REPISALUD es el REPositorio Institucional de SALUD del Instituto de Salud Carlos III (ISCIII) y sus Fundaciones, el Centro Nacional de Investigaciones Cardiovasculares (CNIC) y el Centro Nacional de Investigaciones Oncológicas (CNIO), en el que se recoge en un único archivo digital y de acceso libre, la producción científica y académica de estos centros de referencia en sus áreas.

Informes y estudios institucionales del ISCIII sobre COVID-19

Disruption of NIPBL/Scc2 in Cornelia de Lange Syndrome provokes cohesin genome-wide redistribution with an impact in the transcriptome. 

Cornelia de Lange syndrome (CdLS) is a rare disease affecting multiple organs and systems during development. Mutations in the cohesin loader, NIPBL/Scc2, were first described and are the most frequent in clinically diagnosed CdLS patients. The molecular mechanisms driving CdLS phenotypes are not u...

The role of Meis transcription factors in the epicardium 

A single layer of cells could be perceived as insignificant in comparison to a whole organ. However, extensive evidence has shown that the epicardium, the outermost layer of the heart, is essential for cardiac development and regeneration. Epicardium-derived cells (EPDCs) and epicardial signalling ...

miRNA dynamics in T cell activation 

MiRNA repertoire of T cells undergoes extensive changes in response to activation. Beyond a global decrease in miRNA levels few hours after activation, some individual miRNAs are specifically up-regulated or down-regulated. We have assessed miRNA expression and post-transcriptional modification kin...

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