Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7900
Título
CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response
Autor(es)
Galindo-Albarrán, Ariel O | López-Portales, Oscar H | Gutiérrez-Reyna, Darely Y | Rodríguez-Jorge, Otoniel | Sánchez-Villanueva, José Antonio | Ramírez-Pliego, Oscar | Bergon, Aurélie | Loriod, Béatrice | Holota, Hélène | Imbert, Jean | Hernández-Mendoza, Armando | Ferrier, Pierre | Carrillo-de Santa Pau, Enrique | Valencia, Alfonso CNIO | Spicuglia, Salvatore | Santana, M Angélica
Fecha de publicación
2016-11-15
Cita
Cell Rep. 2016;17(8):2151-2160.
Idioma
Inglés
Tipo de documento
journal article
Resumen
To better understand why human neonates show a poor response to intracellular pathogens, we compared gene expression and histone modification profiles of neonatal naive CD8+ T cells with that of their adult counterparts. We found that neonatal lymphocytes have a distinct epigenomic landscape associated with a lower expression of genes involved in T cell receptor (TCR) signaling and cytotoxicity and a higher expression of genes involved in the cell cycle and innate immunity. Functional studies corroborated that neonatal CD8+ T cells are less cytotoxic, transcribe antimicrobial peptides, and produce reactive oxygen species. Altogether, our results show that neonatal CD8+ T cells have a specific genetic program biased toward the innate immune response. These findings will contribute to better diagnosis and management of the neonatal immune response.
Palabras clave
MESH
Adult | CD8-Positive T-Lymphocytes | Cytotoxicity, Immunologic | Epigenesis, Genetic | Gene Expression Profiling | Gene Expression Regulation, Developmental | Humans | Immunity, Innate | Infant, Newborn | Transcription Factors
Versión en línea
DOI
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