Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8330
Título
Downregulation of mTOR Signaling Increases Stem Cell Population Telomere Length during Starvation of Immortal Planarians
Autor(es)
Fecha de publicación
2019-08
Cita
Stem Cell Reports. 2019; 13(2):405-18
Idioma
Inglés
Tipo de documento
journal article
Resumen
Reduction of caloric intake delays and prevents age-associated diseases and extends the life span in many organisms. It may be that these benefits are due to positive effects of caloric restriction on stem cell function. We use the planarian model Schmidtea mediterranea, an immortal animal that adapts to long periods of starvation by shrinking in size, to investigate the effects of starvation on telomere length. We show that the longest telomeres are a general signature of planarian adult stem cells. We also observe that starvation leads to an enrichment of stem cells with the longest telomeres and that this enrichment is dependent on mTOR signaling. We propose that one important effect of starvation for the rejuvenation of the adult stem cell pool is through increasing the median telomere length in somatic stem cells. Such a mechanism has broad implications for how dietary effects on aging are mediated at the whole-organism level.
Palabras clave
SMG-1 | Aging | Fasting | Immortal | mTOR | Neoblast | Planarian | Starvation | Stem cell | Telomere
Versión en línea
DOI
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