REPISALUD es el REPositorio Institucional de SALUD del Instituto de Salud Carlos III (ISCIII) y sus Fundaciones, el Centro Nacional de Investigaciones Cardiovasculares (CNIC) y el Centro Nacional de Investigaciones Oncológicas (CNIO), en el que se recoge en un único archivo digital y de acceso libre, la producción científica y académica de estos centros de referencia en sus áreas.

Informes y estudios institucionales del ISCIII sobre COVID-19

Extracellular vesicles from Listeria monocytogenes-infected dendritic cells alert the innate immune response. 

Communication through cell-cell contacts and extracellular vesicles (EVs) enables immune cells to coordinate their responses against diverse types of pathogens. The function exerted by EVs in this context depends on the proteins and nucleic acids loaded into EVs, which elicit specific responses inv...

Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells. 

Alpha-2-macroglobulin (A2M) is a protease inhibitor that regulates extracellular matrix (ECM) stability and turnover. Here, we show that A2M is expressed by endothelial cells (ECs) from human eye choroid. We demonstrate that retinal pigment epithelium (RPE)-conditioned medium induces A2M expression...

Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy. 

Although genotyping allows family screening and influences risk-stratification in patients with nonischemic dilated cardiomyopathy (DCM) or isolated left ventricular systolic dysfunction (LVSD), its result is negative in a significant number of patients, limiting its widespread adoption. This stud...

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