989 22768 13 4,43 21269877 cysteinyl-tRNA synthetase isoform a [Homo sapiens] 1,482 0,567 17,609 … 183 82794 14 8,24 41352061 metalloprotease 1 [Homo sapiens] 1,481 0,566 9,206 … 118 117338 15 9,45 209413738 ribophorin II isoform 2 precursor [Homo sapiens] 1,479 0,565 3,547 … 745 67681 19 7,05 19923193 heat shock 70kD protein binding protein [Homo sapiens] 1,479 0,564 18,318 … 89 41305 9 5,11 5174735 tubulin, beta, 2 [Homo sapiens] 1,478 0,563 9,346 18,771 6422 49799 22 5,98 6274552 signal transducer and activator of transcription 1 isoform alpha [Homo sapiens] 1,477 0,563 19,891 19,486 1575 87280 34 5,54 19923142 karyopherin beta 1 [Homo sapiens] 1,477 0,563 18,711 … 967 97108 17 6,73 4506693 ribosomal protein S17 [Homo sapiens] 1,477 0,562 17,100 … 223 15540 6 10,99 4502643 chaperonin containing TCP1, subunit 6A isoform a [Homo sapiens] 1,475 0,561 16,243 6,920 1466 57988 27 5,33 194248088 sulfatase modifying factor 2 isoform b precursor [Homo sapiens] 1,475 0,561 10,558 … 357 35914 6 5,22 156071462 solute carrier family 25, member A6 [Homo sapiens] 1,471 0,556 18,792 5,318 237 32845 11 6,3 31377697 glycosyltransferase 25 domain containing 1 [Homo sapiens] 1,454 0,540 5,653 12,998 100 71590 13 8,55 4504437 heme oxygenase (decyclizing) 1 [Homo sapiens] 1,451 0,537 3,533 … 259 32798 9 5,5 22749415 integral membrane protein 1 [Homo sapiens] 1,447 0,533 7,637 … 57 80477 9 8,96 45439306 aspartyl-tRNA synthetase [Homo sapiens] 1,445 0,531 0,862 … 47 57100 7 8,45 62240992 cysteinyl-tRNA synthetase isoform c [Homo sapiens] 1,445 0,531 4,470 … 188 94578 16 6,33 14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 1,443 0,529 10,239 9,523 974 122780 27 6,23 4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens] 1,439 0,526 17,863 4,003 356 29537 11 7,57 108773810 leucyl-tRNA synthetase [Homo sapiens] 1,438 0,524 4,186 17,132 364 134379 34 5,39 4503477 eukaryotic translation elongation factor 1 beta 2 [Homo sapiens] 1,433 0,519 3,333 … 350 24748 5 5,81 162417971 signal peptidase complex subunit 2 homolog [Homo sapiens] 1,432 0,518 19,544 … 310 24987 9 5,04 15431301 ribosomal protein L7 [Homo sapiens] 1,429 0,515 18,384 14,876 287 29207 15 5,14 13569962 RAB1B, member RAS oncogene family [Homo sapiens] 1,428 0,514 19,187 19,213 1784 22157 11 10,53 6005854 prohibitin 2 isoform 2 [Homo sapiens] 1,420 0,505 18,240 14,484 939 33276 17 6,84 42544159 heat shock 105kD [Homo sapiens] 1,419 0,505 10,472 … 108 96804 25 7,05 24797086 importin 5 [Homo sapiens] 1,418 0,504 16,854 3,958 1235 125464 33 9,14 4826952 proteasome 26S non-ATPase subunit 5 [Homo sapiens] 1,417 0,503 3,329 … 334 56160 15 5,94 4885425 v-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 1 [Homo sapiens 1,407 0,493 19,985 … 90 21285 9 7,96 112380628 lysosomal-associated membrane protein 1 [Homo sapiens] 1,406 0,492 18,827 … 903 44854 8 6,23 105990514 filamin B, beta (actin binding protein 278) [Homo sapiens] 1,403 0,489 18,514 10,847 3704 277990 87 5,8 4557235 acyl-Coenzyme A dehydrogenase, very long chain isoform 1 precursor [Homo s 1,397 0,483 18,747 5,355 501 70345 19 4,96 124494254 ErbB3-binding protein 1 [Homo sapiens] 1,394 0,480 17,567 … 105 43759 11 6,95 23308607 minor histocompatibility antigen 13 isoform 1 [Homo sapiens] 1,393 0,478 19,764 … 58 41462 5 5,8 4503529 eukaryotic translation initiation factor 4A isoform 1 [Homo sapiens] 1,392 0,477 17,258 1,628 753 46125 18 5,6 205277394 coenzyme A synthase isoform c [Homo sapiens] 1,389 0,474 6,575 … 169 65299 9 9,06 31542319 epsilon subunit of coatomer protein complex isoform a [Homo sapiens] 1,387 0,472 9,837 … 1040 34460 12 5,47 39725636 transmembrane emp24 protein transport domain containing 9 [Homo sapiens] 1,387 0,472 12,873 … 242 27260 8 5,45 5729779 COP9 signalosome subunit 8 isoform 1 [Homo sapiens] 1,383 0,468 3,197 … 461 23211 7 5,28 5031973 protein disulfide isomerase A6 [Homo sapiens] 1,382 0,467 18,099 13,531 1492 48091 17 9,25 54607043 glucocerebrosidase precursor [Homo sapiens] 1,381 0,465 8,786 7,479 279 59678 14 5,78 88703043 sorting nexin 6 isoform a [Homo sapiens] 1,380 0,464 12,409 … 121 33549 8 8,88 4502203 ADP-ribosylation factor 3 [Homo sapiens] 1,380 0,464 17,135 … 979 20588 12 6,4 25777600 proteasome 26S non-ATPase subunit 1 [Homo sapiens] 1,379 0,463 10,210 … 307 105769 21 9,73 30410792 proteasome activator subunit 2 [Homo sapiens] 1,375 0,460 17,634 … 823 27384 11 7,5 5803227 tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide [H 1,373 0,458 19,688 3,553 1927 29155 23 5,25 41327764 aldo-keto reductase family 7, member A2 [Homo sapiens] 1,372 0,457 19,556 15,929 459 39564 9 6,32 58761486 chaperonin containing TCP1, subunit 3 isoform b [Homo sapiens] 1,371 0,455 12,266 13,332 594 60424 23 6,91 5031635 cofilin 1 (non-muscle) [Homo sapiens] 1,370 0,454 17,496 … 1567 18491 13 5,51 5031573 ARP3 actin-related protein 3 homolog [Homo sapiens] 1,370 0,454 19,274 18,969 816 47341 16 8,67 5453595 adenylyl cyclase-associated protein [Homo sapiens] 1,367 0,451 19,738 5,315 3778 51641 19 4,68 4503377 dihydropyrimidinase-like 2 [Homo sapiens] 1,363 0,447 11,147 … 2477 62255 21 5,54 33469985 FK506 binding protein 9 [Homo sapiens] 1,361 0,445 13,478 13,053 202 63044 15 8,27 30240932 EH-domain containing 1 [Homo sapiens] 1,360 0,443 17,496 7,897 585 60589 29 7,36 4505773 prohibitin [Homo sapiens] 1,356 0,439 17,475 … 856 29786 16 5,74 23110944 proteasome alpha 6 subunit [Homo sapiens] 1,352 0,435 18,202 … 690 27382 10 5,3 4505991 peptidylprolyl isomerase C [Homo sapiens] 1,350 0,433 5,800 … 296 22749 3 4,7 4506005 protein phosphatase 1, catalytic subunit, beta isoform 1 [Homo sapiens] 1,347 0,429 15,982 2,789 700 37163 13 7,56 24430151 proteasome 26S ATPase subunit 1 [Homo sapiens] 1,342 0,424 19,289 2,791 398 49154 19 6,65 13775198 SH3 domain binding glutamic acid-rich protein like 3 [Homo sapiens] 1,340 0,422 8,216 … 188 10431 6 7,64 4757900 calreticulin precursor [Homo sapiens] 1,339 0,421 17,698 2,871 2218 48112 20 8,69 9910280 UDP-glucose ceramide glucosyltransferase-like 1 [Homo sapiens] 1,330 0,411 19,943 7,593 1016 177078 32 9,34 7661910 tetratricopeptide repeat domain 35 [Homo sapiens] 1,326 0,407 15,027 … 392 34811 8 6,17 224177556 lanosterol synthase isoform 2 [Homo sapiens] 1,324 0,405 18,333 … 276 82146 19 5,35 4502049 aldo-keto reductase family 1, member B1 [Homo sapiens] 1,320 0,400 13,060 … 473 35830 9 5,7 189181759 electron transfer flavoprotein, alpha polypeptide isoform b [Homo sapiens] 1,318 0,399 19,806 0,600 763 30007 17 6,21 9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens] 1,311 0,391 14,423 10,450 670 66152 19 9,92 5803013 endoplasmic reticulum protein 29 isoform 1 precursor [Homo sapiens] 1,308 0,387 19,010 … 736 28975 15 5,7 24307939 chaperonin containing TCP1, subunit 5 (epsilon) [Homo sapiens] 1,305 0,384 17,786 14,483 995 59633 31 9,16 4757944 CD81 antigen [Homo sapiens] 1,303 0,382 15,909 … 691 25792 4 4,85 4502105 annexin IV [Homo sapiens] 1,302 0,381 17,805 2,269 995 36062 21 9,6 155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [Homo sapiens] 1,297 0,375 15,404 … 60 231170 30 7,01 94557299 protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 2 [Homo sapien 1,295 0,373 2,914 … 119 65481 12 4,63 21361547 ribonuclease/angiogenin inhibitor [Homo sapiens] 1,293 0,371 17,334 5,092 537 49941 13 6,5 26667180 calcium/calmodulin-dependent protein kinase II delta isoform 3 [Homo sapiens] 1,287 0,364 19,346 … 176 56334 10 5,2 4503841 