Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/11791
Título
Serum lipid profile in subjects with traumatic spinal cord injury
Autor(es)
Laclaustra, Martin CNIC | Van Den Berg, Elizabeth Louise Maayken | Hurtado-Roca, Yamilee CNIC | Castellote, Juan Manuel ISCIII
Fecha de publicación
2015
Cita
PLoS One. 2015 Feb 23;10(2):e0115522.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Few large studies have examined the relationship between spinal cord injury (SCI) and lipid profile. We studied serum lipid concentrations in subjects with traumatic SCI in relation to the degree of neurological involvement and time since injury, and compared them with values from a reference sample for the Spanish population (DRECE study).
A retrospective cohort was built from 177 consecutive cases with traumatic SCI admitted to the SCI unit of the Miguel Servet Hospital in Aragon (Spain). Outcome measures (cholesterol, triglycerides, HDL-c and LDL-c levels) were analyzed according to the ASIA Impairment Scale (AIS), neurological level of injury (involvement of all limbs vs. only lower limbs), and time since injury. All analyses were adjusted for age and sex.
Cases without preserved motor function (AIS A or B) had lower total and HDL cholesterol than the others (-11.4 [-21.5, -1.4] mg/dL total cholesterol and -5.1 [-8.8, -1.4] mg/dL HDL-c), and cases with all-limb involvement had lower total, HDL, and LDL cholesterol than those with only lower-limb involvement (-14.0 [-24.6, -3.4] mg/dL total cholesterol, -4.1 [-8.0, -0.2] mg/dL HDL-c, and -10.0 [-19.7, -0.3] mg/dL LDL-c) (all p<0.05). No association was found between lipid concentrations and time since injury. Concentrations of lipid subfractions and triglycerides in SCI subjects were lower than in sex- and age-stratified values from the reference sample.
A high degree of neurological involvement in SCI (anatomically higher lesions and AIS A or B) is associated with lower total cholesterol and HDL-c.
MESH
Adolescent | Adult | Cholesterol, HDL | Cholesterol, LDL | Female | Humans | Male | Middle Aged | Retrospective Studies | Spinal Cord Injuries | Triglycerides | Young Adult
Versión en línea
DOI
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