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Título
Amino acid biosynthetic pathways as antifungal targets for fungal infections
Autor(es)
Alcazar-Fuoli, Laura ISCIII
Fecha de publicación
2016
Cita
Virulence. 2016 May 18;7(4):376-8.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Aspergillus fumigatus is an opportunistic pathogen and ubiquitous in the environment. In humans,
A. fumigatus can cause a wide range of infections whose symptoms are directly determined by the immunological status of the host.
1 Superficial infections are related to local trauma or overgrowth of the fungus in burns; under
occlusive dressings; after corneal trauma (keratitis); or in
the sinuses, mouth, nose, or ear canal. Allergic forms of
the diseases are caused by an exaggerated response of the
immune system to colonization of the airways with
Aspergillus
. In addition, invasive aspergillosis (IA), usu-
ally acquired through inhalation of conidia and further
fungal growth in the lung, is a systemic infection that
affects immunosuppressed patients. IA represents one of
the main cause of morbidity and mortality for infection
complications in patients with hematological malignan-
cies, hemopoietic stem cell and solid organ recipients
and patients with other immunodeficiencies.
MESH
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DOI
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