ATP-dependent DNA helicase II, 70 kDa subunit [Homo sapiens] 1,286 0,363 1,370 … 448 69799 25 5,51 38202257 neutral alpha-glucosidase AB isoform 2 [Homo sapiens] 1,285 0,362 19,515 12,893 1642 106807 37 6,31 116805340 glycyl-tRNA synthetase [Homo sapiens] 1,280 0,357 19,585 1,720 1449 83113 30 5,27 4507677 heat shock protein 90kDa beta, member 1 [Homo sapiens] 1,280 0,356 18,969 10,534 7427 92411 46 9,16 20127486 mannose 6 phosphate receptor binding protein 1 [Homo sapiens] 1,277 0,353 3,941 2,739 1116 47018 17 7,58 48762932 chaperonin containing TCP1, subunit 8 (theta) [Homo sapiens] 1,275 0,350 19,666 4,035 876 59583 29 7,67 20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo sapiens] 1,271 0,346 19,439 7,219 3337 57081 29 5,61 19923483 GTPase Rab14 [Homo sapiens] 1,268 0,343 18,389 … 879 23882 13 5 21361114 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 1,267 0,342 19,123 … 247 34040 10 8,32 51100974 myosin ID [Homo sapiens] 1,262 0,336 16,975 11,639 1396 116129 47 4,8 157502193 proteasome 26S non-ATPase subunit 13 isoform 1 [Homo sapiens] 1,260 0,333 16,588 … 140 42918 8 5,25 7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 1,257 0,330 8,398 … 718 34302 14 6,43 148536853 coatomer protein complex, subunit alpha isoform 2 [Homo sapiens] 1,255 0,327 8,700 11,847 334 138258 19 5,65 13376840 WD repeat domain 61 [Homo sapiens] 1,255 0,327 10,834 … 423 33560 7 5,74 63252886 prolyl 4-hydroxylase, alpha I subunit isoform 1 precursor [Homo sapiens] 1,067 0,093 10,692 5,989 1201 60929 23 6,05 10716563 calnexin precursor [Homo sapiens] 1,253 0,325 19,307 5,367 1471 67526 21 4,47 5031599 actin related protein 2/3 complex subunit 2 [Homo sapiens] 1,252 0,325 19,801 10,248 809 34311 18 6,01 4885417 ubiquitin-conjugating enzyme E2-25K isoform 1 [Homo sapiens] 1,251 0,323 14,854 … 192 22393 9 6,61 5453603 chaperonin containing TCP1, subunit 2 [Homo sapiens] 1,249 0,321 19,357 8,217 2160 57452 29 6,23 4759034 eukaryotic translation termination factor 1 [Homo sapiens] 1,244 0,316 7,675 … 228 49000 12 5,38 192455698 glutathione peroxidase 8 [Homo sapiens] 1,240 0,310 5,379 7,891 80 23866 6 5,67 47132622 5'-methylthioadenosine phosphorylase [Homo sapiens] 1,240 0,310 13,204 … 239 31216 11 8,8 63252888 prolyl 4-hydroxylase, alpha I subunit isoform 2 precursor [Homo sapiens] 1,237 0,306 19,141 … 1343 61011 21 6,23 13259510 dynactin 1 isoform 1 [Homo sapiens] 1,236 0,306 13,693 … 258 141607 36 8,8 40068518 phosphogluconate dehydrogenase [Homo sapiens] 1,236 0,305 18,062 … 936 53106 18 6,4 6912586 6-phosphogluconolactonase [Homo sapiens] 1,235 0,305 18,703 … 742 27530 8 4,91 22538465 proteasome beta 3 subunit [Homo sapiens] 1,234 0,304 17,974 … 883 22933 10 5,16 18491024 dipeptidyl peptidase III [Homo sapiens] 1,233 0,302 13,088 … 290 82538 9 5,13 28178832 isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor [Homo sapiens] 1,233 0,302 11,447 … 117 55842 8 5,62 4759274 thioredoxin-like 1 [Homo sapiens] 1,230 0,299 12,033 … 175 32231 10 10,73 4502491 complement component 1, q subcomponent binding protein precursor [Homo sa 1,226 0,294 19,916 18,331 533 31343 6 5,54 10880989 RAB18, member RAS oncogene family [Homo sapiens] 1,226 0,294 19,775 … 524 22963 9 6,75 77404397 staphylococcal nuclease domain containing 1 [Homo sapiens] 1,220 0,287 19,761 6,330 1091 101934 38 6,71 25777615 proteasome 26S non-ATPase subunit 7 [Homo sapiens] 1,218 0,285 10,638 … 592 37002 14 6,66 4826659 F-actin capping protein beta subunit [Homo sapiens] 1,215 0,281 15,919 0,577 1088 30609 18 5,37 4758032 coatomer protein complex, subunit beta 2 (beta prime) [Homo sapiens] 1,214 0,280 18,485 17,683 228 102422 18 8,53 4826898 profilin 1 [Homo sapiens] 1,213 0,279 18,796 13,793 2418 15045 12 5,76 205277386 glucosamine-fructose-6-phosphate aminotransferase [Homo sapiens] 1,211 0,276 16,789 7,592 677 76710 26 6,31 5453607 chaperonin containing TCP1, subunit 7 isoform a [Homo sapiens] 1,206 0,270 18,114 0,942 944 59329 22 9,27 192448443 FK506 binding protein 10 [Homo sapiens] 1,203 0,267 15,608 … 187 64204 20 5,4 33695095 ras-related GTP-binding protein RAB10 [Homo sapiens] 1,199 0,261 9,853 … 529 22455 12 5,94 21361416 related RAS viral (r-ras) oncogene homolog 2 isoform a [Homo sapiens] 1,198 0,261 13,751 … 441 23385 10 6,7 4506685 ribosomal protein S13 [Homo sapiens] 1,198 0,260 10,959 … 170 17212 7 8,68 195539395 proteasome 26S ATPase subunit 6 [Homo sapiens] 1,194 0,256 16,985 8,984 201 45768 5 8,8 10835063 nucleophosmin 1 isoform 1 [Homo sapiens] 1,191 0,252 18,806 … 765 32555 9 6,01 167614485 acetyl-coenzyme A acyltransferase 2 [Homo sapiens] 1,186 0,246 12,174 … 267 41898 7 6,17 48255889 protein kinase C substrate 80K-H isoform 1 [Homo sapiens] 1,184 0,244 15,478 7,847 397 59388 16 6,27 17978519 vacuolar protein sorting 26 A isoform 1 [Homo sapiens] 1,180 0,238 4,586 … 205 38146 15 8,64 5031593 actin related protein 2/3 complex subunit 5 [Homo sapiens] 1,179 0,238 5,392 … 175 16310 4 6,21 22538467 proteasome beta 4 subunit [Homo sapiens] 1,173 0,230 14,275 … 1644 29185 9 5,41 38202255 threonyl-tRNA synthetase [Homo sapiens] 1,165 0,220 18,778 15,275 471 83382 28 6,21 4502107 annexin 5 [Homo sapiens] 1,159 0,213 18,762 1,625 13556 35914 25 5,89 16507237 heat shock 70kDa protein 5 [Homo sapiens] 1,156 0,209 19,302 3,887 12466 72288 36 5,64 208973246 quinoid dihydropteridine reductase [Homo sapiens] 1,150 0,202 12,129 … 450 25773 8 8,62 21361657 protein disulfide-isomerase A3 precursor [Homo sapiens] 1,149 0,201 18,649 14,331 2294 56747 30 6,17 4505775 solute carrier family 25 member 3 isoform b precursor [Homo sapiens] 1,147 0,198 10,422 3,447 82 39933 10 10,44 5803149 coated vesicle membrane protein [Homo sapiens] 1,146 0,196 13,715 3,695 546 22746 10 5,32 49574508 N-Acetylglucosamine kinase [Homo sapiens] 1,143 0,193 19,074 4,454 737 37352 14 7,86 6005842 proline synthetase co-transcribed homolog [Homo sapiens] 1,143 0,193 6,651 … 170 30325 9 8,75 98986464 transmembrane emp24 domain-containing protein 10 precursor [Homo sapiens 1,143 0,192 13,764 … 710 24960 8 5,34 5453559 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d isoform a 1,141 0,190 8,729 … 720 18480 10 5,18 156627575 UDP-N-acetylglucosamine pyrophosphorylase 1 [Homo sapiens] 1,140 0,188 16,996 … 432 56992 16 4,69 203098013 all-trans-13,14-dihydroretinol saturase [Homo sapiens] 1,140 0,188 9,118 … 161 66777 10 5,88 7661922 RAB21, member RAS oncogene family [Homo sapiens] 1,131 0,177 19,724 … 463 24332 11 6,77 46852147 mitochondrial isoleucine tRNA synthetase [Homo sapiens] 1,130 0,177 15,127 … 180 113719 13 5,57 6005942 valosin-containing protein [Homo sapiens] 1,130 0,176 18,338 17,470 2277 89266 36 5,25 10863945 ATP-dependent DNA helicase II [Homo sapiens] 1,128 0,174 16,909 … 878 82652 22 4,79 4507669 tumor protein, translationally-controlled 1 [Homo sapiens] 1,127 0,172 17,573 13,971 723 19583 10 6,12 4502205 ADP-ribosylation factor 4 [Homo sapiens] 1,126 0,172 9,961 … 654 20498 13 6,1 4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens] 1,126 0,171 15,860 … 577 28415 14 5,5 33589861 RAB31, member RAS oncogene family [Homo sapiens] 1,125 0,171 15,924 … 100 21686 10 6,11 149589008 peptidase D [Homo sapiens] 1,125 0,170 13,414 … 235 54513 10 8,23 5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens] 1,123 0,168 5,257 … 227 47337 6 5,16 6912238 peroxiredoxin 5 isoform a precursor [Homo sapiens] 1,122 0,165 13,925 … 369 22012 11 6,1 4504981 galectin-1 [Homo sapiens] 