Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/9945
Título
Lineage tracking of origin and fate of smooth muscle cells in atherosclerosis
Autor(es)
Bentzon, Jacob F CNIC | Majesky, Mark W
Fecha de publicación
2018-03
Cita
Cardiovasc Res. 2018; 114(4):492-500
Idioma
Inglés
Tipo de documento
journal article
Resumen
Advances in lineage-tracking techniques have provided new insights into the origins and fates of smooth muscle cells (SMCs) in atherosclerosis. Yet new tools present new challenges for data interpretation that require careful consideration of the strengths and weaknesses of the methods employed. At the same time, discoveries in other fields have introduced new perspectives on longstanding questions about steps in atherogenesis that remain poorly understood. In this article, we address both the challenges and opportunities for a better understanding of the mechanisms by which cells appearing as or deriving from SMCs accumulate in atherosclerosis.
MESH
Actins | Animals | Atherosclerosis | Biomarkers | Gene Expression Regulation, Developmental | Humans | Muscle, Smooth, Vascular | Myocytes, Smooth Muscle | Neovascularization, Physiologic | Phenotype | Signal Transduction | Cell Differentiation | Cell Lineage
Versión en línea
DOI
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