1,120 0,163 17,093 … 5654 14706 6 6,05 24431933 reticulon 4 isoform B [Homo sapiens] 1,119 0,163 19,963 … 844 40293 10 7,53 4506371 RAB5B, member RAS oncogene family [Homo sapiens] 1,119 0,162 17,255 … 655 23692 10 5,54 13027378 glucosamine-6-phosphate deaminase 1 [Homo sapiens] 1,117 0,160 19,352 … 300 32648 12 8,44 19913414 adaptor-related protein complex 2, alpha 1 subunit isoform 1 [Homo sapiens] 1,117 0,159 3,376 … 376 107478 32 4,75 24307879 dynein, cytoplasmic 1, intermediate chain 2 [Homo sapiens] 1,116 0,159 14,964 … 389 71412 8 6,9 4502013 adenylate kinase 2 isoform a [Homo sapiens] 1,115 0,157 18,529 … 445 26461 9 6,39 21361144 proteasome 26S ATPase subunit 3 [Homo sapiens] 1,112 0,154 8,392 … 440 49172 21 9,36 4505257 moesin [Homo sapiens] 1,112 0,153 19,811 5,166 2737 67778 41 8,76 21618331 carnitine acetyltransferase isoform 1 precursor [Homo sapiens] 1,111 0,151 13,421 … 91 70830 15 6,31 24307969 cytoplasmic FMR1 interacting protein 1 isoform a [Homo sapiens] 1,110 0,150 9,612 … 104 145089 27 6,77 157389005 calpain 2 isoform 1 [Homo sapiens] 1,109 0,150 18,045 3,881 521 79959 19 5,44 62241042 glutamyl-prolyl tRNA synthetase [Homo sapiens] 1,106 0,145 13,362 … 359 170483 38 5,65 4757766 Rho GTPase activating protein 1 [Homo sapiens] 1,105 0,144 18,659 9,759 576 50404 23 4,96 24119203 tropomyosin 3 isoform 2 [Homo sapiens] 1,102 0,140 18,304 … 1476 29015 23 7,01 41393561 leucine aminopeptidase 3 [Homo sapiens] 1,097 0,134 14,876 … 301 56131 18 6,54 4504445 heterogeneous nuclear ribonucleoprotein A1 isoform a [Homo sapiens] 1,096 0,132 17,664 … 983 34175 13 6,15 4506203 proteasome beta 7 subunit proprotein [Homo sapiens] 1,088 0,122 19,552 … 497 29946 10 10,25 6912396 glyoxylate reductase/hydroxypyruvate reductase [Homo sapiens] 1,086 0,119 18,609 … 370 35646 11 8,07 4507813 UDP-glucose dehydrogenase [Homo sapiens] 1,081 0,113 18,148 … 768 54989 21 5,38 38327039 heat shock 70kDa protein 4 [Homo sapiens] 1,081 0,112 15,654 2,830 1139 94271 32 4,89 149999606 mannosyl-oligosaccharide glucosidase isoform 1 [Homo sapiens] 1,077 0,107 19,694 … 558 91861 19 5,72 4758012 clathrin heavy chain 1 [Homo sapiens] 1,073 0,102 19,195 9,314 3858 191493 65 6,66 223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1 [Homo sapiens] 1,073 0,101 3,685 … 223 85074 8 6,22 4507953 tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide [H 1,065 0,091 17,908 6,409 3384 27728 20 5,24 4506181 proteasome subunit alpha type 2 [Homo sapiens] 1,065 0,091 19,903 … 1282 25882 11 11,48 4503971 GDP dissociation inhibitor 1 [Homo sapiens] 1,065 0,091 13,868 … 421 50550 12 5,71 21361497 acyl-Coenzyme A dehydrogenase family, member 9 [Homo sapiens] 1,063 0,088 3,256 … 268 68717 12 5,37 48255935 CD44 antigen isoform 1 precursor [Homo sapiens] 1,062 0,087 19,419 … 236 81487 8 8,57 7706441 vacuolar protein sorting 29 isoform 1 [Homo sapiens] 1,056 0,079 5,664 … 274 20493 4 6,23 4506189 proteasome alpha 7 subunit [Homo sapiens] 1,056 0,079 16,189 … 598 27870 11 6,03 21361794 TIP120 protein [Homo sapiens] 1,055 0,077 18,141 9,766 946 136289 32 8,44 4507521 transketolase isoform 1 [Homo sapiens] 1,053 0,074 17,848 … 2371 67835 25 6,23 5031595 actin related protein 2/3 complex subunit 4 isoform a [Homo sapiens] 1,052 0,073 7,120 … 163 19654 9 5,26 48255966 UDP-glucose pyrophosphorylase 2 isoform a [Homo sapiens] 1,050 0,070 13,394 12,728 1028 56905 28 6,67 4759270 translin [Homo sapiens] 1,049 0,069 12,476 … 318 26167 11 9,1 4506013 protein phosphatase 1, regulatory subunit 7 [Homo sapiens] 1,049 0,069 13,223 … 313 41539 11 6,43 4557237 acetyl-Coenzyme A acetyltransferase 1 precursor [Homo sapiens] 1,047 0,067 7,773 1,971 392 45171 12 10,09 5032027 retinoblastoma binding protein 4 isoform a [Homo sapiens] 1,045 0,064 1,588 … 130 47626 4 5 42794771 thioredoxin domain containing 5 isoform 1 precursor [Homo sapiens] 1,040 0,057 19,907 15,753 419 47599 18 7,71 4503609 electron-transfer-flavoprotein, beta polypeptide isoform 1 [Homo sapiens] 1,039 0,056 14,023 … 211 27826 14 5,09 6681764 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa [Homo sapi 1,039 0,055 3,534 … 262 42483 15 6,7 7706757 H(+)-transporting two-sector ATPase [Homo sapiens] 1,037 0,052 14,723 … 356 28245 11 6,61 11055992 serine carboxypeptidase 1 precursor [Homo sapiens] 1,033 0,047 14,576 … 414 50798 8 5,7 45827806 atlastin 3 [Homo sapiens] 1,025 0,036 17,254 2,119 750 60503 23 7,53 51873036 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) isoform 1 precurs 1,025 0,036 8,200 … 47 115861 17 9,24 5803225 tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide 1,022 0,032 19,814 6,422 1927 29155 23 7,82 4885539 protein-L-isoaspartate (D-aspartate) O-methyltransferase [Homo sapiens] 1,022 0,031 15,882 … 537 24621 16 4,83 171846268 Ts translation elongation factor, mitochondrial precursor [Homo sapiens] 1,021 0,029 0,967 … 233 35368 5 8,6 5729877 heat shock 70kDa protein 8 isoform 1 [Homo sapiens] 1,015 0,021 18,917 15,810 5420 70854 33 5,35 20986531 mitogen-activated protein kinase 1 [Homo sapiens] 1,011 0,015 10,738 … 262 41363 15 8,98 17999541 vacuolar protein sorting 35 [Homo sapiens] 1,010 0,014 19,647 11,946 1321 91649 33 6,63 186972143 tripeptidyl peptidase II [Homo sapiens] 1,009 0,013 16,610 … 273 138263 20 5,05 4506195 proteasome beta 2 subunit [Homo sapiens] 1,008 0,012 19,665 … 386 22822 9 11,65 119395729 cathepsin A isoform a precursor [Homo sapiens] 1,007 0,010 2,805 … 358 56197 8 5,29 32171186 B-cell receptor-associated protein 31 isoform b [Homo sapiens] 1,005 0,007 15,763 … 479 27974 15 6,96 4557305 fructose-bisphosphate aldolase A [Homo sapiens] 1,004 0,006 15,093 13,980 8764 39395 19 4,78 188497754 hexokinase 1 isoform HKI [Homo sapiens] 1,004 0,005 16,430 … 750 102420 37 6,18 112421122 DnaJ (Hsp40) homolog, subfamily C, member 13 [Homo sapiens] 1,002 0,003 19,520 … 131 254252 32 7,26 4757768 Rho GDP dissociation inhibitor (GDI) alpha [Homo sapiens] 1,001 0,001 14,667 12,756 870 23193 7 8,96 5031571 actin-related protein 2 isoform b [Homo sapiens] 1,000 -0,001 19,230 10,950 398 44732 9 6,83 109148542 alanyl-tRNA synthetase [Homo sapiens] 0,998 -0,003 13,741 12,519 558 106743 28 5,13 156564403 pyruvate dehydrogenase (lipoamide) beta [Homo sapiens] 0,997 -0,004 16,577 … 313 39208 11 5,7 10863927 peptidylprolyl isomerase A [Homo sapiens] 0,996 -0,006 16,617 6,130 1583 18001 11 5,51 126012562 low density lipoprotein-related protein 1 [Homo sapiens] 0,993 -0,010 15,277 … 390 504276 39 5,57 7549809 plastin 3 [Homo sapiens] 0,993 -0,011 19,047 9,982 1407 70766 36 5,84 28178825 isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] 0,990 -0,014 4,400 … 152 46630 12 5,82 19923362 Thy-1 cell surface antigen preproprotein [Homo sapiens] 0,990 -0,015 18,556 12,721 256 17923 2 4,73 15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo sapiens] 0,986 -0,021 14,053 … 142 118317 13 6,59 7524354 dimethylarginine dimethylaminohydrolase 2 [Homo sapiens] 0,986 -0,021 15,739 … 310 29625 10 8,48 6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 0,985 -0,022 19,569 … 299 31521 11 6,35 12408656 calpain 1, large subunit [Homo sapiens] 0,984 -0,023 12,898 17,900 449 81838 30 6,29 63253298 spermidine synthase [Homo sapiens] 0,982 -0,026 14,401 … 283 33803 8 5,39 21735621 mitochondrial malate dehydrogenase precursor [Homo sapiens] 0,982 -0,027 19,457 9,498 2145 35481 15 5,02 4505029 leukotriene A4 hydrolase [Homo sapiens] 0,981 -0,028 18,531 1,546 396 69241 18 7,85 38201690 RAP2B, member of RAS oncogene family [Homo sapiens] 0,979 -0,030 1,131 … 148 20491 7 5,52 4507949 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, be 0,977 -0,034 19,212 18,396 1441 28065 20 4,74 22538444 tumor protein p53 inducible protein 3 [Homo sapiens] 0,975 -0,036 3,068 … 103 35514 10 7,68 4507877 vinculin isoform VCL [Homo sapiens] 0,975 -0,037 18,883 2,511 5872 116649 79 9,96 52145310 hexose-6-phosphate dehydrogenase precursor [Homo sapiens] 0,975 -0,037 15,321 … 244 88836 19 6,45 4503571 enolase 1 [Homo sapiens] 0,973 -0,040 19,786 3,924 12943 47139 27 5,6 24234688 heat shock 70kDa protein 9 precursor [Homo sapiens] 0,972 -0,040 17,972 7,944 1816 73635 29 5,87 7705987 glycolipid transfer protein [Homo sapiens] 0,972 -0,041 15,010 … 134 23834 5 4,71 14917113 signal recognition particle receptor, beta subunit [Homo sapiens] 0,972 -0,041 8,569 … 216 29633 13 5,21 4503583 epoxide hydrolase 1 [Homo sapiens] 0,971 -0,043 10,628 … 70 52915 11 5,6 7657069 ERO1-like [Homo sapiens] 0,969 -0,045 18,125 2,555 525 54358 17 5,42 7656991 coronin, actin binding protein, 1C isoform 1 [Homo sapiens] 0,969 -0,046 15,212 … 396 53215 12 4,82 5454158 valyl-tRNA synthetase [Homo sapiens] 0,966 -0,049 14,647 … 392 140387 20 5,55 5031597 actin related protein 2/3 complex subunit 3 [Homo sapiens] 0,966 -0,049 7,915 … 120 20533 6 5,8 71565154 class III alcohol dehydrogenase, chi subunit [Homo sapiens] 0,965 -0,051 5,793 … 146 39698 11 8,56 73486658 aspartate aminotransferase 2 precursor [Homo sapiens] 0,962 -0,056 5,021 6,207 308 47487 8 8,42 6912278 COMM domain containing 3 [Homo sapiens] 0,962 -0,056 14,161 … 200 22137 6 8,22 70995211 peroxisomal enoyl-coenzyme A hydratase-like protein [Homo sapiens] 0,961 -0,057 11,245 … 364 35793 8 6 156631005 proteasome 26S non-ATPase subunit 8 [Homo sapiens] 0,960 -0,059 15,423 … 176 39587 9 8,87 224496106 small fragment nuclease [Homo sapiens] 0,958 -0,061 9,704 … 453 26816 9 5,49 33946329 ras related v-ral simian leukemia viral oncogene homolog A [Homo sapiens] 0,957 -0,064 15,371 … 593 23552 9 5,83 19913424 ATPase, H+ transporting, lysosomal V1 subunit A [Homo sapiens] 0,954 -0,068 17,072 16,236 748 68260 28 8,03 20127408 mitochondrial trifunctional protein, alpha subunit precursor [Homo sapiens] 0,953 -0,069 18,628 4,171 2182 82947 33 8,6 23110925 proteasome beta 6 subunit [Homo sapiens] 0,952 -0,071 4,414 … 112 25341 5 5,66 94721239 isoleucine tRNA synthetase [Homo sapiens] 0,951 -0,073 19,141 13,785 350 144406 29 11,56 4503057 crystallin, alpha B [Homo sapiens] 0,946 -0,080 18,834 2,509 2935 20146 12 4,96 4758756 nucleosome assembly protein 1-like 1 [Homo sapiens] 0,945 -0,081 9,695 … 247 45346 7 8,85 4885281 glutamate dehydrogenase 1 [Homo sapiens] 0,944 -0,082 15,298 … 642 61359 19 4,7 188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sapiens] 0,944 -0,083 19,220 … 340 58450 15 6,04 91199540 dihydrolipoamide dehydrogenase precursor [Homo sapiens] 0,942 -0,086 9,849 … 237 54143 13 8,34 4501867 aconitase 2, mitochondrial precursor [Homo sapiens] 0,937 -0,094 17,515 … 343 85372 26 4,63 11321601 phosphofructokinase, platelet [Homo sapiens] 0,937 -0,094 15,206 2,768 1028 85542 32 5,7 6005721 ER lipid raft associated 2 isoform 1 [Homo sapiens] 0,932 -0,102 19,679 … 157 37815 5 7,29 5453543 aldo-keto reductase family 1, member C1 [Homo sapiens] 0,932 -0,102 19,661 … 628 36765 17 6,59 4502419 biliverdin reductase B (flavin reductase (NADPH)) [Homo sapiens] 0,931 -0,104 18,594 … 836 22105 5 9,52 33589854 biliverdin reductase A [Homo sapiens] 0,928 -0,108 14,899 0,861 273 33407 10 5,51 4504169 glutathione synthetase [Homo sapiens] 0,927 -0,109 13,983 … 211 52352 16 6,3 4503117 cystatin B [Homo sapiens] 0,926 -0,111 16,157 … 241 11133 4 8,91 4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens] 0,926 -0,111 15,879 18,865 880 28462 14 5,06 223029410 talin 1 [Homo sapiens] 0,926 -0,112 19,336 17,055 8445 269599 85 8,47 23510338 ubiquitin-activating enzyme E1 [Homo sapiens] 0,925 -0,112 19,434 1,319 2660 117774 42 5,83 5803023 lectin, mannose-binding 2 precursor [Homo sapiens] 0,925 -0,113 19,228 9,935 454 40203 11 6,01 5730023 RuvB-like 2 [Homo sapiens] 0,925 -0,113 14,690 … 192 51125 15 9 66392203 NME1-NME2 protein [Homo sapiens] 0,924 -0,114 19,390 12,631 1304 30118 15 5,3 11321585 guanine nucleotide-binding protein, beta-1 subunit [Homo sapiens] 0,923 -0,116 18,142 … 177 37353 9 6,8 4826878 oxidative-stress responsive 1 [Homo sapiens] 0,921 -0,119 17,121 … 160 57986 6 7,64 4505641 proliferating cell nuclear antigen [Homo sapiens] 0,920 -0,120 6,317 … 425 28750 10 4,97 7706497 UMP-CMP kinase 1 isoform a [Homo sapiens] 0,919 -0,122 16,716 … 1233 25838 17 5,74 4506193 proteasome beta 1 subunit [Homo sapiens] 0,917 -0,125 19,514 … 1341 26472 13 6,57 4505591 peroxiredoxin 1 [Homo sapiens] 0,915 -0,128 19,399 19,872 991 22096 17 5,57 6598323 GDP dissociation inhibitor 2 isoform 1 [Homo sapiens] 0,914 -0,130 16,953 8,457 1956 50631 26 4,63 5031631 scavenger receptor class B, member 2 [Homo sapiens] 0,913 -0,131 15,791 10,491 1066 54255 14 7,45 9845509 ras-related C3 botulinum toxin substrate 1 isoform Rac1b [Homo sapiens] 0,912 -0,132 11,402 … 374 23452 8 5,53 4502285 ATPase, Ca++ transporting, slow twitch 2 isoform 2 [Homo sapiens] 0,912 -0,133 17,811 … 225 109620 20 5,49 14249382 abhydrolase domain containing 14B [Homo sapiens] 0,909 -0,138 15,344 … 398 22332 6 5,08 10835049 ras homolog gene family, member A [Homo sapiens] 0,909 -0,138 15,990 … 722 21754 10 5,33 4502549 calmodulin 2 [Homo sapiens] 0,905 -0,144 17,857 … 271 16827 5 5,32 5453790 nicotinamide N-methyltransferase [Homo sapiens] 0,903 -0,147 13,821 10,586 612 29555 9 8,28 4557032 L-lactate dehydrogenase B [Homo sapiens] 0,903 -0,148 17,588 … 2464 36615 17 8,52 4505705 phosphoprotein enriched in astrocytes 15 [Homo sapiens] 0,897 -0,156 4,858 … 257 15031 5 5,45 5174529 methionine adenosyltransferase II, alpha [Homo sapiens] 0,897 -0,157 14,636 13,880 226 43633 7 5,88 4506209 proteasome 26S ATPase subunit 2 [Homo sapiens] 0,893 -0,164 11,028 … 151 48603 21 9,31 66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 0,891 -0,167 7,051 … 209 26707 11 9,41 38327625 citrate synthase precursor [Homo sapiens] 0,888 -0,171 9,661 14,081 157 51680 12 6,81 21361370 brain glycogen phosphorylase [Homo sapiens] 0,888 -0,172 16,675 18,472 887 96635 35 6,4 23397696 copine I isoform a [Homo sapiens] 0,888 -0,172 11,034 … 231 59022 12 6,67 157266300 membrane alanine aminopeptidase precursor [Homo sapiens] 0,885 -0,177 19,629 4,309 2862 109471 41 7,6 4504483 hypoxanthine phosphoribosyltransferase 1 [Homo sapiens] 0,883 -0,179 7,504 … 207 24564 6 5,16 15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens] 0,883 -0,179 19,232 … 880 102672 21 5,19 19913432 ATPase, H+ transporting, lysosomal, V0 subunit d1 [Homo sapiens] 0,882 -0,180 11,409 … 148 40303 4 7,57 4826686 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 [Homo sapiens] 0,880 -0,184 14,412 … 908 82380 28 9,97 4506221 proteasome 26S non-ATPase subunit 12 isoform 1 [Homo sapiens] 0,879 -0,186 15,198 … 180 52871 13 5,63 5802966 destrin isoform a [Homo sapiens] 0,879 -0,186 16,684 … 366 18493 8 5,47 4506063 cAMP-dependent protein kinase, regulatory subunit alpha 1 [Homo sapiens] 0,877 -0,190 16,391 10,495 228 42955 15 10,85 4502551 calumenin isoform a precursor [Homo sapiens] 0,876 -0,190 15,112 7,813 594 37084 11 9,73 41393545 RAB5C, member RAS oncogene family isoform b [Homo sapiens] 0,873 -0,196 19,458 13,472 1629 23468 11 6,41 5453597 F-actin capping protein alpha-1 subunit [Homo sapiens] 0,864 -0,211 19,709 2,541 803 32902 12 9,85 34147513 RAB7, member RAS oncogene family [Homo sapiens] 0,863 -0,212 19,684 17,200 2031 23475 17 4,09 10864011 sulfide dehydrogenase like [Homo sapiens] 0,862 -0,215 17,757 … 198 49929 21 9,41 41322923 plectin 1 isoform 11 [Homo sapiens] 0,854 -0,227 16,560 … 4516 515884 202 9,35 55770888 early endosome antigen 1, 162kD [Homo sapiens] 0,854 -0,228 17,059 3,789 767 162367 54 8,43 20149619 dehydrogenase/reductase (SDR family) member 7B [Homo sapiens] 0,853 -0,230 3,507 … 231 35097 6 6,01 14043072 heterogeneous nuclear ribonucleoprotein A2/B1 isoform B1 [Homo sapiens] 0,850 -0,235 13,431 3,636 2106 37407 16 8,32 4507761 ubiquitin and ribosomal protein L40 precursor [Homo sapiens] 0,847 -0,240 13,687 … 285 14719 5 6,08 4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens] 0,846 -0,241 17,151 19,693 190 36045 9 5,72 189083849 delta-aminolevulinic acid dehydratase [Homo sapiens] 0,843 -0,247 19,770 … 177 36271 9 6,58 4504327 mitochondrial trifunctional protein, beta subunit precursor [Homo sapiens] 0,837 -0,257 10,158 18,370 349 51262 21 6,95 4502599 carbonyl reductase 1 [Homo sapiens] 0,832 -0,265 19,751 17,412 2031 30356 15 5,05 4885063 fructose-bisphosphate aldolase C [Homo sapiens] 0,832 -0,266 16,400 … 942 39431 12 8,47 33413400 esterase D/formylglutathione hydrolase [Homo sapiens] 0,831 -0,267 18,452 … 404 31442 10 8,14 4503151 cathepsin K preproprotein [Homo sapiens] 0,828 -0,272 18,424 … 3266 36942 6 7,74 24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo sapiens] 0,827 -0,273 15,265 … 199 91021 11 5,48 148277065 thioredoxin reductase 1 isoform 1 [Homo sapiens] 0,827 -0,275 19,772 … 662 60382 15 10,48 8922699 CNDP dipeptidase 2 [Homo sapiens] 0,824 -0,279 7,401 … 303 52746 14 4,76 55749490 syntenin isoform 1 [Homo sapiens] 0,823 -0,281 1,563 … 458 32424 8 6,19 4507185 sepiapterin reductase [Homo sapiens] 0,822 -0,282 3,361 … 495 28031 9 6,74 4502317 vacuolar H+ ATPase E1 isoform a [Homo sapiens] 0,822 -0,282 19,237 17,182 459 26129 18 5,22 7669492 glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] 0,822 -0,284 19,878 9,789 58282 36030 22 4,76 19913410 major vault protein [Homo sapiens] 0,821 -0,284 19,441 5,988 3181 99266 47 5,85 4505145 malic enzyme 2, NAD(+)-dependent, mitochondrial [Homo sapiens] 0,818 -0,290 15,827 … 149 65402 18 10,11 12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 0,816 -0,294 19,822 6,953 31844 226392 151 5,69 7657015 hypothetical protein LOC51493 [Homo sapiens] 0,815 -0,296 14,488 8,070 193 55175 21 4,29 62530384 dodecenoyl-Coenzyme A delta isomerase precursor [Homo sapiens] 0,814 -0,297 12,098 … 144 32795 6 4,72 4502315 ATPase, H+ transporting, lysosomal V1 subunit C1 [Homo sapiens] 0,812 -0,301 11,446 … 153 43914 3 5,45 4758208 dual specificity phosphatase 3 [Homo sapiens] 0,811 -0,301 18,681 … 436 20465 9 6,26 4507249 signal transducing adaptor molecule 1 [Homo sapiens] 0,811 -0,302 6,977 … 188 59142 6 10,16 167466173 heat shock 70kDa protein 1B [Homo sapiens] 0,808 -0,307 16,282 4,929 1894 70009 30 4,71 20127454 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohy 0,806 -0,311 18,379 0,871 1431 64575 32 5,52 63252913 gelsolin-like capping protein [Homo sapiens] 0,806 -0,311 16,360 1,341 807 38474 8 8,81 115430223 galectin 3 [Homo sapiens] 0,804 -0,314 16,126 8,879 887 26136 8 4,76 4827050 ubiquitin specific protease 14 isoform a [Homo sapiens] 0,804 -0,315 13,254 17,332 294 56033 21 5,7 118402586 glyoxalase I [Homo sapiens] 0,803 -0,317 16,890 … 410 20764 7 9,77 4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sapiens] 0,802 -0,318 3,182 … 231 56659 10 10,19 4505753 bisphosphoglycerate mutase 1 [Homo sapiens] 0,795 -0,330 13,058 7,472 1275 28786 15 7,53 19923748 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate comp 0,793 -0,335 8,609 2,410 270 48724 8 8,16 5802974 peroxiredoxin 3 isoform a precursor [Homo sapiens] 0,790 -0,340 14,590 … 1509 27675 7 8,92 5729875 progesterone receptor membrane component 1 [Homo sapiens] 0,789 -0,341 14,652 2,870 471 21658 10 4,8 7656952 calcyclin binding protein isoform 1 [Homo sapiens] 0,788 -0,345 16,015 … 144 26194 11 5,87 13236587 transmembrane protein 43 [Homo sapiens] 0,787 -0,346 16,327 … 179 44847 10 7,55 4885049 cardiac muscle alpha actin 1 proprotein [Homo sapiens] 0,785 -0,349 18,225 16,561 8563 41992 26 7,66 4504771 eukaryotic translation initiation factor 6 isoform a [Homo sapiens] 0,782 -0,354 4,151 … 276 26582 7 6,08 88999583 myosin, light chain 6, alkali, smooth muscle and non-muscle isoform 2 [Homo s 0,782 -0,355 18,092 … 840 16950 11 8,9 7330335 chloride intracellular channel 4 [Homo sapiens] 0,778 -0,362 13,853 11,182 732 28754 15 6,34 8922712 septin 11 [Homo sapiens] 0,775 -0,368 16,270 19,010 1008 49367 20 5,85 29568111 myosin regulatory light chain 9 isoform a [Homo sapiens] 0,773 -0,372 11,929 … 1126 19814 11 7,66 189571662 delta-sarcoglycan isoform 3 [Homo sapiens] 0,769 -0,379 3,803 … 131 32051 11 6,29 12056473 N-acetylneuraminic acid phosphate synthase [Homo sapiens] 0,767 -0,382 9,973 … 214 40281 4 6,74 4507645 triosephosphate isomerase 1 isoform 1 [Homo sapiens] 0,762 -0,391 18,250 17,748 2740 26653 16 6,52 153251270 calcineurin-like phosphoesterase domain containing 1 isoform a [Homo sapiens 0,762 -0,392 19,516 … 164 35526 5 4,58 6912328 dimethylarginine dimethylaminohydrolase 1 isoform 1 [Homo sapiens] 0,759 -0,397 18,579 11,292 165 31102 16 5,63 7706322 homeobox prox 1 [Homo sapiens] 0,759 -0,398 19,726 … 665 28051 10 6,82 18201905 glucose phosphate isomerase [Homo sapiens] 0,758 -0,399 19,406 4,145 1996 63107 29 5,08 4503327 cytochrome b5 reductase 3 isoform m [Homo sapiens] 0,757 -0,402 19,202 16,289 2652 34213 15 6,43 33286418 pyruvate kinase, muscle isoform M2 [Homo sapiens] 0,754 -0,407 19,954 18,603 12721 57900 32 9,06 11056044 pyrophosphatase 1 [Homo sapiens] 0,752 -0,411 19,952 … 1003 32639 15 5,61 26051231 lactamase, beta isoform a [Homo sapiens] 0,750 -0,416 17,592 … 145 60655 8 9,16 5174539 cytosolic malate dehydrogenase [Homo sapiens] 0,749 -0,416 19,640 18,643 902 36403 17 6,19 4504041 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypept 0,746 -0,423 10,806 12,409 489 40425 12 6,06 158937236 aminopeptidase puromycin sensitive [Homo sapiens] 0,745 -0,425 16,805 9,100 525 103211 23 7,71 9951915 adenosylhomocysteinase isoform 1 [Homo sapiens] 0,744 -0,427 19,340 10,513 426 47685 12 5,16 31543380 Parkinson disease protein 7 [Homo sapiens] 0,743 -0,428 14,504 … 330 19878 12 7,13 7661678 RAP1B, member of RAS oncogene family [Homo sapiens] 0,743 -0,428 19,813 7,197 4128 20812 10 6,51 14719392 cofilin 2 [Homo sapiens] 0,743 -0,429 3,842 … 800 18725 11 6,97 5174391 aldo-keto reductase family 1, member A1 [Homo sapiens] 0,742 -0,431 14,608 0,541 349 36550 11 6,02 63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens] 0,740 -0,435 18,950 10,638 3398 32856 35 5,88 16306548 seryl-tRNA synthetase [Homo sapiens] 0,739 -0,437 19,058 16,574 295 58740 14 6,59 8659555 aconitase 1 [Homo sapiens] 0,737 -0,440 18,030 … 538 98337 18 4,76 22027538 programmed cell death 6 interacting protein isoform 1 [Homo sapiens] 0,736 -0,441 13,052 … 661 95963 29 6,3 18379349 vesicle amine transport protein 1 [Homo sapiens] 0,736 -0,442 19,866 6,599 1445 41893 17 7,67 62198232 3-hydroxy-3-methylglutaryl CoA lyase [Homo sapiens] 0,729 -0,456 6,617 … 126 34338 7 5,92 4506017 protein phosphatase 2, catalytic subunit, alpha isoform [Homo sapiens] 0,729 -0,456 8,517 … 142 35571 4 8,5 33356177 protein tyrosine phosphatase, non-receptor type 11 [Homo sapiens] 0,727 -0,460 7,576 … 62 67968 12 4,57 49574502 cytochrome b5 reductase 1 [Homo sapiens] 0,724 -0,465 17,174 6,691 294 34073 13 8,28 5453740 myosin, light chain 12A, regulatory, non-sarcomeric [Homo sapiens] 0,721 -0,472 19,382 … 1279 19781 8 7,88 4758638 peroxiredoxin 6 [Homo sapiens] 0,718 -0,477 19,098 … 1052 25019 16 5,41 13236495 crystallin, zeta isoform a [Homo sapiens] 0,714 -0,487 10,176 7,130 118 35185 12 8,27 4757834 BCL2-associated athanogene 2 [Homo sapiens] 0,713 -0,488 6,380 … 240 23757 15 10,51 4502011 adenylate kinase 1 [Homo sapiens] 0,713 -0,489 19,156 … 1080 21621 11 8,75 153218487 KDEL (Lys-Asp-Glu-Leu) containing 2 [Homo sapiens] 0,711 -0,491 10,620 12,658 136 58535 14 6,4 4501887 actin, gamma 1 propeptide [Homo sapiens] 0,711 -0,491 19,883 … 17546 41766 27 5,62 71037379 liver glycogen phosphorylase [Homo sapiens] 0,706 -0,503 16,041 0,033 533 97087 26 5,46 37594464 nudix-type motif 5 [Homo sapiens] 0,704 -0,506 17,440 … 343 24312 7 6,02 5454028 related RAS viral (r-ras) oncogene homolog [Homo sapiens] 0,704 -0,506 13,849 16,886 642 23466 12 4,5 21464101 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, ga 0,703 -0,508 17,856 17,197 1287 28285 18 8,3 5453549 peroxiredoxin 4 [Homo sapiens] 0,700 -0,515 17,268 12,764 1066 30521 13 6,45 4501885 beta actin [Homo sapiens] 0,697 -0,520 19,467 1,849 6030 41710 25 9,5 94557308 L-3-hydroxyacyl-Coenzyme A dehydrogenase precursor [Homo sapiens] 0,693 -0,529 17,224 … 429 34272 13 8,25 5453599 capping protein (actin filament) muscle Z-line, alpha 2 [Homo sapiens] 0,691 -0,533 16,078 17,884 568 32929 12 6,01 4758086 cysteine and glycine-rich protein 1 isoform 1 [Homo sapiens] 0,690 -0,535 16,461 … 623 20554 5 6,03 41406084 glutathione peroxidase 1 isoform 1 [Homo sapiens] 0,689 -0,538 5,789 … 205 22075 5 6,78 194097323 mitochondrial short-chain enoyl-coenzyme A hydratase 1 precursor [Homo sapi 0,686 -0,544 11,176 … 314 31367 9 6,1 4505701 pyridoxal kinase [Homo sapiens] 0,681 -0,555 17,456 … 344 35080 10 4,96 45387945 family with sequence similarity 62 (C2 domain containing) member B [Homo sa 0,675 -0,567 7,908 … 233 98840 22 5,34 4504175 glutathione S-transferase mu 2 isoform 1 [Homo sapiens] 0,669 -0,579 18,309 … 592 25728 20 5,81 47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens] 0,662 -0,594 11,804 5,299 2959 32970 27 7,02 7657347 mitochondrial carrier 2 [Homo sapiens] 0,662 -0,595 2,521 … 127 33309 8 6,15 5902102 small nuclear ribonucleoprotein D1 polypeptide 16kDa [Homo sapiens] 0,660 -0,600 12,385 … 154 13273 1 4,95 148352329 cell division cycle 10 isoform 2 [Homo sapiens] 0,657 -0,605 17,721 14,771 560 50549 19 8,49 112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo sapiens] 0,630 -0,666 19,238 12,060 1725 274439 93 7,01 33636742 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 isoform a precursor [Homo 0,650 -0,621 0,457 … 174 87043 15 5,26 166795301 prenylcysteine oxidase 1 [Homo sapiens] 0,648 -0,626 18,679 … 627 56604 16 4,78 4503143 cathepsin D preproprotein [Homo sapiens] 0,639 -0,646 19,959 … 2698 44524 15 5,37 14165435 heterogeneous nuclear ribonucleoprotein K isoform b [Homo sapiens] 0,637 -0,650 19,713 … 1022 50944 22 5,07 14150100 nucleoside-triphosphatase C1orf57 [Homo sapiens] 0,636 -0,653 6,535 … 165 20700 8 4,94 88853865 isoamyl acetate-hydrolyzing esterase 1 homolog [Homo sapiens] 0,635 -0,656 18,705 … 91 27581 6 5,23 134142815 es1 protein isoform Ia precursor [Homo sapiens] 0,634 -0,658 17,849 … 117 28153 7 11,36 5031857 L-lactate dehydrogenase A isoform 1 [Homo sapiens] 0,631 -0,664 19,882 15,406 16418 36665 27 5,9 4505763 phosphoglycerate kinase 1 [Homo sapiens] 0,631 -0,665 18,926 18,333 3688 44586 29 4,79 4758484 glutathione-S-transferase omega 1 [Homo sapiens] 0,622 -0,686 19,170 3,587 266 27548 16 5,42 121114298 cullin 4B isoform 1 [Homo sapiens] 0,621 -0,687 0,812 … 174 103916 22 5,58 48762920 liver phosphofructokinase [Homo sapiens] 0,621 -0,687 19,441 … 135 84964 19 9,11 4506243 polypyrimidine tract-binding protein 1 isoform a [Homo sapiens] 0,619 -0,693 19,975 … 430 59596 14 6,45 5453916 progesterone receptor membrane component 2 [Homo sapiens] 0,618 -0,694 19,722 … 588 23804 10 6,38 5803011 enolase 2 [Homo sapiens] 0,611 -0,710 16,582 5,931 2281 47239 14 6,13 9845297 diablo isoform 1 precursor [Homo sapiens] 0,602 -0,733 16,834 … 148 27114 9 5,98 76496475 acyl-Coenzyme A dehydrogenase, very long chain isoform 2 precursor [Homo s 0,597 -0,745 13,290 … 286 68015 14 5,31 41322916 plectin 1 isoform 6 [Homo sapiens] 0,596 -0,746 19,674 … 4898 531466 227 9,87 114155144 tropomyosin 3 isoform 4 [Homo sapiens] 0,594 -0,752 11,674 … 1278 28853 27 9,21 12025678 actinin, alpha 4 [Homo sapiens] 0,583 -0,778 19,771 0,608 5241 104788 55 5,11 4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo sapiens] 0,581 -0,783 19,450 … 142 24412 8 5,76 4757952 cell division cycle 42 isoform 1 [Homo sapiens] 0,575 -0,797 14,743 … 613 21245 5 4,67 5453704 ADP-ribosylation-like factor 6 interacting protein 5 [Homo sapiens] 0,573 -0,803 8,005 … 517 21600 5 6,85 33598968 LIM domain only 7 isoform 1 [Homo sapiens] 0,571 -0,809 18,506 … 291 153575 26 5 5729770 tripeptidyl-peptidase I preproprotein [Homo sapiens] 0,570 -0,811 13,958 2,222 794 61210 8 9,83 23308751 3-hydroxyisobutyrate dehydrogenase [Homo sapiens] 0,558 -0,840 19,549 14,590 392 35306 8 4,73 23510451 N-acylaminoacyl-peptide hydrolase [Homo sapiens] 0,554 -0,853 7,691 … 241 81173 7 6,84 38044288 gelsolin isoform b [Homo sapiens] 0,552 -0,858 19,771 … 4716 80591 31 7,56 24475586 ependymin related protein 1 precursor [Homo sapiens] 0,546 -0,873 3,871 … 276 38126 12 7,45 116063573 filamin A, alpha isoform 1 [Homo sapiens] 0,543 -0,880 19,973 14,119 25719 279843 118 4,91 146229327 arylsulfatase A isoform b [Homo sapiens] 0,538 -0,894 16,845 … 589 44852 7 4,94 4758018 calponin 2 isoform a [Homo sapiens] 0,538 -0,894 6,028 … 686 33675 12 6,64 19913428 vacuolar H+ATPase B2 [Homo sapiens] 0,537 -0,898 16,523 … 1054 56465 19 9,27 4502171 adenine phosphoribosyltransferase isoform a [Homo sapiens] 0,530 -0,915 5,843 … 274 19595 9 5,32 189011546 N-acylsphingosine amidohydrolase 1 isoform b [Homo sapiens] 0,523 -0,935 18,111 3,282 211 46474 5 4,71 20270355 galactose mutarotase [Homo sapiens] 0,523 -0,936 0,975 … 84 37742 8 4,84 4504301 histone cluster 1, H4a [Homo sapiens] 0,522 -0,938 4,390 … 98 11360 5 5,46 17986283 tubulin, alpha 1a [Homo sapiens] 0,521 -0,941 19,606 … 10986 50104 19 6,42 13129092 transmembrane protein 109 [Homo sapiens] 0,519 -0,945 19,719 … 242 26194 7 6,39 4504183 glutathione transferase [Homo sapiens] 0,515 -0,958 18,816 19,345 4421 23341 13 10,66 19424132 NIMA-related kinase 7 [Homo sapiens] 0,513 -0,962 18,871 … 297 34528 13 8,63 189458812 glucan (1,4-alpha-), branching enzyme 1 [Homo sapiens] 0,509 -0,974 19,134 14,691 507 80409 26 6,73 14110414 heterogeneous nuclear ribonucleoprotein D isoform c [Homo sapiens] 0,503 -0,990 19,042 … 253 32814 10 4,33 38505218 putative acyl-CoA dehydrogenase [Homo sapiens] 0,502 -0,995 9,789 … 215 87209 15 8,06 38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens] 0,501 -0,997 0,696 … 56 128008 23 8,45 5031875 lamin A/C isoform 2 [Homo sapiens] 0,500 -1,000 18,293 12,742 1610 65096 44 5,26 7657603 heme binding protein 2 [Homo sapiens] 0,496 -1,011 19,329 … 356 22861 8 6,22 4503987 gamma-glutamyl hydrolase precursor [Homo sapiens] 0,492 -1,023 7,955 … 361 35941 9 9,61 19923437 adenylate kinase 3 [Homo sapiens] 0,486 -1,042 16,568 … 346 25550 18 6,92 4505621 prostatic binding protein [Homo sapiens] 0,484 -1,048 17,452 … 1474 21044 10 10,14 32189392 peroxiredoxin 2 isoform a [Homo sapiens] 0,480 -1,058 16,981 … 1711 21878 10 5,77 8922601 ADP-ribosylation factor-like 10C [Homo sapiens] 0,472 -1,084 13,342 … 820 21525 10 5,3 21361621 phosphoglucomutase 1 [Homo sapiens] 0,469 -1,091 19,821 5,711 1357 61411 30 6,51 41152086 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6 [Homo 0,469 -1,094 18,782 … 802 42594 19 8,97 62420888 dipeptidyl peptidase 7 preproprotein [Homo sapiens] 0,467 -1,100 19,895 2,290 449 54307 17 6,32 110611228 utrophin [Homo sapiens] 0,466 -1,103 19,920 … 88 394220 44 8,3 4507149 superoxide dismutase 1, soluble [Homo sapiens] 0,460 -1,119 14,165 … 324 15926 4 7,88 223555975 tropomyosin 4 isoform 1 [Homo sapiens] 0,460 -1,121 15,323 15,038 1157 32703 24 5,55 48255905 transgelin [Homo sapiens] 0,456 -1,132 18,351 18,288 3954 22596 20 5,82 22538442 cathepsin Z preproprotein [Homo sapiens] 0,456 -1,134 17,972 14,642 325 33846 3 6,2 33286420 pyruvate kinase, muscle isoform M1 [Homo sapiens] 0,451 -1,150 17,232 … 10223 58025 33 5,6 41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 0,450 -1,151 11,479 … 3393 228858 77 8,72 194097350 actinin, alpha 1 isoform a [Homo sapiens] 0,433 -1,208 18,226 0,291 9623 105502 59 7,49 38016911 stomatin isoform a [Homo sapiens] 0,428 -1,224 15,185 8,306 862 31711 17 5,71 189181666 hexosaminidase A preproprotein [Homo sapiens] 0,423 -1,242 12,146 … 801 60664 16 8,85 93102364 SWAP-70 protein [Homo sapiens] 0,419 -1,254 5,148 … 175 68954 9 5,75 4501891 actinin, alpha 1 isoform b [Homo sapiens] 0,415 -1,270 18,361 … 309 102993 19 6,61 117189975 heterogeneous nuclear ribonucleoprotein C isoform a [Homo sapiens] 0,404 -1,306 9,869 … 162 33650 8 5,71 27734917 phospholipase B domain containing 2 [Homo sapiens] 0,403 -1,310 18,685 4,559 778 65430 9 4,8 29788785 tubulin, beta [Homo sapiens] 0,400 -1,322 19,839 14,384 7513 49639 23 8,21 63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens] 0,391 -1,355 17,996 13,908 1998 32797 31 6,4 4505405 glycoprotein (transmembrane) nmb isoform b precursor [Homo sapiens] 0,384 -1,380 13,408 … 2518 62603 5 5,94 51873064 mannosidase, alpha, class 2B, member 1 precursor [Homo sapiens] 0,382 -1,389 1,175 … 127 113672 13 6,29 20149498 ferritin, light polypeptide [Homo sapiens] 0,370 -1,433 18,094 … 1979 20007 10 8,53 4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sapiens] 0,368 -1,444 16,980 … 611 62042 16 6,51 4506787 IQ motif containing GTPase activating protein 1 [Homo sapiens] 0,367 -1,445 18,661 19,770 5532 189134 84 10,56 4502565 calpain, small subunit 1 [Homo sapiens] 0,354 -1,497 18,249 … 1006 28298 10 9,46 119372308 galactosidase, beta 1 isoform a preproprotein [Homo sapiens] 0,330 -1,597 17,497 14,547 505 76027 9 7,9 4503379 dihydropyrimidinase-like 3 [Homo sapiens] 0,328 -1,609 13,481 … 1395 61924 22 4,6 4826657 caldesmon 1 isoform 2 [Homo sapiens] 0,312 -1,680 11,488 … 460 62626 24 6,47 40317626 thrombospondin 1 precursor [Homo sapiens] 0,309 -1,692 14,661 … 679 129300 25 5,53 4505467 5' nucleotidase, ecto [Homo sapiens] 0,303 -1,723 19,342 12,734 617 63327 27 5,52 25188179 voltage-dependent anion channel 3 isoform b [Homo sapiens] 0,300 -1,739 8,996 … 509 30639 10 5,63 16933540 fibroblast activation protein, alpha subunit [Homo sapiens] 0,292 -1,777 18,050 9,355 939 87657 31 8,85 4504373 hexosaminidase B preproprotein [Homo sapiens] 0,288 -1,798 19,826 … 1124 63071 25 4,78 8922673 parvin, alpha [Homo sapiens] 0,283 -1,821 15,425 … 324 42217 12 5,42 56682959 ferritin, heavy polypeptide 1 [Homo sapiens] 0,219 -2,192 19,777 19,777 832 21212 10 5,43 217330598 glyoxalase domain containing 4 [Homo sapiens] 0,275 -1,861 10,732 … 153 33212 11 8,35 18765694 dipeptidylpeptidase IV [Homo sapiens] 0,272 -1,880 19,665 4,084 330 88222 23 6,08 154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) isoform 2 [Homo sapiens] 0,265 -1,917 18,828 18,592 2853 284364 123 9,15 94721252 vesicle-associated membrane protein-associated protein A isoform 2 [Homo sa 0,260 -1,943 9,674 … 225 27875 8 8,76 4503139 cathepsin B preproprotein [Homo sapiens] 0,256 -1,963 17,948 … 9705 37797 7 9,08 116734847 amylo-1,6-glucosidase, 4-alpha-glucanotransferase isoform 1 [Homo sapiens] 0,254 -1,978 8,407 … 131 174652 18 5,74 164698494 septin 9 isoform a [Homo sapiens] 0,246 -2,026 17,961 … 955 65361 18 4,95 4507879 voltage-dependent anion channel 1 [Homo sapiens] 0,229 -2,129 14,136 … 1130 30754 14 9,94 4503037 cellular repressor of E1A-stimulated genes [Homo sapiens] 0,227 -2,139 8,119 … 516 24059 2 5,84 15451856 caveolin 1 [Homo sapiens] 0,218 -2,199 17,508 … 710 20458 8 4,84 62414289 vimentin [Homo sapiens] 0,193 -2,373 19,903 6,231 48345 53619 50 7,66 167830475 milk fat globule-EGF factor 8 protein isoform a [Homo sapiens] 0,138 -2,859 14,687 … 314 43078 9 6,84 221316622 dystonin isoform 3 [Homo sapiens] 0,117 -3,090 15,007 … 23 633274 91 9,42 117306169 prolylcarboxypeptidase isoform 2 preproprotein [Homo sapiens] 0,110 -3,179 7,967 … 261 58062 9 6,15 34485714 Ras-related protein Rab-23 [Homo sapiens] 0,097 -3,371 18,675 … 620 26643 11 4,93 4504957 lysosomal-associated membrane protein 2 isoform A precursor [Homo sapiens] 0,068 -3,876 19,705 … 501 44932 4 6,41 133925809 inter-alpha (globulin) inhibitor H3 preproprotein [Homo sapiens] 0,036 -4,797 9,134 … 132 99787 15 7,99 1 Table S3. Proteins expressed at lower level in both male and female skin fibroblasts from HGPS patients compared with age-matched female and male healthy controls. RSD: relative standard deviation Common name (GI Acc. Code) Protein name Male HGPS vs. control Female HGPS vs. control Silac ratio RSD Mascot Score Silac ratio RSD Mascot Score NQO1 (4505415) NAD(P)H menadione oxidoreductase 1, dioxin-inducible isoform a -5,72 3,67 1968 -3,71 18,79 2735 ATP5F1 (21361565) ATP syn, H+ trans, mitochondrial F0 complex, subunit B1 precursor -3,65 16,52 577 -1,66 6,62 835 PHGDH (23308577) phosphoglycerate dehydrogenase -3,56 11,52 327 -2,06 8,28 304 RPS5 (13904870) ribosomal protein S5 -3,51 14,35 638 -3,27 8,31 297 RPS6 (17158044) ribosomal protein S6 -3,17 4,94 281 -2,02 19,84 285 SSR1 (169404009) signal sequence receptor, alpha -2,99 7,99 197 -1,63 4,15 354 RPL13 (15431295) ribosomal protein L13 -2,98 16,73 427 -2,64 1,45 232 ATP5C1 (4885079) ATP syn, H+ transp, mit F1, gamma subunit isoform H (heart) precursor -2,88 2,49 162 -1,97 9,49 171 RPL23 (17105394) ribosomal protein L23a -2,82 4,07 288 -2,08 8,96 135 ATP50 (4502303) mit ATP synth, O subunit precursor -2,80 9,64 339 -1,59 16,49 524 Col1A1(110349772) alpha 1 type I collagen preproprot -2,77 3,98 370 -2,97 10,86 397 RPL7A (4506661) ribosomal protein L7a -2,70 17,20 581 -2,17 13,2 940 HDLBP (4885409) high density lipoprot binding protein -2,65 19,31 314 -3,46 13,65 709 LRPPRC (31621305) leucine-rich PPR motif-containing protein -2,65 4,10 581 -2,00 13,87 248 ANXA2 (50845388) annexin A2 isoform 1 -2,58 16,03 5158 -1,68 19,01 3158 RPS3A (4506723) ribosomal protein S3a -2,56 14,34 375 -2,40 15,82 441 RPL15 (15431293) ribosomal protein L15 -2,51 10,01 243 -1,99 15,65 232 ATP5A1 (4757810) ATP synthase, H+ transporting, mit F1 complex, α subunit precursor -2,45 17,65 847 -1,78 13,23 2415 RPL10 (15431288) ribosomal protein L10 -2,45 0,67 653 -2,17 18,62 417 RPS2 (4506707) ribosomal protein S2 -2,43 8,44 883 -1,98 7,38 770 DDOST (20070197) dolichyl-diphosphooligosaccharide- protein glycosyltransf precursor -2,38 18,01 597 -1,67 6,15 740 CKAP4 (19920317) cytoskeleton-associated protein 4 -2,33 4,07 2823 -1,95 18,27 2281 COL6A1 (87196339) collagen, type VI, alpha 1 precursor -2,32 15,46 489 -1,81 18,06 2167 COL1A2 (48762934) alpha 2 type I collagen -2,30 6,84 488 -2,95 8,73 288 RPS4X (4506725) ribosom protein S4, X-linked X isof. -2,28 6,50 584 -1,80 15,86 575 PRKCDBP (47132587) protein kinase C, delta binding protein -2,28 15,25 257 -2,17 18 738 RPL18 (4506607) ribosomal protein L18 -2,26 6,03 1000 -1,77 19,84 1054 AHNAK (61743954) AHNAK nucleoprotein isoform 1 -2,25 9,27 3062 -1,93 3,62 3409 RPS9 (14141193) ribosomal protein S9 -2,22 19,01 345 -2,33 19,63 260 RPL8 (4506663) ribosomal protein L8 -2,20 1,90 397 -1,78 12,76 146 RPL6 (16753227) ribosomal protein L6 -2,19 16,01 1120 -1,83 7,90 912 RPS7 (4506741) ribosomal protein S7 -2,16 7,74 581 -1,75 18,91 508 RPL9 (15431303) ribosomal protein L9 -2,12 1,10 745 -1,77 14,52 468 IKBIP (42491362 IKK interacting protein isoform 2 -2,12 7,32 258 -2,49 14,39 744 GNB2L1 (5174447) guanine nucleotide binding protein (G protein), beta polypeptide2-like 1 -2,11 3,16 890 -1,55 4,04 745 RPL14 (78000181) ribosomal protein L14 -2,1 11,04 512 -2,6 18,58 640 RPL10A (15431288) ribosomal protein L10a -2,08 11,38 518 -1,77 3,84 321 RPS25 (4506707) ribosomal protein S25 -2,08 7,06 178 -2,21 13,08 129 RPS8 (4506743) ribosomal protein S8 -2,07 14,23 651 -1,9 5,56 587 RPL3 (4506649) ribosomal protein L3 isoform a -2,05 4,17 150 -1,82 9,79 110 2 PSAT1 (17402893) phosphoserine aminotransf 1 isof 1 -2,01 4,56 764 -2,04 7,23 165 EHD2 (21361462) EH-domain containing 2 -2,01 15,76 1142 -1,67 10 761 RPL18A (11415026) ribosomal protein L18a -2,00 6,92 53 -1,60 16,36 88 TALDO1 (58031879) transaldolase 1 -1,97 17,46 844 -1,65 1,46 439 SERPINH1 (32454741) serine (cys) proteinase inhibitor,cladeH,member 1 precurs -1,96 3,54 5072 -5,60 8,05 2396 PNP (157168362) nucleoside phosphorylase -1,95 10,06 247 -1,94 8,30 323 GSTM3 (23065552) glutathione S-transferase mu 3 -1,93 18,87 908 -2,95 17,03 534 RPL19 (4506609) ribosomal protein L19 -1,93 11,45 421 -2,01 19,43 337 GSTK1 (7705704) glutathione S-transferase kappa 1 isoform a -1,92 4,57 647 -2,03 18,82 677 ATP5B (32189394) mitochondrial ATP synthase beta subunit precursor -1,88 2,73 3132 -1,52 7,25 3067 RPSA (9845502) ribosomal protein SA -1,86 18,38 959 -2,09 2,86 407 TPD52L2 (40805868) tumor protein D52-like 2 isoform c -1,85 15,73 562 -3,28 18,04 557 ACAA1 (4501853) acetyl-CoA acyltransfer 1 isoform a -1,80 13,56 583 -2,16 14,15 116 YWHAH (4507951) tyrosine 3-monooxygen/tryptophan 5-monooxygen activat protein, eta polypeptide -1,79 15,68 992 -1,50 17,85 726 PTRF (42734430) Pol I and transcript release factor -1,79 2,65 3259 -1,82 15,55 3236 RPL23 (4506605) ribosomal protein L23 -1,78 8,26 218 -1,72 13,31 224 RPLP0 (4506667) ribosomal protein P0 -1,76 17,37 403 -2,41 2,43 678 PSME1 (5453990) proteasome activa subunit 1 isoform 1 -1,74 15,19 401 -1,55 19,70 592 RPS3 (15718687) ribosomal protein S3 -1,74 4,24 609 -1,71 11,18 645 FKBP3 (4503727) FK506 binding protein 3, 25kDa -1,72 15,08 147 -1,81 16,24 111 SPCS3 (11345462) signal peptidase complex subunit 3 -1,71 0,87 125 -1,52 7,89 175 YARS (4507947) tyrosyl-tRNA synthetase -1,71 12,84 206 -1,53 10,02 177 FAM3C (7661714) family with sequence similarity 3, member C precursor -1,71 2,11 525 -1,76 19,81 376 RRBP1 (110611218) ribosome binding protein 1 -1,70 2,25 561 -2,43 12,72 626 TAGLN2 (4507357) transgelin 2 -1,68 9,67 4263 -2,22 16,2 3350 SHMT2 (19923315) serine hydroxymethyltransf 2 (mit.) -1,68 17,90 335 -1,64 19,55 348 MAP1B (153945728) microtubule-associated protein 1B -1,66 7,32 223 -1,65 19,98 180 SEPT2 (4758158) septin 2 -1,62 19,38 793 -2,25 12,63 515 RPS16 (4506691) ribosomal protein S16 -1,61 2,07 189 -1,63 17,12 152 MRC2 (110624774) mannose receptor, C type 2 -1,60 2,14 140 -2,78 18,72 184 FSCN1 (4507115) fascin 1 -1,57 19,41 712 -1,93 19,59 447 P4HA2 (4758868) prolyl 4-hydroxyl, α-II isof 1 precur -1,57 11,61 225 -3,65 16,2 401 CLIC1 (14251209) chloride intracellular channel 1 -1,54 3,69 855 -1,72 15,33 649 HSP90AB1 (20149594) heat shock 90kDa protein 1, beta -1,52 12,77 2797 -2,11 12,94 3133 MME (116256327) membrane metallo-endopeptidase -1,52 4,85 494 -1,93 4,34 1568 NARS (4758762) asparaginyl-tRNA synthetase -1,52 15,98 504 -1,5 5,44 726 ARL3 (4757774) ADP-ribosylation factor-like 3 -1,51 10,96 457 -1,80 3,46 234 SYNCRIP (23397427) synaptotagmin binding, cytoplasmic RNA interacting protein -1,50 18,46 449 -1,67 18,6 257 NAPA (47933379) N-ethylmaleimide-sensitive factor attachment protein, alpha -1,50 15,87 452 -1,93 5,20 1155 CD44 (48255937) CD44 antigen isoform 2 precursor ---- ---- ---- -2,54 4,44 68 CD44 (48255935) CD44 antigen isoform 1 precursor -1,96 5,78 844 ---- ---- ---- 1 Table S4. Proteins expressed at higher level in both male and female skin fibroblasts from HGPS patients compared with age-matched female and male healthy controls. RSD: relative standard deviation Common name (GI Acc. Code) Protein name Male HGPS vs. control Female HGPS vs. control Silac ratio RSD Mascot Score Silac ratio RSD Mascot Score PLOD2 (33636742) procollagen-lysine, 2- oxoglutarate 5-dioxygenase 2 isoform a precursor 6,16 15,00 280 1,54 0,46 174 EPDR1 (24475586) ependymin related protein 1 precursor 3,72 14,52 400 1,83 3,87 276 PLBD2 (27734917) phospholipase B domain containing 2 3,47 19,45 470 2,48 4,56 778 ENO2 (5803011) enolase 2 2,98 0,14 2414 1,64 5,93 2281 TUBB (29788785) tubulin, beta 2,89 18,92 38 2,50 14,38 7513 AK3 (19923437) adenylate kinase 3 2,72 9,68 753 2,06 16,57 346 LDHA (5031857 L-lactate dehydrogenase A isoform 1 2,48 19,59 130 1,58 15,41 16418 HEXB (4504373) hexosaminidase B preproprotein 2,49 9,11 1344 3,48 19,83 1124 HEXA (189181666) hexosaminidase A preproprotein 2,38 19,81 138 2,37 12,15 801 TPM2 (47519616) tropomyosin 2 (beta) isoform 2 2,29 17,48 1938 1,51 5,3 2959 PCYOX1 (166795301) prenylcysteine oxidase 1 2,19 5,69 383 1,54 18,68 627 LMO7 (33598968) LIM domain only 7 isoform 1 2,10 17,31 455 1,75 18,51 291 CTSD (4503143) cathepsin D preproprotein 2,05 1,41 1872 1,56 19,96 2698 TPP1 (5729770) tripeptidyl-peptidase I preproprotein 1,89 19,26 253 1,75 2,22 794 CTSB (4503139) cathepsin B preproprotein 1,80 2,19 5497 3,90 17,94 9705 FTL (20149498) ferritin, light polypeptide 1,63 6,58 1114 2,70 18,09 1979 HIBADH (23308751) 3-hydroxyisobutyrate dehydrogenase 1,62 1,80 392 1,79 14,59 896 PGRMC2 (5453916) progesterone receptor membrane component 2 1,62 6,92 1156 1,62 19,72 588 PGK1 (4505763) phosphoglycerate kinase 1 1,57 17,52 602 2,12 13,34 820 APRT (4502171) adenine phosphoribosyltransf isoform a 1,57 13,54 546 1,72 14,74 613 ARL8B (8922601) ADP-ribosylation factor-like 10C 1,56 16,48 2287 1,59 18,33 3688 CDC42 (4757952) cell division cycle 42 isoform 1 1,56 19,63 409 1,89 5,84 274 FTH1 (56682959) ferritin, heavy polypeptide 1 1,53 2,6 551 4,57 19,78 832 PKM (33286420) pyruvate kinase, muscle 1,54 4,02 9242 2,22 17,23 10223 CDC10 (148352329) cell division cycle 10 isoform 2 1,51 3,83 359 1,52 14,77 560 FLNA (116063573) filamin A, alpha isoform 1 1,52 5,13 12591 1,84 14,12 25719